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List of works by David Agus

17-Allylamino-17-demethoxygeldanamycin induces the degradation of androgen receptor and HER-2/neu and inhibits the growth of prostate cancer xenografts

scientific article

2C4, a monoclonal antibody against HER2, disrupts the HER kinase signaling pathway and inhibits ovarian carcinoma cell growth

scientific article published on December 2005

A Phase I, open-label, dose-escalation study of continuous once-daily oral treatment with afatinib in patients with advanced solid tumors

scientific article published on 15 December 2012

A cross-platform toolkit for mass spectrometry and proteomics

scientific article

A high-content image-based method for quantitatively studying context-dependent cell population dynamics

scientific article

A perspective on protein profiling of blood

scientific article

A phase II trial of docetaxel and erlotinib as first-line therapy for elderly patients with androgen-independent prostate cancer

scientific article

A physical sciences network characterization of non-tumorigenic and metastatic cells

scientific article published on January 2013

Anterior gradient 2 (AGR2): blood-based biomarker elevated in metastatic prostate cancer associated with the neuroendocrine phenotype.

scientific article published on 21 August 2012

Antibody to vascular endothelial growth factor slows growth of an androgen-independent xenograft model of prostate cancer

scientific article published in October 2002

Applications of Proteomics in Prostate Cancer

Beta-2-microglobulin expression correlates with high-grade prostate cancer and specific defects in androgen signaling

scientific article published on August 2010

Beta-2-microglobulin is an androgen-regulated secreted protein elevated in serum of patients with advanced prostate cancer

scientific article

Body image predicts quality of life in men with prostate cancer

scientific article

CVS-3983, a selective matriptase inhibitor, suppresses the growth of androgen independent prostate tumor xenografts

scientific article published in November 2004

Cancer-associated fibroblasts derived from EGFR-TKI-resistant tumors reverse EGFR pathway inhibition by EGFR-TKIs

scientific article

Clinical proteomics: the promises and challenges of mass spectrometry-based biomarker discovery.

scientific article published on July 2006

Copy number and targeted mutational analysis reveals novel somatic events in metastatic prostate tumors

scientific article

Correlating nuclear morphometric patterns with estrogen receptor status in breast cancer pathologic specimens

scientific article published on 04 September 2018

David Agus: A new strategy in the war on cancer

2010 video of a TEDMED 2009 talk

Deep learned tissue "fingerprints" classify breast cancers by ER/PR/Her2 status from H&E images

scientific article published on 29 April 2020

Deep learning-enabled breast cancer hormonal receptor status determination from base-level H&E stains

scientific article published on 16 November 2020

Dehydroascorbic acid, a blood-brain barrier transportable form of vitamin C, mediates potent cerebroprotection in experimental stroke

scientific article

Detection of androgen receptor mutations in circulating tumor cells in castration-resistant prostate cancer

scientific article

Ductal adenocarcinoma of the prostate

scientific article published on 01 June 2004

Dysregulated expression of androgen-responsive and nonresponsive genes in the androgen-independent prostate cancer xenograft model CWR22-R1.

scientific article

Effects of the herbal extract PC-SPES on microtubule dynamics and paclitaxel-mediated prostate tumor growth inhibition.

scientific article published in November 2002

Efficacy and safety of single-agent pertuzumab (rhuMAb 2C4), a human epidermal growth factor receptor dimerization inhibitor, in castration-resistant prostate cancer after progression from taxane-based therapy

scientific article

Eligibility and outcomes reporting guidelines for clinical trials for patients in the state of a rising prostate-specific antigen: recommendations from the Prostate-Specific Antigen Working Group

scientific article

Epigenetic changes mediated by polycomb repressive complex 2 and E2a are associated with drug resistance in a mouse model of lymphoma.

scientific article published on 4 May 2016

Epithelial membrane protein-1 is a biomarker of gefitinib resistance.

scientific article

Evolutionary modeling of combination treatment strategies to overcome resistance to tyrosine kinase inhibitors in non-small cell lung cancer

scientific article published on 25 October 2011

HER kinase axis receptor dimer partner switching occurs in response to EGFR tyrosine kinase inhibition despite failure to block cellular proliferation

scientific article

HER-2/neu (p185neu) protein expression in the natural or treated history of prostate cancer

Impact of protein stability, cellular localization, and abundance on proteomic detection of tumor-derived proteins in plasma

scientific article

Inhibition of HER-kinase activation prevents ERK-mediated degradation of PPARgamma

scientific article published on June 2004

Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase

scientific article published on April 2001

Intolerance of uncertainty, cognitive complaints, and cancer-related distress in prostate cancer survivors.

scientific article published on 2 June 2014

Intracellular kinetics of the androgen receptor shown by multimodal Image Correlation Spectroscopy (mICS).

scientific article published on 03 March 2016

JUN-Mediated Downregulation of EGFR Signaling Is Associated with Resistance to Gefitinib in EGFR-mutant NSCLC Cell Lines

scientific article

Ligand responsiveness in human prostate cancer: structural analysis of mutant androgen receptors from LNCaP and CWR22 tumors.

scientific article published on May 2000

Monitoring dynamic cytotoxic chemotherapy response in castration-resistant prostate cancer using plasma cell-free DNA (cfDNA)

scientific article published on 15 May 2019

MultiCellDS: a standard and a community for sharing multicellular data

scholarly article published 9 December 2016

Multiparameter computational modeling of tumor invasion

scientific article

Pharmacologic inhibition of Pim kinases alters prostate cancer cell growth and resensitizes chemoresistant cells to taxanes

scientific article

Phase 1/2 study of orteronel (TAK-700), an investigational 17,20-lyase inhibitor, with docetaxel-prednisone in metastatic castration-resistant prostate cancer

scientific article

Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer

scientific article published on 03 March 2020

Phase I clinical study of pertuzumab, a novel HER dimerization inhibitor, in patients with advanced cancer

scientific article published on 07 February 2005

Phase I/II study of bortezomib plus docetaxel in patients with advanced androgen-independent prostate cancer

scientific article published on 01 February 2007

Phase I/II trial of orteronel (TAK-700)--an investigational 17,20-lyase inhibitor--in patients with metastatic castration-resistant prostate cancer

scientific article published on 13 January 2014

Phase II study of cilengitide (EMD 121974, NSC 707544) in patients with non-metastatic castration resistant prostate cancer, NCI-6735. A study by the DOD/PCF prostate cancer clinical trials consortium

scientific article

Phase III, randomized, double-blind, multicenter trial comparing orteronel (TAK-700) plus prednisone with placebo plus prednisone in patients with metastatic castration-resistant prostate cancer that has progressed during or after docetaxel-based th

scientific article published on 26 January 2015

Positron emission tomography of a human prostate cancer xenograft: association of changes in deoxyglucose accumulation with other measures of outcome following androgen withdrawal

scientific article published on 01 July 1998

Precursor-ion mass re-estimation improves peptide identification on hybrid instruments

scientific article

Predictors of affect following treatment decision-making for prostate cancer: conversations, cognitive processing, and coping

scientific article published in May 2009

Prostate cancer cell cycle regulators: response to androgen withdrawal and development of androgen independence

scientific article published on 01 November 1999

ProteoWizard: open source software for rapid proteomics tools development

scientific article

Quantifying differences in cell line population dynamics using CellPD.

scientific article

Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition

scientific article published on 12 March 2012

Raloxifene, an oestrogen-receptor-beta-targeted therapy, inhibits androgen-independent prostate cancer growth: results from preclinical studies and a pilot phase II clinical trial.

scientific article published in April 2006

Response of prostate cancer to anti-Her-2/neu antibody in androgen-dependent and -independent human xenograft models

scientific article published on 01 October 1999

Safety and Efficacy of Docetaxel, Bevacizumab, and Everolimus for Castration-resistant Prostate Cancer (CRPC).

scientific article

Safety and pharmacokinetics of high-dose gefitinib in patients with solid tumors: results of a phase I study.

scientific article published on 15 October 2011

Single cell dynamic phenotyping

scientific article

Stromal cell oxidation: a mechanism by which tumors obtain vitamin C

scientific article published on 01 September 1999

Suberoylanilide hydroxamic acid, an inhibitor of histone deacetylase, suppresses the growth of prostate cancer cells in vitro and in vivo

scientific article published on 01 September 2000

Survival analysis of genome-wide gene expression profiles of prostate cancers identifies new prognostic targets of disease relapse.

scientific article

TMEFF2 is an androgen-regulated gene exhibiting antiproliferative effects in prostate cancer cells

scientific article published on July 2002

Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth

scientific article published in August 2002

Targeting the HER-kinase axis in cancer

scientific article published on February 2004

The Impact of Microenvironmental Heterogeneity on the Evolution of Drug Resistance in Cancer Cells

scientific article published on 15 July 2015

The current state of preclinical prostate cancer animal models

scientific article

Update on HER-kinase-directed therapy in prostate cancer.

scientific article

Vitamin C crosses the blood-brain barrier in the oxidized form through the glucose transporters

scientific article

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