Search filters

List of works by David A. Sinclair

A Blueprint for Developing Therapeutic Approaches That Increase Healthspan and Delay Death

scientific article published on 07 April 2010

A NEW MOUSE MODEL TO UNRAVEL THE MECHANISM OF SIRT1 ACTIVATION

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

scientific article

A high-confidence interaction map identifies SIRT1 as a mediator of acetylation of USP22 and the SAGA coactivator complex

scientific article

A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse

scientific article

AGING INSACCHAROMYCES CEREVISIAE

scientific article published in 1998

Accelerated Aging and Nucleolar Fragmentation in Yeast sgs1 Mutants ⬇️

scientific article published on August 29, 1997

Acetylation of the C terminus of Ku70 by CBP and PCAF controls Bax-mediated apoptosis

scientific article published in March 2004

Age and life expectancy clocks based on machine learning analysis of mouse frailty

scientific article published on 15 September 2020

Aging-like phenotype and defective lineage specification in SIRT1-deleted hematopoietic stem and progenitor cells

scientific article

Amino Acid Restriction Triggers Angiogenesis via GCN2/ATF4 Regulation of VEGF and H2S Production.

scientific article published in March 2018

Analysis of 41 cancer cell lines reveals excessive allelic loss and novel mutations in the SIRT1 gene

scientific article published on 15 January 2012

Assays for NAD+-Dependent Reactions and NAD+ Metabolites

scientific article published on 01 January 2018

Bax-inhibiting peptide protects cells from polyglutamine toxicity caused by Ku70 acetylation

scientific article

Berberine protects against high fat diet-induced dysfunction in muscle mitochondria by inducing SIRT1-dependent mitochondrial biogenesis

scientific article

Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3

scientific journal article

Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose-response framework

scientific article published on 7 March 2007

CELL BIOLOGY: An Age of Instability

scientific article published in Science

CPNE2: A NEW REGULATOR OF LYSOSOMAL-MITOCHONDRIAL FUNCTION INVOLVED IN AGING AND DISEASE

article published in 2018

Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase

scientific article

Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism

scientific article published on July 2013

Characterization of murine SIRT3 transcript variants and corresponding protein products

scientific article published on November 2010

Comparing the Effects of Low-Protein and High-Carbohydrate Diets and Caloric Restriction on Brain Aging in Mice

scientific article published on 01 November 2018

Control of Expression of One-carbon Metabolism Genes ofSaccharomyces cerevisiaeIs Mediated by a Tetrahydrofolate-responsive Protein Binding to a Glycine Regulatory Region Including a Core 5′-CTTCTT-3′ Motif

scientific article published in Journal of Biological Chemistry

Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability

scientific article published on 19 December 2015

DISCOVERY OF A NOVEL CIRCULATING PEPTIDOME IN HUMAN SERUM THAT CORRELATES WITH AGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

DISRUPTING THE EPIGENOME IN NOVEL NICE MICE TO STUDY AGE-RELATED COGNITIVE DECLINE

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

DIVERGENT REGULATION OF SIRT1 MEDIATES THE ENDOCRINE RESPONSE TO CALORIE RESTRICTION

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

David A. Sinclair, Ph.D is interviewed by Vicki Glaser

scientific article published in February 2008

Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging

scientific article

Design and synthesis of compounds that extend yeast replicative lifespan

scientific article

Design, synthesis, and biological evaluation of sirtinol analogues as class III histone/protein deacetylase (Sirtuin) inhibitors

scientific article

Dietary restriction involves NAD⁺ -dependent mechanisms and a shift toward oxidative metabolism.

scientific article published on 25 September 2014

Dietary restriction: standing up for sirtuins

scientific article published on August 2010

Drugs for preventing malaria in pregnant women in endemic areas: any drug regimen versus placebo or no treatment

scientific article published on 10 October 2014

Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions

scientific article published on 01 September 2018

EVIDENCE THAT EPIGENETIC ALTERATIONS DRIVE MAMMALIAN AGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice.

scientific article published on June 2016

Epigenetic changes during aging and their reprogramming potential

scientific article published on 01 February 2019

Evaluation of resveratrol, green tea extract, curcumin, oxaloacetic acid, and medium-chain triglyceride oil on life span of genetically heterogeneous mice

scientific article

Evidence for a common mechanism of SIRT1 regulation by allosteric activators

scientific article

Extrachromosomal rDNA circles--a cause of aging in yeast

scientific article (publication date: 26 December 1997)

Flavonoid apigenin is an inhibitor of the NAD+ ase CD38: implications for cellular NAD+ metabolism, protein acetylation, and treatment of metabolic syndrome

scientific article published on 19 November 2012

Frailty biomarkers in humans and rodents: Current approaches and future advances

scientific article published on 17 April 2019

GLTSCR2/PICT1 links mitochondrial stress and Myc signaling.

scientific article

Guidelines for the use and interpretation of assays for monitoring autophagy

scientific article

HST2 mediates SIR2-independent life-span extension by calorie restriction

scientific article

IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING

IN VIVO CELLULAR REPROGRAMMING FOR TISSUE REGENERATION AND AGE REVERSAL

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

INVESTIGATING THE DNA DAMAGE RESPONSE AS A DRIVER OF EPIGENETIC CHANGE DURING AGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

Identification of a SIRT1 mutation in a family with type 1 diabetes

scientific article published on March 2013

Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice.

scientific article

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging.

scientific article published in March 2018

Impairment of an Endothelial NAD-HS Signaling Network Is a Reversible Cause of Vascular Aging

scientific article published on 01 February 2019

Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1

scientific article (publication date: 22 November 2002)

LONG-LIVED ANIMAL MODELS AND HEALTH-SPAN EXTENSION IN STUDIES OF AGING

scholarly article in Innovation in Aging, vol. 1, Suppl 1, June 2017

Lifespan: Why We Age - and Why We Don't Have To

non-fiction book on human longevity

Lifespan: Why We Age - and Why We Don't Have To

hardback edition (en)

Longevity regulation in Saccharomyces cerevisiae: linking metabolism, genome stability, and heterochromatin

scientific article

Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects

scientific article published in Scientific Reports

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

scientific article (publication date: 28 May 1999)

MSN2 and MSN4 link calorie restriction and TOR to sirtuin-mediated lifespan extension in Saccharomyces cerevisiae.

scientific article

Mammalian sirtuins: biological insights and disease relevance

scientific article (publication date: 2010)

Manipulation of a nuclear NAD + salvage pathway delays aging without altering steady-state NAD + levels.

scientific article published in Journal of Biological Chemistry

Manipulation of a nuclear NAD+ salvage pathway delays aging without altering steady-state NAD+ levels

scientific article

Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay

scientific article published on January 2013

Metformin improves healthspan and lifespan in mice

scientific article

Mitohormesis and metabolic health: The interplay between ROS, cAMP and sirtuins

scientific article published on 24 July 2019

Molecular Biology of Aging

scientific article published on 01 January 1999

Molecular and Cellular Characterization of SIRT1 Allosteric Activators

scientific article published on 01 January 2019

Molecular mechanisms of yeast aging

scientific article published on 01 April 1998

Mosquito larval source management for controlling malaria

scientific article published on 29 August 2013

Multiple basal cell carcinomas in a patient with myotonic dystrophy type 1

scientific article published on 08 March 2019

NAD PRECURSORS AS INTERVENTIONS FOR AGE-RELATED DISEASES AND EXTENDING HUMAN HEALTHSPAN

scholarly article in Innovation in Aging, vol. 1, Suppl 1, June 2017

NAD+ DEPLETION AS A CAUSE OF INFLAMMAGING

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast.

scientific article

Nampt/PBEF/Visfatin: a regulator of mammalian health and longevity?

scientific article published on 13 July 2006

Negative regulation of STAT3 protein-mediated cellular respiration by SIRT1 protein

scientific article

Neuronal sirtuin1 mediates retinal vascular regeneration in oxygen-induced ischemic retinopathy.

scientific article published on 4 August 2013

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice.

scientific article published in March 2018

Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae

scientific article

Nicotinamide mononucleotide (NMN) supplementation ameliorates the impact of maternal obesity in mice: comparison with exercise.

scientific article published on 8 November 2017

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

article

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged …

scholarly article

Nutrient-sensitive mitochondrial NAD+ levels dictate cell survival

scientific article

O-GlcNAcylation regulates breast cancer metastasis via SIRT1 modulation of FOXM1 pathway.

scientific article published on 27 June 2016

Oogonial stem cells as a model to study age-associated infertility in women.

scientific article published on 22 April 2015

Oxidative Priority, Meal Frequency, and the Energy Economy of Food and Activity: Implications for Longevity, Obesity, and Cardiometabolic Disease.

scientific article

Paradigms and pitfalls of yeast longevity research

scientific article

Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae

scientific article published on August 1999

Prolyl isomerase Pin1 regulates neuronal differentiation via β-catenin

scientific journal article

Publisher Correction: Age and life expectancy clocks based on machine learning analysis of mouse frailty

scientific article published on 08 October 2020

Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach.

scientific article published on 23 December 2017

Quantitative proteomic analysis of extracellular vesicle subgroups isolated by an optimized method combining polymer-based precipitation and size exclusion chromatography

scientific article published on 27 April 2021

Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice

scientific article

Redistribution of silencing proteins from telomeres to the nucleolus is associated with extension of life span in S. cerevisiae.

scientific article

Reprogramming to recover youthful epigenetic information and restore vision

scientific article published on 02 December 2020

Response to: "If the Metabolic Winter Is Coming, When Will It Be Summer?" (Metab Syndr Relat Disord 2017;15:3).

scientific article

Restoring stem cells - all you need is NAD(.).

scientific article published on 24 June 2016

Resveratrol Improves Vascular Function and Mitochondrial Number but Not Glucose Metabolism in Older Adults.

scientific article published on 16 March 2017

Resveratrol accelerates erythroid maturation by activation of FoxO3 and ameliorates anemia in beta-thalassemic mice

scientific article published on 23 August 2013

Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

scientific article

Resveratrol improves health and survival of mice on a high-calorie diet

scientific article (publication date: 16 November 2006)

Resveratrol inhibits pathologic retinal neovascularization in Vldlr(-/-) mice

scientific article

Role of the N-terminal region of Rap1p in the transcriptional activation of glycolytic genes in Saccharomyces cerevisiae

scientific article

SIRT1 Limits Adipocyte Hyperplasia through c-Myc Inhibition

scientific article published on 11 December 2015

SIRT1 deacetylase in SF1 neurons protects against metabolic imbalance

scientific article

SIRT1 is essential for normal cognitive function and synaptic plasticity

scientific article

SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function

scientific article

SIRT1 mRNA expression may be associated with energy expenditure and insulin sensitivity

scientific article

SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging

scientific article

SIRT2 controls the pentose phosphate switch

scientific article published on 13 May 2014

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

scientific article

SRT1720 improves survival and healthspan of obese mice

scientific article

SRT2104 extends survival of male mice on a standard diet and preserves bone and muscle mass

scientific article

Selective Sirt2 inhibition by ligand-induced rearrangement of the active site.

scientific article

Sex differences in the response to dietary restriction in rodents.

scientific article

Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling

scientific article

Sir2 histone deacetylase prevents programmed cell death caused by sustained activation of the Hog1 stress-activated protein kinase

scientific article

Sirtuin 1 and sirtuin 3: physiological modulators of metabolism

scientific article

Sirtuin activators and inhibitors: Promises, achievements, and challenges.

scientific article published on 22 March 2018

Sirtuin activators mimic caloric restriction and delay ageing in metazoans

scientific article (publication date: 5 August 2004)

Sirtuin1 over-expression does not impact retinal vascular and neuronal degeneration in a mouse model of oxygen-induced retinopathy.

scientific article

Sirtuins and NAD in the Development and Treatment of Metabolic and Cardiovascular Diseases

article

Sirtuins for healthy neurons

Sirtuins: a conserved key unlocking AceCS activity

scientific article published on December 2006

Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.

scientific article published on 6 November 2017

Small molecule SIRT1 activators for the treatment of aging and age-related diseases

scientific article published on 16 January 2014

Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

scientific article

Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan

scientific article (publication date: 11 September 2003)

Small molecules that regulate lifespan: evidence for xenohormesis

scientific article

Small-molecule allosteric activators of sirtuins

scientific article

Stress-dependent regulation of FOXO transcription factors by the SIRT1 deacetylase

scientific article

Synthesis and Assay of SIRT1-Activating Compounds

scientific article (publication date: 2016)

TPE or not TPE? It's no longer a question

scientific article

Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles

scientific article published on 01 January 2019

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

scientific article published on 28 March 2019

The "metabolic winter" hypothesis: a cause of the current epidemics of obesity and cardiometabolic disease

scientific article

The Longevity of Sirtuins ⬇️

scientific article published on December 27, 2012

The SIRT1 activator SRT1720 extends lifespan and improves health of mice fed a standard diet

scientific article

The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth

scientific article

The Sirt1 activator SRT3025 expands hematopoietic stem and progenitor cells and improves hematopoiesis in Fanconi anemia mice.

scientific article published on 22 May 2015

The ageing epigenome: damaged beyond repair?

scientific article

The enzyme CD38 (a NAD glycohydrolase, EC 3.2.2.5) is necessary for the development of diet-induced obesity.

scientific article

The intersection between aging and cardiovascular disease

scientific article

The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice

scientific article

The role of nuclear architecture in genomic instability and ageing

scientific article published on September 2007

The role of protein arginine methylation in the formation of silent chromatin

scientific article

Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence.

scientific article published in March 2018

Therapeutic potential of resveratrol: the in vivo evidence

scientific article (publication date: June 2006)

Toward a unified theory of caloric restriction and longevity regulation

scientific article

Type 5 adenylyl cyclase increases oxidative stress by transcriptional regulation of manganese superoxide dismutase via the SIRT1/FoxO3a pathway

scientific article published on 27 March 2013

UNCOVERING THE CONNECTION BETWEEN GENOMIC AND EPIGENOMIC STABILITY DURING AGING WITH EXOGENOUS DNA REPAIR PROTEINS

article published in 2018

UNDERSTANDING WHY WE GROW OLD AS WE GROW OLDER

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

USING PROTEOMICS TO ELUCIDATE HOW VOLUNTARY EXERCISE COMBATS AGING PHENOTYPES IN MTDNA MUTATOR MICE

scholarly article in Innovation in Aging, vol. 2, Suppl 1, November 2018

When stem cells grow old: phenotypes and mechanisms of stem cell aging

scientific article

Why NAD(+) Declines during Aging: It's Destroyed

scientific article published on June 2016

Xenohormesis: sensing the chemical cues of other species

scientific article published on May 2008

Yeast life-span extension by calorie restriction is independent of NAD fluctuation

scientific article

Paulina is supported by:

About Paulina

Help