List of works - John J Tanner

A Conserved Active Site Tyrosine Residue of Proline Dehydrogenase Helps Enforce the Preference for Proline over Hydroxyproline as the Substrate † ‡

scientific article

A Super-Clustering Approach for Fully Automated Single Particle Picking in Cryo-EM

scientific article published on 30 August 2019

AutoCryoPicker: an unsupervised learning approach for fully automated single particle picking in Cryo-EM images

scientific article published on 13 June 2019

Biochemical Characterization of the Two-Component Flavin-Dependent Monooxygenase Involved in Valanimycin Biosynthesis

scientific article published on 22 December 2020

Bioinformatics Methods for Mass Spectrometry-Based Proteomics Data Analysis

scientific article published on 20 April 2020

Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.

scientific article published on 15 July 2017

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes

scientific article published on 28 August 2020

Characterization of a unique class C acid phosphatase from Clostridium perfringens.

scientific article published on 10 April 2009

Conservation of functionally important global motions in an enzyme superfamily across varying quaternary structures

scientific article

Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase

scientific article

Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics

scientific article

Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate.

scientific article published on 27 March 2017

Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate

scientific article published on 18 March 2020

Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer

scientific article published on 07 December 2018

Crystal Structures and Kinetics of Monofunctional Proline Dehydrogenase Provide Insight into Substrate Recognition and Conformational Changes Associated with Flavin Reduction and Product Release

scientific article

Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus

scientific article

Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation

scientific article

Crystal structure and immunogenicity of the class C acid phosphatase from Pasteurella multocida

scientific article

Crystal structure and tartrate inhibition of Legionella pneumophila histidine acid phosphatase

scientific article

Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens

scientific article

Crystal structure of an antigen-binding fragment bound to single-stranded DNA 1 1Edited by I. A. Wilson ⬇️

scientific article published on December 7, 2001

Crystallization and preliminary crystallographic analysis of the proline dehydrogenase domain of the multifunctional PutA flavoprotein fromEscherichia coli ⬇️

scientific article published on November 21, 2001

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase.

scientific article

Determination of Protein Oligomeric Structure from Small-Angle X-ray Scattering.

scientific article published on 20 January 2018

Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1

scientific article

Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A.

scientific article published in November 2017

EF5 Is the High-Affinity Mg(2+) Site in ALG-2

scientific article

Empirical power laws for the radii of gyration of protein oligomers.

scientific article published on 15 September 2016

Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA.

scientific article published on 14 October 2016

Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA).

scientific article published on 18 December 2013

Evidence that the C-terminal domain of a type B PutA protein contributes to aldehyde dehydrogenase activity and substrate channeling.

scientific article

Exploring structurally conserved solvent sites in protein families.

scientific article

Expression, purification and crystallization of an atypical class C acid phosphatase from Mycoplasma bovis ⬇️

scientific article published on September 30, 2011

First evidence for substrate channeling between proline catabolic enzymes: a validation of domain fusion analysis for predicting protein-protein interactions.

scientific article

Flavin-N5 Covalent Intermediate in the Non-redox Dehalogenation Reaction Catalyzed by an Atypical Flavoenzyme.

scientific article published on 8 November 2017

Functional Role for the Conformationally Mobile Phenylalanine 223 in the Reaction of Methylenetetrahydrofolate Reductase from Escherichia coli

scientific article

Identification of a Conserved Histidine as Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein

scientific article published on 8 June 2017

Identification of the NAD(P)H Binding Site of Eukaryotic UDP-Galactopyranose Mutase

scientific article

Impact of disease-Linked mutations targeting the oligomerization interfaces of aldehyde dehydrogenase 7A1.

scientific article published on 10 January 2017

Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

scientific article published on 02 February 2020

Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity.

scientific article

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction.

scientific article published on 2 February 2016

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1

scientific article published on 27 October 2020

Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.

scientific article published on 24 August 2015

Involvement of the β3-α3 Loop of the Proline Dehydrogenase Domain in Allosteric Regulation of Membrane Association of Proline Utilization A

scientific article

Kinetic and Structural Characterization of Tunnel-Perturbing Mutants in Bradyrhizobium japonicum Proline Utilization A

scientific article

MRSAD: using anomalous dispersion from S atoms collected at Cu Kα wavelength in molecular-replacement structure determination ⬇️

scientific article published on September 19, 2003

Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase.

scientific article published on 23 June 2017

NAD+ promotes assembly of the active tetramer of aldehyde dehydrogenase 7A1

scientific article published on 18 September 2018

Proline: Mother Nature's cryoprotectant applied to protein crystallography

scientific article

Quaternary structure, conformational variability and global motions of phosphoglucosamine mutase

scientific article published on 08 August 2011

Recognition of Nucleoside Monophosphate Substrates by Haemophilus influenzae Class C Acid Phosphatase

scientific article

Redox Modulation of Oligomeric State in Proline Utilization A

scientific article published on 01 June 2018

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects ⬇️

scientific article published on April 13, 2011

Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.

scientific article

SAXS fingerprints of aldehyde dehydrogenase oligomers

scientific article

SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data

scientific article published on 20 December 2019

STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.

scientific article

Solution structures of chicken parvalbumin 3 in the Ca(2+)-free and Ca(2+)-bound states

scientific article

Steric Control of the Rate-Limiting Step of UDP-Galactopyranose Mutase

scientific article published on 18 May 2018

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline.

scientific article published on 23 December 2017

Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.

scientific article

Structural Biology of Proline Catabolic Enzymes.

scientific article

Structural Determinants of Flavin Dynamics in a Class B Monooxygenase

scientific article published on 23 November 2020

Structural Determinants of Oligomerization of Δ1-Pyrroline-5-Carboxylate Dehydrogenase: Identification of a Hexamerization Hot Spot

scientific article

Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.

scientific article published on 26 March 2018

Structural Studies of Yeast Δ 1 -Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State

scientific article

Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy

scientific article published on 25 October 2019

Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants

scientific article published on 21 December 2018

Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1

scientific article published on 25 July 2019

Structural basis of the inhibition of class C acid phosphatases by adenosine 5′‐phosphorothioate ⬇️

scientific article published on October 10, 2011

Structure and characterization of a class 3B proline utilization A: Ligand-induced dimerization and importance of the C-terminal domain for catalysis.

scientific article

Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum)

scientific article published on 11 June 2020

Structure of Avian Thymic Hormone, a High-Affinity Avian β-Parvalbumin, in the Ca2+-Free and Ca2+-Bound States

scientific article

Structure, function, and mechanism of proline utilization A (PutA).

scientific article

Structures of Proline Utilization A Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function

scientific article

Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site

scientific article

Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course

scientific article published on 24 November 2016

Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens ⬇️

scientific article published on January 1, 2013

The Biological Buffer Bicarbonate/CO2 Potentiates H2O2-Mediated Inactivation of Protein Tyrosine Phosphatases ⬇️

scientific article published on September 19, 2011

The Proline Cycle As a Potential Cancer Therapy Target.

scientific article published on 12 April 2018

The Structure of the Antibiotic Deactivating, N-hydroxylating Rifampicin Monooxygenase.

scientific article published on 24 August 2016

The Structure of the Proline Utilization A Proline Dehydrogenase Domain Inactivated by N -Propargylglycine Provides Insight into Conformational Changes Induced by Substrate Binding and Flavin Reduction ,

scientific article

The three-dimensional structural basis of type II hyperprolinemia

scientific article

Trapping conformational states of a flavin-dependent N-monooxygenase in crystallo reveals protein and flavin dynamics

scientific article published on 28 July 2020

Unique structural features and sequence motifs of proline utilization A (PutA).

scientific article published on January 2012

List of works by John J Tanner

A Conserved Active Site Tyrosine Residue of Proline Dehydrogenase Helps Enforce the Preference for Proline over Hydroxyproline as the Substrate † ‡

A Super-Clustering Approach for Fully Automated Single Particle Picking in Cryo-EM

AutoCryoPicker: an unsupervised learning approach for fully automated single particle picking in Cryo-EM images

Biochemical Characterization of the Two-Component Flavin-Dependent Monooxygenase Involved in Valanimycin Biosynthesis

Bioinformatics Methods for Mass Spectrometry-Based Proteomics Data Analysis

Biophysical investigation of type A PutAs reveals a conserved core oligomeric structure.

Cautionary Tale of Using Tris(alkyl)phosphine Reducing Agents with NAD+-Dependent Enzymes

Characterization of a unique class C acid phosphatase from Clostridium perfringens.

Conservation of functionally important global motions in an enzyme superfamily across varying quaternary structures

Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase

Contributions of unique active site residues of eukaryotic UDP-galactopyranose mutases to substrate recognition and active site dynamics

Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate.

Covalent Modification of the Flavin in Proline Dehydrogenase by Thiazolidine-2-Carboxylate

Crystal Structure of Aldehyde Dehydrogenase 16 Reveals Trans-Hierarchical Structural Similarity and a New Dimer

Crystal Structures and Kinetics of Monofunctional Proline Dehydrogenase Provide Insight into Substrate Recognition and Conformational Changes Associated with Flavin Reduction and Product Release

Crystal Structures and Small-angle X-ray Scattering Analysis of UDP-galactopyranose Mutase from the Pathogenic Fungus Aspergillus fumigatus

Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation

Crystal structure and immunogenicity of the class C acid phosphatase from Pasteurella multocida

Crystal structure and tartrate inhibition of Legionella pneumophila histidine acid phosphatase

Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens

Crystal structure of an antigen-binding fragment bound to single-stranded DNA 1 1Edited by I. A. Wilson ⬇️

Crystallization and preliminary crystallographic analysis of the proline dehydrogenase domain of the multifunctional PutA flavoprotein fromEscherichia coli ⬇️

Crystallization of recombinant Haemophilus influenzae e (P4) acid phosphatase.

Determination of Protein Oligomeric Structure from Small-Angle X-ray Scattering.

Diethylaminobenzaldehyde is a covalent, irreversible inactivator of ALDH7A1

Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A.

EF5 Is the High-Affinity Mg(2+) Site in ALG-2

Empirical power laws for the radii of gyration of protein oligomers.

Engineering a trifunctional proline utilization A chimaera by fusing a DNA-binding domain to a bifunctional PutA.

Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA).

Evidence that the C-terminal domain of a type B PutA protein contributes to aldehyde dehydrogenase activity and substrate channeling.

Exploring structurally conserved solvent sites in protein families.

Expression, purification and crystallization of an atypical class C acid phosphatase from Mycoplasma bovis ⬇️

First evidence for substrate channeling between proline catabolic enzymes: a validation of domain fusion analysis for predicting protein-protein interactions.

Flavin-N5 Covalent Intermediate in the Non-redox Dehalogenation Reaction Catalyzed by an Atypical Flavoenzyme.

Functional Role for the Conformationally Mobile Phenylalanine 223 in the Reaction of Methylenetetrahydrofolate Reductase from Escherichia coli

Identification of a Conserved Histidine as Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein

Identification of the NAD(P)H Binding Site of Eukaryotic UDP-Galactopyranose Mutase

Impact of disease-Linked mutations targeting the oligomerization interfaces of aldehyde dehydrogenase 7A1.

Impaired folate binding of serine hydroxymethyltransferase 8 from soybean underlies resistance to the soybean cyst nematode

Importance of the C-Terminus of Aldehyde Dehydrogenase 7A1 for Oligomerization and Catalytic Activity.

In Crystallo Capture of a Covalent Intermediate in the UDP-Galactopyranose Mutase Reaction.

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1

Inactivation of protein tyrosine phosphatases by dietary isothiocyanates.

Involvement of the β3-α3 Loop of the Proline Dehydrogenase Domain in Allosteric Regulation of Membrane Association of Proline Utilization A

Kinetic and Structural Characterization of Tunnel-Perturbing Mutants in Bradyrhizobium japonicum Proline Utilization A

MRSAD: using anomalous dispersion from S atoms collected at Cu Kα wavelength in molecular-replacement structure determination ⬇️

Multiple functionalities of reduced flavin in the non-redox reaction catalyzed by UDP-galactopyranose mutase.

NAD+ promotes assembly of the active tetramer of aldehyde dehydrogenase 7A1

Proline: Mother Nature's cryoprotectant applied to protein crystallography

Quaternary structure, conformational variability and global motions of phosphoglucosamine mutase

Recognition of Nucleoside Monophosphate Substrates by Haemophilus influenzae Class C Acid Phosphatase

Redox Modulation of Oligomeric State in Proline Utilization A

Redox Regulation of Protein Tyrosine Phosphatases: Structural and Chemical Aspects ⬇️

Resolving the cofactor-binding site in the proline biosynthetic enzyme human pyrroline-5-carboxylate reductase 1.

SAXS fingerprints of aldehyde dehydrogenase oligomers

SAXSDom: Modeling multidomain protein structures using small-angle X-ray scattering data

STRUCTURAL VIROLOGY. X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability.

Solution structures of chicken parvalbumin 3 in the Ca(2+)-free and Ca(2+)-bound states

Steric Control of the Rate-Limiting Step of UDP-Galactopyranose Mutase

Structural Basis for the Substrate Inhibition of Proline Utilization A by Proline.

Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1.

Structural Biology of Proline Catabolic Enzymes.

Structural Determinants of Flavin Dynamics in a Class B Monooxygenase

Structural Determinants of Oligomerization of Δ1-Pyrroline-5-Carboxylate Dehydrogenase: Identification of a Hexamerization Hot Spot

Structural Evidence for Rifampicin Monooxygenase Inactivating Rifampicin by Cleaving Its Ansa-Bridge.

Structural Studies of Yeast Δ 1 -Pyrroline-5-carboxylate Dehydrogenase (ALDH4A1): Active Site Flexibility and Oligomeric State

Structural analysis of pathogenic mutations targeting Glu427 of ALDH7A1, the hot spot residue of pyridoxine-dependent epilepsy

Structural and Biochemical Characterization of Aldehyde Dehydrogenase 12, the Last Enzyme of Proline Catabolism in Plants

Structural and biochemical consequences of pyridoxine-dependent epilepsy mutations that target the aldehyde binding site of aldehyde dehydrogenase ALDH7A1

Structural basis of the inhibition of class C acid phosphatases by adenosine 5′‐phosphorothioate ⬇️

Structure and characterization of a class 3B proline utilization A: Ligand-induced dimerization and importance of the C-terminal domain for catalysis.

Structure and function of a flavin-dependent S-monooxygenase from garlic (Allium sativum)

Structure of Avian Thymic Hormone, a High-Affinity Avian β-Parvalbumin, in the Ca2+-Free and Ca2+-Bound States

Structure, function, and mechanism of proline utilization A (PutA).

Structures of Proline Utilization A Reveal the Fold and Functions of the Aldehyde Dehydrogenase Superfamily Domain of Unknown Function

Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site

Synchrotron-based macromolecular crystallography module for an undergraduate biochemistry laboratory course

Targeting UDP-Galactopyranose Mutases from Eukaryotic Human Pathogens ⬇️