List of works - David Colquhoun

'Complementary & Alternative Medicine' (CAM): Ethical And Policy Issues

scientific article published on 01 February 2016

A failure of the review process? Comment on Ahsin et al. Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee. Pain 2009;147:60-6.

scientific article published on 18 February 2010

A human congenital myasthenia-causing mutation (epsilon L78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties.

scientific article published on 24 February 2005

A note on correlations in single ion channel records

scientific article published in February 1987

A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor

scientific article

A response to critiques of 'The reproducibility of research and the misinterpretation of p-values'

scientific article published on 06 November 2019

A very bad report on regulating complementary medicine

scientific article published on July 2008

ATP receptor-mediated synaptic currents in the central nervous system

scientific article

Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus

scientific article published in October 1992

Activation of ion channels in the frog endplate by several analogues of acetylcholine ⬇️

scientific article published on 01 February 1991

Acupuncture Is Theatrical Placebo

scientific article

Acupuncture for 'frequent attenders' with medically unexplained symptoms

scientific article

Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors

scientific article published on 14 September 2009

Agonist-activated ion channels

scientific article

An analysis of the action of a false transmitter at the neuromuscular junction ⬇️

scientific article published on April 1, 1977

An investigation of the false discovery rate and the misinterpretation of p-values

scientific article

An uncommon scientist with a lot of common sense

scientific article published in June 2002

Analysis of end-plate current fluctuations produced by acetylcholine and acetylmonoethylcholine in rat muscle [proceedings] ⬇️

scientific article published on November 1, 1976

Association of contemporary sensitive troponin I levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: results from the LIPID Study (Long-Term Intervention With Pravastatin in Isch

scientific article published on 30 October 2013

Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events ⬇️

article by A. G. Hawkes et al published 29 September 1992 in Philosophical Transactions of the Royal Society B

At sea with SEAS: the first clinical endpoint trial for ezetimibe, treatment of patients with mild to moderate aortic stenosis, ends with mixed results and more controversy.

scientific article published on 7 July 2009

Atlantic salmon bath challenged with Moritella viscosa--pathogen invasion and host response

scientific article published on 8 April 2009

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

scientific article

Call for doctors not to practice homeopathy or refer to homeopaths

scientific article published on April 15, 2011

Challenging the tyranny of impact factors.

scientific article

Clinical Exercise Stress Testing in Adults (2014).

scientific article published on 02 March 2015

College of medicine is Prince's Foundation reincarnated

scientific article published in the British Medical Journal

Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia ⬇️

scientific article published on November 10, 2010

Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes

scientific article published in November 1994

Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones.

scientific article published in August 1991

Conductance of channels opened by acetylcholine-like drugs in muscle end-plate

scientific article published on January 17, 1975

Correction to 'The reproducibility of research and the misinterpretation of p-values'.

scientific article

Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells

scientific article

Dietary intervention to lower serum cholesterol

scientific article published in June 2009

Doctor Who? Inappropriate use of titles by some alternative "medicine" practitioners

scientific article

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle ⬇️

scientific article published on 01 July 1976

Effects of pravastatin on coronary events in 2073 patients with low levels of both low-density lipoprotein cholesterol and high-density lipoprotein cholesterol: results from the LIPID study

scientific article published in May 2004

Five ways to fix statistics

scientific article published in November 2017

From Muscle Endplate to Brain Synapses: A Short History of Synapses and Agonist-Activated Ion Channels ⬇️

scientific article published on March 1, 1998

From shut to open: what can we learn from linear free energy relationships?

scientific article published on December 2005

Function and structure in glycine receptors and some of their relatives

scientific article

Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings.

scientific article

How long does a molecule stay on the receptor? Explanation of a paradox ⬇️

scientific article published on May 1, 1970

How to impose microscopic reversibility in complex reaction mechanisms

scientific article

Improved persistence with non-vitamin-K oral anticoagulants compared with warfarin in patients with atrial fibrillation: recent Australian experience.

scientific article

In praise of single channel kinetics

scientific article published on 18 July 2016

Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease

scientific article published on 03 April 2015

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction

scientific article published in September 1985

Ion channels: this year's Nobel prize in physiology or medicine

scientific article published in October 1991

Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms

article by David Colquhoun et al published 15 November 1996 in Philosophical Transactions of the Royal Society A

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study

scientific article

Letter by Colquhoun et al regarding article "Effect size estimates of lifestyle and dietary changes on all-cause mortality in coronary artery disease patients: a systematic review".

scientific article published in July 2006

Lipid-modifying therapy in the elderly

scientific article

Long-term risk stratification for survivors of acute coronary syndromes. Results from the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study. LIPID Study Investigators

scientific article published in July 2001

Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits

scientific article published on 13 October 2005

Medium- to long-term persistence with non-vitamin-K oral anticoagulants in patients with atrial fibrillation: Australian experience.

scientific article

Midregional proadrenomedullin and its change predicts recurrent major coronary events and heart failure in stable coronary heart disease patients: the LIPID study

scientific article published on 24 January 2014

Modes of action of gallamine at the neuromuscular junction [proceedings] ⬇️

scientific article published on May 1, 1979

Neher and Sakmann win Nobel Prize for patch-clamp work

scientific article published in December 1991

Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study

scientific article published on 10 October 2005

Omega-3 Fatty Acids for Secondary Prevention

On the nature of partial agonism in the nicotinic receptor superfamily

scientific article

On the stochastic properties of single ion channels ⬇️

scientific article published on March 6, 1981

Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound

scientific article

PTSD symptoms associated with myocardial infarction: practical clinical implications

scientific article

Perspectives on: conformational coupling in ion channels: allosteric coupling in ligand-gated ion channels

scientific article published on December 2012

Prevalence of mixed dyslipidemia among Australian patients undergoing lipid-modifying therapy

scientific article published on January 2013

Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes

scientific article published in February 1998

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits

scientific article published on 24 January 2003

Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration ⬇️

scientific article published on December 22, 1992

Real-time PCR detection of Moritella viscosa, the likely causal agent of winter-ulcer in Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss.

scientific article

Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes

scientific article (publication date: 23 July 2002)

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour

scientific article published in April 1997

Recommendations are made in the absence of any good treatments

scientific article published on 30 August 2017

Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones

scientific article published in August 1990

Regimen to increase HDL cholesterol levels may improve cholesterol profiles. Commentary

scientific article published in June 2005

Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Trial: to what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?

scientific article published in March 2002

Relaxation and Fluctuations of Membrane Currents that Flow through Drug-Operated Channels

article by David Colquhoun et al published 14 November 1977 in Proceedings of the Royal Society B

Relaxation and fluctuations of membrane currents that flow through drug-operated channels

scientific article published on November 1977

Response to comment by Loiselle & Ramchandra (2015)

scientific article

Scarcely credible treatments do not merit university attention

scientific article published on 6 March 2012

Science degrees without the science

scientific article

Secondary prevention of cardiovascular events with long-term pravastatin in patients with diabetes or impaired fasting glucose: results from the LIPID trial

scientific article published in October 2003

Secret remedies: 100 years on.

scientific article published on 10 December 2009

Should NICE evaluate complementary and alternative medicines?

scientific article published on March 2007

Single channels activated by high concentrations of GABA in superior cervical ganglion neurones of the rat.

scientific article

Single-channel activations and concentration jumps: comparison of recombinant NR1a/NR2A and NR1a/NR2D NMDA receptors

scientific article

Single-channel analysis of an NMDA receptor possessing a mutation in the region of the glutamate binding site

scientific article published on September 2000

Single-channel and whole-cell currents evoked by acetylcholine in dissociated sympathetic neurons of the rat.

scientific article

Single-channel conductances of NMDA receptors expressed from cloned cDNAs: comparison with native receptors ⬇️

article by Peter Stern et al published 22 December 1992 in Proceedings of the Royal Society B

Single-channel currents from recombinant NMDA NR1a/NR2D receptors expressed in Xenopus oocytes.

scientific article

Single-channel study of the spasmodic mutation alpha1A52S in recombinant rat glycine receptors

scientific article published on March 2007

Stochastic properties of ion channel openings and bursts in a membrane patch that contains two channels: evidence concerning the number of channels present when a record containing only single openings is observed

scientific article published in June 1990

Structural abnormalities of the AChR caused by mutations underlying congenital myasthenic syndromes

scientific article published on September 2003

The A to Z of the wellbeing industry: from Angelic Reiki to patient centred care. Wellbeing is big business, but how much of it works?

scientific article

The Reproducibility Of Research And The Misinterpretation Of P Values

The action of tubocurarine at the neuromuscular junction [proceedings]

scientific article published on November 1, 1978

The actions of tubocurarine at the frog neuromuscular junction ⬇️

scientific article published on August 1, 1979

The arrogance of trying to sum up abilities in a number.

scientific article published in March 2009

The binding of labelled tetrodotoxin and cobra toxin by the rat diaphragm ⬇️

scientific article published on March 1, 1973

The binding of tetrodotoxin and α-bungarotoxin to normal and denervated mammalian muscle ⬇️

scientific article published on July 1, 1974

The binding of tritium-labelled tetrodotoxin to non-myelinated nerve ⬇️

scientific article published on July 1, 1972

The distributions of the apparent open times and shut times in a single channel record when brief events cannot be detected

article by A. G. Hawkes et al published 15 September 1990 in Philosophical Transactions of the Royal Society A

The ion channel properties of a rat recombinant neuronal nicotinic receptor are dependent on the host cell type

scientific article

The long activations of α2 glycine channels can be described by a mechanism with reaction intermediates ("flip"). ⬇️

scientific article published on February 2011

The modes of action of gallamine

scientific article published in March 1981

The pharmacological actions of polymethylene bistrimethylammonium salts.

scientific article published in February 1997

The quality of maximum likelihood estimates of ion channel rate constants

scientific article

The quantitative analysis of drug-receptor interactions: a short history

scientific article

The rate of equilibration in a competitive n drug system and the auto-inhibitory equations of enzyme kinetics: some properties of simple models for passive sensitization

scientific article published in June 1968

The reproducibility of research and the misinterpretation of p-values

scientific article published on 6 December 2017

Trust me, I'm a scientist

scientific article published in the British Medical Journal

Unravelling the paradox

scientific article published on 01 December 1992

Use of fibrates in clinical practice: Queensland Lipid Group consensus recommendations ⬇️

scientific article published on September 1, 2012

Very low levels of atherogenic lipoproteins and the risk for cardiovascular events: a meta-analysis of statin trials

scientific article published on August 2014

What have we learned from single ion channels?

article published in 2007

What to do about CAM?

scientific article published on October 2007

Why the Schild method is better than Schild realised

scientific article

List of works by David Colquhoun

'Complementary & Alternative Medicine' (CAM): Ethical And Policy Issues

A failure of the review process? Comment on Ahsin et al. Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee. Pain 2009;147:60-6.

A human congenital myasthenia-causing mutation (epsilon L78P) of the muscle nicotinic acetylcholine receptor with unusual single channel properties.

A note on correlations in single ion channel records

A reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptor

A response to critiques of 'The reproducibility of research and the misinterpretation of p-values'

A very bad report on regulating complementary medicine

ATP receptor-mediated synaptic currents in the central nervous system

Activation of N-methyl-D-aspartate receptors by L-glutamate in cells dissociated from adult rat hippocampus

Activation of ion channels in the frog endplate by several analogues of acetylcholine ⬇️

Acupuncture Is Theatrical Placebo

Acupuncture for 'frequent attenders' with medically unexplained symptoms

Agonist and blocking actions of choline and tetramethylammonium on human muscle acetylcholine receptors

Agonist-activated ion channels

An analysis of the action of a false transmitter at the neuromuscular junction ⬇️

An investigation of the false discovery rate and the misinterpretation of p-values

An uncommon scientist with a lot of common sense

Analysis of end-plate current fluctuations produced by acetylcholine and acetylmonoethylcholine in rat muscle [proceedings] ⬇️

Association of contemporary sensitive troponin I levels at baseline and change at 1 year with long-term coronary events following myocardial infarction or unstable angina: results from the LIPID Study (Long-Term Intervention With Pravastatin in Isch

Asymptotic distributions of apparent open times and shut times in a single channel record allowing for the omission of brief events ⬇️

At sea with SEAS: the first clinical endpoint trial for ezetimibe, treatment of patients with mild to moderate aortic stenosis, ends with mixed results and more controversy.

Atlantic salmon bath challenged with Moritella viscosa--pathogen invasion and host response

Binding, gating, affinity and efficacy: the interpretation of structure-activity relationships for agonists and of the effects of mutating receptors

Call for doctors not to practice homeopathy or refer to homeopaths

Challenging the tyranny of impact factors.

Clinical Exercise Stress Testing in Adults (2014).

College of medicine is Prince's Foundation reincarnated

Combination therapy of statin and ezetimibe for the treatment of familial hypercholesterolemia ⬇️

Comparison of neuronal nicotinic receptors in rat sympathetic neurones with subunit pairs expressed in Xenopus oocytes

Conductance and kinetic properties of single nicotinic acetylcholine receptor channels in rat sympathetic neurones.

Conductance of channels opened by acetylcholine-like drugs in muscle end-plate

Correction to 'The reproducibility of research and the misinterpretation of p-values'.

Currents through single glutamate receptor channels in outside-out patches from rat cerebellar granule cells

Dietary intervention to lower serum cholesterol

Doctor Who? Inappropriate use of titles by some alternative "medicine" practitioners

Effects of inhibitors of the binding of iodinated alpha-bungarotoxin to acetylcholine receptors in rat muscle ⬇️

Effects of pravastatin on coronary events in 2073 patients with low levels of both low-density lipoprotein cholesterol and high-density lipoprotein cholesterol: results from the LIPID study

Five ways to fix statistics

From Muscle Endplate to Brain Synapses: A Short History of Synapses and Agonist-Activated Ion Channels ⬇️

From shut to open: what can we learn from linear free energy relationships?

Function and structure in glycine receptors and some of their relatives

Glutamate activation of a single NMDA receptor-channel produces a cluster of channel openings.

How long does a molecule stay on the receptor? Explanation of a paradox ⬇️

How to impose microscopic reversibility in complex reaction mechanisms

Improved persistence with non-vitamin-K oral anticoagulants compared with warfarin in patients with atrial fibrillation: recent Australian experience.

In praise of single channel kinetics

Indications for Omega-3 Long Chain Polyunsaturated Fatty Acid in the Prevention and Treatment of Cardiovascular Disease

Ion channel block by acetylcholine, carbachol and suberyldicholine at the frog neuromuscular junction

Ion channels: this year's Nobel prize in physiology or medicine

Joint distributions of apparent open and shut times of single-ion channels and maximum likelihood fitting of mechanisms

Leptin, but not adiponectin, is a predictor of recurrent cardiovascular events in men: results from the LIPID study

Letter by Colquhoun et al regarding article "Effect size estimates of lifestyle and dietary changes on all-cause mortality in coronary artery disease patients: a systematic review".

Lipid-modifying therapy in the elderly

Long-term risk stratification for survivors of acute coronary syndromes. Results from the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Study. LIPID Study Investigators

Maximum likelihood fitting of single channel NMDA activity with a mechanism composed of independent dimers of subunits

Medium- to long-term persistence with non-vitamin-K oral anticoagulants in patients with atrial fibrillation: Australian experience.

Midregional proadrenomedullin and its change predicts recurrent major coronary events and heart failure in stable coronary heart disease patients: the LIPID study

Modes of action of gallamine at the neuromuscular junction [proceedings] ⬇️

Neher and Sakmann win Nobel Prize for patch-clamp work

Neither plasma coenzyme Q10 concentration, nor its decline during pravastatin therapy, is linked to recurrent cardiovascular disease events: a prospective case-control study from the LIPID study

Omega-3 Fatty Acids for Secondary Prevention

On the nature of partial agonism in the nicotinic receptor superfamily

On the stochastic properties of single ion channels ⬇️

Openings of the rat recombinant alpha 1 homomeric glycine receptor as a function of the number of agonist molecules bound

PTSD symptoms associated with myocardial infarction: practical clinical implications

Perspectives on: conformational coupling in ion channels: allosteric coupling in ligand-gated ion channels

Prevalence of mixed dyslipidemia among Australian patients undergoing lipid-modifying therapy

Properties of human glycine receptors containing the hyperekplexia mutation alpha1(K276E), expressed in Xenopus oocytes

Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits

Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration ⬇️

Real-time PCR detection of Moritella viscosa, the likely causal agent of winter-ulcer in Atlantic salmon Salmo salar and rainbow trout Oncorhynchus mykiss.

Recessive inheritance and variable penetrance of slow-channel congenital myasthenic syndromes

Recombinant nicotinic receptors, expressed in Xenopus oocytes, do not resemble native rat sympathetic ganglion receptors in single-channel behaviour

Recommendations are made in the absence of any good treatments

Rectification of currents activated by nicotinic acetylcholine receptors in rat sympathetic ganglion neurones

Regimen to increase HDL cholesterol levels may improve cholesterol profiles. Commentary

Relationship between lipid levels and clinical outcomes in the Long-term Intervention with Pravastatin in Ischemic Disease (LIPID) Trial: to what extent is the reduction in coronary events with pravastatin explained by on-study lipid levels?

Relaxation and Fluctuations of Membrane Currents that Flow through Drug-Operated Channels

Relaxation and fluctuations of membrane currents that flow through drug-operated channels