List of works - Odile Filhol

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

scientific article published on 13 February 2019

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

scientific article published on 08 May 2020

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels.

scientific article published on 26 April 2011

A phosphatase cascade by which rewarding stimuli control nucleosomal response

scientific article

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2

scientific article

Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

scientific article published in Journal of Biological Chemistry

CK2 accumulation at the axon initial segment depends on sodium channel Nav1.

scientific article published on 7 August 2014

Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein.

scholarly article

Casein kinase II and polyamines may interact in the response of adrenocortical cells to their trophic hormone

scientific article published on 01 October 1991

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation ⬇️

scientific article published on October 15, 1992

Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer ⬇️

scientific article published on August 1, 1997

Chemical features of the protein kinase CK2 polyamine binding site.

scientific article published in February 1997

Coexpression of both alpha and beta subunits is required for assembly of regulated casein kinase II.

scientific article

Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma

scientific article published on 10 July 2018

Crystallization and preliminary x-ray diffraction analysis of the regulatory subunit of human protein kinase CK2

scientific article published on 01 April 1999

Cytoplasmic and nuclear distribution of casein kinase II: characterization of the enzyme uptake by bovine adrenocortical nuclear preparation

scientific article published on 01 October 1990

DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons

scientific article

DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active.

scientific article

DSIR: assessing the design of highly potent siRNA by testing a set of cancer-relevant target genes ⬇️

scientific article

Direct identification of a polyamine binding domain on the regulatory subunit of the protein kinase casein kinase 2 by photoaffinity labeling

scientific article published on 01 July 1995

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

scientific article published on 04 November 2019

Dissecting subdomains involved in multiple functions of the CK2beta subunit

scientific article published on 01 January 1999

Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation?

scientific article published on November 2002

Engrailed homeoprotein secretion is a regulated process.

scientific article

Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma

scientific article published on 17 January 2020

FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

scientific article published on 10 April 2015

HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2

scientific article

Highlighting protein kinase CK2 movement in living cells

scientific article published in June 2005

Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

scientific article

Identification of chemical inhibitors of protein-kinase CK2 subunit interaction

scientific article published on 14 June 2008

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

scientific article published on 03 February 2017

In vitro and in vivo assays of protein kinase CK2 activity.

scientific article published on January 2010

Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.

scientific article

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469

scientific article published on 01 November 2000

Modulation of the molecular organization and activity of casein kinase 2 by naturally occurring polyamines.

scientific article published in January 1994

Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD).

scientific article published on 4 August 2015

Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer

scientific article published on 30 January 2007

Oligomeric casein kinase II isoforms are expressed in bovine tissues and adrenocortical cells in culture

scientific article published on 01 January 1994

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth

scientific article

Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition.

scientific article

Protein kinase CK2 and cell polarity.

scientific article

Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.

scientific article published on 5 October 2016

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

scientific article published on 20 May 2015

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

scientific article published on June 2009

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

scientific article published on 15 August 2007

Protein kinase CK2 regulates CDC25B phosphatase activity

scientific article (publication date: 16 January 2003)

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays

scientific article published on 29 December 2010

Protein kinases curb cell death.

scientific article published on 10 May 2011

Quaternary structure of casein kinase 2. Characterization of multiple oligomeric states and relation with its catalytic activity.

scientific article published in April 1995

Regulation of epithelial to mesenchymal transition: CK2β on stage.

scientific article published on 14 July 2011

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells

scientific journal article

Searching interaction partners of protein kinase CK2beta subunit by two-hybrid screening.

scientific article

Spatial organization of the extracellular matrix regulates cell-cell junction positioning.

scientific article

Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells.

scientific article published on 31 August 2017

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell.

scientific article

Targeting AU-rich element-mediated mRNA decay with a truncated active form of the zinc-finger protein TIS11b/BRF1 impairs major hallmarks of mammary tumorigenesis

scientific article published on 26 March 2019

The antiapoptotic protein ICBP90 is a target for protein kinase 2.

scientific article published in December 2004

The disruption of adherens junctions is associated with a decrease of E-cadherin phosphorylation by protein kinase CK2.

scientific article published in June 2000

The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2

scientific article (publication date: 8 October 1999)

The size-speed-force relationship governs migratory cell response to tumorigenic factors.

scientific article

The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory β-subunit ⬇️

scientific article published on June 22, 1998

The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

scientific article published on 22 March 2018

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.

scientific article

Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.

scientific article published on November 2001

[Has protein kinase CK2 a role in the intracellular mitogenic signalling?]

scientific article published on 01 January 1995

[Protein kinase CK2 and cancer: further clues are accumulating]

scientific article published on 01 March 2002

[Therapeutic agents targetting protein-protein interactions: myth or reality?]

scientific article published on 01 March 2007

p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.

scientific article published on 5 June 2006

List of works by Odile Filhol

2-Aminothiazole Derivatives as Selective Allosteric Modulators of the Protein Kinase CK2. 2. Structure-Based Optimization and Investigation of Effects Specific to the Allosteric Mode of Action

A RUNX2 stabilization pathway mediates physiologic and pathologic bone formation

A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels.

A phosphatase cascade by which rewarding stimuli control nucleosomal response

Antitumor activity of pyridocarbazole and benzopyridoindole derivatives that inhibit protein kinase CK2

Binding of Polyamines to an Autonomous Domain of the Regulatory Subunit of Protein Kinase CK2 Induces a Conformational Change in the Holoenzyme

CK2 accumulation at the axon initial segment depends on sodium channel Nav1.

Casein kinase 2 inhibits the renaturation of complementary DNA strands mediated by p53 protein.

Casein kinase II and polyamines may interact in the response of adrenocortical cells to their trophic hormone

Casein kinase II and the tumor suppressor protein P53 associate in a molecular complex that is negatively regulated upon P53 phosphorylation ⬇️

Characterization of two different cytoplasmic protein tyrosine kinases from human breast cancer ⬇️

Chemical features of the protein kinase CK2 polyamine binding site.

Coexpression of both alpha and beta subunits is required for assembly of regulated casein kinase II.

Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma

Crystallization and preliminary x-ray diffraction analysis of the regulatory subunit of human protein kinase CK2

Cytoplasmic and nuclear distribution of casein kinase II: characterization of the enzyme uptake by bovine adrenocortical nuclear preparation

DARPP-32 interaction with adducin may mediate rapid environmental effects on striatal neurons

DNA topoisomerase II and casein kinase II associate in a molecular complex that is catalytically active.

DSIR: assessing the design of highly potent siRNA by testing a set of cancer-relevant target genes ⬇️

Direct identification of a polyamine binding domain on the regulatory subunit of the protein kinase casein kinase 2 by photoaffinity labeling

Discovery of holoenzyme-disrupting chemicals as substrate-selective CK2 inhibitors

Dissecting subdomains involved in multiple functions of the CK2beta subunit

Dynamic localization/association of protein kinase CK2 subunits in living cells: a role in its cellular regulation?

Engrailed homeoprotein secretion is a regulated process.

Ex-Vivo Treatment of Tumor Tissue Slices as a Predictive Preclinical Method to Evaluate Targeted Therapies for Patients with Renal Carcinoma

FRET-based screening assay using small-molecule photoluminescent probes in lysate of cells overexpressing RFP-fused protein kinases.

HIRIP3 is a nuclear phosphoprotein interacting with and phosphorylated by the serine-threonine kinase CK2

Highlighting protein kinase CK2 movement in living cells

Identification of a cryptic protein kinase CK2 phosphorylation site in human complement protease Clr, and its use to probe intramolecular interaction.

Identification of chemical inhibitors of protein-kinase CK2 subunit interaction

In Search of Small Molecule Inhibitors Targeting the Flexible CK2 Subunit Interface

In vitro and in vivo assays of protein kinase CK2 activity.

Live-cell fluorescence imaging reveals the dynamics of protein kinase CK2 individual subunits.

Mitotic phosphorylation of DNA topoisomerase II alpha by protein kinase CK2 creates the MPM-2 phosphoepitope on Ser-1469

Modulation of the molecular organization and activity of casein kinase 2 by naturally occurring polyamines.

Modulatory role of the anti-apoptotic protein kinase CK2 in the sub-cellular localization of Fas associated death domain protein (FADD).

Nuclear localization of protein kinase CK2 catalytic subunit (CK2alpha) is associated with poor prognostic factors in human prostate cancer

Oligomeric casein kinase II isoforms are expressed in bovine tissues and adrenocortical cells in culture

Pharmacological inhibition of LIM kinase stabilizes microtubules and inhibits neoplastic growth

Polarity Reversal by Centrosome Repositioning Primes Cell Scattering during Epithelial-to-Mesenchymal Transition.

Protein kinase CK2 and cell polarity.

Protein kinase CK2 controls T-cell polarization through dendritic cell activation in response to contact sensitizers.

Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity

Protein kinase CK2 in health and disease: Cellular functions of protein kinase CK2: a dynamic affair.

Protein kinase CK2 phosphorylation of EB2 regulates its function in the production of Epstein-Barr virus infectious viral particles.

Protein kinase CK2 regulates CDC25B phosphatase activity

Protein kinase CK2α subunit over-expression correlates with metastatic risk in breast carcinomas: quantitative immunohistochemistry in tissue microarrays

Protein kinases curb cell death.

Quaternary structure of casein kinase 2. Characterization of multiple oligomeric states and relation with its catalytic activity.

Regulation of epithelial to mesenchymal transition: CK2β on stage.

Regulation of the proapoptotic functions of prostate apoptosis response-4 (Par-4) by casein kinase 2 in prostate cancer cells

Searching interaction partners of protein kinase CK2beta subunit by two-hybrid screening.

Spatial organization of the extracellular matrix regulates cell-cell junction positioning.

Stem Cell-Like Properties of CK2β-down Regulated Mammary Cells.

Structure-function analysis of the beta regulatory subunit of protein kinase CK2 by targeting embryonic stem cell.

Targeting AU-rich element-mediated mRNA decay with a truncated active form of the zinc-finger protein TIS11b/BRF1 impairs major hallmarks of mammary tumorigenesis

The antiapoptotic protein ICBP90 is a target for protein kinase 2.

The disruption of adherens junctions is associated with a decrease of E-cadherin phosphorylation by protein kinase CK2.

The multifunctional herpes simplex virus IE63 protein interacts with heterogeneous ribonucleoprotein K and with casein kinase 2

The size-speed-force relationship governs migratory cell response to tumorigenic factors.

The tight association of protein kinase CK2 with plasma membranes is mediated by a specific domain of its regulatory β-subunit ⬇️

The tyrosine-kinase inhibitor sunitinib targets vascular endothelial (VE)-cadherin: a marker of response to antitumoural treatment in metastatic renal cell carcinoma

Unbalanced expression of CK2 kinase subunits is sufficient to drive epithelial-to-mesenchymal transition by Snail1 induction.

Visualization and molecular analysis of nuclear import of protein kinase CK2 subunits in living cells.

[Has protein kinase CK2 a role in the intracellular mitogenic signalling?]

[Protein kinase CK2 and cancer: further clues are accumulating]

[Therapeutic agents targetting protein-protein interactions: myth or reality?]

p53-dependent inhibition of mammalian cell survival by a genetically selected peptide aptamer that targets the regulatory subunit of protein kinase CK2.