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List of works by David Gems

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

scientific article

Against the oxidative damage theory of aging: superoxide dismutases protect against oxidative stress but have little or no effect on life span in Caenorhabditis elegans

scientific article published on December 2008

Ageing. Yeast longevity gene goes public

scientific article published in March 2001

Ageing: A lethal side-effect

scientific article published in Nature

Ageing: Microarraying mortality

scientific article published in July 2003

Aging in a very short-lived nematode

scientific article published on 01 September 2004

Aging: To Treat, or Not to Treat?

article

Alternative Perspectives on Aging in Caenorhabditis elegans: Reactive Oxygen Species or Hyperfunction?

scientific article

An 'instant gene bank' method for gene cloning by mutant complementation.

scientific article

An abundantly expressed mucin-like protein from Toxocara canis infective larvae: the precursor of the larval surface coat glycoproteins

scientific article published on February 1996

An autonomously replicating plasmid transforms Aspergillus nidulans at high frequency

scientific article

Anthranilate fluorescence marks a calcium-propagated necrotic wave that promotes organismal death in C. elegans

scientific article published in July 2013

Benchmarks for ageing studies

scientific article published in Nature

Beyond the evolutionary theory of ageing, from functional genomics to evo-gero

scientific article published on 10 March 2006

Body size, insulin/IGF signaling and aging in the nematode Caenorhabditis elegans

scientific article published in January 2003

Broad spectrum detoxification: the major longevity assurance process regulated by insulin/IGF-1 signaling?

scientific article

C. elegans ageing is accelerated by a self-destructive reproductive programme

scientific article published in 2023

Cell-nonautonomous effects of dFOXO/DAF-16 in aging

scientific article published on 06 February 2014

Clustering of genetically defined allele classes in the Caenorhabditis elegans DAF-2 insulin/IGF-1 receptor

scientific article

Comment on "Brain IRS2 signaling coordinates life span and nutrient homeostasis"

scientific article published on 01 May 2008

Coordinated multitissue transcriptional and plasma metabonomic profiles following acute caloric restriction in mice.

scientific article

DAF-16/FoxO directly regulates an atypical AMP-activated protein kinase gamma isoform to mediate the effects of insulin/IGF-1 signaling on aging in Caenorhabditis elegans

scientific article

DamID in C. elegans reveals longevity-associated targets of DAF-16/FoxO

scientific article

Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans

scientific article published on 7 March 2006

Dietary restriction in C. elegans: from rate-of-living effects to nutrient sensing pathways

scientific article

Dietary restriction in long-lived dwarf flies

scientific article published in April 2002

Dietary restriction in the nematode Caenorhabditis elegans

scientific article published on 01 January 2007

Effects of resveratrol on lifespan in Drosophila melanogaster and Caenorhabditis elegans

scientific article

Effects of sex and insulin/insulin-like growth factor-1 signaling on performance in an associative learning paradigm in Caenorhabditis elegans

scientific article

Erratum to "Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans" [Mech. Ageing Dev. 127 (5) (2006) 458-472]

scientific journal article

Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice

scientific article

Evolutionary conservation of regulated longevity assurance mechanisms

scientific article published on January 2007

Excessive folate synthesis limits lifespan in the C. elegans: E. coli aging model.

scientific article

Extraordinary plasticity in aging in Strongyloides ratti implies a gene-regulatory mechanism of lifespan evolution

scientific article published in August 2006

Genes and ageing: beyond good and evil in the senescent cell

scientific article published on 01 March 2001

Genetics of longevity in model organisms: debates and paradigm shifts

scientific article

Increased life span from overexpression of superoxide dismutase in Caenorhabditis elegans is not caused by decreased oxidative damage

scientific article

Insulin/IGF-1 and hypoxia signaling act in concert to regulate iron homeostasis in Caenorhabditis elegans

scientific article (publication date: 2012)

Interventions to Slow Aging in Humans: Are We Ready?

scientific article

Is more life always better? The new biology of aging and the meaning of life

scientific article published on 01 July 2003

LET-60 RAS modulates effects of insulin/IGF-1 signaling on development and aging in Caenorhabditis elegans

scientific article published in October 2005

Long-lived dwarf mice: are bile acids a longevity signal?

scientific article published on 01 August 2007

Longevity in Caenorhabditis elegans reduced by mating but not gamete production

scientific article published in February 1996

Longevity of Indy mutant Drosophila not attributable to Indy mutation

scholarly article

Manipulation of in vivo iron levels can alter resistance to oxidative stress without affecting ageing in the nematode C. elegans

scientific article

Measurement of H2O2 within living Drosophila during aging using a ratiometric mass spectrometry probe targeted to the mitochondrial matrix

scientific article published on March 2011

Mechanisms of ageing: public or private?

scientific article

Metabolic rate is not reduced by dietary-restriction or by lowered insulin/IGF-1 signalling and is not correlated with individual lifespan in Drosophila melanogaster

scientific article published in August 2004

Metformin retards aging in C. elegans by altering microbial folate and methionine metabolism.

scientific article published on March 2013

Multiple copies of MATE elements support autonomous plasmid replication in Aspergillus nidulans

scientific article published in April 1996

New label-free automated survival assays reveal unexpected stress resistance patterns during C. elegans aging

scientific article published on 16 July 2019

No increase in lifespan in Caenorhabditis elegans upon treatment with the superoxide dismutase mimetic EUK-8

scientific article published on 01 January 2003

No influence of Indy on lifespan in Drosophila after correction for genetic and cytoplasmic background effects

scientific article

RILM: a web-based resource to aid comparative and functional analysis of the insulin and IGF-1 receptor family.

scientific article

Sex and death: what is the connection?

scientific article

Sex-specific effects of the DAF-12 steroid receptor on aging in Caenorhabditis elegans

scientific article

Shared transcriptional signature in Caenorhabditis elegans Dauer larvae and long-lived daf-2 mutants implicates detoxification system in longevity assurance

scientific article

Shorter life and reduced fecundity can increase colony fitness in virtual Caenorhabditis elegans

scientific article published on 16 April 2020

Stress-response hormesis and aging: "that which does not kill us makes us stronger".

scientific article

Superoxide dismutase mimetics elevate superoxide dismutase activity in vivo but do not retard aging in the nematode Caenorhabditis elegans

scientific article

The 'mitoflash' probe cpYFP does not respond to superoxide

scientific article published in October 2014

The aging-disease false dichotomy: understanding senescence as pathology

scientific article published on 16 June 2015

The mysterious case of the C. elegans gut granule: death fluorescence, anthranilic acid and the kynurenine pathway

scientific article published in 2013

The mystery of C. elegans aging: an emerging role for fat. Distant parallels between C. elegans aging and metabolic syndrome?

scientific article published on 27 February 2012

The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans

scientific article published on 06 January 2014

Tragedy and delight: the ethics of decelerated ageing.

scientific article

Transcript profiles of long- and short-lived adults implicate protein synthesis in evolved differences in ageing in the nematode Strongyloides ratti

scientific article published on 13 November 2008

Treating aging: progress toward dietary restriction mimetics ⬇️

scientific article published on October 21, 2010

Unraveling the biological roles of reactive oxygen species

scientific article published on April 2011

What are the effects of maternal and pre-adult environments on ageing in humans, and are there lessons from animal models?

scientific article

What is an anti-aging treatment?

scientific article published on 11 July 2014

Worms need microbes too: microbiota, health and aging in Caenorhabditis elegans ⬇️

scientific article published on August 1, 2013

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