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List of works by Alison Motsinger-Reif

A Balanced Accuracy Fitness Function Leads to Robust Analysis using Grammatical Evolution Neural Networks in the Case of Class Imbalance

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies

scientific article published on 24 May 2019

A Genetic Response Score for Hydrochlorothiazide Use: Insights From Genomics and Metabolomics Integration

scientific article published on 5 July 2016

A balanced accuracy function for epistasis modeling in imbalanced datasets using multifactor dimensionality reduction.

scientific article

A comparison of DMET Plus microarray and genome-wide technologies by assessing population substructure

scientific article published on January 2016

A comparison of GE optimized neural networks and decision trees

A comparison of analytical methods for genetic association studies

scientific article published in December 2008

A comparison of analytical methods for genetic association studies

A comparison of association methods for cytotoxicity mapping in pharmacogenomics

scientific article published on 14 December 2011

A comparison of internal model validation methods for multifactor dimensionality reduction in the case of genetic heterogeneity

scientific article

A comparison of internal validation techniques for multifactor dimensionality reduction

scientific article

A comparison of multifactor dimensionality reduction and L1-penalized regression to identify gene-gene interactions in genetic association studies

scientific article published on 6 January 2011

A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.

scientific article published on November 2012

A genome-wide study of lipid response to fenofibrate in Caucasians: a combined analysis of the GOLDN and ACCORD studies

scientific article published on 21 March 2016

A new explained-variance based genetic risk score for predictive modeling of disease risk

scientific article

A novel canine model of immune thrombocytopenia: has immune thrombocytopenia (ITP) gone to the dogs?

scientific article

A predictive model for efavirenz dosing

scientific article published in January 2012

ABCB1 and GST polymorphisms associated with TP53 status in breast cancer

article published in 2007

Abstract LB-177: Novel approaches for improving interpretation and predictive models of comparative genomic hybridization data

Abstract LB-246: Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations

Abstract PD07-10: Breast Cancer Patients Carrying the CYP2C8*3 Variant Are More Likely To Achieve Clinical Complete Response from Neoadjuvant Paclitaxel Treatment

Abstract PD10-07: Patients carrying CYP2C8*3 are at increased risk of paclitaxel-induced neuropathy

Accuracy of SNPs to predict risk of HLA alleles associated with drug-induced hypersensitivity events across racial groups

scientific article published on 17 June 2015

Alfaxalone anesthesia in bullfrogs (Lithobates catesbeiana) by injection or immersion

scientific article

Alterations in metabolic pathways and networks in Alzheimer's disease

scientific article published on 9 April 2013

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease-An emerging role for gut microbiome

Altered bile acid profile associates with cognitive impairment in Alzheimer's disease—An emerging role for gut microbiome

Alternative Cross-Over Strategies and Selection Techniques for Grammatical Evolution Optimized Neural Networks

An Introduction to Terminology and Methodology of Chemical Synergy-Perspectives from Across Disciplines

scientific article

An R package implementation of multifactor dimensionality reduction

scientific article

An adaptive permutation approach for genome-wide association study: evaluation and recommendations for use.

scientific article published on 14 June 2014

An investigation of gene-gene interactions in dose-response studies with Bayesian nonparametrics

scientific article

Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.

scientific article

Are plasma level and CYP genotypes predictors of liver injury in an Ethiopian population?

scientific article published on January 1, 2012

Assessing the utility of whole genome amplified DNA as a template for DMET Plus array

article

Association of breed and histopathological grade in canine mast cell tumours.

scientific article

Association of dilated cardiomyopathy with the striatin mutation genotype in boxer dogs

scientific article published on 28 August 2013

Auriculotherapy for pain management: a systematic review and meta-analysis of randomized controlled trials

scientific article

Bayesian neural networks for detecting epistasis in genetic association studies ⬇️

scientific article

Beyond IC50s: Towards Robust Statistical Methods for in vitro Association Studies.

scientific article

Bile acids targeted metabolomics and medication classification data in the ADNI1 and ADNIGO/2 cohorts

scientific article published on 17 October 2019

Blood Lead Toxicity Analysis of Multipurpose Canines and Military Working Dogs

CD1d-restricted human natural killer T cells are highly susceptible to human immunodeficiency virus 1 infection

scientific article

CYP2C8*3 increases risk of neuropathy in breast cancer patients treated with paclitaxel

scientific article published on 14 February 2013

CYP2C8*3 predicts benefit/risk profile in breast cancer patients receiving neoadjuvant paclitaxel

scientific article published on 18 April 2012

Canine hereditary ataxia in old english sheepdogs and gordon setters is associated with a defect in the autophagy gene encoding RAB24

scientific article (publication date: February 2014)

Canine urothelial carcinoma: genomically aberrant and comparatively relevant.

scientific article published on 18 March 2015

Carboplatin/taxane-induced gastrointestinal toxicity: a pharmacogenomics study on the SCOTROC1 trial

scientific article published on 21 July 2015

Characterization of canine osteosarcoma by array comparative genomic hybridization and RT-qPCR: signatures of genomic imbalance in canine osteosarcoma parallel the human counterpart.

scientific article published on 11 August 2011

Characterization of conserved and nonconserved imprinted genes in swine

scientific article

Cheminformatics approach to exploring and modeling trait-associated metabolite profiles

scientific article published on 24 June 2019

Clinical applications of whole-genome association studies: future applications at the bedside

scientific article published on July 2006

Clinical trial evidence of the promise of pharmacogenomics warfarin dosing algorithms

scientific article published in June 2012

Common and rare genetic markers of lipid variation in subjects with type 2 diabetes from the ACCORD clinical trial

scientific article published in 2017

Comparative Exposure Assessment Using Silicone Passive Samplers Indicates Domestic Dogs are Sentinels to Support Human Health Research

scientific article published on 13 May 2020

Comparative cytogenetic characterization of primary canine melanocytic lesions using array CGH and fluorescence in situ hybridization

scientific article

Comparing metabolomic and pathologic biomarkers alone and in combination for discriminating Alzheimer's disease from normal cognitive aging

scientific article published on 27 June 2013

Comparison of approaches for machine-learning optimization of neural networks for detecting gene-gene interactions in genetic epidemiology

scientific article published in May 2008

Comparison of smoking-related DNA methylation between newborns from prenatal exposure and adults from personal smoking

scientific article published on 19 September 2019

Comparison of venous sampling methods for thromboelastography in clinically normal dogs

scientific article published in December 2012

Complex gene–gene interactions in multiple sclerosis: a multifactorial approach reveals associations with inflammatory genes

article

Comprehensive genomic characterization of five canine lymphoid tumor cell lines

scientific article

Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity

scientific article published on 20 August 2013

Current Methods for Quantifying Drug Synergism

scientific article published on 22 July 2019

Data simulation software for whole-genome association and other studies in human genetics.

scientific article

Differences in X-chromosome transcriptional activity and cholesterol metabolism between placentae from swine breeds from Asian and Western origins

scientific article

Differentially expressed microRNAs and affected biological pathways revealed by modulated modularity clustering (MMC) analysis of human preeclamptic and IUGR placentas.

scientific article published on 30 April 2013

Discussing gene-gene interaction: warning--translating equations to English may result in jabberwocky

scientific article published in January 2007

Discussion of a Genome‐Wide Association Approach to Determine HIV‐1 Set Point in African Americans

article

Do genetic polymorphisms of nevirapine metabolic, transport and antigen recognition enzymes play a role in nevirapine toxicity risk?

scientific article published on January 1, 2012

Drug Transporter and Metabolizing Enzyme Gene Variants and Nonnucleoside Reverse-Transcriptase Inhibitor Hepatotoxicity

article

Effect of CYP2B6, ABCB1, and CYP3A5 polymorphisms on efavirenz pharmacokinetics and treatment response: an AIDS Clinical Trials Group study

scientific article

Effects of acepromazine maleate on platelet function assessed by use of adenosine diphosphate activated- and arachidonic acid- activated modified thromboelastography in healthy dogs

scientific article published in May 2012

Eigenvector metabolite analysis reveals dietary effects on the association among metabolite correlation patterns, gene expression, and phenotypes.

scientific article published on 20 September 2016

Embracing Integrative Multiomics Approaches

scientific article

Epigenome-Wide Association Study of DNA Methylation and Adult Asthma in the Agricultural Lung Health Study

scientific article published on 07 May 2020

Erratum to: Application of next generation sequencing to CEPH cell lines to discover variants associated with FDA approved chemotherapeutics.

scientific article published on 17 September 2014

Evaluating the role of admixture in cancer therapy via in vitro drug response and multivariate genome-wide associations

scientific article published on 28 August 2015

Evaluation of calling algorithms for array-CGH.

scientific article published on 25 October 2013

Evaluation of genetic risk score models in the presence of interaction and linkage disequilibrium

scientific article published on 23 July 2013

Evaluation of polymorphisms in the sulfonamide detoxification genes CYB5A and CYB5R3 in dogs with sulfonamide hypersensitivity

scientific article published on 21 July 2012

Evaluation of polymorphisms in the sulfonamide detoxification genes NAT2, CYB5A, and CYB5R3 in patients with sulfonamide hypersensitivity

scientific article published on October 2012

Evaluation of thromboelastography for prediction of clinical bleeding in thrombocytopenic dogs after total body irradiation and hematopoietic cell transplantation

scientific article

Ex-Vivo Modeling for Heritability Assessment and Genetic Mapping in Pharmacogenomics

scientific article published on 01 July 2011

Exploring epistasis in candidate genes for rheumatoid arthritis

scientific article

Feature Selection using a Random Forests Classifier for the Integrated Analysis of Multiple Data Types

Fibrate pharmacogenomics: expanding past the genome

scientific article published on 17 March 2020

Functional genomic approaches for the study of fetal/placental development in swine with special emphasis on imprinted genes.

scientific article published in January 2009

GPNN: power studies and applications of a neural network method for detecting gene-gene interactions in studies of human disease

scientific article

Gene expression and linkage analysis implicate CBLB as a mediator of rituximab resistance

scientific article published on 5 December 2017

Gene profiling of canine B-cell lymphoma reveals germinal center and postgerminal center subtypes with different survival times, modeling human DLBCL.

scientific article published on 19 June 2013

Gene selection and cancer type classification of diffuse large-B-cell lymphoma using a bivariate mixture model for two-species data

scientific article

Gene set analysis methods: a systematic comparison.

scientific article

Genetic Predictors of Cardiovascular Mortality During Intensive Glycemic Control in Type 2 Diabetes: Findings From the ACCORD Clinical Trial

scientific article

Genetic Programming Neural Networks: A Powerful Bioinformatics Tool for Human Genetics

scientific article

Genetic Tools for Coronary Risk Assessment in Type 2 Diabetes: A Cohort Study From the ACCORD Clinical Trial

scientific article published on 27 September 2018

Genetic Variants in CPA6 and PRPF31 are Associated with Variation in Response to Metformin in Individuals with Type 2 Diabetes.

scientific article published on 12 April 2018

Genetic Variants in HSD17B3, SMAD3, and IPO11 Impact Circulating Lipids in Response to Fenofibrate in Individuals With Type 2 Diabetes.

scientific article published on 24 July 2017

Genetic and environmental risk for lymphoma in boxer dogs

scientific article published on 15 July 2020

Genetic basis for adverse events after smallpox vaccination

scientific article published on July 2008

Genetic heterogeneity beyond CYP2C8*3 does not explain differential sensitivity to paclitaxel-induced neuropathy

scientific article

Genetic heterogeneity is not as threatening as you might think

scientific article published on 01 November 2007

Genetic variation in the mitochondrial enzyme carbamyl-phosphate synthetase I predisposes children to increased pulmonary artery pressure following surgical repair of congenital heart defects: a validated genetic association study

scientific article published on 29 November 2006

Genome-Wide Association Study in Immunocompetent Patients with Delayed Hypersensitivity to Sulfonamide Antimicrobials

scientific article

Genome-wide DNA copy number analysis and targeted transcriptional analysis of canine histiocytic malignancies identifies diagnostic signatures and highlights disruption of spindle assembly complex

scientific article published on 23 April 2019

Genome-wide assessment of recurrent genomic imbalances in canine leukemia identifies evolutionarily conserved regions for subtype differentiation

scientific article published on 3 June 2015

Genome-wide association and pharmacological profiling of 29 anticancer agents using lymphoblastoid cell lines

scientific article

Genome-wide association studies in pharmacogenomics: successes and lessons

scientific article

Genomic profiling in CEPH cell lines distinguishes between the camptothecins and indenoisoquinolines

scientific article

Genomic profiling reveals extensive heterogeneity in somatic DNA copy number aberrations of canine hemangiosarcoma

scientific article

Global tests of P-values for multifactor dimensionality reduction models in selection of optimal number of target genes.

scientific article

Grammatical evolution decision trees for detecting gene-gene interactions

scientific article published on 18 November 2010

Hemochromatosis gene polymorphisms, mitochondrial haplogroups, and peripheral lipoatrophy during antiretroviral therapy

scientific article published in March 2008

Human genomic association studies: a primer for the infectious diseases specialist

scientific article published on 9 May 2007

Human natural killer T cells are heterogeneous in their capacity to reprogram their effector functions

scientific article

Identification and replication of loci involved in camptothecin-induced cytotoxicity using CEPH pedigrees

scientific article

Identification and simian immunodeficiency virus infection of CD1d-restricted macaque natural killer T cells

scientific article

Identifying individual risk rare variants using protein structure guided local tests (POINT)

scientific article published on 19 February 2019

Identifying individual risk rare variants using protein structure-guided local tests (POINT)

Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study

scientific article published on 6 September 2006

In vitro iatrogenic hemolysis of canine packed red blood cells during various rapid transfusion techniques

scientific article published on 03 November 2020

Incorporating Concomitant Medications into Genome-Wide Analyses for the Study of Complex Disease and Drug Response

scientific article published on 17 August 2016

Initial evaluation of nighttime restlessness in a naturally occurring canine model of osteoarthritis pain.

scientific article

Insights into the inhibition of platelet activation by omega-3 polyunsaturated fatty acids: Beyond aspirin and clopidogrel

scientific article published on 28 May 2011

Institutional profile. UNC Institute for Pharmacogenomics and Individualized Therapy: interdisciplinary research for individual care

scientific article

Integrated analysis of genetic and proteomic data identifies biomarkers associated with adverse events following smallpox vaccination

scientific article

International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study.

scientific article published on 16 April 2018

Interview: A Discussion on Genome-Wide Associations in Pharmacogenomics ⬇️

scientific article published on March 1, 2013

Knockoff Boosted Tree for Model-Free Variable Selection

scientific article published on 23 September 2020

Linkage Disequilibrium in Genetic Association Studies Improves the Performance of Grammatical Evolution Neural Networks

scientific article published on 01 April 2007

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

scientific article published on 12 October 2019

Loss of power in two-stage residual-outcome regression analysis in genetic association studies

scientific article published on 31 August 2012

Low-Dose Silver Nanoparticle Surface Chemistry and Temporal Effects on Gene Expression in Human Liver Cells

scientific article published on 29 March 2020

Lymphoblastoid cell lines models of drug response: successes and lessons from this pharmacogenomic model

scientific article

Maternal smoking impacts key biological pathways in newborns through epigenetic modification in Utero

scientific article published on 25 November 2016

Metabolic network failures in Alzheimer's disease: A biochemical road map.

scientific article published on 21 March 2017

Metabolomic signatures of drug response phenotypes for ketamine and esketamine in subjects with refractory major depressive disorder: new mechanistic insights for rapid acting antidepressants

scientific article published on 20 September 2016

Methylenetetrahydrofolate reductase genetic polymorphisms and toxicity to 5-FU-based chemoradiation in rectal cancer

scientific article published on November 2011

Modulation of GLP-1 Levels by a Genetic Variant That Regulates the Cardiovascular Effects of Intensive Glycemic Control in ACCORD.

scientific article published on 28 November 2017

Molecular cytogenetic characterization of canine histiocytic sarcoma: A spontaneous model for human histiocytic cancer identifies deletion of tumor suppressor genes and highlights influence of genetic background on tumor behavior

scientific article

Morphologic and molecular analysis of 39 spontaneous feline pulmonary carcinomas.

scientific article published on 7 September 2011

Multifactor dimensionality reduction as a filter-based approach for genome wide association studies

scientific article published on 21 November 2011

Multifactor dimensionality reduction for detecting gene-gene and gene-environment interactions in pharmacogenomics studies

scientific article

Multifactor dimensionality reduction reveals gene-gene interactions associated with multiple sclerosis susceptibility in African Americans

scientific article

Multifactor dimensionality reduction: an analysis strategy for modelling and detecting gene-gene interactions in human genetics and pharmacogenomics studies

scientific article

Multilocus genetic interactions and response to efavirenz-containing regimens: an adult AIDS clinical trials group study

scientific article

Multivariate methods and software for association mapping in dose-response genome-wide association studies

scientific article published on 12 December 2012

Naturally occuring canine cancers: powerful models for stimulating pharmacogenomic advancement in human medicine.

scientific article published in December 2013

Neural networks for genetic epidemiology: past, present, and future

scientific article published on 17 July 2008

Nonlinear Dose-Response Modeling of High-Throughput Screening Data Using an Evolutionary Algorithm

scientific article published on 01 April 2020

Novel human genetic variants associated with extrapulmonary tuberculosis: a pilot genome wide association study

scientific article

Novel methods for detecting epistasis in pharmacogenomics studies

scientific article published on September 2007

Operative factors associated with short-term outcome in horses with large colon volvulus: 47 cases from 2006 to 2013.

scientific article

Optimization of grammatical evolution decision trees

Optimization of nonlinear dose- and concentration-response models utilizing evolutionary computation

scientific article published on 25 June 2010

PGxClean: a quality control GUI for the Affymetrix DMET chip and other candidate gene studies with non-biallelic alleles

article

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid

scientific article published on 23 January 2020

Pharmacogenetic Analysis of the Model-Based Pharmacokinetics of Five Anti-HIV Drugs: How Does This Influence the Effect of Aging?

scientific article published on 3 December 2017

Pharmacogenomic characterization of US FDA-approved cytotoxic drugs

scientific article

Pharmacometabolomic Assessment of Metformin in Non-diabetic, African Americans

scientific article published on 14 June 2016

Pharmacometabolomic Assessments of Atenolol and Hydrochlorothiazide Treatment Reveal Novel Drug Response Phenotypes

scientific article

Pharmacometabolomics Informs About Pharmacokinetic Profile of Methylphenidate

Polymorphism modulates symptomatic response to antiarrhythmic drug therapy in patients with lone atrial fibrillation

scientific article

Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis

scientific article

Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study

scientific article

Positive association between a glutathione-S-transferase polymorphism and lymphoma in dogs

scientific article published on 29 September 2012

Power of grammatical evolution neural networks to detect gene-gene interactions in the presence of error

scientific article

Prevalence of onychectomy in cats presented for veterinary care near Raleigh, NC and educational attitudes toward the procedure

scientific article published on 25 July 2013

Quality of reporting on randomised controlled trials of auriculotherapy for pain

scientific article published on 12 April 2011

Race and smoking status associated with paclitaxel drug response in patient-derived lymphoblastoid cell lines

scientific article published on 15 September 2020

Refining tumor-associated aneuploidy through 'genomic recoding' of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

scientific article

Relationship between mechanical thresholds and limb use in dogs with coxofemoral joint oa-associated pain and the modulating effects of pain alleviation from total hip replacement on mechanical thresholds

scientific article published on 11 February 2014

Relative Quantification and Higher-Order Modeling of the Plasma Glycan Cancer Burden Ratio in Ovarian Cancer Case-Control Samples

scientific article

Replication study of CYP4F2 association with warfarin response in an Israeli population

scientific article published in June 2012

Risk factor interactions and genetic effects associated with post-operative atrial fibrillation

scientific article published in January 2006

Risk score modeling of multiple gene to gene interactions using aggregated-multifactor dimensionality reduction

scientific article

Shift work in nurses: contribution of phenotypes and genotypes to adaptation

scientific article

Single-nucleotide polymorphism data support the general unrelatedness of the males in the agricultural health study

scientific article

Sphingolipid Metabolic Pathway Impacts Thiazide Diuretics Blood Pressure Response: Insights From Genomics, Metabolomics, and Lipidomics.

scientific article published on 29 December 2017

Synergistic Chemotherapy Drug Response Is a Genetic Trait in Lymphoblastoid Cell Lines

scientific article published on 15 October 2019

Targeted metabolomics and medication classification data from participants in the ADNI1 cohort

scientific article published on 17 October 2017

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: Monitoring County-Level Vulnerability Using Visualization, Statistical Modeling, and Machine Learning

scientific article published on 05 January 2021

The COVID-19 Pandemic Vulnerability Index (PVI) Dashboard: monitoring county level vulnerability

scientific article published on 13 August 2020

The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs

scientific article published on 23 May 2017

The effect of alternative permutation testing strategies on the performance of multifactor dimensionality reduction

scientific article

The effect of reduction in cross-validation intervals on the performance of multifactor dimensionality reduction

scientific article published in September 2006

The effect of retrospective sampling on estimates of prediction error for multifactor dimensionality reduction

scientific article

The influence of Neanderthal alleles on cytotoxic response

scientific article published on 23 October 2018

The influence of packed cell volume versus plasma proteins on thromboelastographic variables in canine blood

scientific article published on 25 June 2020

The steroid metabolome in women with premenstrual dysphoric disorder during GnRH agonist-induced ovarian suppression: effects of estradiol and progesterone addback.

scientific article published on 8 August 2017

Thromboelastographic monitoring of the effect of unfractionated heparin in healthy dogs

scientific article published on 12 October 2016

Transcriptional profiling of human placentas from pregnancies complicated by preeclampsia reveals disregulation of sialic acid acetylesterase and immune signalling pathways.

scientific article

Twice-daily application of HIV microbicides alter the vaginal microbiota

scientific article published on 18 December 2012

Understanding the Evolutionary Process of Grammatical Evolution Neural Networks for Feature Selection in Genetic Epidemiology

scholarly article published 28 September 2006

Untargeted metabolomic profiling identifies disease-specific signatures in food allergy and asthma

scientific article published on 25 October 2019

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

scientific article

VH1-44 gene usage defines a subset of canine B-cell lymphomas associated with better patient survival

scientific article published on 21 November 2013

Variation in the glucose transporter gene SLC2A2 is associated with glycemic response to metformin

scientific article published on 08 August 2016

Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups

scientific article

α-Hydroxybutyric Acid Is a Selective Metabolite Biomarker of Impaired Glucose Tolerance

scientific article published on 5 April 2016

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