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List of works by Jan Wijnholds

"Basal Cell Migration" in Regeneration of the Corneal Wound-Bed

scientific article published on 01 January 2019

A family of drug transporters: the multidrug resistance-associated proteins.

scientific article

A new CRB1 rat mutation links Müller glial cells to retinal telangiectasia.

scientific article

A single amino acid substitution (Cys249Trp) in Crb1 causes retinal degeneration and deregulates expression of pituitary tumor transforming gene Pttg1.

scientific article

AAV Gene Augmentation Therapy for CRB1-Associated Retinitis Pigmentosa

scientific article published in January 2018

AAV Serotype Testing on Cultured Human Donor Retinal Explants

scientific article published in January 2018

Binding of a bZip protein to the estrogen-inducible apoVLDL II promoter

scientific article published on 01 September 1994

Bone spicule pigment formation in retinitis pigmentosa: insights from a mouse model.

scientific article

CLINICAL AND GENETIC CHARACTERISTICS OF MALE PATIENTS WITH RPGR-ASSOCIATED RETINAL DYSTROPHIES: A Long-Term Follow-up Study

scientific article published on 8 March 2018

CRB2 Loss in Rod Photoreceptors Is Associated with Progressive Loss of Retinal Contrast Sensitivity ⬇️

scientific article published on 21 August 2019

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice

scientific article

CRB2 in immature photoreceptors determines the superior-inferior symmetry of the developing retina to maintain retinal structure and function

scientific article published on 01 September 2018

Characterization of Pax-6 and Hoxa-1 binding to the promoter region of the neural cell adhesion molecule L1

scientific article published on 01 September 1994

Characterization of the MRP4- and MRP5-mediated transport of cyclic nucleotides from intact cells

scientific article (publication date: 16 May 2003)

Characterization of the transport of nucleoside analog drugs by the human multidrug resistance proteins MRP4 and MRP5

scientific article (publication date: May 2003)

Cloning and characterisation of a nuclear, site specific ssDNA binding protein.

scientific article published on July 1995

Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides.

scientific article published on 2 September 2008

Crb1 is a determinant of retinal apical Müller glia cell features

scientific article published on 01 November 2007

Crumbs 2 prevents cortical abnormalities in mouse dorsal telencephalon.

scientific article

Crumbs homologue 1 in polarity and blindness.

scientific article published in November 2004

Crumbs homologue 1 is required for maintenance of photoreceptor cell polarization and adhesion during light exposure

scientific journal article

Crumbs2 mediates ventricular layer remodelling to form the spinal cord central canal

scientific article published on 09 March 2020

Crumbs2 promotes cell ingression during the epithelial-to-mesenchymal transition at gastrulation

scientific journal article

Defining Phenotype, Tropism, and Retinal Gene Therapy Using Adeno-Associated Viral Vectors (AAVs) in New-Born Brown Norway Rats with a Spontaneous Mutation in Crb1

scientific article

Differential susceptibility of multidrug resistance protein-1 deficient mice to DSS and TNBS-induced colitis.

scientific article published in September 2002

Estrogen-inducible and liver-specific expression of the chicken Very Low Density Apolipoprotein II gene locus in transgenic mice.

scientific article

GFAP-driven GFP expression in activated mouse Müller glial cells aligning retinal blood vessels following intravitreal injection of AAV2/6 vectors

scientific article

Gene therapy into photoreceptors and Müller glial cells restores retinal structure and function in CRB1 retinitis pigmentosa mouse models

scientific article published on 20 February 2015

Genetic and Molecular Approaches to Study Neuronal Migration in the Developing Cerebral Cortex

scientific article published on 5 May 2017

Genotypic and Phenotypic Characteristics of CRB1-Associated Retinal Dystrophies: A Long-Term Follow-up Study

scientific article published on 13 March 2017

Human iPSC-Derived Retinas Recapitulate the Fetal CRB1 CRB2 Complex Formation and Demonstrate that Photoreceptors and Müller Glia Are Targets of AAV5

scientific article published on 04 April 2019

In vivo confocal imaging of the retina in animal models using scanning laser ophthalmoscopy

scientific article published on 26 September 2005

Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein

scientific article published on 01 November 1997

Isolation of Crb1, a mouse homologue of Drosophila crumbs, and analysis of its expression pattern in eye and brain

scientific article published in January 2002

Loss of CRB2 in Müller glial cells modifies a CRB1-associated retinitis pigmentosa phenotype into a Leber congenital amaurosis phenotype

scientific article published on 01 January 2019

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene ⬇️

scientific article published on September 21, 2012

MPP3 is required for maintenance of the apical junctional complex, neuronal migration, and stratification in the developing cortex.

scientific article published in May 2013

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.

scientific article published on 25 July 2013

MPP5 recruits MPP4 to the CRB1 complex in photoreceptors

scientific article

MRP6 (ABCC6) detection in normal human tissues and tumors.

scientific article published on April 2002

Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides.

scientific article

Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia.

scientific article

Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background

scientific article

Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage ⬇️

scientific article published on September 7, 1998

Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs

scientific article

Noninvasive, in vivo assessment of mouse retinal structure using optical coherence tomography

scientific article

PALS1 is essential for retinal pigment epithelium structure and neural retina stratification.

scientific article

Pals1/Mpp5 is required for correct localization of Crb1 at the subapical region in polarized Muller glia cells

scientific journal article

Pax-3-DNA interaction: flexibility in the DNA binding and induction of DNA conformational changes by paired domains.

scientific article published on August 1994

Pax: gene regulators in the developing nervous system.

scientific article

Production of iPS-Derived Human Retinal Organoids for Use in Transgene Expression Assays.

scientific article

Protein O-Glucosyltransferase 1 (POGLUT1) Promotes Mouse Gastrulation through Modification of the Apical Polarity Protein CRUMBS2

scientific article

Pseudoxanthoma elasticum: a clinical, histopathological, and molecular update.

scientific article

RPGR-Associated Dystrophies: Clinical, Genetic, and Histopathological Features

scientific article published on 28 January 2020

Retinogenesis of the Human Fetal Retina: An Apical Polarity Perspective

scientific article published on 29 November 2019

Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies.

scientific article published in September 2000

Specific tools for targeting and expression in Müller glial cells

scientific article published on 19 March 2014

TMEM16B, a novel protein with calcium-dependent chloride channel activity, associates with a presynaptic protein complex in photoreceptor terminals

scientific article

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis

scientific article

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

scientific article published on 2 February 2014

The CRB1 Complex: Following the Trail of Crumbs to a Feasible Gene Therapy Strategy.

scientific article published on 05 April 2017

The CRB1 and adherens junction complex proteins in retinal development and maintenance.

scientific article published on 06 February 2014

The Spectrum of Structural and Functional Abnormalities in Female Carriers of Pathogenic Variants in the RPGR Gene

article

The apical complex couples cell fate and cell survival to cerebral cortical development

scientific article

The human multidrug resistance protein MRP5 transports folates and can mediate cellular resistance against antifolates.

scientific article

The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes.

scientific article published on 15 March 2006

The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy.

scientific article published on April 2004

Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells.

scientific article published in December 2002

Towards understanding CRUMBS function in retinal dystrophies.

scientific article published on October 2006

Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1.

scientific article published in December 1997

c/CEPB, a chicken transcription factor of the leucine-zipper C/EBP family [corrected]

scientific article published in August 1992

cGMP transport by vesicles from human and mouse erythrocytes

scientific article published on 01 January 2007

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