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List of works by Gerald I. Shulman

13C NMR isotopomer analysis of anaplerotic pathways in INS-1 cells

scientific article published on 9 August 2004

13C and 31P NMR studies on the effects of increased plasma free fatty acids on intramuscular glucose metabolism in the awake rat

scientific article published on 01 April 1997

13C/31P NMR studies on the mechanism of insulin resistance in obesity ⬇️

scientific article published on March 1, 1998

A Membrane-Bound Diacylglycerol Species Induces PKCϵ-Mediated Hepatic Insulin Resistance

scientific article published on 26 August 2020

A Non-invasive Method to Assess Hepatic Acetyl-CoA In Vivo

scientific article published on 18 January 2017

A Role of the Inflammasome in the Low Storage Capacity of the Abdominal Subcutaneous Adipose Tissue in Obese Adolescents

scientific article published on 30 December 2015

A cluster of metabolic defects caused by mutation in a mitochondrial tRNA.

scientific article

A common variant in the patatin-like phospholipase 3 gene (PNPLA3) is associated with fatty liver disease in obese children and adolescents

scientific article published on October 2010

A comparison of (13)C NMR measurements of the rates of glutamine synthesis and the tricarboxylic acid cycle during oral and intravenous administration of [1-(13)C]glucose

scientific article

A controlled-release mitochondrial protonophore reverses hypertriglyceridemia, nonalcoholic steatohepatitis, and diabetes in lipodystrophic mice

scientific article published on 22 March 2017

A critical evaluation of mass isotopomer distribution analysis of gluconeogenesis in vivo

scientific article published on 01 July 1999

A feed-forward regulatory loop in adipose tissue promotes signaling by the hepatokine FGF21

scientific article published on 17 December 2020

A guide to analysis of mouse energy metabolism

scientific article published on 28 December 2011

A high-fat, ketogenic diet causes hepatic insulin resistance in mice, despite increasing energy expenditure and preventing weight gain

scientific article

A novel13C NMR method to assess intracellular glucose concentration in muscle, in vivo ⬇️

scientific article published on February 1, 1998

A prevalent variant in PPP1R3A impairs glycogen synthesis and reduces muscle glycogen content in humans and mice

scientific article

A role for mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M) in the regulation of hepatic gluconeogenesis

scientific article published on 04 February 2014

A β-peptide agonist of the GLP-1 receptor, a class B GPCR.

scientific article

AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation

scientific article

AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia.

scientific article published on 30 December 2015

Ablation of PRDM16 and beige adipose causes metabolic dysfunction and a subcutaneous to visceral fat switch.

scientific article published on January 2014

Abnormal glucose homeostasis in skeletal muscle-specific PGC-1alpha knockout mice reveals skeletal muscle-pancreatic beta cell crosstalk

scientific article

Absence of ANGPTL4 in adipose tissue improves glucose tolerance and attenuates atherogenesis.

scientific article published on 22 March 2018

Absence of Carbohydrate Response Element Binding Protein in Adipocytes Causes Systemic Insulin Resistance and Impairs Glucose Transport

scientific article

Acetate mediates a microbiome-brain-β-cell axis to promote metabolic syndrome

scientific journal article

Acetyl-CoA Carboxylase Inhibition Reverses NAFLD and Hepatic Insulin Resistance but Promotes Hypertriglyceridemia in Rodents.

scientific article

Acetylation of TUG protein promotes the accumulation of GLUT4 glucose transporters in an insulin-responsive intracellular compartment

scientific article

Activation of the farnesoid X receptor improves lipid metabolism in combined hyperlipidemic hamsters

scientific article

AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency

scientific article

Additive effects of hyperinsulinemia and ischemia on myocardial GLUT1 and GLUT4 translocation in vivo

scientific article published on 01 November 1998

Adipocyte JAK2 Regulates Hepatic Insulin Sensitivity Independently of Body Composition, Liver Lipid Content, and Hepatic Insulin Signaling

scientific article

Adipocyte JAK2 mediates growth hormone-induced hepatic insulin resistance

scientific article published on 09 February 2017

Adipocyte-specific overexpression of FOXC2 prevents diet-induced increases in intramuscular fatty acyl CoA and insulin resistance

scientific article published in June 2005

Adipose glucocorticoid action influences whole-body metabolism via modulation of hepatic insulin action

scientific article published on 28 March 2019

Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity

scientific article published on 09 January 2009

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

scientific article (publication date: 8 February 2001)

Adipsin preserves beta cells in diabetic mice and associates with protection from type 2 diabetes in humans

scientific article published on 07 November 2019

Adrenalectomy improves diabetes in A-ZIP/F-1 lipoatrophic mice by increasing both liver and muscle insulin sensitivity

scientific article published in July 2002

Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis

scientific article published in February 2007

Akt2 is required for hepatic lipid accumulation in models of insulin resistance.

scientific article

Alterations in postprandial hepatic glycogen metabolism in type 2 diabetes

scientific article published in December 2004

Altered In Vivo Lipid Fluxes and Cell Dynamics in Subcutaneous Adipose Tissues Are Associated With the Unfavorable Pattern of Fat Distribution in Obese Adolescent Girls

scientific article published on 01 April 2019

Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy

scientific article

An ERK/Cdk5 axis controls the diabetogenic actions of PPARγ.

scientific article

Angptl8 antisense oligonucleotide improves adipose lipid metabolism and prevents diet-induced NAFLD and hepatic insulin resistance in rodents

scientific article published in March 2018

Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells and Stat3 signaling in obese animals

scientific article published on 31 December 2006

Anti-inflammatory effects of oestrogen mediate the sexual dimorphic response to lipid-induced insulin resistance

scientific article published on 04 July 2019

Anti-myostatin antibody increases muscle mass and strength and improves insulin sensitivity in old mice

scientific article published on 8 February 2016

Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation

scientific article

ApoA5 knockdown improves whole-body insulin sensitivity in high-fat-fed mice by reducing ectopic lipid content.

scientific article

Apolipoprotein C3 gene variants in nonalcoholic fatty liver disease

scientific article

Apolipoprotein CIII overexpressing mice are predisposed to diet-induced hepatic steatosis and hepatic insulin resistance

scientific article

Argininosuccinate synthetase regulates hepatic AMPK linking protein catabolism and ureagenesis to hepatic lipid metabolism

scientific article published on 31 May 2016

Assessment of Hepatic Mitochondrial Oxidation and Pyruvate Cycling in NAFLD by (13)C Magnetic Resonance Spectroscopy

scientific article published on July 2016

Assessment of in vivo mitochondrial metabolism by magnetic resonance spectroscopy

scientific article

Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity

scientific article published in April 2002

Astroglial contribution to brain energy metabolism in humans revealed by 13C nuclear magnetic resonance spectroscopy: elucidation of the dominant pathway for neurotransmitter glutamate repletion and measurement of astrocytic oxidative metabolism

scientific article

Author Correction: Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo

scientific article published on 01 March 2019

Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight

scientific article published on 28 January 2008

CD301b(+) Mononuclear Phagocytes Maintain Positive Energy Balance through Secretion of Resistin-like Molecule Alpha

scientific article published on 23 August 2016

CGI-58 knockdown in mice causes hepatic steatosis but prevents diet-induced obesity and glucose intolerance

scientific article

CGI-58 knockdown sequesters diacylglycerols in lipid droplets/ER-preventing diacylglycerol-mediated hepatic insulin resistance

scientific article published on 9 January 2013

Cellular mechanism by which estradiol protects female ovariectomized mice from high-fat diet-induced hepatic and muscle insulin resistance

scientific article published on 30 January 2013

Cellular mechanism of insulin resistance in nonalcoholic fatty liver disease

scientific article

Cellular mechanism of insulin resistance in skeletal muscle.

scientific article published in January 2002

Cellular mechanism of insulin resistance: potential links with inflammation

scientific article published on 01 December 2003

Cellular mechanisms by which FGF21 improves insulin sensitivity in male mice

scientific article

Cellularity and adipogenic profile of the abdominal subcutaneous adipose tissue from obese adolescents: association with insulin resistance and hepatic steatosis

scientific article

Central adiposity and its metabolic correlates in obese adolescent girls.

scientific article published in July 1995

Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis

scientific article

Cerebral lactate turnover after electroshock: in vivo measurements by 1H/13C magnetic resonance spectroscopy

scientific article published on November 1, 1992

Characterization of the hyperphagic response to dietary fat in the MC4R knockout mouse.

scientific article

Chemical and genetic evidence for the involvement of Wnt antagonist Dickkopf2 in regulation of glucose metabolism.

scientific article

Chronic activation of AMP kinase results in NRF-1 activation and mitochondrial biogenesis

scientific article

Chylomicron- and VLDL-derived lipids enter the heart through different pathways: in vivo evidence for receptor- and non-receptor-mediated fatty acid uptake

scientific article

Comparative MR study of hepatic fat quantification using single-voxel proton spectroscopy, two-point dixon and three-point IDEAL.

scientific article

Comparative effects of monomethylsuccinate and glucose on insulin secretion from perifused rat islets.

scientific article

Continuous fat oxidation in acetyl-CoA carboxylase 2 knockout mice increases total energy expenditure, reduces fat mass, and improves insulin sensitivity

scholarly article

Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo.

scientific article published in December 2000

Contrasting effects of fish oil and safflower oil on hepatic peroxisomal and tissue lipid content

scientific article

Contribution of hepatic glycogenolysis to glucose production in humans in response to a physiological increase in plasma glucagon concentration

scientific article published on 01 February 1995

Contribution of net hepatic glycogen synthesis to disposal of an oral glucose load in humans.

scientific article published in May 2001

Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period

scientific article published on 01 January 1996

Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis.

scientific article

Controlled-release mitochondrial protonophore (CRMP) reverses dyslipidemia and hepatic steatosis in dysmetabolic nonhuman primates

scientific article published on 01 October 2019

Controlled-release mitochondrial protonophore reverses diabetes and steatohepatitis in rats

scientific article

Correction: A Prevalent Variant in PPP1R3A Impairs Glycogen Synthesis and Reduces Muscle Glycogen Content in Humans and Mice.

scientific article published on 23 December 2008

Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression

scientific article

Cytosolic and mitochondrial malic enzyme isoforms differentially control insulin secretion

scientific article

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop

Decreased insulin-stimulated ATP synthesis and phosphate transport in muscle of insulin-resistant offspring of type 2 diabetic parents

scientific article

Decreased transcription of ChREBP-α/β isoforms in abdominal subcutaneous adipose tissue of obese adolescents with prediabetes or early type 2 diabetes: associations with insulin resistance and hyperglycemia

scientific article published on 3 December 2012

Defective activation of skeletal muscle and adipose tissue lipolysis in type 1 diabetes mellitus during hypoglycemia

scientific article published in April 2003

Defective fatty acid oxidation in mice with muscle-specific acyl-CoA synthetase 1 deficiency increases amino acid use and impairs muscle function

scientific article published on 11 April 2019

Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice

scientific article (publication date: October 2004)

Dehydration and insulinopenia are necessary and sufficient for euglycemic ketoacidosis in SGLT2 inhibitor-treated rats

scientific article published in Nature Communications

Deletion of the Mammalian INDY Homolog Mimics Aspects of Dietary Restriction and Protects against Adiposity and Insulin Resistance in Mice

scholarly article by Andreas L. Birkenfeld et al published October 2011 in Cell Metabolism

Deletion of the alpha-arrestin protein Txnip in mice promotes adiposity and adipogenesis while preserving insulin sensitivity ⬇️

scientific article

Deletion of the diabetes candidate gene Slc16a13 in mice attenuates diet-induced ectopic lipid accumulation and insulin resistance

scientific article published on 01 July 2021

Deletion of the mammalian INDY homolog mimics aspects of dietary restriction and protects against adiposity and insulin resistance in mice

scientific article

Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype

scientific article

Development of insulin resistance in mice lacking PGC-1α in adipose tissues.

scientific article

Diabetes in mice with selective impairment of insulin action in Glut4-expressing tissues

scientific article

Diacylglycerol activation of protein kinase Cε and hepatic insulin resistance

scientific article

Diacylglycerol-mediated insulin resistance

scientific article

Differential effect of hyperglycemia and hyperinsulinemia on pathways of hepatic glycogen repletion

scientific article published on 01 May 1991

Differential effects of rosiglitazone on skeletal muscle and liver insulin resistance in A-ZIP/F-1 fatless mice

scientific article published in June 2003

Differential effects of safflower oil versus fish oil feeding on insulin-stimulated glycogen synthesis, glycolysis, and pyruvate dehydrogenase flux in skeletal muscle: a 13C nuclear magnetic resonance study.

scientific article

Differential time course of glucagon's effect on glycogenolysis and gluconeogenesis in the conscious dog

scientific article published on 01 March 1981

Direct assessment of hepatic mitochondrial oxidative and anaplerotic fluxes in humans using dynamic 13C magnetic resonance spectroscopy

scientific article published on 08 December 2013

Direct assessment of liver glycogen storage by 13C nuclear magnetic resonance spectroscopy and regulation of glucose homeostasis after a mixed meal in normal subjects.

scientific article published on January 1996

Disordered lipid metabolism and the pathogenesis of insulin resistance

scientific article

Disruption of Adipose Rab10-Dependent Insulin Signaling Causes Hepatic Insulin Resistance.

scientific article

Disruption of IRS-2 causes type 2 diabetes in mice

scientific article

Disruption of neural signal transducer and activator of transcription 3 causes obesity, diabetes, infertility, and thermal dysregulation

scientific journal article

Dissociation of Muscle Insulin Resistance from Alterations in Mitochondrial Substrate Preference

scientific article published on 06 October 2020

Dissociation of inositol-requiring enzyme (IRE1α)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice

scientific article published on 28 November 2011

Dissociation of the glucose and lipid regulatory functions of FoxO1 by targeted knockin of acetylation-defective alleles in mice

scientific article published on November 2011

Downregulation of ADIPOQ and PPARγ2 gene expression in subcutaneous adipose tissue of obese adolescents with hepatic steatosis

scientific article published on 18 February 2010

Dual role of proapoptotic BAD in insulin secretion and beta cell survival

scientific journal article

Early life exposure to maternal insulin resistance has persistent effects on hepatic NAFLD in juvenile nonhuman primates

scientific article

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

scientific article published on 01 December 2014

Ectopic fat in insulin resistance, dyslipidemia, and cardiometabolic disease

scientific article published on September 2014

Ectopic lipid deposition mediates insulin resistance in adipose specific 11β-hydroxysteroid dehydrogenase type 1 transgenic mice

scientific article published on 19 December 2018

Effect of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside infusion on in vivo glucose and lipid metabolism in lean and obese Zucker rats.

scientific article

Effect of AMPK activation on muscle glucose metabolism in conscious rats

scientific article published on 01 May 1999

Effect of a sustained reduction in plasma free fatty acid concentration on intramuscular long-chain fatty Acyl-CoAs and insulin action in type 2 diabetic patients

scientific article

Effect of aging on muscle mitochondrial substrate utilization in humans

scientific article

Effect of chronic hyperglycemia on in vivo insulin secretion in partially pancreatectomized rats.

scientific article published on October 1987

Effect of dietary protein on in vivo insulin action and liver glycogen repletion.

scientific article published in August 1989

Effect of epinephrine on muscle glycogenolysis and insulin-stimulated muscle glycogen synthesis in humans

scientific article published on 01 January 1998

Effect of glucose, independent of changes in insulin and glucagon secretion, on alanine metabolism in the conscious dog.

scientific article published on February 1980

Effect of hepatic nerves on disposition of an intraduodenal glucose load

scientific article published on 01 September 1993

Effect of hyperglycemia independent of changes in insulin or glucagon on lipolysis in the conscious dog

scientific article published on 01 April 1980

Effect of insulin on glycerol production in obese adolescents ⬇️

scientific article published on April 1, 1998

Effect of triiodothyronine on mitochondrial energy coupling in human skeletal muscle

scientific article

Effect of weight loss on insulin sensitivity and intramuscular long-chain fatty acyl-CoAs in morbidly obese subjects

scientific article published in October 2002

Effects of a novel glycogen synthase kinase-3 inhibitor on insulin-stimulated glucose metabolism in Zucker diabetic fatty (fa/fa) rats

scientific article published in October 2002

Effects of caffeine on muscle glycogen utilization and the neuroendocrine axis during exercise

scientific article published on 01 June 2000

Effects of depletion exercise and light training on muscle glycogen supercompensation in men

scientific article

Effects of free fatty acid elevation on postabsorptive endogenous glucose production and gluconeogenesis in humans.

scientific article published in May 2000

Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity

scientific article

Effects of insulin-like growth factor I on glucose metabolism in rats with liver cirrhosis

scientific article published in December 1997

Effects of pioglitazone on intramyocellular fat metabolism in patients with type 2 diabetes mellitus

scientific article

Effects of rexinoids on glucose transport and insulin-mediated signaling in skeletal muscles of diabetic (db/db) mice

scientific article published on 2 March 2004

Efficacy and Metabolic Effects of Metformin and Troglitazone in Type II Diabetes Mellitus ⬇️

scientific article published on March 26, 1998

Elevated hepatic expression of H19 long noncoding RNA contributes to diabetic hyperglycemia.

scientific article published on 17 May 2018

Enhanced fasting glucose turnover in mice with disrupted action of TUG protein in skeletal muscle

scientific article published on 06 June 2013

Enhancement of the gluconeogenic flux of hepatic glycogen repletion by a phenacyl imidazolium compound in vivo

scientific article published on 01 January 1993

Etiology of insulin resistance

scientific article

FGF1 and FGF19 reverse diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article published on 28 April 2015

FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis

scientific article

Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes

scholarly article

Fatty acid amide hydrolase ablation promotes ectopic lipid storage and insulin resistance due to centrally mediated hypothyroidism.

scientific article

Fatty acid infusion selectively impairs insulin action on Akt1 and protein kinase C lambda /zeta but not on glycogen synthase kinase-3.

scientific article published on 2 July 2002

Fish oil regulates adiponectin secretion by a peroxisome proliferator-activated receptor-gamma-dependent mechanism in mice

scientific article published on 01 April 2006

Fish oil selectively improves heart function in a mouse model of lipid-induced cardiomyopathy

scientific article published on April 2013

Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade

scientific article published on 01 June 1999

Free fatty acids in obesity and type 2 diabetes: defining their role in the development of insulin resistance and beta-cell dysfunction.

scientific article

GPA protects the nigrostriatal dopamine system by enhancing mitochondrial function

scientific article

Gene knockout of Acc2 has little effect on body weight, fat mass, or food intake

scientific article

Genetic Ablation of miR-33 Increases Food Intake, Enhances Adipose Tissue Expansion, and Promotes Obesity and Insulin Resistance

scientific article published in February 2018

Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.

scientific article

Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity

scientific article published in October 2003

Glucagon stimulates gluconeogenesis by INSP3R1-mediated hepatic lipolysis

scientific article published on 04 March 2020

Glucose metabolism distal to a critical coronary stenosis in a canine model of low-flow myocardial ischemia

scientific article published on July 1996

Glucose plus insulin regulate fat oxidation by controlling the rate of fatty acid entry into the mitochondria.

scientific article

Glucose toxicity and the development of diabetes in mice with muscle-specific inactivation of GLUT4

scientific article

Glycerol-3-phosphate acyltransferase 1 deficiency in ob/ob mice diminishes hepatic steatosis but does not protect against insulin resistance or obesity

scientific article

Glycogen loading alters muscle glycogen resynthesis after exercise

scientific article published on 01 February 2000

Hepatic Diacylglycerol-Associated Protein Kinase Cε Translocation Links Hepatic Steatosis to Hepatic Insulin Resistance in Humans

scientific article

Hepatic Hdac3 promotes gluconeogenesis by repressing lipid synthesis and sequestration

scientific article

Hepatic Inositol 1,4,5 Trisphosphate Receptor Type 1 Mediates Fatty Liver.

scientific article published on 11 November 2016

Hepatic Insulin Resistance Is Not Pathway Selective in Humans With Nonalcoholic Fatty Liver Disease

scientific article published on 08 December 2020

Hepatic acetyl CoA links adipose tissue inflammation to hepatic insulin resistance and type 2 diabetes

scientific article published on 5 February 2015

Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

scientific article published on 8 February 2004

Hepatic glycogen metabolism in type 1 diabetes after long-term near normoglycemia.

scientific article published in January 2002

Hepatic insulin resistance in mice with hepatic overexpression of diacylglycerol acyltransferase 2

scientific article

Hepatic mitogen-activated protein kinase phosphatase 1 selectively regulates glucose metabolism and energy homeostasis

scientific article

Hepatic overexpression of glycerol-sn-3-phosphate acyltransferase 1 in rats causes insulin resistance

scientific article

Hormone-sensitive lipase knockout mice have increased hepatic insulin sensitivity and are protected from short-term diet-induced insulin resistance in skeletal muscle and heart

scientific article published on 8 February 2005

Hyperglucagonemia precedes a decline in insulin secretion and causes hyperglycemia in chronically glucose-infused rats

scientific article published on 23 August 2011

Hypomorphic mutation of PGC-1beta causes mitochondrial dysfunction and liver insulin resistance

scientific article published on December 2006

Hypophosphatemia promotes lower rates of muscle ATP synthesis

scientific article published on 23 June 2016

Hypopituitarism associated with a hypothalamic CMV infection in a patient with AIDS

scientific article published on 01 February 1992

Imeglimin lowers glucose primarily by amplifying glucose-stimulated insulin secretion in high-fat-fed rodents

scientific article published on 12 July 2016

Immunocytochemical localization of alpha-protein kinase C in rat pancreatic beta-cells during glucose-induced insulin secretion ⬇️

scientific article published on October 1, 1992

Immunoneutralization of endogenous glucagon reduces hepatic glucose output and improves long-term glycemic control in diabetic ob/ob mice

scientific article published in October 2006

Impact of CD1d deficiency on metabolism.

scientific article

Impaired insulin sensitivity among nondiabetic patients with a recent TIA or ischemic stroke ⬇️

scientific article published on May 13, 2003

Impaired mitochondrial substrate oxidation in muscle of insulin-resistant offspring of type 2 diabetic patients

scientific article

Impairment of insulin-stimulated glucose transport and ERK activation by adipocyte-specific knockout of PKC-λ produces a phenotype characterized by diminished adiposity and enhanced insulin suppression of hepatic gluconeogenesis

scientific article published on 10 September 2013

Implantable insulin infusion devices

scientific article published on 01 November 1982

In vivo NMR investigation of intramuscular glucose metabolism in conscious rats

scientific article published on 01 July 1997

In vivo studies on the mechanism of methylene cyclopropyl acetic acid and methylene cyclopropyl glycine-induced hypoglycemia

scientific article published on 26 February 2018

Inactivation of fatty acid transport protein 1 prevents fat-induced insulin resistance in skeletal muscle

scientific journal article

Inclusion of low amounts of fructose with an intraduodenal glucose load markedly reduces postprandial hyperglycemia and hyperinsulinemia in the conscious dog.

scientific article published in February 2002

Increased brain lactate concentrations without increased lactate oxidation during hypoglycemia in type 1 diabetic individuals

scientific article published on 28 May 2013

Increased brain monocarboxylic acid transport and utilization in type 1 diabetes

scientific article

Increased energy expenditure and insulin sensitivity in the high bone mass DeltaFosB transgenic mice.

scientific article published on 04 September 2008

Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice

scientific article published in August 2000

Increased glucose transport-phosphorylation and muscle glycogen synthesis after exercise training in insulin-resistant subjects

scientific article published on 01 October 1996

Increased prevalence of insulin resistance and nonalcoholic fatty liver disease in Asian-Indian men.

scholarly article

Increased substrate oxidation and mitochondrial uncoupling in skeletal muscle of endurance-trained individuals

scholarly article

Indy knockdown in mice mimics elements of dietary restriction

scientific article published on August 2011

Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity

scientific journal article

Influence of the hepatic eukaryotic initiation factor 2alpha (eIF2alpha) endoplasmic reticulum (ER) stress response pathway on insulin-mediated ER stress and hepatic and peripheral glucose metabolism

scientific article

Influence of the route of glucose administration on hepatic glycogen repletion

scientific article published on 01 November 1989

Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner

scientific article

Inhibition of protein kinase Cepsilon prevents hepatic insulin resistance in nonalcoholic fatty liver disease

scientific journal article

Inhibitory effect of pregnancy on counterregulatory hormone responses to hypoglycemia in awake rat.

scientific article published in October 1993

Inositol 1,4,5-trisphosphate receptor type II (InsP3R-II) is reduced in obese mice, but metabolic homeostasis is preserved in mice lacking InsP3R-II.

scientific article

Insulin receptor Thr1160 phosphorylation mediates lipid-induced hepatic insulin resistance

scientific article

Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta)

scientific article (publication date: June 2001)

Insulin resistance in tetracycline-repressible Munc18c transgenic mice

scientific article published in August 2003

Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids.

scientific article

Insulin-stimulated tyrosine protein kinase. Characterization and relation to the insulin receptor

scientific article published on 01 April 1984

Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways

scientific article

Intense exercise stimulates albumin synthesis in the upright posture

scientific article published on 01 January 2000

Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents

scientific article

Intramuscular glycogen and intramyocellular lipid utilization during prolonged exercise and recovery in man: a 13C and 1H nuclear magnetic resonance spectroscopy study

scientific article published on 01 February 2000

Intramyocellular lipid concentrations are correlated with insulin sensitivity in humans: a 1H NMR spectroscopy study.

scientific article published in January 1999

Knockdown of the gene encoding Drosophila tribbles homologue 3 (Trib3) improves insulin sensitivity through peroxisome proliferator-activated receptor-γ (PPAR-γ) activation in a rat model of insulin resistance ⬇️

scientific article published on December 29, 2010

Lacteal junction zippering protects against diet-induced obesity.

scientific article published in August 2018

Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation

scientific article published on 29 December 2017

Leptin mediates postprandial increases in body temperature through hypothalamus-adrenal medulla-adipose tissue crosstalk

scientific article published on 01 April 2020

Leptin reverses diabetes by suppression of the hypothalamic-pituitary-adrenal axis

scientific article

Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy

scientific article

Lipid metabolism and adipokine levels in fatty acid-binding protein null and transgenic mice

scientific article

Lipid-dependent control of hepatic glycogen stores in healthy humans.

scientific article

Lipid-induced hepatic insulin resistance

scientific article published on August 2013

Lipid-induced insulin resistance: unravelling the mechanism

scientific article

Liver fatty acid binding protein is required for high rates of hepatic fatty acid oxidation but not for the action of PPARalpha in fasting mice

scientific article

Liver-specific loss of long chain acyl-CoA synthetase-1 decreases triacylglycerol synthesis and beta-oxidation and alters phospholipid fatty acid composition

scientific article published on August 2009

Local lactate perfusion of the ventromedial hypothalamus suppresses hypoglycemic counterregulation

scientific article published in March 2003

Local ventromedial hypothalamus glucopenia triggers counterregulatory hormone release

scientific article published on 01 February 1995

Local ventromedial hypothalamus glucose perfusion blocks counterregulation during systemic hypoglycemia in awake rats.

scientific article

Loss of Nucleobindin-2 Causes Insulin Resistance in Obesity without Impacting Satiety or Adiposity

scientific article published on 01 July 2018

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

scientific article published on 17 January 2017

Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction

scientific article published on 01 July 2000

Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo

scholarly article

Low adiponectin levels in adolescent obesity: a marker of increased intramyocellular lipid accumulation

scientific article published in May 2003

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure

scientific article published on 9 January 2012

Low-flow ischemia leads to translocation of canine heart GLUT-4 and GLUT-1 glucose transporters to the sarcolemma in vivo

scientific article published on 01 January 1997

Lysophosphatidic acid activates peroxisome proliferator activated receptor-γ in CHO cells that over-express glycerol 3-phosphate acyltransferase-1

scientific article (publication date: 20 April 2011)

MAPK phosphatase-1 facilitates the loss of oxidative myofibers associated with obesity in mice

scientific article published on 16 November 2009

MARCH1 regulates insulin sensitivity by controlling cell surface insulin receptor levels.

scientific article published on 31 August 2016

MMAB promotes negative feedback control of cholesterol homeostasis

scientific article published on 08 November 2021

Macrophage-specific de Novo Synthesis of Ceramide Is Dispensable for Inflammasome-driven Inflammation and Insulin Resistance in Obesity

scientific article

Magnetic resonance spectroscopy studies of human metabolism

scientific article

Mass and positional isotopomer analysis of glucose metabolism in periportal and pericentral hepatocytes.

scientific article published in November 1995

Measurements of the anaplerotic rate in the human cerebral cortex using 13C magnetic resonance spectroscopy and [1-13C] and [2-13C] glucose

scientific article

Mechanism by Which Caloric Restriction Improves Insulin Sensitivity in Sedentary Obese Adults

scientific article

Mechanism by which arylamine N-acetyltransferase 1 ablation causes insulin resistance in mice ⬇️

scientific article published on 13 December 2017

Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle

scientific article

Mechanism by which glucose and insulin inhibit net hepatic glycogenolysis in humans ⬇️

scientific article published on March 15, 1998

Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes

scientific article (publication date: May 2002)

Mechanism for leptin's acute insulin-independent effect to reverse diabetic ketoacidosis

scientific article published on 23 January 2017

Mechanism of free fatty acid-induced insulin resistance in humans

scientific article

Mechanism of glucose intolerance in mice with dominant negative mutation of CEACAM1.

scientific article

Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease.

scientific article published on 27 May 2004

Mechanism of insulin resistance in A-ZIP/F-1 fatless mice

scientific article published on 01 March 2000

Mechanism of muscle glycogen autoregulation in humans.

scientific article

Mechanism of troglitazone action in type 2 diabetes

scientific article published on 01 May 2000

Mechanisms by which a Very-Low-Calorie Diet Reverses Hyperglycemia in a Rat Model of Type 2 Diabetes

scientific article

Mechanisms for insulin resistance: common threads and missing links

scientific article (publication date: 2 March 2012)

Mechanisms of Insulin Action and Insulin Resistance

scientific article published on 01 October 2018

Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver

scientific article

Mechanisms of insulin resistance in humans and possible links with inflammation

scientific article

Mechanisms underlying the onset of oral lipid-induced skeletal muscle insulin resistance in humans

scientific article published on March 2013

Membrane bound diacylglycerols explain the dissociation of hepatic insulin resistance from steatosis in MTTP-/- mice

scientific article published on 09 September 2020

Metabolic control analysis of hepatic glycogen synthesis in vivo

scientific article published on 18 March 2020

Metabolic control analysis of insulin-stimulated glucose disposal in rat skeletal muscle.

scientific article published on September 1999

Metabolic defects in lean nondiabetic offspring of NIDDM parents: a cross-sectional study.

scientific article published in June 1997

Metabolic effects of IGF-I and insulin in spontaneously diabetic BB/w rats

scientific article published on 01 February 1991

Metformin inhibits gluconeogenesis via a redox-dependent mechanism in vivo.

scientific article

Metformin suppresses gluconeogenesis by inhibiting mitochondrial glycerophosphate dehydrogenase

scientific article

Mice lacking MAP kinase phosphatase-1 have enhanced MAP kinase activity and resistance to diet-induced obesity

scientific article

Mitochondrial Dysfunction, Insulin Resistance, and Potential Genetic Implications

scientific article published on 01 April 2020

Mitochondrial GTP insensitivity contributes to hypoglycemia in hyperinsulinemia hyperammonemia by inhibiting glucagon release

scientific article

Mitochondrial GTP regulates glucose-stimulated insulin secretion

scientific journal article

Mitochondrial dysfunction and type 2 diabetes

scientific article (publication date: 21 January 2005)

Mitochondrial dysfunction contributes to impaired insulin secretion in INS-1 cells with dominant-negative mutations of HNF-1alpha and in HNF-1alpha-deficient islets.

scientific article published on 17 April 2009

Mitochondrial dysfunction due to long-chain Acyl-CoA dehydrogenase deficiency causes hepatic steatosis and hepatic insulin resistance

scientific article

Mitochondrial dysfunction in the elderly: possible role in insulin resistance

scientific article (publication date: 16 May 2003)

Mitochondrial glycerol-3-phosphate acyltransferase-1 is essential in liver for the metabolism of excess acyl-CoAs

scientific journal article

Mitochondrial-Targeted Catalase Protects Against High-Fat Diet-Induced Muscle Insulin Resistance by Decreasing Intramuscular Lipid Accumulation

scientific article

Molecular mechanisms of insulin resistance in humans and their potential links with mitochondrial dysfunction

scientific article

Mouse cardiac acyl coenzyme a synthetase 1 deficiency impairs Fatty Acid oxidation and induces cardiac hypertrophy

scientific article

Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle

scientific article published on 15 July 2008

Muscle-specific activation of Ca(2+)/calmodulin-dependent protein kinase IV increases whole-body insulin action in mice.

scientific article published on 11 April 2014

Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes

scientific article published in August 2007

Muscle-specific knockout of PKC-λ impairs glucose transport and induces metabolic and diabetic syndromes.

scientific article published in October 2007

N-acylphosphatidylethanolamine, a gut- derived circulating factor induced by fat ingestion, inhibits food intake.

scientific article published in November 2008

Neuronal UCP1 expression suggests a mechanism for local thermogenesis during hibernation.

scientific article

New insights into the pathogenesis of insulin resistance in humans using magnetic resonance spectroscopy

scientific article

Niclosamide ethanolamine-induced mild mitochondrial uncoupling improves diabetic symptoms in mice

scientific article

Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

scientific article published on 6 October 2017

Nonalcoholic Fatty Liver Disease as a Nexus of Metabolic and Hepatic Diseases

scientific article published on 29 August 2017

Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes

scientific article published on February 2014

Noninvasive assessment of hepatic triglyceride content in humans with 13C nuclear magnetic resonance spectroscopy

scientific article published on 01 July 1996

Normalization of blood glucose in diabetic rats with phlorizin treatment reverses insulin-resistant glucose transport in adipose cells without restoring glucose transporter gene expression.

scientific article

Nuclear magnetic resonance studies of hepatic glucose metabolism in humans.

scientific article

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

scientific article published on 29 June 2020

Obesity-associated improvements in metabolic profile through expansion of adipose tissue

scientific article

Ostα-/- mice exhibit altered expression of intestinal lipid absorption genes, resistance to age-related weight gain, and modestly improved insulin sensitivity.

scientific article published on 31 December 2013

Overexpression of Glut4 protein in muscle increases basal and insulin-stimulated whole body glucose disposal in conscious mice.

scientific article

Overexpression of the LAR (leukocyte antigen-related) protein-tyrosine phosphatase in muscle causes insulin resistance

scientific article

Overexpression of uncoupling protein 3 in skeletal muscle protects against fat-induced insulin resistance

scientific article published in July 2007

PGC-1alpha negatively regulates hepatic FGF21 expression by modulating the heme/Rev-Erb(alpha) axis

scientific article

PKC-theta knockout mice are protected from fat-induced insulin resistance

scientific article

PKCλ haploinsufficiency prevents diabetes by a mechanism involving alterations in hepatic enzymes.

scientific article

PP2A inhibition results in hepatic insulin resistance despite Akt2 activation

scientific article published on October 2013

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation

article published in 2010

PPARγ-induced cardiolipotoxicity in mice is ameliorated by PPARα deficiency despite increases in fatty acid oxidation.

scientific article

Paradoxical coupling of triglyceride synthesis and fatty acid oxidation in skeletal muscle overexpressing DGAT1.

scientific article published on 12 August 2009

Paradoxical effects of increased expression of PGC-1alpha on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism

scholarly article

Pathogenesis of hypothyroidism-induced NAFLD is driven by intra- and extrahepatic mechanisms

scientific article published on 10 October 2017

Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus

scientific article

Pathways of glycogen repletion

scientific article published on October 1, 1992

Persistent changes in myocardial glucose metabolism in vivo during reperfusion of a limited-duration coronary occlusion

scientific article published on 01 February 2000

Phosphoenolpyruvate cycling via mitochondrial phosphoenolpyruvate carboxykinase links anaplerosis and mitochondrial GTP with insulin secretion

scientific article

Phosphoinositide profiling in complex lipid mixtures using electrospray ionization mass spectrometry

scientific article published on 15 June 2003

Physiological role of AMP-activated protein kinase in the heart: graded activation during exercise

scientific article published on 20 May 2003

Physiological role of cholecystokinin in meal-induced insulin secretion in conscious rats. Studies with L 364718, a specific inhibitor of CCK-receptor binding.

scientific article published on October 1987

Pioglitazone improves insulin sensitivity among nondiabetic patients with a recent transient ischemic attack or ischemic stroke

scientific article published in May 2003

Pleotropic effects of leptin to reverse insulin resistance and diabetic ketoacidosis

scientific article published on 10 March 2016

Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning

scientific article

Prevalence of abnormal glucose tolerance following a transient ischemic attack or ischemic stroke

scientific article published in January 2005

Prevention of diet-induced hepatic steatosis and hepatic insulin resistance by second generation antisense oligonucleotides targeted to the longevity gene mIndy (Slc13a5)

scientific article

Prevention of fat-induced insulin resistance by salicylate

scientific article

Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein

scientific article published on December 2009

Prevention of hepatic steatosis and hepatic insulin resistance in mitochondrial acyl-CoA:glycerol-sn-3-phosphate acyltransferase 1 knockout mice

scientific journal article

Propionate Increases Hepatic Pyruvate Cycling and Anaplerosis and Alters Mitochondrial Metabolism

scientific article published on 21 March 2016

Publisher Correction: Non-invasive assessment of hepatic mitochondrial metabolism by positional isotopomer NMR tracer analysis (PINTA).

scientific article published on 31 January 2018

Quantitative analysis of glycogen repletion by nuclear magnetic resonance spectroscopy in the conscious rat.

scientific article published on August 1987

Quantitative analysis of the pathways of glycogen repletion in periportal and perivenous hepatocytes in vivo ⬇️

scientific article published on March 5, 1991

Reduced heart size and increased myocardial fuel substrate oxidation in ACC2 mutant mice

scientific journal article

Reduced intestinal lipid absorption and body weight-independent improvements in insulin sensitivity in high-fat diet-fed Park2 knockout mice.

scientific article published on 10 May 2016

Reduced mitochondrial density and increased IRS-1 serine phosphorylation in muscle of insulin-resistant offspring of type 2 diabetic parents.

scientific article

Regulation of exogenous and endogenous glucose metabolism by insulin and acetoacetate in the isolated working rat heart. A three tracer study of glycolysis, glycogen metabolism, and glucose oxidation.

scientific article published on December 1997

Regulation of hepatic energy metabolism and gluconeogenesis by BAD

scientific article published on February 2014

Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance

scientific article

Regulation of hepatic glucose metabolism in health and disease

scientific article

Regulation of hepatic mitochondrial oxidation by glucose-alanine cycling during starvation in humans

scientific article published on 01 November 2019

Regulation of hypothalamic malonyl-CoA by central glucose and leptin.

scholarly article

Regulation of metabolic responses by adipocyte/macrophage Fatty Acid-binding proteins in leptin-deficient mice

scientific article published on July 2006

Regulation of mitochondrial biogenesis

scientific article

Regulation of mitochondrial biogenesis by lipoprotein lipase in muscle of insulin-resistant offspring of parents with type 2 diabetes

scientific article

Regulation of net hepatic glycogenolysis and gluconeogenesis by epinephrine in humans

scientific article published on 19 May 2009

Reply to Constantin-Teodosiu et al.: mice with genetic PDH activation are not protected from high-fat diet-induced muscle insulin resistance

scientific article published on 23 January 2015

Reply to Monetti et al.: Hepatic steatosis and diacylglycerol-mediated hepatic insulin resistance in acyl-CoA:diacylglycerol acyltransferase 2 (DGAT2) transgenic mice.

scientific article

Resistance to high-fat diet-induced obesity and insulin resistance in mice with very long-chain acyl-CoA dehydrogenase deficiency

scientific article published on May 2010

Resistance to high-fat diet-induced obesity but exacerbated insulin resistance in mice overexpressing preadipocyte factor-1 (Pref-1): a new model of partial lipodystrophy

scientific article published on 03 October 2008

Resistance to thyroid hormone is associated with raised energy expenditure, muscle mitochondrial uncoupling, and hyperphagia

scientific article

Resolution of non-alcoholic steatohepatitis after growth hormone replacement in a pediatric liver transplant patient with panhypopituitarism

scientific article published on 20 October 2016

Response to burgess

scientific article published on February 2015

Retinol saturase modulates lipid metabolism and the production of reactive oxygen species.

scientific article published on 16 September 2017

Reversal of diet-induced hepatic steatosis and hepatic insulin resistance by antisense oligonucleotide inhibitors of acetyl-CoA carboxylases 1 and 2.

scientific article published on 16 February 2006

Reversal of hypertriglyceridemia, fatty liver disease, and insulin resistance by a liver-targeted mitochondrial uncoupler

scientific article

Reversal of muscle insulin resistance by weight reduction in young, lean, insulin-resistant offspring of parents with type 2 diabetes

scientific article

Reversal of muscle insulin resistance with exercise reduces postprandial hepatic de novo lipogenesis in insulin resistant individuals

scientific article

Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes

scientific article

Role of caspase-1 in regulation of triglyceride metabolism.

scientific article published on 4 March 2013

Role of diacylglycerol activation of PKCθ in lipid-induced muscle insulin resistance in humans

scientific article

Role of patatin-like phospholipase domain-containing 3 on lipid-induced hepatic steatosis and insulin resistance in rats

scientific article published on 25 January 2013

Roles of Diacylglycerols and Ceramides in Hepatic Insulin Resistance

scientific article published on 24 May 2017

SGLT2 deletion improves glucose homeostasis and preserves pancreatic beta-cell function ⬇️

scientific article

STAT3 inhibition of gluconeogenesis is downregulated by SirT1

scientific article published on 22 March 2009

Saturated and unsaturated fat induce hepatic insulin resistance independently of TLR-4 signaling and ceramide synthesis in vivo

scientific article published on 09 July 2013

Second-generation antisense oligonucleotides against β-catenin protect mice against diet-induced hepatic steatosis and hepatic and peripheral insulin resistance

scientific article published on 7 December 2015

Selective Chemical Inhibition of PGC-1α Gluconeogenic Activity Ameliorates Type 2 Diabetes.

scientific article published on March 2017

Sensitivity of lipid metabolism and insulin signaling to genetic alterations in hepatic peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression

scientific article published on 14 April 2009

Short-term food restriction followed by controlled refeeding promotes gorging behavior, enhances fat deposition, and diminishes insulin sensitivity in mice

scientific article published on 13 March 2015

Short-term overnutrition induces white adipose tissue insulin resistance through sn-1,2-diacylglycerol - PKCε - insulin receptorT1160 phosphorylation

scientific article published on 07 January 2021

Simultaneous insulinlike growth factor I and insulin resistance in obese Zucker rats

scientific article published on June 1, 1992

SirT1 knockdown in liver decreases basal hepatic glucose production and increases hepatic insulin responsiveness in diabetic rats

scholarly article

SirT1 regulates adipose tissue inflammation

scientific article published on December 2011

Sirtuin-1 regulation of mammalian metabolism

scientific article published in January 2011

Skeletal Muscle Insulin Resistance Promotes Increased Hepatic De Novo Lipogenesis, Hyperlipidemia, and Hepatic Steatosis in the Elderly ⬇️

scientific article published on July 24, 2012

Skeletal Muscle-Specific Deletion of MKP-1 Reveals a p38 MAPK/JNK/Akt Signaling Node that Regulates Obesity-Induced Insulin Resistance.

scientific article published on 9 January 2018

Skeletal muscle lipid metabolism with obesity

scientific article published on 27 December 2002

Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues

scientific article published on 24 October 2008

Sodium glucose cotransporter-2 inhibitors: Understanding the mechanisms for therapeutic promise and persisting risks

scientific article published on 12 August 2020

Sources of carbon for hepatic glycogen synthesis in the conscious dog ⬇️

scientific article published on August 1, 1991

Spectroscopic imaging of glutamate C4 turnover in human brain

scientific article published on 01 November 2000

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

scientific article published on 16 August 2010

Substrate cycling between pyruvate and oxaloacetate in awake normal and 3,3'-5-triiodo-L-thyronine-treated rats.

scientific article published in August 1994

Suppression of diacylglycerol acyltransferase-2 (DGAT2), but not DGAT1, with antisense oligonucleotides reverses diet-induced hepatic steatosis and insulin resistance

scientific journal article

Synaptic glutamate release by ventromedial hypothalamic neurons is part of the neurocircuitry that prevents hypoglycemia

scientific article published in May 2007

TFAM Enhances Fat Oxidation and Attenuates High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle

scientific article published on 14 May 2019

Targeted expression of catalase to mitochondria prevents age-associated reductions in mitochondrial function and insulin resistance.

scientific article

Targeting foxo1 in mice using antisense oligonucleotide improves hepatic and peripheral insulin action

scientific article published in July 2006

Targeting pyruvate carboxylase reduces gluconeogenesis and adiposity and improves insulin resistance

scientific article published on 19 February 2013

The "obese insulin-sensitive" adolescent: importance of adiponectin and lipid partitioning

scientific article

The Contribution of Blood Lactate to Brain Energy Metabolism in Humans Measured by Dynamic 13C Nuclear Magnetic Resonance Spectroscopy

scientific article

The H19/let-7 double-negative feedback loop contributes to glucose metabolism in muscle cells.

scientific article published on 15 November 2014

The Role of Leptin in Maintaining Plasma Glucose During Starvation.

scientific article

The SHP-1 protein tyrosine phosphatase negatively modulates glucose homeostasis

scientific article published on 16 April 2006

The circulating metabolome of human starvation

article published in 2018

The deacetylase Sirt6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.

scientific article published on 8 November 2012

The effect of leptin is enhanced by microinjection into the ventromedial hypothalamus.

scientific article published in January 1997

The effect of salicylates on insulin sensitivity.

scientific article published in December 2001

The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes

scientific article

The human longevity gene homolog INDY and interleukin-6 interact in hepatic lipid metabolism

scientific article

The mammalian INDY homolog is induced by CREB in a rat model of type 2 diabetes

scientific article

The omentum of obese girls harbors small adipocytes and browning transcripts

scientific article published on 26 March 2020

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

scientific article published on 4 January 2016

The role of AMP-activated protein kinase in mitochondrial biogenesis

scientific article

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

scientific article published on June 2014

The role of intramyocellular lipids during hypoglycemia in patients with intensively treated type 1 diabetes

scientific article published on 5 July 2005

The role of muscle insulin resistance in the pathogenesis of atherogenic dyslipidemia and nonalcoholic fatty liver disease associated with the metabolic syndrome.

scientific article published on August 2010

The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance.

scientific article

The role of skeletal muscle insulin resistance in the pathogenesis of the metabolic syndrome

scholarly article

The role of the carbohydrate response element-binding protein in male fructose-fed rats

scientific article

Thyroid hormone receptor-α gene knockout mice are protected from diet-induced hepatic insulin resistance

scientific article

Thyroid hormone receptor-β agonists prevent hepatic steatosis in fat-fed rats but impair insulin sensitivity via discrete pathways.

scientific article published on 07 May 2013

Time course of the defective alpha-cell response to hypoglycemia in diabetic BB rats.

scientific article

Tissue-specific differences in the development of insulin resistance in a mouse model for type 1 diabetes

scientific article

Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance

scientific article published on 5 June 2001

Transgenic mice deficient in the LAR protein-tyrosine phosphatase exhibit profound defects in glucose homeostasis.

scientific article published in March 1998

Transgenic mice overexpressing GLUT-1 protein in muscle exhibit increased muscle glycogenesis after exercise

scientific article published on 01 April 2000

Transgenic overexpression of protein-tyrosine phosphatase 1B in muscle causes insulin resistance, but overexpression with leukocyte antigen-related phosphatase does not additively impair insulin action

scientific article published on 18 March 2004

Treating fatty liver and insulin resistance

scientific article published on November 2013

Triiodothyronine treatment increases substrate cycling between pyruvate carboxylase and malic enzyme in perfused rat liver

scientific article published on 01 November 1995

Tumor progression locus 2 (TPL2) regulates obesity-associated inflammation and insulin resistance

scientific article

Type 2 diabetes mellitus

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UCP2 mediates ghrelin's action on NPY/AgRP neurons by lowering free radicals

scientific article published on 30 July 2008

Uncoupling Hepatic Oxidative Phosphorylation Reduces Tumor Growth in Two Murine Models of Colon Cancer

scientific article published on 01 July 2018

Uncoupling protein-2 decreases the lipogenic actions of ghrelin

scientific article

Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes.

scientific article published on June 2001

Unraveling the cellular mechanism of insulin resistance in humans: new insights from magnetic resonance spectroscopy

scientific article published in August 2004

Urocortin 2 modulates glucose utilization and insulin sensitivity in skeletal muscle

scholarly article

Ventromedial hypothalamic lesions in rats suppress counterregulatory responses to hypoglycemia.

scientific article published on April 1994

XBP1s Is an Anti-lipogenic Protein

scientific article

[2,4-13 C2 ]-beta-Hydroxybutyrate metabolism in human brain

scientific article

[New views on the etiology of type II diabetes with Nuclear Magnetic Resonance Spectroscopy]

scientific article published on 01 January 1996

cAMP-responsive element-binding protein (CREB)-regulated transcription coactivator 2 (CRTC2) promotes glucagon clearance and hepatic amino acid catabolism to regulate glucose homeostasis.

scientific article published on 17 April 2013

n-3 Fatty acids preserve insulin sensitivity in vivo in a peroxisome proliferator-activated receptor-alpha-dependent manner.

scientific article published on 24 January 2007

³¹P-magnetization transfer magnetic resonance spectroscopy measurements of in vivo metabolism

scientific article

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