Search filters

List of works by Richard Weinshilboum

3'-Phosphoadenosine-5'-phosphosulfate: photoaffinity ligand for sulfotransferase enzymes

scientific article published in January 1991

A comprehensive analysis of breast cancer microbiota and host gene expression.

scientific article published on 30 November 2017

A comprehensive examination of CYP19 variation and breast density

scientific article published in March 2007

A comprehensive examination of CYP19 variation and risk of breast cancer using two haplotype-tagging approaches

scientific article

A network-based phenotype mapping approach to identify genes that modulate drug response phenotypes

scientific article

A phase I study of cytembena

scientific article published on March 1, 1976

A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2.

scientific article

A proposed nomenclature system for the cytosolic sulfotransferase (SULT) superfamily

scientific article published on March 2004

Abstract 5488: Utilizing a pathway based analysis of genome wide association data to identify biomarkers of toxicity in breast cancer patients

article

Accuracy of Electronic Medical Record Medication Reconciliation in Emergency Department Patients

scientific article published on 19 March 2015

Acetaminophen-NAPQI Hepatotoxicity: A Cell Line Model System Genome-Wide Association Study ⬇️

scientific article published on December 22, 2010

Acquired chromosomal anomalies in chronic lymphocytic leukemia patients compared with more than 50,000 quasi-normal participants

scientific article

Aggresome formation and pharmacogenetics: sulfotransferase 1A3 as a model system

scientific article published in December 2004

Anastrozole Aromatase Inhibitor Plasma Drug Concentration Genome-Wide Association Study: Functional Epistatic Interaction Between SLC38A7 and ALPPL2

scientific article published on 18 March 2019

Anastrozole has an association between degree of estrogen suppression and outcomes in early breast cancer and is a ligand for estrogen receptor α

scientific article published on 25 February 2020

Antiestrogen pathway (aromatase inhibitor)

scientific article published on July 2009

Aromatase inhibitor-associated bone fractures: a case-cohort GWAS and functional genomics

scientific article

Aromatase inhibitors, estrogens and musculoskeletal pain: estrogen-dependent T-cell leukemia 1A (TCL1A) gene-mediated regulation of cytokine expression ⬇️

scientific article published on March 9, 2012

Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen

scientific article

Association of the Polygenic Scores for Personality Traits and Response to Selective Serotonin Reuptake Inhibitors in Patients with Major Depressive Disorder

scientific article published on 6 March 2018

Author Correction: Regulation of sister chromatid cohesion by nuclear PD-L1

scientific article published on 07 July 2020

Automated discovery of drug treatment patterns for endocrine therapy of breast cancer within an electronic medical record ⬇️

scientific article published on December 1, 2011

BRCA1/2 Mutations and Bevacizumab in the Neoadjuvant Treatment of Breast Cancer: Response and Prognosis Results in Patients With Triple-Negative Breast Cancer From the GeparQuinto Study

article

Benefits of and Barriers to Pharmacogenomics-Guided Treatment for Major Depressive Disorder.

scientific article published in February 2018

Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.

scientific article

Betaine-homocysteine methyltransferase: Human liver genotype–phenotype correlation ⬇️

scientific article published on October 21, 2010

Breast cancer chemoprevention pharmacogenomics: Deep sequencing and functional genomics of the ZNF423 and CTSO genes

scientific article published on 21 August 2017

Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms

scientific article published on July 2008

CD38 expression, function, and gene resequencing in a human lymphoblastoid cell line-based model system

scientific article

CYP2C19 variation and citalopram response

scientific article

CYP2D6 genotype and adjuvant tamoxifen: meta-analysis of heterogeneous study populations

scientific article published on 23 September 2013

CYP2D6 genotype, antidepressant use, and tamoxifen metabolism during adjuvant breast cancer treatment

scientific article

CYP2D6 metabolism and patient outcome in the Austrian Breast and Colorectal Cancer Study Group trial (ABCSG) 8. ⬇️

scientific article published on 4 December 2012

Calcium inhibition of rat liver catechol-O-methyltransferase ⬇️

scientific article published on March 1, 1976

Calmodulin-like protein 3 is an estrogen receptor alpha coregulator for gene expression and drug response in a SNP, estrogen, and SERM-dependent fashion

scientific article published on 18 August 2017

Cancer pharmacogenomics and pharmacoepidemiology: setting a research agenda to accelerate translation

scientific article

Canine red blood cell thiopurine S-methyltransferase: companion animal pharmacogenetics

scientific article published on December 2002

Cardiovascular pharmacogenomics and individualized drug therapy

scientific article

Cat Red Blood Cell ThiopurineS-Methyltransferase: Companion Animal Pharmacogenetics ⬇️

scientific article published on November 10, 2003

Catechol O-methyltransferase pharmacogenomics: human liver genotype-phenotype correlation and proximal promoter studies

scientific article

Catechol-o-methyltransferase in rat erythrocyte and three other tissues: comparison of biochemical properties after removal of inhibitory calcium

scientific article published in November 1976

Catecholestrogen sulfation: possible role in carcinogenesis

scientific article published in March 2002

Cefazolin administration and 2-methyl-1,3,4-thiadiazole-5-thiol in human tissue: possible relationship to hypoprothrombinemia

scientific article published in October 2002

Characterization of the basis for differences in serum DBH activity in immature and adult rats by use of homologous antibody ⬇️

scientific article published on October 1, 1979

Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with reduced NT-proANP, increased stroke and higher diastolic blood pressure.

scientific article published on 2 September 2015

Circulating atrial natriuretic peptide genetic association study identifies a novel gene cluster associated with stroke in whites

scientific article

Citalopram and escitalopram plasma drug and metabolite concentrations: genome-wide associations

scientific article

Clinical validation of genetic variants associated with in vitro chemotherapy-related lymphoblastoid cell toxicity

scientific article published on 9 May 2017

Clonal expansion of antitumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy

scientific article published on 27 May 2016

Cohort Profile: The Right Drug, Right Dose, Right Time: Using Genomic Data to Individualize Treatment Protocol (RIGHT Protocol)

scientific article published on 01 February 2020

Comparison of 99mTc-Sestamibi Molecular Breast Imaging and Breast MRI in Patients With Invasive Breast Cancer Receiving Neoadjuvant Chemotherapy

scientific article published on 05 June 2019

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure

scholarly article published 17 November 2017

Considerations for automated machine learning in clinical metabolic profiling: Altered homocysteine plasma concentration associated with metformin exposure.

scientific article published in January 2018

Coprescription of tamoxifen and medications that inhibit CYP2D6.

scientific article

Copy number variation and cytidine analogue cytotoxicity: a genome-wide association approach

scientific article

Correlation of erythrocyte catechol-O-methyltransferase activity between siblings

scientific article published in December 1974

Cytochrome P450 2D6 and homeobox 13/interleukin-17B receptor: combining inherited and tumor gene markers for prediction of tamoxifen resistance

scientific article published on September 2008

Cytosolic 5'-nucleotidase III (NT5C3): gene sequence variation and functional genomics

scientific article

DNA methyltransferase expression in triple-negative breast cancer predicts sensitivity to decitabine

scientific article published on 30 April 2018

Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancer

scientific article published on 01 October 2019

Dehydroepiandrosterone sulfotransferase gene (STD): localization to human chromosome band 19q13.3.

scientific article

Detecting Associations between Major Depressive Disorder Treatment and Essential Hypertension using Electronic Health Records

scientific article published on 7 April 2014

Developmental patterns of catechol-O-methyltransferase in genetically different rat strains: enzymatic and immunochemical studies

scientific article published in January 1980

ERICH3: vesicular association and antidepressant treatment response

scientific article published on 23 November 2020

Ecto-5'-nucleotidase and thiopurine cellular circulation: association with cytotoxicity

scientific article

Effect of cytochrome CYP2C19 metabolizing activity on antidepressant response and side effects: Meta-analysis of data from genome-wide association studies

Effect of resveratrol on 17beta-estradiol sulfation by human hepatic and jejunal S9 and recombinant sulfotransferase 1E1.

scientific article published on 22 October 2007

Electrophoretic analysis of low and high activity forms of catechol-O-methyltransferase in human erythrocytes

scientific article published on January 1, 1992

Electrophysiological Neuroimaging using sLORETA Comparing 22 Age Matched Male and Female Schizophrenia Patients

scientific article

Endocrine therapy in 2009: consideration of the tumor and the host.

scientific article published in February 2009

Establishing and characterizing patient-derived xenografts using pre-chemotherapy percutaneous biopsy and post-chemotherapy surgical samples from a prospective neoadjuvant breast cancer study

scientific article published on 6 December 2017

Estrogen, SNP-Dependent Chemokine Expression and Selective Estrogen Receptor Modulator Regulation

scientific article published on 11 February 2016

Estrogens and their precursors in postmenopausal women with early breast cancer receiving anastrozole

scientific article

Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials

scientific article published on 31 August 2011

Evolution of butyrylcholinesterase in higher primates: An immunochemical study ⬇️

scientific article published on January 1, 1984

Exome sequencing reveals frequent deleterious germline variants in cancer susceptibility genes in women with invasive breast cancer undergoing neoadjuvant chemotherapy

scientific article

Exploring hepsin functional genetic variation association with disease specific protein expression in bipolar disorder: Applications of a proteomic informed genomic approach

scientific article

FKBP5 genetic variation: association with selective serotonin reuptake inhibitor treatment outcomes in major depressive disorder

scientific article published on March 2013

Functional genetic polymorphisms in the aromatase gene CYP19 vary the response of breast cancer patients to neoadjuvant therapy with aromatase inhibitors

scientific article

Gemcitabine and arabinosylcytosin pharmacogenomics: genome-wide association and drug response biomarkers

scientific article

Gemcitabine pharmacogenomics: deoxycytidine kinase and cytidylate kinase gene resequencing and functional genomics

scientific article published on 12 June 2008

Gene set analysis of purine and pyrimidine antimetabolites cancer therapies

scientific article

Genetic Polymorphisms in the Long Noncoding RNA MIR2052HG Offer a Pharmacogenomic Basis for the Response of Breast Cancer Patients to Aromatase Inhibitor Therapy

scientific article published on 10 October 2016

Genetic diversity and function in the human cytosolic sulfotransferases.

scientific article

Genetic nondiscrimination legislation: a critical prerequisite for pharmacogenomics data sharing

scientific article

Genetic segregation analysis of red blood cell (RBC) histamine N-methyltransferase (HNMT) activity

scientific article published in January 1993

Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study

scientific article published on 23 June 2015

Genetics of red cell COMT activity: Analysis of thermal stability and family data ⬇️

scientific article published on January 1, 1981

Genome-wide association studies in pharmacogenomics: successes and lessons

scientific article

Genome-wide association studies of drug response and toxicity: an opportunity for genome medicine

scientific article

Genome-wide association study of response to methotrexate in early rheumatoid arthritis patients ⬇️

article

Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors

scientific article

Genomics and Drug Response ⬇️

scientific article published on March 24, 2011

Germline genome-wide association studies in women receiving neoadjuvant chemotherapy with or without bevacizumab

scientific article published on 01 June 2018

Glutathione S-transferase T1 and M1: gene sequence variation and functional genomics

scientific article published on December 2007

Glutathione S-transferase omega 1 and omega 2 pharmacogenomics

scientific article published on 25 April 2006

Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy

scientific article

Glutathione s-transferase p1: gene sequence variation and functional genomic studies

scientific article published on June 2008

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization

scientific article

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes

scientific article

Human 3'-phosphoadenosine 5'-phosphosulfate synthetase: radiochemical enzymatic assay, biochemical properties, and hepatic variation

scientific article

Human 3beta-hydroxysteroid dehydrogenase types 1 and 2: Gene sequence variation and functional genomics

scientific article published on 08 June 2007

Human Biochemical Genetics of Plasma Dopamine-β-Hydroxylase and Erythrocyte Catechol-O-Methyltransferase ⬇️

scientific article published on January 1, 1978

Human Erythrocyte Proteinl-Isoaspartyl Methyltransferase: Heritability of Basal Activity and Genetic Polymorphism for Thermal Stability ⬇️

scientific article published on October 15, 1997

Human S-adenosylhomocysteine hydrolase: common gene sequence variation and functional genomic characterization

scientific article

Human SULT1A1 gene: copy number differences and functional implications

scientific article

Human SULT1A3 pharmacogenetics: gene duplication and functional genomic studies

scientific article

Human aromatase: gene resequencing and functional genomics

scientific article published in December 2005

Human arsenic methyltransferase (AS3MT) pharmacogenetics: gene resequencing and functional genomics studies

scientific article

Human betaine-homocysteine methyltransferase (BHMT) and BHMT2: common gene sequence variation and functional characterization

scientific article published on 23 May 2008

Human brain phenol sulfotransferase: biochemical properties and regional localization

scientific article published on September 1984

Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.

scientific article published in June 1996

Human catecholamine sulfotransferase (SULT1A3) pharmacogenetics: functional genetic polymorphism ⬇️

scientific article published on November 1, 2003

Human cytosolic sulfotransferase database mining: identification of seven novel genes and pseudogenes

scientific article

Human dehydroepiandrosterone sulfotransferase gene: molecular cloning and structural characterization

scientific article

Human erythrocyte histamine N-methyltransferase: radiochemical microassay and biochemical properties

scientific article published on July 1985

Human erythrocyte thiol methyltransferase: radiochemical microassay and biochemical properties

scientific article published on September 1979

Human estrogen sulfotransferase (SULT1E1) pharmacogenomics: gene resequencing and functional genomics

scientific article

Human histamine N-methyltransferase pharmacogenetics: cloning and expression of kidney cDNA.

scientific article published on March 1994

Human histamine N-methyltransferase pharmacogenetics: gene resequencing, promoter characterization, and functional studies of a common 5'-flanking region single nucleotide polymorphism (SNP)

scientific article (publication date: 15 August 2002)

Human hydroxysteroid sulfotransferase SULT2B1 pharmacogenomics: gene sequence variation and functional genomics

scientific article published on 11 May 2007

Human intestinal phenol sulfotransferase: assay conditions, activity levels and partial purification of the thermolabile form

scientific article published in May 1989

Human kidney thiopurine methyltransferase. Purification and biochemical properties.

scientific article

Human liver methionine cycle: MAT1A and GNMT gene resequencing, functional genomics, and hepatic genotype-phenotype correlation

scientific article

Human liver nicotinamide N-methyltransferase: ion-pairing radiochemical assay, biochemical properties and individual variation

scientific article published on January 1990

Human liver thermostable phenol sulfotransferase: photoaffinity labeling with 2-iodo-4-azidophenol

scientific article

Human liver thiopurine methyltransferase pharmacogenetics: biochemical properties, liver-erythrocyte correlation and presence of isozymes

scientific article published on August 1, 1992

Human liver xanthine oxidase: Nature and extent of individual variation

scientific article published on December 1, 1991

Human methylenetetrahydrofolate reductase pharmacogenomics: gene resequencing and functional genomics

scientific article published in April 2006

Human monoamine oxidase. Lack of brain and platelet correlation

scientific article published in June 1986

Human nicotinamide N-methyltransferase gene: molecular cloning, structural characterization and chromosomal localization

scientific article

Human nicotinamide N-methyltransferase pharmacogenetics

Human nicotinamide N-methyltransferase pharmacogenetics: gene sequence analysis and promoter characterization

scientific article

Human phenol sulfotransferase: correlation of brain and platelet activities

scientific article published in April 1985

Human phenol sulfotransferases SULT1A2 and SULT1A1: genetic polymorphisms, allozyme properties, and human liver genotype-phenotype correlations

scientific article published on August 1999

Human phenylethanolamine N-methyltransferase genetic polymorphisms and exercise-induced epinephrine release

scientific article published on 18 March 2008

Human phenylethanolamine N-methyltransferase pharmacogenomics: gene re-sequencing and functional genomics

scientific article published on 8 November 2005

Human sulfotransferase SULT1C1 pharmacogenetics: gene resequencing and functional genomic studies

scientific article

Human sulfotransferase SULT2A1 pharmacogenetics: genotype-to-phenotype studies

scientific article

Human sulfotransferases SULT1C1 and SULT1C2: cDNA characterization, gene cloning, and chromosomal localization

scientific article

Human thiopurine S-methyltransferase pharmacogenetics: variant allozyme misfolding and aggresome formation

scientific article

Identification of a novel percent mammographic density locus at 12q24.

scientific article

Immune Mediator Pharmacogenomics: TCL1A SNPs and Estrogen-Dependent Regulation of Inflammation

scientific article published on August 2017

Implementation of preemptive DNA sequence–based pharmacogenomics testing across a large academic medical center: The Mayo-Baylor RIGHT 10K Study

scientific article published in 2022

Implementing Genomic Medicine in the Clinic

Implementing genomic medicine in the clinic: the future is here

scientific article published on 10 January 2013

Incidental genetic findings in randomized clinical trials: recommendations from the Genomics and Randomized Trials Network (GARNET).

scientific article

Influence of SULT1A1 genetic variation on age at menopause, estrogen levels, and response to hormone therapy in recently postmenopausal white women

scientific article published on 13 June 2016

Inheritance and drug response

scientific article

Inheritance of human plasma dopamine-beta-hydroxylase thermal stability

scientific article

Inheritance of human platelet thermolabile phenol sulfotransferase (TL PST) activity

scientific article published on January 1988

Inheritance of low erythrocyte catechol-o-methyltransferase activity in man

scientific article

Inheritance of low serum immunoglobulin D

scientific article published on August 1978

Inheritance of very low serum dopamine-beta-hydroxylase activity

scientific article published on September 1975

Inhibition of rat liver catechol-O-methyltransferase by lanthanum. neodymium and europium

scientific article published on August 1976

Intensification of mercaptopurine/methotrexate maintenance chemotherapy may increase the risk of relapse for some children with acute lymphoblastic leukemia

scientific article published in April 2003

Interindividual variability in acetaminophen sulfation by human fetal liver: implications for pharmacogenetic investigations of drug-induced birth defects

scientific article published in March 2008

Interview: An Interview with Pharmacogenomics for the Breast Cancer Special Focus Issue ⬇️

scientific article published on April 1, 2012

Interview: Richard M Weinshilboum Talks to Hannah Branch, Assistant Commissioning Editor ⬇️

scientific article published on February 1, 2013

Investigation of Efavirenz Discontinuation in Multi-ethnic Populations of HIV-positive Individuals by Genetic Analysis

scientific article

Ketamine and ketamine metabolites as novel estrogen receptor ligands: Induction of cytochrome P450 and AMPA glutamate receptor gene expression

scientific article published on 2 April 2018

Leveraging an Electronic Health Record-Linked Biorepository to Generate a Metformin Pharmacogenomics Hypothesis

scientific article published on 23 March 2015

MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

Maintenance therapy of childhood acute lymphoblastic leukemia revisited-Should drug doses be adjusted by white blood cell, neutrophil, or lymphocyte counts?

scientific article published on 22 July 2016

Mammographic breast density response to aromatase inhibition

scientific article published on 6 March 2013

Merging pharmacometabolomics with pharmacogenomics using '1000 Genomes' single-nucleotide polymorphism imputation: selective serotonin reuptake inhibitor response pharmacogenomics

scientific article

Metabolomics: a global biochemical approach to drug response and disease

scientific article

Metformin pharmacogenomics: biomarkers to mechanisms

scientific article

Methionine adenosyltransferase 2A/2B and methylation: gene sequence variation and functional genomics

scientific article

Methotrexate/6-mercaptopurine maintenance therapy influences the risk of a second malignant neoplasm after childhood acute lymphoblastic leukemia: results from the NOPHO ALL-92 study

scientific article published on 17 February 2009

Methylation pharmacogenetics: catechol O-methyltransferase, thiopurine methyltransferase, and histamine N-methyltransferase

scientific article

Methylation pharmacogenetics: thiopurine methyltransferase as a model system

scientific article published on September 1, 1992

Methylenetetrahydrofolate reductase haplotype tag single-nucleotide polymorphisms and risk of breast cancer.

scientific article

Microassay of human erythrocyte catechol-O-methyltransferase: Removal of inhibitory calcium ion with chelating resin ⬇️

scientific article published on January 20, 1975

Model-based unsupervised learning informs metformin-induced cell-migration inhibition through an AMPK-independent mechanism in breast cancer

scientific article published on 10 March 2017

Monogenic inheritance of catechol-O-methyltransferase activity in the rat -- biochemical and genetic studies

scientific article published on April 1, 1979

Mood Stabilizing Antiepileptic Treatment Response in Bipolar Disorder: A Genome-Wide Association Study

scientific article published on 05 July 2020

Mouse Nicotinamide N-Methyltransferase Gene: Molecular Cloning, Structural Characterization, and Chromosomal Localization ⬇️

scientific article published on August 1, 1998

Mouse liver nicotinamide N-methyltransferase: cDNA cloning, expression, and nucleotide sequence polymorphisms

scientific article published on November 1997

Mouse thiopurine methyltransferase pharmacogenetics: correlation of immunoreactive protein and enzymatic activity

scientific article published in February 1990

Mouse thiopurine methyltransferase pharmacogenetics: monogenic inheritance.

scientific article published in March 1987

Multi-omics driven predictions of response to acute phase combination antidepressant therapy: a machine learning approach with cross-trial replication

scientific article published on 07 October 2021

Mutational Landscapes of Sequential Prostate Metastases and Matched Patient Derived Xenografts during Enzalutamide Therapy

scientific article

Mycophenolic acid response biomarkers: A cell line model system-based genome-wide screen ⬇️

scientific article published on March 23, 2011

Myelotoxicity after high-dose methotrexate in childhood acute leukemia is influenced by 6-mercaptopurine dosing but not by intermediate thiopurine methyltransferase activity

scientific article

N-acetyltransferase 1 and 2 genotypes do not predict response or toxicity to treatment with mesalamine and sulfasalazine in patients with ulcerative colitis

scientific article

Natriuretic peptide pharmacogenetics: Membrane metallo-endopeptidase (MME): Common gene sequence variation, functional characterization and degradation ⬇️

scientific article published on August 6, 2010

Natriuretic peptide receptor-3 gene (NPR3): nonsynonymous polymorphism results in significant reduction in protein expression because of accelerated degradation

scientific article published on 14 March 2013

New insights into the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation.

scientific article

New insights on the pharmacogenomics of antidepressant response from the GENDEP and STAR*D studies: rare variant analysis and high-density imputation

Nomenclature for alleles of the thiopurine methyltransferase gene

scientific article published on April 2013

Olsalazine and 6-mercaptopurine-related bone marrow suppression: A possible drug-drug interaction

scientific article published on October 1, 1997

PANOPLY: Omics-Guided Drug Prioritization Method Tailored to an Individual Patient

scientific article published on 01 December 2018

Pathophysiology of postoperative ileus

scientific article published on February 1, 1977

Pathway-Based Analysis of Genome-Wide Association Data Identified SNPs in HMMR as Biomarker for Chemotherapy- Induced Neutropenia in Breast Cancer Patients

scientific article published on 13 March 2018

Pemetrexed and oxaliplatin for metastatic colorectal cancer: results of a phase I Mayo Cancer Center Research Consortium trial, MC0248.

scientific article

PharmGKB summary: very important pharmacogene information for GSTT1.

scientific article published on August 2012

Pharmacogenetics and pharmacogenomics: development, science, and translation

scientific article published on January 2006

Pharmacogenetics of acute azathioprine toxicity: relationship to thiopurine methyltransferase genetic polymorphism

scientific article published in August 1989

Pharmacogenetics of human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1): gene resequencing, sequence variation, and functional genomics

scientific article published on June 2003

Pharmacogenetics of methyl conjugation

scientific article published on January 1, 1983

Pharmacogenetics: inherited variation in amino acid sequence and altered protein quantity

scientific article published on April 2004

Pharmacogenomic Discovery to Function and Mechanism: Breast Cancer as a Case Study

scientific article

Pharmacogenomics and patient care: one size does not fit all.

scientific article published on September 2012

Pharmacogenomics of aromatase inhibitors in postmenopausal breast cancer and additional mechanisms of anastrozole action

scientific article published on 23 July 2020

Pharmacogenomics of endocrine therapy in breast cancer.

scientific article published on January 2008

Pharmacogenomics: Precision Medicine and Drug Response

scientific article published in November 2017

Pharmacogenomics: bench to bedside

scientific article published in September 2004

Pharmacogenomics: candidate gene identification, functional validation and mechanisms

scientific article

Pharmacogenomics: catechol O-methyltransferase to thiopurine S-methyltransferase

scientific article published on 29 June 2006

Pharmacogenomics: challenges and opportunities

scientific article published on November 2006

Pharmacometabolomics informs Pharmacogenomics

scientific article published on July 2016

Phenol Sulfotransferase Pharmacogenetics in Humans: Association of CommonSULT1A1Alleles with TS PST Phenotype ⬇️

scientific article published on October 9, 1997

Phenol sulfotransferase in humans: properties, regulation, and function

scientific article

Phenolsulphotransferase: enzyme activity and endogenous inhibitors in the human erythrocyte

scientific article published on July 1, 1979

Plasma Dopamine-Beta-hydroxylase Activity and Catecholamine Levels in Anesthetized Dogs Following Acute Hemorrhage ⬇️

scientific article published on November 1, 1975

Polygenic risk scores for major depressive disorder and neuroticism as predictors of antidepressant response: Meta-analysis of three treatment cohorts

scientific article published in PLoS ONE

Preclinical discovery of candidate genes to guide pharmacogenetics during phase I development: the example of the novel anticancer agent ABT-751.

scientific article published on July 2013

Preemptive Pharmacogenomic Testing for Precision Medicine: A Comprehensive Analysis of Five Actionable Pharmacogenomic Genes Using Next-Generation DNA Sequencing and a Customized CYP2D6 Genotyping Cascade

scientific article published on 3 March 2016

Preemptive genotyping for personalized medicine: design of the right drug, right dose, right time-using genomic data to individualize treatment protocol

scientific article

Primer on medical genomics. Part XII: Pharmacogenomics--general principles with cancer as a model

scientific article published on March 2004

Proportional Release of Norepinephrine and Dopamine-β-Hydroxylase from Sympathetic Nerves ⬇️

scientific article published on December 24, 1971

Rabbit lung indolethylamine N-methyltransferase. cDNA and gene cloning and characterization

scientific article

Rat phenol sulfotransferase. Assay procedure, developmental changes, and glucocorticoid regulation

scientific article

Re: Concordance between CYP2D6 genotypes obtained from tumor-derived and germline DNA.

scientific article published on 3 April 2014

Regulation of sister chromatid cohesion by nuclear PD-L1

scientific article published on 29 April 2020

Research directions in the clinical implementation of pharmacogenomics - An Overview of US programs and projects

scientific article published on 20 February 2018

Richard Weinshilboum: Pharmacogenetics: The future is here!

scientific article published in May 2003

Role of the glutathione metabolic pathway in lung cancer treatment and prognosis: a review

scientific article

SLCO1B1 polymorphisms and plasma estrone conjugates in postmenopausal women with ER+ breast cancer: genome-wide association studies of the estrone pathway.

scientific article

SULT1A1, CYP2C19 and disease-free survival in early breast cancer patients receiving tamoxifen

scientific article published on 3 October 2011

Selective Estrogen Receptor Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression: Individualized Breast Cancer Prevention ⬇️

scientific article published on June 13, 2013

Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization ⬇️

scientific article published on February 6, 2012

Serum dopamine beta-hydroxylase ⬇️

scientific article published on June 1, 1978

Severe 6-thioguanine-induced marrow aplasia in a child with acute lymphoblastic leukemia and inherited thiopurine methyltransferase deficiency

scientific article

Single-nucleotide polymorphism biomarkers of adjuvant anastrozole-induced estrogen suppression in early breast cancer

scientific article published on 08 July 2020

Spontaneous murine tumors in the development of patient-derived xenografts: a potential pitfall

scientific article published on 11 June 2019

Strategic plan for lung vascular research: An NHLBI-ORDR Workshop Report

scientific article

Structural Basis of Substrate Recognition in Thiopurine S -Methyltransferase † ‡

scientific article

Studying treatment resistance in depression using patient derived neurons in vitro.

scientific article published in June 2019

Sulfate and methyldopa metabolism: metabolite patterns and platelet phenol sulfotransferase activity

scientific article published in March 1985

Sulfation pharmacogenetics: correlation of human platelet and small intestinal phenol sulfotransferase

scientific article

TCL1A Single-Nucleotide Polymorphisms and Estrogen-Mediated Toll-Like Receptor-MYD88-Dependent Nuclear Factor-κB Activation: Single-Nucleotide Polymorphism- and Selective Estrogen Receptor Modulator-Dependent Modification of Inflammation and Immune

scientific article published on 14 June 2017

TCL1A, a novel transcription factor and a co-regulator of NF-кB p65: SNP and estrogen-dependence

scientific article published on 28 March 2018

TPMT genetic variants are associated with increased rejection with azathioprine use in heart transplantation

scientific article published on December 2013

TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response

scientific article published on 04 August 2020

TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression

scientific article published on 21 March 2013

The Gordon Wilson Lecture. The Mayo model: one path to an academic medical center.

scientific article published on January 2002

The Pharmacogenomics Research Network Translational Pharmacogenetics Program: overcoming challenges of real-world implementation

scientific article published on 19 March 2013

The Relationship between COMT Genotype and the Clinical Effectiveness of Tolcapone, a COMT Inhibitor, in Patients with Parkinson's Disease

scholarly article by Derek J Chong et al published May 2000 in Clinical Neuropharmacology

The Role of the Aryl Hydrocarbon Receptor (AHR) in Immune and Inflammatory Diseases

scientific article published in 2018

The SNP rs6500843 in 16p13.3 is associated with survival specifically among chemotherapy-treated breast cancer patients

scientific article published on April 2015

The eSNV-detect: a computational system to identify expressed single nucleotide variants from transcriptome sequencing data

scientific article

The effect of CYP2D6 drug-drug interactions on hydrocodone effectiveness

scientific article

The genomic revolution and medicine

scientific article published in August 2002

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

scientific article

The lncRNA MIR2052HG regulates ERα levels and aromatase inhibitor resistance through LMTK3 by recruiting EGR1

The novel function of tumor protein D54 in regulating pyruvate dehydrogenase and metformin cytotoxicity in breast cancer

article published in 2019

The therapeutic revolution

scientific article published in November 1987

Theoretical 3D model of histamine N-methyltransferase: insights into the effects of a genetic polymorphism on enzymatic activity and thermal stability

scientific article

Thiopurine S-methyltransferase pharmacogenetics: autophagy as a mechanism for variant allozyme degradation

scientific article

Thiopurine S-methyltransferase pharmacogenetics: chaperone protein association and allozyme degradation

scientific article published in September 2003

Thiopurine S-methyltransferase pharmacogenetics: functional characterization of a novel rapidly degraded variant allozyme

scientific article

Thiopurine S-methyltransferase pharmacogenetics: variant allele functional and comparative genomics

scientific article

Thiopurine methyltransferase activity in red blood cells of dogs

scientific article published in March 2004

Thiopurine methyltransferase polymorphic tandem repeat: genotype-phenotype correlation analysis

scientific article published on August 2000

Thiopurine methyltransferase. Aromatic thiol substrates and inhibition by benzoic acid derivatives.

scientific article published in November 1983

Thiopurine methyltransferase: mouse kidney and liver assay conditions, biochemical properties and strain variation

scientific article published on November 1985

Thiopurine methyltransferase: structure-activity relationships for benzoic acid inhibitors and thiophenol substrates

scientific article published in March 1986

Thiopurine pathway

scientific article

Thiopurine pharmacogenomics: association of SNPs with clinical response and functional validation of candidate genes

scientific article

Toxicity and metabolism in mice of 2,6-dithiopurine, a potential chemopreventive agent.

scientific article published in August 1995

Treatment outcomes of depression: the pharmacogenomic research network antidepressant medication pharmacogenomic study

scientific article published on June 2014

Tumor Sequencing and Patient-Derived Xenografts in the Neoadjuvant Treatment of Breast Cancer

scientific article

Two‐Phase Designs to Follow‐Up Genome‐Wide Association Signals With DNA Resequencing Studies ⬇️

scientific article published on January 24, 2013

Using EHR-Linked Biobank Data to Study Metformin Pharmacogenomics

scientific article

Using the gene ontology to scan multilevel gene sets for associations in genome wide association studies

scientific article published on 7 December 2011

Validation of the 17-item Hamilton Depression Rating Scale definition of response for adults with major depressive disorder using equipercentile linking to Clinical Global Impression scale ratings: analysis of Pharmacogenomic Research Network Antide

scientific article

Variation in anastrozole metabolism and pharmacodynamics in women with early breast cancer

scientific article

Very important pharmacogene summary: sulfotransferase 1A1.

scientific article published on June 2009

Very important pharmacogene summary: thiopurine S-methyltransferase

scientific article

Paulina is supported by:

About Paulina

Help