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List of works by Lars Kuepfer

A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

scientific article

A Physiologically Based Pharmacokinetic Model of Isoniazid and Its Application in Individualizing Tuberculosis Chemotherapy

scientific article published on August 2016

A computational systems biology software platform for multiscale modeling and simulation: integrating whole-body physiology, disease biology, and molecular reaction networks.

scientific article published on 24 February 2011

A mechanistic, model-based approach to safety assessment in clinical development

scientific article

A model-based assay design to reproduce in vivo patterns of acute drug-induced toxicity

scientific article published on 29 August 2017

A systematic evaluation of the use of physiologically based pharmacokinetic modeling for cross-species extrapolation

scientific article

Applied Concepts in PBPK Modeling: How to Build a PBPK/PD Model

scientific article published on 21 September 2016

Bayesian Population Physiologically-Based Pharmacokinetic (PBPK) Approach for a Physiologically Realistic Characterization of Interindividual Variability in Clinically Relevant Populations

scientific article

Clinical translation in the virtual liver network

scientific article

Efficient classification of complete parameter regions based on semidefinite programming

scientific article

Enabling multiscale modeling in systems medicine

scientific article

Ensemble modeling for analysis of cell signaling dynamics.

scientific article

Evaluation of the efficacy and safety of rivaroxaban using a computer model for blood coagulation

scientific article

In vivo imaging of systemic transport and elimination of xenobiotics and endogenous molecules in mice.

scientific article

Integrating cellular metabolism into a multiscale whole-body model

scientific article

Metabolic flux distributions: genetic information, computational predictions, and experimental validation.

scientific article published on 16 March 2010

Metabolic functions of duplicate genes in Saccharomyces cerevisiae

scientific article published in October 2005

Model-based contextualization of in vitro toxicity data quantitatively predicts in vivo drug response in patients.

scientific article

Model-guided identification of a therapeutic strategy to reduce hyperammonemia in liver diseases

scientific article

Modeling and Simulation of In Vivo Drug Effects.

scientific article

Multiscale Mechanistic Modeling in Pharmaceutical Research and Development

scientific article published on January 1, 2012

Multiscale modeling reveals inhibitory and stimulatory effects of caffeine on acetaminophen-induced toxicity in humans.

scientific article published on 28 January 2017

Physiologically-based modelling in mice suggests an aggravated loss of clearance capacity after toxic liver damage

scientific article published on 24 July 2017

Representative Sinusoids for Hepatic Four-Scale Pharmacokinetics Simulations

scientific article

Spatio-temporal simulation of first pass drug perfusion in the liver

scientific article

Stoichiometric modelling of microbial metabolism.

scientific article published in January 2014

The virtual liver: state of the art and future perspectives

scientific article

Towards whole-body systems physiology.

scientific article published on September 2010

Using expression data for quantification of active processes in physiologically based pharmacokinetic modeling

scientific article

Zonated quantification of steatosis in an entire mouse liver.

scientific article published on 11 April 2016