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List of works by Laura J. Blair

A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51.

scientific article

Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.

scientific article published on 03 September 2013

Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency.

scientific article

Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy

scientific article published on 12 December 2008

Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau.

scientific article published on 19 April 2013

Catalysis of proline isomerization and molecular chaperone activity in a tug-of-war

scientific article published on 27 November 2020

Chaperone signalling complexes in Alzheimer's disease.

scientific article published on April 2009

Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress

scientific article published in 2023

DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins.

scientific article published on 3 June 2016

Dynamic Aha1 co-chaperone binding to human Hsp90

scientific article published on 06 August 2019

Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus

scientific article published on 04 June 2019

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

scientific article

Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics.

scientific article published on December 2011

Facilitating Akt clearance via manipulation of Hsp70 activity and levels.

scientific article

Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism

scientific article

Hsc70 rapidly engages tau after microtubule destabilization

scientific article

Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels

scientific article published on 30 July 2020

Hsp90 Heterocomplexes Regulate Steroid Hormone Receptors: From Stress Response to Psychiatric Disease ⬇️

scientific article published on 25 December 2018

Hsp90 activator Aha1 drives production of pathological tau aggregates

scientific article published on 21 August 2017

Hsp90 and FKBP51: complex regulators of psychiatric diseases

scientific article published in January 2018

Human cyclophilin 40 unravels neurotoxic amyloids

scientific article

Imbalance of Hsp70 family variants fosters tau accumulation

scientific article published on 27 December 2012

Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies.

scientific article published on 22 December 2017

Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma

scientific article published on 20 December 2017

LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice

scientific article

MicroRNA-511 Binds to FKBP5 mRNA, Which Encodes a Chaperone Protein, and Regulates Neuronal Differentiation

scientific article published on 21 June 2016

Noncontact Rotational Head Injury Produces Transient Cognitive Deficits but Lasting Neuropathological Changes.

scientific article published on 6 January 2016

Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden

scientific article

Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice.

scientific article

Potential synergy between tau aggregation inhibitors and tau chaperone modulators.

scientific article

Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins

scientific article published on 09 January 2019

Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance

scientific article

Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease

scientific article published on 18 September 2019

Spermidine/spermine-N1-acetyltransferase ablation impacts tauopathy-induced polyamine stress response

scientific article published on 29 June 2019

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex

scientific article published in Nature Communications

Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease

scientific article

Targeting the FKBP51/GR/Hsp90 Complex to Identify Functionally Relevant Treatments for Depression and PTSD

scientific article published on 19 June 2018

Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation

scientific article published on May 2013

Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy

scientific article

The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling

scientific article published on 01 January 2019

The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules.

scientific article

The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. ⬇️

scientific article

The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease

scientific article

The multiple facets of the Hsp90 machine

scientific article published on 01 February 2019

The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance

scientific article

Trifunctional High-Throughput Screen Identifies Promising Scaffold To Inhibit Grp94 and Treat Myocilin-Associated Glaucoma.

scientific article published on 5 February 2018

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