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List of works by Luciano D'Adamio

A role for tau in learning, memory and synaptic plasticity

scientific article published on 16 February 2018

A single tyrosine residue in the amyloid precursor protein intracellular domain is essential for developmental function.

scientific article

APP and APLP2 interact with the synaptic release machinery and facilitate transmitter release at hippocampal synapses

scientific article published on 9 November 2015

APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant

scientific article

APP is cleaved by Bace1 in pre-synaptic vesicles and establishes a pre-synaptic interactome, via its intracellular domain, with molecular complexes that regulate pre-synaptic vesicles functions

scientific article

APP is phosphorylated by TrkA and regulates NGF/TrkA signaling

scientific article published in August 2011

Abolishing Tau cleavage by caspases at Aspartate421 causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

scientific article published on 08 August 2017

Alternative, non-secretase processing of Alzheimer's beta-amyloid precursor protein during apoptosis by caspase-6 and -8.

scientific article published in July 1999

Amyloid Precursor Protein (APP) May Act as a Substrate and a Recognition Unit for CRL4CRBN and Stub1 E3 Ligases Facilitating Ubiquitination of Proteins Involved in Presynaptic Functions and Neurodegeneration

scientific article published on 20 June 2016

Amyloid beta protein precursor is phosphorylated by JNK-1 independent of, yet facilitated by, JNK-interacting protein (JIP)-1.

scientific article published on 13 August 2003

Amyloid-beta protein precursor (AbetaPP) intracellular domain-associated protein-1 proteins bind to AbetaPP and modulate its processing in an isoform-specific manner.

scientific article

An intracellular threonine of amyloid-β precursor protein mediates synaptic plasticity deficits and memory loss

scientific article

Apoptosis-linked gene 2-deficient mice exhibit normal T-cell development and function

scientific article

Autosomal recessive hypercholesterolemia protein interacts with and regulates the cell surface level of Alzheimer's amyloid beta precursor protein

scientific article

BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate.

scientific article published on August 2008

BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2

scientific article

CD3 eta and CD3 zeta are alternatively spliced products of a common genetic locus and are transcriptionally and/or post-transcriptionally regulated during T-cell development

scientific article

CD3 zeta/eta/theta locus is colinear with and transcribed antisense to the gene encoding the transcription factor Oct-1.

scientific article published on September 1993

CD74 interacts with APP and suppresses the production of Abeta

scientific article

Caspase-9 mediates synaptic plasticity and memory deficits of Danish dementia knock-in mice: caspase-9 inhibition provides therapeutic protection

scientific article published on 10 December 2012

Central role of the scaffold protein tumor necrosis factor receptor-associated factor 2 in regulating endoplasmic reticulum stress-induced apoptosis

scientific article published on 18 November 2005

Characterization of thymus-derived lymphocytes expressing Ti alpha-beta CD3 gamma delta epsilon zeta-zeta, Ti alpha-beta CD3 gamma delta epsilon eta-eta or Ti alpha-beta CD3 gamma delta epsilon zeta-zeta/zeta-eta antigen receptor isoforms: analysis

scientific article published on 01 October 1990

Cloning of AIP1, a novel protein that associates with the apoptosis-linked gene ALG-2 in a Ca2+-dependent reaction

scientific article

Co-receptor (CD4/CD8) engagement enhances CD3-induced apoptosis in thymocytes. Implications for negative selection

scientific article published on 01 September 1994

Common acute lymphoblastic leukemia antigen (CALLA) is active neutral endopeptidase 24.11 ("enkephalinase"): direct evidence by cDNA transfection analysis

scientific article

Correction: Abolishing Tau cleavage by caspases at Aspartate causes memory/synaptic plasticity deficits and pre-pathological Tau alterations

scientific article published on 31 August 2018

Danish and British dementia ITM2b/BRI2 mutations reduce BRI2 protein stability and impair  glutamatergic synaptic transmission

scientific article published on 10 November 2020

Danish dementia mice suggest that loss of function and not the amyloid cascade causes synaptic plasticity and memory deficits

scientific article

Deletion of the γ-secretase subunits Aph1B/C impairs memory and worsens the deficits of knock-in mice modeling the Alzheimer-like familial Danish dementia

scientific article

Dissociation of apoptosis and activation of IL-1beta-converting enzyme/Ced-3 proteases by ALG-2 and the truncated Alzheimer's gene ALG-3

scientific article published on 01 June 1997

Downregulation of enkephalin-mediated inflammatory responses by CDl0/neutral endopeptidase 24.11

scientific article published in Nature

Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role

scientific article published on 2 September 2008

Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory

scientific article published on 20 January 2016

Facilitation of glutamate, but not GABA, release in Familial Alzheimer's APP mutant Knock-in rats with increased β-cleavage of APP

scientific article published on 09 September 2019

Fas, ceramide and serum withdrawal induce apoptosis via a common pathway in a type II Jurkat cell line.

scientific article

Fc gamma RII/III and CD2 expression mark distinct subpopulations of immature CD4-CD8- murine thymocytes: in vivo developmental kinetics and T cell receptor beta chain rearrangement status.

scientific article

Functional cloning of genes regulating apoptosis in neuronal cells.

scientific article

Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2

scientific article (publication date: February 2004)

Generation and initial characterization of FDD knock in mice

scientific article (publication date: 18 November 2009)

Generation of an apoptotic intracellular peptide by gamma-secretase cleavage of Alzheimer's amyloid beta protein precursor.

scientific article published in November 2000

Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage

scientific article

Generation of mouse natural killer (NK) cell activity: effect of interleukin-2 (IL-2) and interferon (IFN) on the in vivo development of natural killer cells from bone marrow (BM) progenitor cells

scientific article published on 01 October 1986

Growth factor receptor-bound protein 2 interaction with the tyrosine-phosphorylated tail of amyloid beta precursor protein is mediated by its Src homology 2 domain.

scientific article published on 30 March 2004

Human natural killer cells and mature T lymphocytes express identical CD3 zeta subunits as defined by cDNA cloning and sequence analysis

scientific article published on 01 August 1990

Hyperphosphorylation of JNK-interacting protein 1, a protein associated with Alzheimer disease.

scientific article

In vitro generation of natural killer cells from SJL/J bone marrow precursors

scientific article published on 01 April 1988

Increased AβPP processing in familial Danish dementia patients.

scientific article published on January 2011

Inhibition of γ-secretase worsens memory deficits in a genetically congruous mouse model of Danish dementia ⬇️

scientific article published on April 26, 2012

Interaction of Alzheimer's presenilin-1 and presenilin-2 with Bcl-X(L). A potential role in modulating the threshold of cell death

scientific article (publication date: 20 August 1999)

Interaction of ApoE3 and ApoE4 isoforms with an ITM2b/BRI2 mutation linked to the Alzheimer disease-like Danish dementia: Effects on learning and memory

scientific article published on 31 October 2015

Interfering with apoptosis: Ca(2+)-binding protein ALG-2 and Alzheimer's disease gene ALG-3

scientific article

Interleukin-1 augments the interleukin-2-dependent generation of natural killer cells from bone marrow precursors

scientific article published on 01 January 1987

Interleukin-2 induces apoptosis in mouse thymocytes

scientific article published on 01 January 1993

Interleukin-4 protects double-negative and CD4 single-positive thymocytes from dexamethasone-induced apoptosis

scientific article published on 01 March 1993

JNK-interacting protein-1 promotes transcription of A beta protein precursor but not A beta precursor-like proteins, mechanistically different than Fe65

scholarly article

Jun NH2-terminal kinase (JNK) interacting protein 1 (JIP1) binds the cytoplasmic domain of the Alzheimer's beta-amyloid precursor protein (APP).

scientific article

Knock-in rats with homozygous PSEN1L435F Alzheimer mutation are viable and show selective γ-secretase activity loss causing low Aβ40/42, high Aβ43

scientific article published on 07 April 2020

LTP and memory impairment caused by extracellular Aβ and Tau oligomers is APP-dependent

scientific article published on 11 July 2017

Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles

scientific article published on 12 September 2009

Memory deficits due to familial British dementia BRI2 mutation are caused by loss of BRI2 function rather than amyloidosis

scientific article

Memory deficits of British dementia knock-in mice are prevented by Aβ-precursor protein haploinsufficiency.

scientific article published in April 2012

Microglia TREM2R47H Alzheimer-linked variant enhances excitatory transmission and reduces LTP via increased TNF-α levels

scientific article published on 24 June 2020

Mitochondrial rhomboid PARL regulates cytochrome c release during apoptosis via OPA1-dependent cristae remodeling

scientific journal article

Negative selection of thymocytes. A novel polymerase chain reaction-based molecular analysis detects requirements for macromolecular synthesis ⬇️

scientific article published on December 1, 1992

Neuronal apoptosis is accompanied by amyloid beta-protein accumulation in the endoplasmic reticulum.

scientific article published on February 2002

Opposite changes in APP processing and human Aβ levels in rats carrying either a protective or a pathogenic APP mutation

scientific article published on 05 February 2020

Organization of the gene encoding common acute lymphoblastic leukemia antigen (neutral endopeptidase 24.11): multiple miniexons and separate 5' untranslated regions

scientific article

Overexpression of CD3 eta during thymic development does not alter the negative selection process

scientific article published on 01 February 1993

Phosphorylation of a tyrosine in the amyloid-beta protein precursor intracellular domain inhibits Fe65 binding and signaling.

scientific article

Pidotimod stimulates natural killer cell activity and inhibits thymocyte cell death

scientific article published on 01 January 1992

Presenilin-dependent transcriptional control of the Abeta-degrading enzyme neprilysin by intracellular domains of betaAPP and APLP

scientific journal article

Presenilin-ryanodine receptor connection.

scientific article published on 30 August 2013

Processing of beta-amyloid precursor-like protein-1 and -2 by gamma-secretase regulates transcription

scientific article (publication date: 15 November 2002)

Proteomic Characterization of a Mouse Model of Familial Danish Dementia ⬇️

scientific article published on April 26, 2012

Regulation of Fas ligand expression and cell death by apoptosis-linked gene 4

scientific journal article

Requirement of the familial Alzheimer's disease gene PS2 for apoptosis. Opposing effect of ALG-3

scientific journal article

Rescue of learning and memory deficits in the human non-syndromic intellectual disability cereblon knockout mouse model by targeting the AMPK-mTORC1 translational pathway

scientific article published on 19 February 2018

Role of Amyloid-β and Tau Proteins in Alzheimer's Disease: Confuting the Amyloid Cascade

scientific article published on 01 January 2019

Role of Amyloid-β and Tau Proteins in Alzheimer’s Disease: Confuting the Amyloid Cascade

scientific article published on 01 January 2018

Role of Cystatin C in Neuroprotection and Its Therapeutic Implications ⬇️

scientific article published on September 23, 2010

SEPT5_v2 is a parkin-binding protein

scientific article (publication date: 7 October 2003)

T-cell receptor isoforms and signal transduction.

scientific article published on February 1991

TNF-α-mediated reduction in inhibitory neurotransmission precedes sporadic Alzheimer's disease pathology in young Trem2R47H  rats

scientific article published on 16 November 2020

The Familial dementia gene ITM2b/BRI2 facilitates glutamate transmission via both presynaptic and postsynaptic mechanisms

article

The amyloid precursor protein (APP) intracellular domain regulates translation of p44, a short isoform of p53, through an IRES-dependent mechanism

scientific article

The common acute lymphoblastic leukemia antigen gene maps to chromosomal region 3 (q21-q27).

scientific article

The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production

scientific article

The gamma-secretase-generated intracellular domain of beta-amyloid precursor protein binds Numb and inhibits Notch signaling

scientific article

The intracellular localization of amyloid beta protein precursor (AbetaPP) intracellular domain associated protein-1 (AIDA-1) is regulated by AbetaPP and alternative splicing.

scientific article

The intracellular threonine of amyloid precursor protein that is essential for docking of Pin1 is dispensable for developmental function.

scientific article

Thymic and peripheral apoptosis of antigen-specific T cells might cooperate in establishing self tolerance.

scientific article published on March 1993

Transgenic expression of the amyloid-beta precursor protein-intracellular domain does not induce Alzheimer's Disease-like traits in vivo

scientific article

Trem2 Splicing and Expression are Preserved in a Human Aβ-producing, Rat Knock-in Model of Trem2-R47H Alzheimer's Risk Variant

scientific article published on 05 March 2020

Tuning of Glutamate, But Not GABA, Release by an Intrasynaptic Vesicle APP Domain Whose Function Can Be Modulated by β- or α-Secretase Cleavage

scientific article published on 24 June 2019

Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo ⬇️

scientific article

Tyr682 in the Aβ-precursor protein intracellular domain regulates synaptic connectivity, cholinergic function, and cognitive performance

scientific article

Tyrosine phosphorylation of the beta-amyloid precursor protein cytoplasmic tail promotes interaction with Shc

scientific article

β- but not γ-secretase proteolysis of APP causes synaptic and memory deficits in a mouse model of dementia

scientific article

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