List of works - Matthias Drosten

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

scientific article

A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant.

scientific article

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

scientific article published on 26 February 2018

Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model.

scientific article published in July 2003

Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes

scientific article published on 09 January 2017

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

scientific article published on 08 April 2019

Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma.

scientific article published in February 2005

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

scientific article published on 12 April 2018

Gene therapeutic approaches for medullary thyroid carcinoma treatment.

scientific article

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

scientific article

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

scientific article published on 22 October 2013

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

scientific article

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

scientific article published on 01 May 2018

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

scientific article published on 21 November 2016

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma

scientific article published on 21 August 2017

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function

scientific article

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

scientific article

Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.

scientific article published on October 2006

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets

scientific article

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

scientific article

Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection

scientific article published in November 2005

Ras and p53: An unsuspected liaison.

scientific article published on 23 January 2015

Ras in epidermal proliferation.

scientific article published on July 2014

Ras signaling is essential for skin development.

scientific article published on 8 July 2013

Requirement for epithelial p38α in KRAS-driven lung tumor progression

scientific article published on 22 January 2020

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

scientific article

Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

scientific article published on August 2004

Targeting the MAPK Pathway in KRAS-Driven Tumors

scientific article published on 01 April 2020

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

scientific article published on 26 March 2018

The RET proto-oncogene: a potential target for molecular cancer therapy.

scientific article published in July 2004

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

scientific article published on 10 September 2020

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

scientific article published on 2 August 2017

Using cells devoid of RAS proteins as tools for drug discovery

scientific article

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

scientific article

List of works by Matthias Drosten

A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer

A new therapeutic approach in medullary thyroid cancer treatment: inhibition of oncogenic RET signaling by adenoviral vector-mediated expression of a dominant-negative RET mutant.

Allele-Specific Mechanisms of Activation of MEK1 Mutants Determine Their Properties.

Antitumor capacity of a dominant-negative RET proto-oncogene mutant in a medullary thyroid carcinoma model.

Clasp2 ensures mitotic fidelity and prevents differentiation of epidermal keratinocytes

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF

Discovery of targeting peptides for selective therapy of medullary thyroid carcinoma.

ERF deletion rescues RAS deficiency in mouse embryonic stem cells.

Gene therapeutic approaches for medullary thyroid carcinoma treatment.

Genetic Validation of Cell Proliferation via Ras-Independent Activation of the Raf/Mek/Erk Pathway.

Genetic analysis of Ras genes in epidermal development and tumorigenesis.

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival.

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma

K-Ras4B phosphorylation at Ser181 is inhibited by calmodulin and modulates K-Ras activity and function

Loss of p53 induces cell proliferation via Ras-independent activation of the Raf/Mek/Erk signaling pathway

Mechanisms of Disease: cancer targeting and the impact of oncogenic RET for medullary thyroid carcinoma therapy.

Modeling K-Ras-driven lung adenocarcinoma in mice: preclinical validation of therapeutic targets

Mutant K-Ras activation of the proapoptotic MST2 pathway is antagonized by wild-type K-Ras.

Novel SRESPHP peptide mediates specific binding to primary medullary thyroid carcinoma after systemic injection

Ras and p53: An unsuspected liaison.

Ras in epidermal proliferation.

Ras signaling is essential for skin development.

Requirement for epithelial p38α in KRAS-driven lung tumor progression

Reversible, interrelated mRNA and miRNA expression patterns in the transcriptome of Rasless fibroblasts: functional and mechanistic implications

Role of MEN2A-derived RET in maintenance and proliferation of medullary thyroid carcinoma.

Targeting the MAPK Pathway in KRAS-Driven Tumors

The Capicua tumor suppressor: a gatekeeper of Ras signaling in development and cancer

The RET proto-oncogene: a potential target for molecular cancer therapy.

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS.

Using cells devoid of RAS proteins as tools for drug discovery

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.