Search filters

List of works by Douglas A Mitchell

A new genome-mining tool redefines the lasso peptide biosynthetic landscape. ⬇️

scientific article published on 28 February 2017

A prevalent peptide-binding domain guides ribosomal natural product biosynthesis

scientific article published on 13 July 2015

Antibacterial drug leads targeting isoprenoid biosynthesis

scientific article

Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics ⬇️

scientific article published on 20 July 2018

Bioinformatic Mapping of Radical S-Adenosylmethionine-Dependent Ribosomally Synthesized and Post-Translationally Modified Peptides Identifies New Cα, Cβ, and Cγ-Linked Thioether-Containing Peptides

scientific article published on 13 May 2019

Bioinformatic and Reactivity-Based Discovery of Linaridins

scientific article published on 10 November 2020

Bioinformatics-Guided Expansion and Discovery of Graspetides

scientific article published on 12 November 2021

Biological characterization of the hygrobafilomycin antibiotic JBIR-100 and bioinformatic insights into the hygrolide family of natural products.

scientific article published on 14 May 2016

Biosynthesis and Chemical Applications of Thioamides

scientific article published on 30 January 2019

Biosynthetic Timing and Substrate Specificity for the Thiopeptide Thiomuracin

scientific article published on 4 October 2016

Catalase-peroxidase activity of iron(III)-TAML activators of hydrogen peroxide

scientific article

Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products

scientific article published on 6 June 2017

Clostridiolysin S, a post-translationally modified biotoxin from Clostridium botulinum

scientific article

Correction to "Orchestration of Enzymatic Processing by Thiazole/Oxazole-Modified Microcin Dehydrogenases"

scientific article published on 19 December 2019

Correction to Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis.

scientific article published on 2 November 2017

Corrigendum to "RiPP antibiotics: biosynthesis and engineering potential" [Curr Opin Microbiol 45 (2018) 61-69]

scientific article published on 01 June 2019

Crystal structure and absolute configuration of (3S,4aS,8aS)-N-tert-butyl-2-[(S)-3-(2-chloro-4-nitro-benzamido)-2-hy-droxy-prop-yl]deca-hydro-isoquinoline-3-carboxamide and (3S,4aS,8aS)-N-tert-butyl-2-{(S)-2-[(S)-1-(2-chloro-4-nitro-benzoyl)pyrrolid

scientific article

Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168.

scientific article published on 25 December 2012

Design and characterization of an active site selective caspase-3 transnitrosating agent.

scientific article

Discovery of a new ATP-binding motif involved in peptidic azoline biosynthesis

scientific article

Discovery of a widely distributed toxin biosynthetic gene cluster

scholarly article

Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin

scientific article published on 26 July 2018

Engineering unnatural variants of plantazolicin through codon reprogramming

scientific article published on 03 July 2013

Enzymatic Reconstitution and Biosynthetic Investigation of the Lasso Peptide Fusilassin

scientific article published on 27 December 2018

Enzymatic reconstitution of ribosomal peptide backbone thioamidation.

scientific article published on 5 March 2018

Expansion of ribosomally produced natural products: a nitrile hydratase- and Nif11-related precursor family

scientific article

Expansion of type II CAAX proteases reveals evolutionary origin of γ-secretase subunit APH-1

scientific article

Functional elucidation of TfuA in peptide backbone thioamidation

scientific article published on 11 March 2021

Functional interactions between posttranslationally modified amino acids of methyl-coenzyme M reductase in Methanosarcina acetivorans

scientific article published on 24 February 2020

Genome mining unveils a class of ribosomal peptides with two amino termini

scientific article published in 2023

HIV protease inhibitors block streptolysin S production

scientific article

HIV-1 Integrase Inhibitor-Inspired Antibacterials Targeting Isoprenoid Biosynthesis

scientific article

Head-to-Head Prenyl Synthases in Pathogenic Bacteria

scientific article published on 24 March 2017

Identification of an Auxiliary Leader Peptide-Binding Protein Required for Azoline Formation in Ribosomal Natural Products.

scientific article

Identification of the minimal cytolytic unit for streptolysin S and an expansion of the toxin family.

scientific article published on 24 July 2015

In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.

scientific article published on June 2016

In Vitro Biosynthesis of the Core Scaffold of the Thiopeptide Thiomuracin

scientific article published on 17 December 2015

In Vitro Biosynthetic Studies of Bottromycin Expand the Enzymatic Capabilities of the YcaO Superfamily

scientific article published on 4 December 2017

Insights into methyltransferase specificity and bioactivity of derivatives of the antibiotic plantazolicin

scientific article

Insights into the mechanism of peptide cyclodehydrations achieved through the chemoenzymatic generation of amide derivatives

scientific article published on 30 May 2013

Lessons learned from the transformation of natural product discovery to a genome-driven endeavor

scientific article

Mechanism of a Class C Radical S-Adenosyl-l-methionine Thiazole Methyl Transferase.

scientific article

Mechanistic Basis for Ribosomal Peptide Backbone Modifications

Microviridin 1777: A Toxic Chymotrypsin Inhibitor Discovered by a Metabologenomic Approach ⬇️

scientific article published on 28 January 2020

Minimum Information about a Biosynthetic Gene cluster.

scientific article published on August 2015

Multitarget drug discovery for tuberculosis and other infectious diseases

scientific article

New developments in RiPP discovery, enzymology and engineering

scientific article published on 16 September 2020

Nucleophilic 1,4-additions for natural product discovery. ⬇️

scientific article

Orchestration of enzymatic processing by thiazole/oxazole-modified microcin dehydrogenases.

scientific article published on 07 January 2014

Plantazolicin is an ultra-narrow spectrum antibiotic that targets the Bacillus anthracis membrane.

scientific article published on 23 December 2015

Plantazolicin, a Novel Microcin B17/Streptolysin S-Like Natural Product from Bacillus amyloliquefaciens FZB42 ⬇️

scientific article published on October 22, 2010

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

scientific article published on 7 September 2017

Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea

Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family

scientific article published on 03 June 2020

Profiling of Microbial Colonies for High-Throughput Engineering of Multistep Enzymatic Reactions via Optically Guided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry

scientific article published on 09 August 2017

RRE-Finder: a Genome-Mining Tool for Class-Independent RiPP Discovery

scientific article published on 01 September 2020

Radical S-Adenosylmethionine Enzymes Involved in RiPP Biosynthesis.

scientific article

Reactivity-Based Screening for Citrulline-Containing Natural Products Reveals a Family of Bacterial Peptidyl Arginine Deiminases

scientific article published on 29 November 2020

Reconstitution and Substrate Specificity of the Radical S-Adenosyl-methionine Thiazole C-Methyltransferase in Thiomuracin Biosynthesis.

scientific article

Reconstitution and Substrate Specificity of the Thioether-Forming Radical S-Adenosylmethionine Enzyme in Freyrasin Biosynthesis

scientific article published on 09 September 2019

Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.

scientific article published on 8 January 2013

RiPP antibiotics: biosynthesis and engineering potential

scientific article published on 10 March 2018

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature

scientific article

S-Nitrosation and regulation of inducible nitric oxide synthase

scientific article

Selectivity, directionality, and promiscuity in peptide processing from a Bacillus sp. Al Hakam cyclodehydratase

scientific article

Streptolysin S-like virulence factors: the continuing sagA.

scientific article published on 08 August 2011

Structural and functional dissection of the heterocyclic peptide cytotoxin streptolysin S.

scientific article

Structural and functional insight into an unexpectedly selective N-methyltransferase involved in plantazolicin biosynthesis

scientific article

Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis.

scientific article published on 20 November 2017

Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS.

scientific article

Structure Prediction and Synthesis of Pyridine-Based Macrocyclic Peptide Natural Products

scientific article published on 26 August 2020

Structure determination and interception of biosynthetic intermediates for the plantazolicin class of highly discriminating antibiotics. ⬇️

scientific article

Structure, Bioactivity, and Resistance Mechanism of Streptomonomicin, an Unusual Lasso Peptide from an Understudied Halophilic Actinomycete

scientific article

Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase.

scientific article published on 14 November 2005

Synthesis of plantazolicin analogues enables dissection of ligand binding interactions of a highly selective methyltransferase

scientific article published on 24 September 2013

Targeted Treatment for Bacterial Infections: Prospects for Pathogen-Specific Antibiotics Coupled with Rapid Diagnostics

scientific article published on 09 October 2015

Targeting Reactive Carbonyls for Identifying Natural Products and Their Biosynthetic Origins. ⬇️

scientific article published on 31 October 2016

The genomic landscape of ribosomal peptides containing thiazole and oxazole heterocycles

scientific article published on 13 October 2015

Thiazole/oxazole-modified microcins: complex natural products from ribosomal templates

scientific article

Thioredoxin catalyzes the S-nitrosation of the caspase-3 active site cysteine

scientific article

Thioredoxin is required for S-nitrosation of procaspase-3 and the inhibition of apoptosis in Jurkat cells.

scholarly article

Undecaprenyl diphosphate synthase inhibitors: antibacterial drug leads

scientific article

Using Genomics for Natural Product Structure Elucidation

scientific article published on 12 October 2015

YcaO domains use ATP to activate amide backbones during peptide cyclodehydrations

scientific article

YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function

scientific article published on 3 March 2017

antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification

scientific article published on 28 April 2017

Paulina is supported by:

About Paulina

Help