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List of works by Enric I. Canela

A Sensitive Enzymatic Method of Sulfite Determination

A Significant Role of the Truncated Ghrelin Receptor GHS-R1b in Ghrelin-induced Signaling in Neurons.

scientific article published on 25 April 2016

A computer program for enzyme kinetics that combines model discrimination, parameter refinement and sequential experimental design.

scientific article

A free derivative program for non-linear regression analysis of enzyme kinetics to be used on small computers

scientific article published in March 1984

A hybrid indoloquinolizidine peptide as allosteric modulator of dopamine D1 receptors

scientific article

A model for adenosine transport and metabolism

scientific article published on October 1992

A model of the pentose phosphate pathway in rat liver cells.

scientific article published in January 1995

A new strategy for the evaluation of force parameters from quantum mechanical computations

A program for deriving rate equations using small computers

scientific article published in January 1983

A program for the numerical integration of enzyme kinetic equations using small computers

scientific article published in November 1984

A quantum chemical study of the enzymatic deamination of benzoadenine derivatives. A theoretical model of the interactions occurring between nucleosides and the active site of adenosine deaminase.

scientific article published on February 1990

A1 Adenosine Receptors Accumulate in Neurodegenerative Structures in Alzheimer's Disease and Mediate Both Amyloid Precursor Protein Processing and Tau Phosphorylation and Translocation

scholarly article by Ester Angulo et al published 5 April 2006 in Brain Pathology

A2A adenosine receptor ligand binding and signalling is allosterically modulated by adenosine deaminase

scientific article published in May 2011

Ab initio study of the protonation and the tautomerism of the 7-aminopyrazolopyrimidine molecule

Accuracy and precision in the determination of stokes radii and molecular masses of proteins by gel filtration chromatography

scientific article published on 01 June 1989

Actin-binding protein alpha-actinin-1 interacts with the metabotropic glutamate receptor type 5b and modulates the cell surface expression and function of the receptor

scientific article

Adenine nucleotides and adenosine metabolism in pig kidney proximal tubule membranes

scientific article published on 01 October 1993

Adenosine (Ado) uptake in brush-border membrane vesicles from rat kidney (BBM)

scientific article published on 01 August 1991

Adenosine A(2A) Receptors and A(2A) Receptor Heteromers as Key Players in Striatal Function

scientific article

Adenosine Deaminase Interacts with A1 Adenosine Receptors in Pig Brain Cortical Membranes

Adenosine deaminase affects ligand-induced signalling by interacting with cell surface adenosine receptors

scientific article published on 01 February 1996

Adenosine metabolism in kidney slices under normoxic conditions.

scientific article

Adenosine-cannabinoid receptor interactions. Implications for striatal function

scientific article

Adenosine-glutamate receptor-receptor interactions in the central nervous system

Adenosine/dopamine receptor-receptor interactions in the central nervous system

scholarly article by Rafael Franco et al published January 2001 in Drug Development Research

Allosteric interactions between agonists and antagonists within the adenosine A2A receptor-dopamine D2 receptor heterotetramer

scientific article

Ammonium toxicity in different cell lines

article

An Improved Purification Procedure for Sulfite Oxidase from Bovine Liver

scientific article published on 01 January 1991

Analysis of ultradian heat production and aortic core temperature rhythms in the rat

scientific article published on 01 March 1993

Application of inverse regression for estimating molecular masses and Stokes radii of globular proteins by gel filtration chromatography.

scientific article published in January 1990

Basic concepts in G-protein-coupled receptor homo- and heterodimerization.

scientific article published on 2 November 2007

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors.

scientific article published on 23 October 2017

Biochemical systems theory: increasing predictive power by using second-order derivatives measurements

scientific article published in April 1991

Cannabinoid receptors CB1 and CB2 form functional heteromers in brain

scientific article published on 24 April 2012

Cell surface adenosine deaminase: much more than an ectoenzyme.

scientific article

Characterization of bovine liver guanine aminohydrolase

scientific article published on 01 January 1981

Characterization of the forms of bovine liver adenosine deaminase

scientific article published on 01 January 1982

Circadian-related heteromerization of adrenergic and dopamine D₄ receptors modulates melatonin synthesis and release in the pineal gland

scientific article

Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors

scientific article (publication date: 17 May 2002)

Cocaine Effects on Dopaminergic Transmission Depend on a Balance between Sigma-1 and Sigma-2 Receptor Expression

scientific article published on 12 February 2018

Cocaine disrupts histamine H3 receptor modulation of dopamine D1 receptor signaling: σ1-D1-H3 receptor complexes as key targets for reducing cocaine's effects.

scientific article published on March 2014

Cocaine inhibits dopamine D2 receptor signaling via sigma-1-D2 receptor heteromers

scientific article

Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer

scientific article

Cognitive Impairment Induced by Delta9-tetrahydrocannabinol Occurs through Heteromers between Cannabinoid CB1 and Serotonin 5-HT2A Receptors

scientific article

Comparative study of chicken liver xanthine dehydrogenase and bovine liver xanthine oxidase. dehydrogenase activity of xanthine oxidase (author's transl)

scientific article published on March 1, 1979

Computer simulation of purine metabolism ⬇️

scientific article published on October 15, 1984

Control analysis of transition times. Extension of analysis and matrix method

scientific article published in February 1991

Cross-communication between Gi and Gs in a G-protein-coupled receptor heterotetramer guided by a receptor C-terminal domain.

scientific article published on 28 February 2018

Detection of heteromerization of more than two proteins by sequential BRET-FRET.

scientific article

Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer.

scientific article

Detection of receptor heteromers involving dopamine receptors by the sequential BRET-FRET technology

scientific article published in January 2013

Determination of the conformational preferences of adenosine at the active site of adenosine deaminase

scientific article published in 1990

Differential effect of amphetamine over the corticotropin-releasing factor CRF2 receptor, the orexin OX1 receptor and the CRF2-OX1 heteroreceptor complex

scientific article published on 19 November 2018

Dimer-based model for heptaspanning membrane receptors

scientific article published on 01 July 2005

Direct involvement of sigma-1 receptors in the dopamine D1 receptor-mediated effects of cocaine

scientific article

Dopamine D1-histamine H3 receptor heteromers provide a selective link to MAPK signaling in GABAergic neurons of the direct striatal pathway

scientific article

Dopamine-galanin receptor heteromers modulate cholinergic neurotransmission in the rat ventral hippocampus.

scientific article

Enzyme kinetic studies from progress curves.

scientific article

Enzyme-enzyme interactions and metabolite channelling: alternative mechanisms and their evolutionary significance.

scientific article published on March 1994

Epidermal growth factor (EGF)-induced up-regulation and agonist- and antagonist-induced desensitization and internalization of A1 adenosine receptors in a pituitary-derived cell line.

scientific article published on January 1999

Evidence for functional pre-coupled complexes of receptor heteromers and adenylyl cyclase

scientific article published on 28 March 2018

Experimental strategy to study the pH dependence of the kinetic behavior of enzymes: practical application to chicken liver xanthine dehydrogenase.

scientific article published in January 1993

Functional selectivity of allosteric interactions within G protein-coupled receptor oligomers: the dopamine D1-D3 receptor heterotetramer.

scientific article

Functional μ-Opioid-Galanin Receptor Heteromers in the Ventral Tegmental Area.

scientific article published on 22 December 2016

G protein-coupled receptor heteromers as new targets for drug development

scientific article published on January 2010

GPCR homomers and heteromers: a better choice as targets for drug development than GPCR monomers?

scientific article published on 05 August 2009

Gi protein coupling to adenosine A1-A2A receptor heteromers in human brain caudate nucleus.

scientific article published on 13 May 2010

Glycogen Structure: an Evolutionary View

Heptaspanning membrane receptors and cytoskeletal/scaffolding proteins: focus on adenosine, dopamine, and metabotropic glutamate receptor function

scientific article

Heterogeneous localization of some purine enzymes in subcellular fractions of rat brain and cerebellum.

scientific article published in March 1986

Heteroreceptor Complexes Formed by Dopamine D1, Histamine H3, and N-Methyl-D-Aspartate Glutamate Receptors as Targets to Prevent Neuronal Death in Alzheimer's Disease

scientific article

Homodimerization of adenosine A2A receptors: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer

scientific article published on February 2004

Homodimerization of adenosine A₁ receptors in brain cortex explains the biphasic effects of caffeine

scientific article

Human adenosine deaminase as an allosteric modulator of human A(1) adenosine receptor: abolishment of negative cooperativity for [H](R)-pia binding to the caudate nucleus

scientific article

Identification and rejection of outliers in enzyme kinetics

scientific article published in October 1988

Immunological identification of A1adenosine receptors in brain cortex

scientific article published on 01 December 1995

Indoloquinolizidine-peptide hybrids as multiple agonists for D1 and D2 dopamine receptors.

scientific article published in September 2009

Interactions between calmodulin, adenosine A2A, and dopamine D2 receptors

scientific article

Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function

scientific article (publication date: August 2008)

Interactions between intracellular domains as key determinants of the quaternary structure and function of receptor heteromers

scientific article

Interdependence between cooperativity and control coefficients.

scientific article published in January 1989

Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers.

scientific article published in November 2014

Kinetic mechanism of chicken liver xanthine dehydrogenase.

scientific article published on January 1988

L-DOPA disrupts adenosine A(2A)-cannabinoid CB(1)-dopamine D(2) receptor heteromer cross-talk in the striatum of hemiparkinsonian rats: biochemical and behavioral studies

scientific article published on 9 January 2014

L-DOPA-treatment in primates disrupts the expression of A(2A) adenosine-CB(1) cannabinoid-D(2) dopamine receptor heteromers in the caudate nucleus

scientific article

Ligand-Induced Phosphorylation, Clustering, and Desensitization of A1Adenosine Receptors

scientific article published on 01 November 1997

Ligand-induced caveolae-mediated internalization of A1 adenosine receptors: morphological evidence of endosomal sorting and receptor recycling

scientific article published on April 2003

Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors

scientific article

Metabolic pathway characterization from transient response data obtained in situ: parameter estimation in S-system models.

scientific article published on May 1993

Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes.

scientific article published on 13 February 2001

Metabotropic glutamate type 1alpha receptor localizes in low-density caveolin-rich plasma membrane fractions

scientific article published in August 2003

Modulation of GH4 Cell Cycle via A1 Adenosine Receptors

article published in 2002

Modulation of adenosine agonist [3H]N6-(R)-phenylisopropyladenosine binding to pig brain cortical membranes by changes of membrane fluidity and of medium physicochemical characteristics.

scientific article

Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease

scientific article published on 09 June 2020

Molecular Evidence of Adenosine Deaminase Linking Adenosine A2A Receptor and CD26 Proteins

scientific article published on 15 February 2018

Molecular mechanisms involved in the adenosine A and A receptor-induced neuronal differentiation in neuroblastoma cells and striatal primary cultures

scientific article

Moonlighting adenosine deaminase: a target protein for drug development

scientific article

Mutual regulation between metabotropic glutamate type 1alpha receptor and caveolin proteins: from traffick to constitutive activity

scientific article published on October 2004

Novel pharmacological targets based on receptor heteromers

scientific article

Old and new ways to calculate the affinity of agonists and antagonists interacting with G-protein-coupled monomeric and dimeric receptors: the receptor-dimer cooperativity index.

scientific article published on 14 June 2007

On the Nested Hierarchical Organization of CNS: Basic Characteristics of Neuronal Molecular Networks

On the molecular basis of the receptor mosaic hypothesis of the engram

scientific article published in August 2004

Optimal association-saturation procedure for estimating association and dissociation rate parameters in receptor studies. Application to solubilized A1 adenosine receptors.

scientific article published on January 1992

Orexin A/Hypocretin Modulates Leptin Receptor-Mediated Signaling by Allosteric Modulations Mediated by the Ghrelin GHS-R1A Receptor in Hypothalamic Neurons.

scientific article published on 17 July 2017

Orexin-corticotropin-releasing factor receptor heteromers in the ventral tegmental area as targets for cocaine

scientific article published on April 2015

Partners for adenosine A1 receptors

scientific article

Performance Indices in Metabolic Systems: a Criterion for Evaluating Effectiveness in Metabolic Regulation

Platforms for the identification of GPCR targets, and of orthosteric and allosteric modulators.

scientific article published on April 2010

Practical Determination of Control Coefficients in Metabolic Pathways

article published in 1990

Preparative purification of adenosine deaminase from human erythrocytes by affinity chromatography

Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers

scientific article

Production of functional recombinant G-protein coupled receptors for heteromerization studies

scientific article published on 31 May 2011

Purification and properties of bovine liver aldehyde oxidase

scientific article published in 1987

Purification of Adenosine Deaminase from Chicken-Egg Yolk by Affinity Column Chromatography

scientific article published on 01 January 1990

Purification properties and functional groups of bovine liver xanthine oxidase

scientific article published in 1987

Quantum Chemical Study of the Electronic and Conformational Characteristics of Adenosine and 8-Substituted Derivatives: Functional Implications in the Mechanism of Reaction of Adenosine Deaminase

scientific article published on 01 February 1990

Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs.

scientific article

Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB1 and CB2 receptors and relevance for Alzheimer's disease and levodopa-induced dyskinesia

scientific article published on 23 August 2017

Receptor-receptor interactions involving adenosine A1 or dopamine D1 receptors and accessory proteins.

scientific article published on 6 October 2006

Regulation of L-Type Calcium Channels in GH4 Cells via A1 Adenosine Receptors

Regulation of epithelial and lymphocyte cell adhesion by adenosine deaminase-CD26 interaction

scientific article

Regulation of heptaspanning-membrane-receptor function by dimerization and clustering

scientific article published on 01 May 2003

Regulation of nitrobenzylthioninosine-sensitive adenosine uptake by cultured kidney cells.

scientific article published on November 1994

Reinterpreting anomalous competitive binding experiments within G protein-coupled receptor homodimers using a dimer receptor model

scientific article published on 22 November 2018

Role of cannabinoid receptor CB2 in HER2 pro-oncogenic signaling in breast cancer

scientific article

Role of histidine residues in agonist and antagonist binding sites of A1 adenosine receptor.

scientific article published in April 1993

Simulation of the purine nucleotide cycle as an anaplerotic process in skeletal muscle.

scientific article published on April 1987

Singular Location and Signaling Profile of Adenosine A2A-Cannabinoid CB1 Receptor Heteromers in the Dorsal Striatum.

scientific article published on 19 January 2017

Solubilization of A1adenosine receptor from pig brain: Characterization and evidence of the role of the cell membrane on the coexistence of high- and low-affinity states

scientific article published on 01 August 1990

Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids

scientific journal article

Striatal pre- and postsynaptic profile of adenosine A(2A) receptor antagonists

scientific article

Stronger Dopamine D1 Receptor-Mediated Neurotransmission in Dyskinesia

scientific article published on 26 October 2014

Targeting CB2-GPR55 receptor heteromers modulates cancer cell signaling.

scientific article

Targeting the dopamine D3 receptor: an overview of drug design strategies

scientific article

The Endocannabinoid System as a Target in Cancer Diseases: Are We There Yet?

scientific article published on 05 April 2019

The adenosine A2A receptor interacts with the actin-binding protein alpha-actinin

scientific journal article

The association of metabotropic glutamate receptor type 5 with the neuronal Ca2+-binding protein 2 modulates receptor function

scientific article

The binding of [3H]R-PIA to A1 adenosine receptors produces a conversion of the high- to the low-affinity state

scientific article published in July 1991

The catalytic site structural gate of adenosine deaminase allosterically modulates ligand binding to adenosine receptors

scientific article published on 27 November 2012

The effects of pH on chicken liver xanthine dehydrogenase

scientific article published in 1987

The influence of ammonium ions on the aggregation of chicken liver xanthine dehydrogenase

scientific article published in 1987

The molybdoenzymes xanthine oxidase and aldehyde oxidase contain fast- and slow-DTNB reacting sulphydryl groups

scientific article published on 01 October 1992

The neuronal Ca(2+) -binding protein 2 (NECAB2) interacts with the adenosine A(2A) receptor and modulates the cell surface expression and function of the receptor

scientific article

The two-state dimer receptor model: a general model for receptor dimers

scientific article published on 24 February 2006

Theoretical Approximation to the Reaction Mechanism of Adenosine Deaminase

Theoretical study of the acidic strength of amino acid side chains

Theoretical study of the hydroxyl nucleophilic attack on the 6-aminopyrimidine molecule: functional implications in the reaction mechanism of nucleoside deaminative enzymes

Theoretical study of the protonation and tautomerization of adenosine, formycin, and their 2-NH2 and 2-F derivatives: functional implications in the mechanism of reaction of adenosine deaminase.

scientific article published in February 1989

Thermodynamic analysis of agonist and antagonist binding to membrane-bound and solubilized A1 adenosine receptors

scientific article published on 01 September 1993

Transcriptional profiling of striatal neurons in response to single or concurrent activation of dopamine D2, adenosine A(2A) and metabotropic glutamate type 5 receptors: focus on beta-synuclein expression

scientific article published on 7 August 2012

Useful pharmacological parameters for G-protein-coupled receptor homodimers obtained from competition experiments. Agonist-antagonist binding modulation.

scientific article published on 28 July 2009

[Purine catabolism in rat brain (author's transl)]

scientific article published on 01 September 1981

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