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List of works by Geoffrey Hammond

'Inductive' charges on atoms in proteins: comparative docking with the extended steroid benchmark set and discovery of a novel SHBG ligand.

scientific article published in November 2005

(Arene)Cl₂Ru(II) complexes with N-coordinated estrogen and androgen isonicotinates: interaction with sex hormone binding globulin and anticancer activity.

scientific article published on 22 December 2010

18F-labeled difluoroestradiols: preparation and preclinical evaluation as estrogen receptor-binding radiopharmaceuticals.

scientific article

37-kDa laminin receptor precursor mediates GnRH-II-induced MMP-2 expression and invasiveness in ovarian cancer cells.

scientific article

A Leu----His substitution at residue 93 in human corticosteroid binding globulin results in reduced affinity for cortisol.

scientific article

A liquid-phase immunoradiometric assay (IRMA) for human sex hormone binding globulin (SHBG)

scientific article published in October 1985

A phylogenetic study of the structural and functional characteristics of corticosteroid binding globulin in primates

scientific article published on 01 February 1985

A role for corticosteroid-binding globulin in delivery of cortisol to activated neutrophils

scientific article published on 01 July 1990

A solid-phase radioimmunoassay for human corticosteroid binding globulin

scientific article published on 01 February 1985

A versatile method for the determination of serum cortisol binding globulin and sex hormone binding globulin binding capacities

scientific article published on 01 July 1983

Access of reproductive steroids to target tissues.

scientific article

An Updated Steroid Benchmark Set and Its Application in the Discovery of Novel Nanomolar Ligands of Sex Hormone-Binding Globulin

scientific article published on 11 March 2008

Author Correction: Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox

scientific article published on 19 March 2018

Automation of steroid radioimmunoassays for clinical and research purposes

scientific article published on July 1, 1979

Biological half-life and transfer of maternal corticosteroid-binding globulin to amniotic fluid in the rabbit

scientific article published on 01 September 1989

Characterization and comparison of recombinant full-length ursine and human sex hormone-binding globulin

scientific article published on 13 December 2021

Characterization and measurement of the plasma alpha- and beta-sex hormone-binding globulin paralogs in salmon.

scientific article

Characterization of a monoclonal antibody to human sex hormone binding globulin

scientific article published in March 1984

Cloning of an ovine 11 beta-hydroxysteroid dehydrogenase complementary deoxyribonucleic acid: tissue and temporal distribution of its messenger ribonucleic acid during fetal and neonatal development

scientific article published on November 1, 1992

Colony-Specific Differences in Endocrine and Immune Responses to an Inflammatory Challenge in Female Sprague Dawley Rats

scientific article

Control of the membrane sex hormone-binding globulin-receptor (SHBG-R) in MCF-7 cells: effect of locally produced SHBG.

scientific article published on May 1998

Corticosteroid-Binding Globulin: Structure-Function Implications from Species Differences

scientific article

Corticosteroid-binding globulin (CBG) production by hepatic and extra-hepatic sites in the ovine fetus; effects of CBG on glucocorticoid negative feedback on pituitary cells in vitro.

scientific article published on July 1995

Corticosteroid-binding globulin biosynthesis in the mouse liver and kidney during postnatal development

scientific article published on 01 February 1993

Corticosteroid-binding globulin is a biomarker of inflammation onset and severity in female rats.

scientific article published on August 2016

Costs and Benefits of Extended Endocrine Strategies for Premenopausal Breast Cancer.

scientific article published in August 2017

Crystal structure of human sex hormone-binding globulin in complex with 2-methoxyestradiol reveals the molecular basis for high affinity interactions with C-2 derivatives of estradiol

scientific article

Crystallization of the N-terminal domain of human sex hormone-binding globulin, the major sex steroid carrier in blood

scientific article published on 01 December 1999

Cytoplasmic accumulation of incompletely glycosylated SHBG enhances androgen action in proximal tubule epithelial cells

scientific article

Development of the external genitalia: perspectives from the spotted hyena (Crocuta crocuta)

scientific article (publication date: 2014)

Differential effects of betamethasone and dexamethasone fetal administration of parturition in sheep

scientific article published on 01 November 1996

Distribution and concentrations of androgens in epithelial and stromal compartments of the human benign hypertrophic prostate

scientific article published on 01 July 1981

Divergent changes in plasma ACTH and pituitary POMC mRNA after cortisol administration to late-gestation ovine fetus.

scientific article published in March 1998

Diverse roles for sex hormone-binding globulin in reproduction.

scientific article

Effect of adrenocorticotropin administration on the biosynthesis of corticosteroid-binding globulin in fetal sheep

scientific article published on 01 April 1991

Effect of burn injury on corticosteroid-binding globulin levels in plasma and wound fluid.

scientific article published in January 1993

Effect of oestrogen treatment on testicular LH/HCG receptors and endogenous steroids in prostatic cancer patients

scientific article published on 01 December 1980

Effects of aggressive encounters on plasma corticosteroid-binding globulin and its ligands in white-crowned sparrows.

scientific article published on 8 July 2009

Effects of sex hormone-binding globulin (SHBG) on androgen bioactivity in vitro.

scientific article

Endogenous steroid levels in the human prostate from birth to old age: a comparison of normal and diseased tissues ⬇️

scientific article (publication date: July 1978)

Establishment of a Mouse Sertoli Cell Line Producing Rat Androgen-binding Protein (ABP) ⬇️

scientific article published on May 1, 1998

Estetrol does not bind sex hormone binding globulin or increase its production by human HepG2 cells.

scientific article

Estrogen receptor alpha gene polymorphisms are associated with idiopathic premature ovarian failure

scientific article published on 13 August 2007

Evidence that fibulin family members contribute to the steroid-dependent extravascular sequestration of sex hormone-binding globulin.

scientific article published on 06 April 2006

Evolving utility of sex hormone-binding globulin measurements in clinical medicine ⬇️

scientific article published on June 1, 2012

Expression and Differential Glycosylation of Human Sex Hormone-Binding Globulin by Mammalian Cell Lines ⬇️

scientific article published on November 1, 1991

Expression of mature pulmonary surfactant-associated protein B (SP-B) in Escherichia coli using truncated human SP-B cDNAs

scientific article published on 01 February 1990

Free estradiol in postmenopausal women with and without endometrial cancer

scientific article published on 01 March 1981

Functional implications of corticosteroid-binding globulin N-glycosylation

scientific article published on 22 December 2017

Glucocorticoid-induced increase in plasma corticosteroid-binding globulin levels in fetal sheep is associated with increased biosynthesis and alterations in glycosylation.

scientific article published in May 1993

Gonadotropin-releasing hormone-I-mediated activation of progesterone receptor contributes to gonadotropin alpha-subunit expression in mouse gonadotrophs.

scientific article

Gonadotropin-releasing hormone-II increases membrane type I metalloproteinase production via beta-catenin signaling in ovarian cancer cells.

scientific article published on 14 January 2011

Gonadotropin-releasing hormone-mediated phosphorylation of estrogen receptor-alpha contributes to fosB expression in mouse gonadotrophs.

scientific article

Hepatocyte nuclear factor-4 controls transcription from a TATA-less human sex hormone-binding globulin gene promoter.

scientific article published in December 1998

High frequency of SERPINA6 polymorphisms that reduce plasma corticosteroid-binding globulin activity in Chinese subjects.

scientific article published on 15 February 2012

Hormonal regulation of corticosteroid-binding globulin biosynthesis in the male rat

scientific article published on April 1, 1992

Human Sex Hormone-Binding Globulin Gene Expression in Transgenic Mice ⬇️

scientific article published on January 1, 1998

Human sex hormone-binding globulin does not provide metabolic protection against diet-induced obesity and dysglycemia in mice.

scientific article published on 15 November 2017

Human sex hormone-binding globulin is expressed in testicular germ cells and not in sertoli cells.

scientific article

Human sex hormone-binding globulin variants associated with hyperandrogenism and ovarian dysfunction.

scientific article

Identification and characterization of a human corticosteroid binding globulin variant with a reduced affinity for cortisol

scientific article published on 01 February 1985

Identification of Avian Corticosteroid-binding Globulin (SerpinA6) Reveals the Molecular Basis of Evolutionary Adaptations in SerpinA6 Structure and Function as a Steroid-binding Protein

scientific article published on 29 March 2016

Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock.

scientific article published in February 1999

Impact of corticosteroid-binding globulin deficiency on pregnancy and neonatal sex.

scientific article published on 19 February 2015

Interaction between corticosteroid binding globulin and activated leukocytes in vitro

scientific article published on 01 October 1990

Interactions between human plasma sex hormone-binding globulin and xenobiotic ligands

scientific article published on 01 December 2000

Interleukin-6 inhibits corticosteroid-binding globulin synthesis by human hepatoblastoma-derived (Hep G2) cells

scientific article published on 01 July 1993

Isolation and characterization of the structural region of the human CBG gene

scientific article published on 01 October 1988

LETTERS TO THE EDITOR: Do Oral Contraceptives Produce Irreversible Effects on Women's Sexuality?

scientific article published on 01 May 2006

Levels of surfactant-associated protein messenger ribonucleic acids in rabbit lung during perinatal development and after hormonal treatment

scientific article published on 01 November 1991

Long-term consequences of ovarian ablation for premenopausal breast cancer

scientific article published on 28 May 2016

Long-term effects of endocrine treatment on serum pituitary hormones in advanced prostatic carcinoma patients

scientific article published on 01 January 1981

Molecular analyses of a human sex hormone-binding globulin variant: evidence for an additional carbohydrate chain

scientific article published on October 1, 1992

Molecular analyses of human corticosteroid-binding globulin. Expression and gene structure

scientific article published on 01 January 1988

Molecular and Cellular Endocrinology. Foreward

scientific article published on 20 September 2009

Molecular and functional characterization of sex hormone binding globulin in zebrafish.

scientific article published on 29 July 2004

Molecular interactions between sex hormone-binding globulin and nonsteroidal ligands that enhance androgen activity

scientific article published on 18 December 2019

Monosaccharide-induced lipogenesis regulates the human hepatic sex hormone-binding globulin gene

scientific article

N-Glycosylation influences human corticosteroid-binding globulin measurements

scientific article published on 01 August 2019

Naturally occurring mutants inform SHBG structure and function.

scientific article

Naturally occurring mutations of human corticosteroid-binding globulin

scientific article published in January 2015

Neutrophil elastase-cleaved corticosteroid-binding globulin is absent in human plasma

scientific article published on 01 January 2019

Novel human corticosteroid-binding globulin variant with low cortisol-binding affinity.

scientific article published on January 2000

O-Glycosylation of human sex hormone-binding globulin is essential for inhibition of estradiol-induced MCF-7 breast cancer cell proliferation.

scientific article

Ontogenesis of UDP-glucuronosyltransferase enzymes in sheep ⬇️

scientific article published on February 23, 2011

Ontogenesis of phase I hepatic drug metabolic enzymes in sheep ⬇️

scientific article published on January 1, 2012

Ontogeny of corticosteroid-binding globulin biosynthesis in the rat.

scientific article published in February 1991

Ovarian ablation for premenopausal breast cancer: A review of treatment considerations and the impact of premature menopause

scientific article published on 22 February 2017

Perinatal fluoxetine effects on social play, the HPA system, and hippocampal plasticity in pre-adolescent male and female rats: Interactions with pre-gestational maternal stress

scientific article

Perinatal fluoxetine increases hippocampal neurogenesis and reverses the lasting effects of pre-gestational stress on serum corticosterone, but not on maternal behavior, in the rat dam.

scientific article

Peroxisome-proliferator receptor gamma represses hepatic sex hormone-binding globulin expression.

scientific article published on 29 January 2009

Phylogenetic comparisons implicate sex hormone-binding globulin in "masculinization" of the female spotted hyena (Crocuta crocuta).

scientific article published on 17 January 2012

Physicochemical characteristics of human sex hormone binding globulin: evidence for two identical subunits.

scientific article

Plasma levels of cortisol and corticosteroid binding globulin during use of Norplant-2 implants

scientific article published on 01 April 1987

Plasma steroid-binding proteins: primary gatekeepers of steroid hormone action

scientific article

Potential functions of plasma steroid-binding proteins.

scientific article published in November 1995

Preclinical profiles of progestins used in formulations of oral contraceptives and hormone replacement therapy.

scientific article

Pro-opiomelanocortin messenger RNA levels increase in the fetal sheep pituitary during late gestation ⬇️

scientific article published on December 1, 1991

Progesterone, androstenedione, testosterone, 5 alpha-dihydrotestosterone and androsterone concentrations in specific regions of the human brain

scientific article published on 01 February 1983

Progressive docking: a hybrid QSAR/docking approach for accelerating in silico high throughput screening

scientific article published on 01 December 2006

Pseudomonas aeruginosa elastase disrupts the cortisol-binding activity of corticosteroid-binding globulin.

scientific article

Rabbit corticosteroid-binding globulin: primary structure and biosynthesis during pregnancy

scientific article published on 01 August 1990

Rabbit sex hormone binding globulin: primary structure, tissue expression, and structure/function analyses by expression in Escherichia coli.

scientific article published in June 1997

Rapid effect of GNRH1 on follicle-stimulating hormone beta gene expression in LbetaT2 mouse pituitary cells requires the progesterone receptor.

scientific article

Repression of the human sex hormone-binding globulin gene in Sertoli cells by upstream stimulatory transcription factors.

scientific article published in December 2004

Resolution of a disordered region at the entrance of the human sex hormone-binding globulin steroid-binding site

scientific article

Resolution of the human sex hormone-binding globulin dimer interface and evidence for two steroid-binding sites per homodimer

scientific article published on 16 July 2001

Resolution of the steroid-binding and dimerization domains of human sex hormone-binding globulin by expression in Escherichia coli.

scientific article

Resveratrol Increases Hepatic SHBG Expression through Human Constitutive Androstane Receptor: a new Contribution to the French Paradox.

scientific article published on 25 September 2017

Rhox5 rules in an evolving saga of reproductive diversity

scientific article published on 22 June 2012

Sea bass (Dicentrarchus labrax) sex hormone binding globulin: molecular and biochemical properties and phylogenetic comparison of its orthologues in multiple fish species.

scientific article

Selective cleavage of human sex hormone-binding globulin by kallikrein-related peptidases and effects on androgen action in LNCaP prostate cancer cells

scientific article published on 30 April 2012

Selective removal of glycosylation sites from sex hormone-binding globulin by site-directed mutagenesis

scientific article published on November 1, 1992

Selective serotonin reuptake inhibitor effects on neural biomarkers of perinatal depression

scientific article published on 01 December 2018

Serum concentrations of total and non-protein-bound oestradiol in patients with breast cancer and in normal controls

scientific article published on 01 January 1982

Serum distribution of two contraceptive progestins: 3-ketodesogestrel and gestodene

scientific article published on 01 October 1994

Serum pregnenolone, progesterone, 17alpha-hydroxyprogesterone, androstenedione, testosterone, 5alpha-dihydrotestosterone and androsterone during puberty in boys

scientific article published on November 1, 1979

Serum sex hormone-binding globulin capacity and the percentage of free estradiol in postmenopausal women with and without endometrial carcinoma. A new biochemical basis for the association between obesity and endometrial carcinoma

scientific article published on 01 November 1980

Serum steroid binding protein concentrations, distribution of progestogens, and bioavailability of testosterone during treatment with contraceptives containing desogestrel or levonorgestrel

scientific article published on 01 July 1984

Serum steroid binding proteins and the bioavailability of estradiol in relation to breast diseases

scientific article published on 01 November 1985

Serum steroids in normal males and patients with prostatic diseases ⬇️

scientific article published on August 1, 1978

Sex hormone binding globulin during an annual reproductive cycle in the hepatopancreas and ovary of pejerrey (Odontesthes bonariensis)

scientific article published on 19 November 2018

Sex hormone binding globulin: Expression throughout early development and adult pejerrey fish, Odontesthes bonariensis

scientific article

Sex hormone-binding globulin expression in sea bass (Dicentrarchus labrax L.) throughout development and the reproductive season.

scientific article published on 19 July 2007

Sex hormone-binding globulin in fish gills is a portal for sex steroids breached by xenobiotics.

scientific article published on 15 May 2008

Sex hormone-binding globulin regulation of androgen bioactivity in vivo: validation of the free hormone hypothesis.

scientific article

Sex hormone-binding globulin--still many questions

Somatostatin is essential for the sexual dimorphism of GH secretion, corticosteroid-binding globulin production, and corticosterone levels in mice.

scientific article

Steroid conjugates of dichloro(6-aminomethylnicotinate)platinum(II): effects on DNA, sex hormone binding globulin, the estrogen receptor, and various breast cancer cell lines.

scientific article published in March 2007

Steroid ligands bind human sex hormone-binding globulin in specific orientations and produce distinct changes in protein conformation

scientific article

Steroid receptor coactivator-3 is required for progesterone receptor trans-activation of target genes in response to gonadotropin-releasing hormone treatment of pituitary cells.

scientific article published on 24 May 2006

Steroid-binding and dimerization domains of human sex hormone-binding globulin partially overlap: steroids and Ca2+ stabilize dimer formation

scientific article published on 01 September 1994

Structure/function analyses of human sex hormone-binding globulin by site-directed mutagenesis

scientific article published on 01 April 1992

Substitutions of tryptophan residues in human corticosteroid-binding globulin: impact on steroid binding and glycosylation

scientific article published on 01 June 1994

Testicular degeneration in Huntington disease.

scientific article

The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility.

scientific article published on 16 March 2004

The amino acid sequence of rat CBG deduced from a cDNA, and identification of CBG mRNA in the liver under different physiological states

scientific article published on 01 October 1988

The effects of estradiol-17° infusion into fetal sheep in late gestation ⬇️

scientific article published on June 1, 1997

The hormonal status of patients with benign prostatic hypertrophy: FSH, LH, TSH and prolactin responses to releasing hormones ⬇️

scientific article published on June 1, 1979

The human fetal adrenal produces cortisol but no detectable aldosterone throughout the second trimester

scientific article published on 12 February 2018

The shbg Gene and Hormone Dependence of Breast Cancer: A Novel Mechanism of Hormone Dependence of MCF-7 Human Breast Cancer Cells Based upon SHBG

scientific article published on 01 October 1999

The simultaneous radioimmunoassay of seven steroids in human spermatic and peripheral venous blood

scientific article published on July 1, 1977

Tissue distribution of alpha 1-proteinase inhibitor messenger ribonucleic acid and its regulation by glucocorticoids in fetal and neonatal sheep

scientific article published on 01 October 1993

Two different corticosteroid-binding globulin variants that lack cortisol-binding activity in a greek woman

scientific article published on 04 September 2012

cis-regulatory elements within the proximal promoter of the rat gene encoding corticosteroid-binding globulin.

scientific article

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