List of works - Anna Bernardi

1,2-Mannobioside mimic: synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity.

scientific article published on July 2007

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

scientific article published on 11 March 2016

A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates

article

A facile stereoselective synthesis of alpha-glycosyl ureas

scientific article published on 02 May 2006

A facile synthesis of α-N-ribosyl-asparagine and α-N-ribosyl-glutamine building blocks.

scientific article published on 24 July 2013

A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models

scientific article

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

scientific article published on 6 February 2014

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide.

scientific article

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

scientific article published on 18 August 2015

An assay for functional dendritic cell-specific ICAM-3-grabbing nonintegrin (DC–SIGN) inhibitors of human dendritic cell adhesion

scientific article published on 25 July 2010

Both El Tor and classical cholera toxin bind blood group determinants.

scientific article published on 28 January 2012

Carbohydrates: A phenol sandwich fights diabetes.

scientific article

Clickable Polymeric Coating for Glycan Microarrays.

scientific article published on January 2017

Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR.

scientific article

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating

scientific article published on 11 November 2015

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

scientific article

Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase.

scientific article published on 28 February 2018

Design and synthesis of glycomimetics: Recent advances

scientific article published on 30 July 2019

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.

scientific article published on 16 February 2017

Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists

scientific article published on 14 November 2010

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

scientific article

Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering

scientific article

Developing a force field for the transition state of the aldol reaction of enolborinates: Evaluation of the use of fixed point charges

Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface

scientific article published on 01 July 2020

Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility.

scientific article published on 5 October 2007

Effective targeting of DC-SIGN by α-fucosylamide functionalized gold nanoparticles.

scientific article

Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors.

scientific article published on 31 January 2013

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

scientific article published on 18 October 2019

First round of a focused library of cholera toxin inhibitors

scientific article published on 9 June 2007

Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.

scientific article published in November 2003

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

scientific article published on 11 February 2016

Glycodendron–rhenium complexes as luminescent probes for lectin sensing

scientific article published on 01 September 2018

HIV microbicides: state-of-the-art and new perspectives on the development of entry inhibitors

scientific article published on July 2010

Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation.

scientific article

Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling

scientific article published on 10 October 2011

Interfering with the sugar code: design and synthesis of oligosaccharide mimics

scientific article

Lewis acid mediated aldol condensations using thioester silyl ketene acetals

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

scientific article published in March 2003

Modeling ganglioside headgroups by conformational analysis and molecular dynamics.

scientific article

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands

scientific article

Monovalent and bivalent N-fucosyl amides as high affinity ligands for Pseudomonas aeruginosa PA-IIL lectin

scientific article published on 17 March 2010

Multivalent glycoconjugates as anti-pathogenic agents ⬇️

scientific article

Observation of a Tricyclic[4.1.0.02,4]heptane During a Michael Addition-Ring Closure Reaction and a Computational Study on Its Mechanism of Formation

scientific article published on 30 October 2017

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

scientific article published on 03 September 2018

One pot synthesis of <i>thio</i>-glycosides <i>via</i> aziridine opening reactions

scientific article published on 07 December 2020

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury.

scientific article published on 10 May 2016

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

scientific article

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

scientific article

Pseudo-mannosylated DC-SIGN ligands as potential adjuvants for HIV vaccines

scientific article published on 27 January 2014

Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition

scientific article published on 22 December 2017

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.

scientific article published on 23 December 2015

Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety.

scientific article published in October 2000

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

scientific article published on 07 July 2011

Selective targeting of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) with mannose-based glycomimetics: synthesis and interaction studies of bis(benzylamide) derivatives of a pseudomannobioside.

scientific article

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

scientific article published on February 2001

Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds.

scientific article

Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core.

scientific article

Stereoselective conjugate addition of lithium and titanium enolates to γ - alkoxy enones

article

Stereoselective synthesis of N-galactofuranosyl amides.

scientific article

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

scientific article published in September 2001

Stereoselective synthesis of glycosyl amides by traceless Staudinger ligation of unprotected glycosyl azides.

scientific article published on 22 April 2008

Stereoselective synthesis of α- and β-glycofuranosyl amides by traceless ligation of glycofuranosyl azides

scientific article published on 19 April 2012

Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design

scientific article

Synthesis and Conformational Analysis of Galactose-Derived Bicyclic Scaffolds

scientific article published in July 2006

Synthesis and cholera toxin binding properties of multivalent GM1 mimics

scientific article published on 30 June 2004

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

scientific article published on 24 March 2007

Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold

scientific article published on 15 June 2016

Synthesis of novel DC-SIGN ligands with an alpha-fucosylamide anchor.

scientific article published in August 2008

Synthesis of potential allosteric modulators of Hsp90 by chemical glycosylation of Eupomatenoid-6

scientific article published on 13 March 2014

Synthesis, Conformational Studies and Mannosidase Stability of a Mimic of 1,2-Mannobioside

scientific article published in December 2004

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

scientific article published on 7 October 2005

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

scientific article

The structural basis for the susceptibility of gangliosides to enzymatic degradation.

scientific article

Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics

scientific article published on 24 May 2017

Traceless Staudinger ligation of glycosyl azides with triaryl phosphines: stereoselective synthesis of glycosyl amides

scientific article published on 01 June 2006

Unique DC-SIGN clustering activity of a small glycomimetic: A lesson for ligand design

scientific article

α-N-Linked glycopeptides: conformational analysis and bioactivity as lectin ligands

scientific article published on 22 March 2012

List of works by Anna Bernardi

1,2-Mannobioside mimic: synthesis, DC-SIGN interaction by NMR and docking, and antiviral activity.

A New Surface Plasmon Resonance Assay for In Vitro Screening of Mannose-Binding Lectin Inhibitors.

A comparison and chemometric analysis of several molecular mechanics force fields and parameter sets applied to carbohydrates

A facile stereoselective synthesis of alpha-glycosyl ureas

A facile synthesis of α-N-ribosyl-asparagine and α-N-ribosyl-glutamine building blocks.

A glycomimetic compound inhibits DC-SIGN-mediated HIV infection in cellular and cervical explant models

A multivalent inhibitor of the DC-SIGN dependent uptake of HIV-1 and Dengue virus

A synthetic divalent cholera toxin glycocalix[4]arene ligand having higher affinity than natural GM1 oligosaccharide.

Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands.

An assay for functional dendritic cell-specific ICAM-3-grabbing nonintegrin (DC–SIGN) inhibitors of human dendritic cell adhesion

Both El Tor and classical cholera toxin bind blood group determinants.

Carbohydrates: A phenol sandwich fights diabetes.

Clickable Polymeric Coating for Glycan Microarrays.

Comprehensive analysis of blood group antigen binding to classical and El Tor cholera toxin B-pentamers by NMR.

Critical Role and Therapeutic Control of the Lectin Pathway of Complement Activation in an Abortion-Prone Mouse Mating

DFG-in and DFG-out homology models of TrkB kinase receptor: induced-fit and ensemble docking.

Design and synthesis of constrained bicyclic molecules as candidate inhibitors of influenza A neuraminidase.

Design and synthesis of glycomimetics: Recent advances

Design of Allosteric Stimulators of the Hsp90 ATPase as New Anticancer Leads.

Design, synthesis and activity evaluation of mannose-based DC-SIGN antagonists

Designing nanomolar antagonists of DC-SIGN-mediated HIV infection: ligand presentation using molecular rods

Detection and quantitative analysis of two independent binding modes of a small ligand responsible for DC-SIGN clustering

Developing a force field for the transition state of the aldol reaction of enolborinates: Evaluation of the use of fixed point charges

Development of C-type lectin-oriented surfaces for high avidity glycoconjugates: towards mimicking multivalent interactions on the cell surface

Effect of structural modifications of ganglioside GM2 on intra-molecular carbohydrate-to-carbohydrate interaction and enzymatic susceptibility.

Effective targeting of DC-SIGN by α-fucosylamide functionalized gold nanoparticles.

Efficient synthesis of phenylene-ethynylene rods and their use as rigid spacers in divalent inhibitors.

Enhancing Potency and Selectivity of a DC-SIGN Glycomimetic Ligand by Fragment-Based Design: Structural Basis

First round of a focused library of cholera toxin inhibitors

Ganglioside GM1 mimics: lipophilic substituents improve affinity for cholera toxin.

Glycoconjugates and Glycomimetics as Microbial Anti-Adhesives

Glycodendron–rhenium complexes as luminescent probes for lectin sensing

HIV microbicides: state-of-the-art and new perspectives on the development of entry inhibitors

Inhibition of DC-SIGN-mediated HIV infection by a linear trimannoside mimic in a tetravalent presentation.

Insights into molecular recognition of Lewis(X) mimics by DC-SIGN using NMR and molecular modelling

Interfering with the sugar code: design and synthesis of oligosaccharide mimics

Lewis acid mediated aldol condensations using thioester silyl ketene acetals

Mimics of ganglioside GM1 as cholera toxin ligands: replacement of the GalNAc residue.

Modeling ganglioside headgroups by conformational analysis and molecular dynamics.

Molecular Dynamics Simulations Reveal the Mechanisms of Allosteric Activation of Hsp90 by Designed Ligands

Monovalent and bivalent N-fucosyl amides as high affinity ligands for Pseudomonas aeruginosa PA-IIL lectin

Multivalent glycoconjugates as anti-pathogenic agents ⬇️

Observation of a Tricyclic[4.1.0.02,4]heptane During a Michael Addition-Ring Closure Reaction and a Computational Study on Its Mechanism of Formation

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin

One pot synthesis of <i>thio</i>-glycosides <i>via</i> aziridine opening reactions

Pharmacological inhibition of mannose-binding lectin ameliorates neurobehavioral dysfunction following experimental traumatic brain injury.

Potent integrin antagonists from a small library of RGD-including cyclic pseudopeptides.

Pseudo-Mannosylated DC-SIGN Ligands as Immunomodulants

Pseudo-mannosylated DC-SIGN ligands as potential adjuvants for HIV vaccines

Rational-Differential Design of Highly Specific Glycomimetic Ligands: Targeting DC-SIGN and Excluding Langerin Recognition

Scaffold Optimisation of Tetravalent Antagonists of the Mannose Binding Lectin.

Second generation mimics of ganglioside GM1 as artificial receptors for cholera toxin: replacement of the sialic acid moiety.

Second generation of fucose-based DC-SIGN ligands : affinity improvement and specificity versus Langerin

Selective targeting of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) with mannose-based glycomimetics: synthesis and interaction studies of bis(benzylamide) derivatives of a pseudomannobioside.

Simulation of carbohydrate-protein interactions: computer-aided design of a second generation GM1 mimic.

Solid-phase synthesis of combinatorial libraries based on enatiomerically pure (1S,2S,4R,5S)-4,5-dihydroxycyclohexan-1,2-dicarboxylic acid scaffolds.

Solution Behavior of Amphiphilic Glycodendrimers with a Rod-Like Core.

Stereoselective conjugate addition of lithium and titanium enolates to γ - alkoxy enones

Stereoselective synthesis of N-galactofuranosyl amides.

Stereoselective synthesis of conformationally constrained cyclohexanediols: a set of molecular scaffolds for the synthesis of glycomimetics.

Stereoselective synthesis of glycosyl amides by traceless Staudinger ligation of unprotected glycosyl azides.

Stereoselective synthesis of α- and β-glycofuranosyl amides by traceless ligation of glycofuranosyl azides

Structure of a glycomimetic ligand in the carbohydrate recognition domain of C-type lectin DC-SIGN. Structural requirements for selectivity and ligand design

Synthesis and Conformational Analysis of Galactose-Derived Bicyclic Scaffolds

Synthesis and cholera toxin binding properties of multivalent GM1 mimics

Synthesis and conformational analysis of an α-d-mannopyranosyl-(1→2)-α-d-mannopyranosyl-(1→6)-α-d-mannopyranose mimic

Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold

Synthesis of novel DC-SIGN ligands with an alpha-fucosylamide anchor.

Synthesis of potential allosteric modulators of Hsp90 by chemical glycosylation of Eupomatenoid-6

Synthesis, Conformational Studies and Mannosidase Stability of a Mimic of 1,2-Mannobioside

Targeting integrins: insights into structure and activity of cyclic RGD pentapeptide mimics containing azabicycloalkane amino acids

Targeting mannose-binding lectin confers long-lasting protection with a surprisingly wide therapeutic window in cerebral ischemia.

The structural basis for the susceptibility of gangliosides to enzymatic degradation.

Towards new cholera prophylactics and treatment: Crystal structures of bacterial enterotoxins in complex with GM1 mimics

Traceless Staudinger ligation of glycosyl azides with triaryl phosphines: stereoselective synthesis of glycosyl amides

Unique DC-SIGN clustering activity of a small glycomimetic: A lesson for ligand design

α-N-Linked glycopeptides: conformational analysis and bioactivity as lectin ligands