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List of works by Eric C Lai

A Drosophila genetic screen yields allelic series of core microRNA biogenesis factors and reveals post-developmental roles for microRNAs ⬇️

scientific article published on 23 September 2011

A Drosophila pasha mutant distinguishes the canonical microRNA and mirtron pathways

scientific article published on December 2008

A broadly conserved pathway generates 3'UTR-directed primary piRNAs

scientific article

A deathly DNase activity for dicer

scientific article published on May 2010

A deeply conserved, noncanonical miRNA hosted by ribosomal DNA.

scientific article

A genome-wide survey of sexually dimorphic expression of Drosophila miRNAs identifies the steroid hormone-induced miRNA let-7 as a regulator of sexual identity.

scientific article

A genome-wide transgenic resource for conditional expression of Drosophila microRNAs

scientific article

A hidden program in Drosophila peripheral neurogenesis revealed: fundamental principles underlying sensory organ diversity

scientific article published on May 2004

A neural m<sup>6</sup>A/Ythdf pathway is required for learning and memory in Drosophila

scientific article published on 05 March 2021

A signaling-induced switch in dicer localization and function

scientific article published in December 2014

A transgenic resource for conditional competitive inhibition of conserved Drosophila microRNAs

scientific article published on 17 June 2015

A view from Drosophila: multiple biological functions for individual microRNAs

scientific article

APP causes an energy crisis.

scientific article published in April 2003

Abundant primary piRNAs, endo-siRNAs, and microRNAs in a Drosophila ovary cell line

scientific article published on 18 June 2009

Adaptive evolution of testis-specific, recently evolved, clustered miRNAs in Drosophila

scientific article published on 18 June 2014

Adaptive regulation of testis gene expression and control of male fertility by the Drosophila hairpin RNA pathway. [Corrected].

scientific article

Adult-specific functions of animal microRNAs

scientific article

Aging Fly Cell Atlas identifies exhaustive aging features at cellular resolution

scientific article published on 15 June 2023

Alteration of miRNA activity via context-specific modifications of Argonaute proteins

scientific article

Alternative miRNA biogenesis pathways and the interpretation of core miRNA pathway mutants

scientific article

Alternative polyadenylation in the nervous system: to what lengths will 3' UTR extensions take us?

scientific article

An extensive allelic series of Drosophila kae1 mutants reveals diverse and tissue-specific requirements for t6A biogenesis.

scientific article

Analysis of Nearly One Thousand Mammalian Mirtrons Reveals Novel Features of Dicer Substrates

scientific article published on September 2015

Antagonism of notch signaling activity by members of a novel protein family encoded by the bearded and enhancer of split gene complexes.

scientific article published on January 2000

Ars2 maintains neural stem-cell identity through direct transcriptional activation of Sox2 ⬇️

scientific journal article

BEN-solo factors partition active chromatin to ensure proper gene activation in Drosophila

scientific article published on 13 December 2019

BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells

scientific article

Bi-functional cross-linking reagents efficiently capture protein-DNA complexes in Drosophila embryos

scientific article published on 13 December 2013

Biological principles of microRNA-mediated regulation: shared themes amid diversity

scientific article

Cancer-associated mutations in DICER1 RNase IIIa and IIIb domains exert similar effects on miRNA biogenesis

scientific article published on 15 August 2019

Characterization of a TUTase/RNase complex required for Drosophila gametogenesis.

scientific article published on 14 December 2016

Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family

scientific journal article

Common and distinct patterns of terminal modifications to mirtrons and canonical microRNAs

scientific article published on 21 December 2011

Complementary miRNA pairs suggest a regulatory role for miRNA:miRNA duplexes

scientific article published in February 2004

Computational and experimental identification of mirtrons in Drosophila melanogaster and Caenorhabditis elegans

scientific article

Computational identification of Drosophila microRNA genes

scientific article published in 2003

Conserved vertebrate mir-451 provides a platform for Dicer-independent, Ago2-mediated microRNA biogenesis

scientific article

Control of microRNA biogenesis and transcription by cell signaling pathways

scientific article

Correction: Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues

scientific article published on April 2017

Cross GTPase-activating protein (CrossGAP)/Vilse links the Roundabout receptor to Rac to regulate midline repulsion

scientific article

DICER1 Is Essential for Self-Renewal of Human Embryonic Stem Cells

scientific article published on 23 August 2018

Deep annotation of Drosophila melanogaster microRNAs yields insights into their processing, modification, and emergence

scientific article

Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus

scientific article published on 12 December 2017

Deep experimental profiling of microRNA diversity, deployment, and evolution across the Drosophila genus

Developmental signaling: shrimp and strawberries help flies make cones

scientific article

Dicer-independent, Ago2-mediated microRNA biogenesis in vertebrates

scientific article

Dicing of viral replication intermediates during silencing of latent Drosophila viruses

scholarly article

Discovery of functional elements in 12 Drosophila genomes using evolutionary signatures

scientific article

Discovery of hundreds of mirtrons in mouse and human small RNA data

scientific article

Distinct mechanisms for microRNA strand selection by Drosophila Argonautes

scientific article

Diverse modes of evolutionary emergence and flux of conserved microRNA clusters

scientific article

Diverse roles for RNA in gene regulation

scientific article

Diversity and dynamics of the Drosophila transcriptome

scientific article

Diversity of miRNAs, siRNAs, and piRNAs across 25 Drosophila cell lines

scientific article

Drosophila Argonaute 1 and its miRNA biogenesis partners are required for oocyte formation and germline cell division

scientific article published on 14 March 2012

Drosophila Neuralized Is a Ubiquitin Ligase that Promotes the Internalization and Degradation of Delta ⬇️

scientific article published on December 1, 2001

Drosophila Tufted Is a Gain-of-Function Allele of the Proneural Gene amos ⬇️

scientific article published on April 1, 2003

Drosophila microRNAs exhibit diverse spatial expression patterns during embryonic development

scientific article

Drosophila piwi mutants exhibit germline stem cell tumors that are sustained by elevated Dpp signaling

scientific article published on 25 July 2013

Dual Strategies for Argonaute2-Mediated Biogenesis of Erythroid miRNAs Underlie Conserved Requirements for Slicing in Mammals

scientific article published in January 2018

Endogenous RNA interference provides a somatic defense against Drosophila transposons

scientific article

Endogenous small interfering RNAs in animals

scientific article published on September 2008

Erratum: Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

scientific article published on 01 September 2008

Evolution of mir-92a underlies natural morphological variation in Drosophila melanogaster

scientific article published on 28 February 2013

Evolution, biogenesis, expression, and target predictions of a substantially expanded set of Drosophila microRNAs

scientific article

Evolutionary flux of canonical microRNAs and mirtrons in Drosophila

scientific article published on January 2010

Exploiting Drosophila genetics to understand microRNA function and regulation

scientific article published in January 2012

Frequent unanticipated alleles of lethal giant larvae in Drosophila second chromosome stocks

scientific article published on 11 March 2009

Functional parameters of Dicer-independent microRNA biogenesis

scientific article published on 29 March 2012

Functional screening identifies miR-315 as a potent activator of Wingless signaling

scholarly article

Functional small RNAs are generated from select miRNA hairpin loops in flies and mammals

scientific article published on 27 March 2013

Functionally distinct regulatory RNAs generated by bidirectional transcription and processing of microRNA loci

scientific article

Genome-wide analysis of drosophila circular RNAs reveals their structural and sequence properties and age-dependent neural accumulation

scientific article

Genome-wide identification of Grainy head targets in Drosophila reveals regulatory interactions with the POU domain transcription factor Vvl.

scientific article published on 31 July 2017

Genome-wide profiling of the 3' ends of polyadenylated RNAs

scientific article

Global patterns of tissue-specific alternative polyadenylation in Drosophila

scientific article

Homeostatic control of Argonaute stability by microRNA availability

scientific article published on 26 May 2013

Homeotic function of Drosophila Bithorax-complex miRNAs mediates fertility by restricting multiple Hox genes and TALE cofactors in the CNS

scientific article

Hox miRNA regulation within the Drosophila Bithorax complex: Patterning behavior

scientific article

Hybrid neurons in a microRNA mutant are putative evolutionary intermediates in insect CO2 sensory systems

scientific article

Insensitive is a corepressor for Suppressor of Hairless and regulates Notch signalling during neural development

scientific article

Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project

scientific article

Intertwined pathways for Argonaute-mediated microRNA biogenesis in Drosophila

scientific article

IsoSCM: improved and alternative 3' UTR annotation using multiple change-point inference

scientific article

Keeping a good pathway down: transcriptional repression of Notch pathway target genes by CSL proteins

scientific article

Lamas in loops

Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species

scientific article

Lessons from microRNA mutants in worms, flies and mice

scientific article published on 17 August 2008

Life in a low calcium home

article published in 2003

Lipid rafts make for slippery platforms

scientific article

Mammalian mirtron genes

scientific article

Maternal mRNA deadenylation and decay by the piRNA pathway in the early Drosophila embryo

scientific article published on 17 October 2010

MicroRNA biogenesis via splicing and exosome-mediated trimming in Drosophila

scientific article

MicroRNA-205 controls neonatal expansion of skin stem cells by modulating the PI(3)K pathway

scientific article published on 25 August 2013

Mirtrons: microRNA biogenesis via splicing

scientific article published on 21 June 2011

Multiple In Vivo Biological Processes Are Mediated by Functionally Redundant Activities of Drosophila mir-279 and mir-996.

scientific article published on 4 June 2015

Natural variation of the amino-terminal glutamine-rich domain in Drosophila argonaute2 is not associated with developmental defects

scientific article (publication date: 17 December 2010)

Neural specificity of the RNA-binding protein Elav is achieved by post-transcriptional repression in non-neural tissues

scientific article published on 17 October 2016

Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development.

scientific article published in May 2001

Neurophysiological defects and neuronal gene deregulation in Drosophila mir-124 mutants

scientific article

New genes often acquire male-specific functions but rarely become essential in Drosophila.

scientific article published in September 2017

Notch cleavage: Nicastrin helps Presenilin make the final cut.

scientific article

Notch signaling: control of cell communication and cell fate

scientific article (publication date: March 2004)

Pervasive regulation of Drosophila Notch target genes by GY-box-, Brd-box-, and K-box-class microRNAs

scientific article

Predicting and validating microRNA targets

scientific article

Protein degradation: four E3s for the notch pathway

scientific article

R2D2 organizes small regulatory RNA pathways in Drosophila

scientific article

RB pockets the cell cycle.

scientific article published in April 2003

RNA sensors and riboswitches: self-regulating messages

scientific article

RNA silencing in Monterey

scientific article published on August 2011

RNAi in Xenopus: look before you leap

scientific article published on June 2011

RNase III-independent microRNA biogenesis in mammalian cells

scientific article

Regulation of Drosophila Neurogenesis byRNA:RNA Duplexes? ⬇️

scientific article published on June 26, 1998

Regulation of embryonic and adult neurogenesis by Ars2

scientific article published on 22 January 2020

Selective Suppression of the Splicing-Mediated MicroRNA Pathway by the Terminal Uridyltransferase Tailor

scientific article published on 2 July 2015

Short cryptic exons mediate recursive splicing in Drosophila.

scientific article published on 9 April 2018

The BEN domain is a novel sequence-specific DNA-binding domain conserved in neural transcriptional repressors

scientific article

The Bearded box, a novel 3' UTR sequence motif, mediates negative post-transcriptional regulation of Bearded and Enhancer of split Complex gene expression.

scientific article published in December 1997

The Drosophila gene Bearded encodes a novel small protein and shares 3′ UTR sequence motifs with multiple Enhancer of split Complex genes ⬇️

scientific article published on October 1, 1997

The Drosophila hairpin RNA pathway generates endogenous short interfering RNAs

scientific article published on 07 May 2008

The Drosophila miR-310 cluster negatively regulates synaptic strength at the neuromuscular junction

scientific article

The Drosophila microRNA iab-4 causes a dominant homeotic transformation of halteres to wings

scientific article

The Hippo pathway regulates hematopoiesis in Drosophila melanogaster

scientific article

The K box, a conserved 3' UTR sequence motif, negatively regulates accumulation of enhancer of split complex transcripts.

scientific article

The evolution and functional diversification of animal microRNA genes

scientific article

The hpRNA/RNAi Pathway Is Essential to Resolve Intragenomic Conflict in the Drosophila Male Germline

The impact of age, biogenesis, and genomic clustering on Drosophila microRNA evolution

scientific article published on 23 July 2013

The long and short of inverted repeat genes in animals: microRNAs, mirtrons and hairpin RNAs

scientific article

The m6A pathway facilitates sex determination in Drosophila.

scientific article

The miR-310/13 cluster antagonizes β-catenin function in the regulation of germ and somatic cell differentiation in the Drosophila testis

scientific article published on July 2013

The mir-279/996 cluster represses receptor tyrosine kinase signaling to determine cell fates in the Drosophila eye.

scientific article published on 14 March 2018

The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila

scientific article (publication date: 13 July 2007)

The nuclear export receptor XPO-1 supports primary miRNA processing in C. elegans and Drosophila

scientific article

The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolution

scientific article published on 30 March 2008

The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta

scientific article

Transcriptional Regulation of the Glutamate/GABA/Glutamine Cycle in Adult Glia Controls Motor Activity and Seizures in Drosophila

scientific article published on 07 May 2019

Transgenic inhibitors of RNA interference in Drosophila

scientific article

Two decades of miRNA biology: lessons and challenges

scientific article

Two distinct mechanisms generate endogenous siRNAs from bidirectional transcription in Drosophila melanogaster

scientific article published on 25 May 2008

Unlocking the secrets of the genome

scientific article

Virus discovery by deep sequencing and assembly of virus-derived small silencing RNAs.

scientific article

Vive la différence: biogenesis and evolution of microRNAs in plants and animals

scientific article

Where new neurons come from

article by Eric C Lai et al published 7 April 2003 in Journal of Cell Biology

Widespread and extensive lengthening of 3' UTRs in the mammalian brain

scientific article published on 21 March 2013

Widespread regulatory activity of vertebrate microRNA* species

scientific article

XPO5 promotes primary miRNA processing independently of RanGTP

scientific article published on 15 April 2020

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

scientific article

miR-124 Regulates Diverse Aspects of Rhythmic Behavior in Drosophila

scientific article published on March 2016

miR-33a/b contribute to the regulation of fatty acid metabolism and insulin signaling

scientific article

miR-486 is essential for muscle function and suppresses a dystrophic transcriptome

scientific article published on 05 May 2022

miR-9a prevents apoptosis during wing development by repressing Drosophila LIM-only

scientific article

miRNA suppression of a Notch repressor directs non-neuronal fate in Drosophila mechanosensory organs

scientific article published in December 2017

miRNAs: whys and wherefores of miRNA-mediated regulation

scientific article

microRNA control of cell-cell signaling during development and disease

scientific article published on 13 June 2008

microRNAs: runts of the genome assert themselves

scientific article published on December 2003

neuralized functions cell-autonomously to regulate a subset of notch-dependent processes during adult Drosophila development.

scientific article published in March 2001

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