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List of works by Xiao Yang

Adam10 is essential for early embryonic cardiovascular development ⬇️

scientific article published on October 1, 2010

Adaptation of SARS-CoV-2 in BALB/c mice for testing vaccine efficacy

scientific article published on 30 July 2020

Altered contractile phenotypes of intestinal smooth muscle in mice deficient in myosin phosphatase target subunit 1

scientific article published on 13 March 2013

Annexin A2 is a discriminative serological candidate in early hepatocellular carcinoma ⬇️

scientific article published on November 27, 2012

Atp4b promoter directs the expression of Cre recombinase in gastric parietal cells of transgenic mice

scientific article published on 01 September 2010

BMP restricts stemness of intestinal Lgr5+ stem cells by directly suppressing their signature genes

scientific article published on 06 January 2017

BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells ⬇️

scientific article published on February 3, 2012

Capn8 promoter directs the expression of Cre recombinase in gastric pit cells of transgenic mice

scientific article published on 01 October 2009

Cardiomyocyte overexpression of miR-27b induces cardiac hypertrophy and dysfunction in mice

scientific article published on 16 August 2011

Centrosomal Nlp is an oncogenic protein that is gene-amplified in human tumors and causes spontaneous tumorigenesis in transgenic mice

scientific article

Delayed re-epithelialization in Ppm1a gene-deficient mice is mediated by enhanced activation of Smad2

scientific article published on 11 October 2011

Detection of epithelial to mesenchymal transition in airways of a bleomycin induced pulmonary fibrosis model derived from an alpha-smooth muscle actin-Cre transgenic mouse

scientific article published on 7 January 2007

Downregulation of microRNA miR-526a by enterovirus inhibits RIG-I-dependent innate immune response.

scientific article

Dysregulated Tgfbr2/ERK-Smad4/SOX2 Signaling Promotes Lung Squamous Cell Carcinoma Formation

scientific article published on 17 June 2019

Effect of TGF-beta/Smad signaling pathway on lung myofibroblast differentiation.

scientific article published on March 2007

Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development.

scientific article published on July 2010

Endothelial Smad4 Maintains Cerebrovascular Integrity by Activating N-Cadherin through Cooperation with Notch ⬇️

scientific article published on March 15, 2011

Establishment of Smad2 conditional gene targeting mice based on the Cre-LoxP system

scientific article published in April 2002

Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs.

scientific article published in December 2004

Ezh2 Acts as a Tumor Suppressor in Kras-driven Lung Adenocarcinoma.

scientific article

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2.

scientific article

Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development.

scientific article

Functional screening for miRNAs targeting Smad4 identified miR-199a as a negative regulator of TGF-β signalling pathway.

scientific article

Functions of autophagy in pathological cardiac hypertrophy

scientific article published on 27 April 2015

Functions of mammalian Smad genes as revealed by targeted gene disruption in mice

scientific article

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.

scientific article published on 15 April 2013

GdX/UBL4A specifically stabilizes the TC45/STAT3 association and promotes dephosphorylation of STAT3 to repress tumorigenesis.

scientific article

Geft is dispensable for the development of the second heart field.

scientific article published in March 2012

Generation and primary phenotypes of imidazoline receptor antisera-selected (IRAS) knockout mice

scientific article published on 04 November 2013

Generation of Smad4/Dpc4 conditional knockout mice

scientific article published on 01 February 2002

Generation of mice with conditional null allele for GdX/Ubl4A ⬇️

scientific article published on January 24, 2012

Genetic Targeting of Organ-Specific Blood Vessels

scientific article published on 15 May 2018

Gly369Cys mutation in mouse FGFR3 causes achondroplasia by affecting both chondrogenesis and osteogenesis

scientific article

Gpr110 deficiency decelerates carcinogen-induced hepatocarcinogenesis via activation of the IL-6/STAT3 pathway

scientific article published on March 2017

Grb-2-associated binder 1 (Gab1) regulates postnatal ischemic and VEGF-induced angiogenesis through the protein kinase A-endothelial NOS pathway

scientific article

HBsAg and HBx knocked into the p21 locus causes hepatocellular carcinoma in mice

scientific article

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice.

scientific article published in April 2000

Hepatitis B virus X protein and the estrogen receptor variant lacking exon 5 inhibit estrogen receptor signaling in hepatoma cells

scientific article

Hepatitis B virus X protein modulates oncogene Yes-associated protein by CREB to promote growth of hepatoma cells.

scientific article

Highly efficient selection of the stable clones expressing antibody-IL-2 fusion protein by a dicistronic expression vector containing a mutant neo gene.

scientific article published on 4 October 2004

Human four-and-a-half LIM family members suppress tumor cell growth through a TGF-beta-like signaling pathway.

scientific article published on 12 January 2009

Identification and analysis of epidermal stem cells from primary mouse keratinocytes.

scientific article published in January 2013

Identification of high proliferative potential precursors with hemangioblastic activity in the mouse aorta-gonad- mesonephros region

scientific article published on 01 March 2007

In Vivo Phosphoproteome Analysis Reveals Kinome Reprogramming in Hepatocellular Carcinoma.

scientific article

Inhibition of endothelial ERK signalling by Smad1/5 is essential for haematopoietic stem cell emergence.

scientific article published on 11 March 2014

Involvement of aberrant miR-139/Jun feedback loop in human gastric cancer.

scientific article published on 10 December 2014

Loss of protein phosphatase 6 in oocytes causes failure of meiosis II exit and impaired female fertility.

scientific article

Maternal and zygotic Zfp57 modulate NOTCH signaling in cardiac development

scientific article published on 6 April 2015

Megakaryocytic Smad4 Regulates Platelet Function Through Syk and ROCK2 Expression

scientific article

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

scientific journal article

MicroRNA Let-7b inhibits keratinocyte migration in cutaneous wound healing by targeting IGF2BP2

scientific article published on 01 February 2017

MicroRNA-365 inhibits vascular smooth muscle cell proliferation through targeting cyclin D1

scientific article

Murine beta-casein gene sequences direct a human tissue plasminogen activator variant expressed in the milk of transgenic mice

scientific article published on 01 December 2002

Mutation analysis of the Smad3 gene in human osteoarthritis.

scientific article published in September 2003

Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure

scientific article

PES1 is a critical component of telomerase assembly and regulates cellular senescence

scientific article published on 15 May 2019

PPM1A regulates antiviral signaling by antagonizing TBK1-mediated STING phosphorylation and aggregation

scientific article

PTEN in smooth muscle cells is essential for colonic immune homeostasis.

scientific article

Potentiation of Smad-mediated transcriptional activation by the RNA-binding protein RBPMS

scientific article

Rapid adaptation of SARS-CoV-2 in BALB/c mice: Novel mouse model for vaccine efficacy

scientific article published on 03 May 2020

Region-specific endodermal signals direct neural crest cells to form the three middle ear ossicles

scientific article published on 22 January 2019

Regulation of large-scale chromatin unfolding by Smad4.

scientific article published on March 2004

Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury.

scientific article published on 9 May 2018

Smad2 and Smad3 have differential sensitivity in relaying TGFβ signaling and inversely regulate early lineage specification

scientific article published on 24 February 2016

Smad4 Deficiency in Smooth Muscle Cells Initiates the Formation of Aortic Aneurysm

scientific article published on 23 December 2015

Smad4 is required for the normal organization of the cartilage growth plate

scientific article published on 01 August 2005

Smad4 represses the generation of memory-precursor effector T cells but is required for the differentiation of central memory T cells

scientific article

Smad4-mediated TGF-beta signaling in tumorigenesis

scientific article

Smooth Muscle Hgs Deficiency Leads to Impaired Esophageal Motility

scientific article published on 22 May 2015

Stomach-specific c-Myc overexpression drives gastric adenoma in mice via AKT/mTOR signaling

scientific article published on 19 November 2020

Subepicardial endothelial cells invade the embryonic ventricle wall to form coronary arteries ⬇️

scientific article published on June 25, 2013

Surfactant protein A promoter directs the expression of Cre recombinase in brain microvascular endothelial cells of transgenic mice.

scientific article published on 16 September 2006

Sustained Akt signaling in articular chondrocytes causes osteoarthritis via oxidative stress-induced senescence in mice

scientific article published on 05 August 2019

Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice.

scientific article

TGF-beta/Smad3 signals repress chondrocyte hypertrophic differentiation and are required for maintaining articular cartilage

scientific article

TGF-β signaling in aortic aneurysm: another round of controversy.

scientific article published on September 2010

Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development.

scientific article

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

scientific journal article

Targeted disruption of Smad4 in cardiomyocytes results in cardiac hypertrophy and heart failure

scientific journal article

Targeted expression of uncoupling protein 2 to mouse liver increases the susceptibility to lipopolysaccharide/galactosamine-induced acute liver injury.

scientific article published in October 2009

Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1

scientific article

The function of miRNA in cardiac hypertrophy

scientific article

The role of Smad signaling in vascular and hematopoietic development revealed by studies using genetic mouse models.

scientific article published on April 2010

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

scientific article

The up-regulation of proteasome subunits and lysosomal proteases in hepatocellular carcinomas of the HBx gene knockin transgenic mice

scientific article published in January 2006

Transforming growth factor β-regulated microRNA-29a promotes angiogenesis through targeting the phosphatase and tensin homolog in endothelium.

scientific article published on 20 February 2013

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

scientific article

Wntless regulates dentin apposition and root elongation in the mandibular molar

scientific article published on 16 January 2015

miR-148a Promoted Cell Proliferation by Targeting p27 in Gastric Cancer Cells ⬇️

scientific article published on May 5, 2011

miR-199-sponge transgenic mice develop physiological cardiac hypertrophy

scientific article published on 14 March 2016

miR-199a impairs autophagy and induces cardiac hypertrophy through mTOR activation

scientific journal article

β-catenin is required in odontoblasts for tooth root formation

scientific article published on 23 January 2013

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