List of works - Martin Peifer

A crucial requirement for Hedgehog signaling in small cell lung cancer

scientific article

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

scientific article

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

scientific article

ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma

scientific article published on 31 March 2017

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo

scientific article published on 05 November 2019

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

scientific article published on 15 February 2018

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer

scientific article

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

scientific article

Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling

scientific article

Benchmarking of mutation diagnostics in clinical lung cancer specimens

scientific article (publication date: 5 May 2011)

CD74-NRG1 fusions in lung adenocarcinoma

scientific article published on 27 January 2014

CGARS: cancer genome analysis by rank sums

scientific article published on 9 January 2014

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer

scientific article

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

scientific article published on 15 April 2021

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation

scientific article

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia

scientific article published on 20 February 2018

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

scientific article published on 25 June 2015

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing

scientific article published in 2015

Comprehensive genomic profiles of small cell lung cancer

scientific article published on 13 July 2015

Copy-number analysis and inference of subclonal populations in cancer genomes using Sclust

scientific article published on 24 May 2018

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

scientific article

Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels

scientific article published on 15 June 2020

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.

scientific article published on June 2017

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

scientific article

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

scientific article

Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer.

scientific article published on 12 September 2016

Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome

scientific article published on 20 July 2017

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

scientific article published on June 2016

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)

scientific article

Hybrid optimization method with general switching strategy for parameter estimation

scientific article

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

scientific article published on 29 June 2016

Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

scientific article

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

scientific article published on 05 October 2009

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients

scientific article published on July 2015

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

scientific article

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

scientific article published on 13 March 2018

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

scientific article published on 20 May 2015

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.

scientific article published on 31 December 2016

Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer.

scientific article published on 19 June 2017

Mixing properties of the Rössler system and consequences for coherence and synchronization analysis.

scientific article published on 18 August 2005

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

scientific article

Mutational dynamics between primary and relapse neuroblastomas.

scientific article

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer

scientific article

On studentising and blocklength selection for the bootstrap on time series.

scientific article published in June 2005

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

scientific article (publication date: 15 April 2009)

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

scientific article

Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting.

scientific article published in March 2007

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

scientific article published on 18 May 2009

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

scientific article published on 29 January 2016

Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer

scientific article

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

scientific article published on September 2017

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm

scientific article published on 21 September 2011

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

scientific article published in July 2012

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

scientific article

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

scientific article published on 14 October 2015

Telomere maintenance is pivotal for high-risk neuroblastoma

scientific article published on 10 December 2015

Testing for directed influences among neural signals using partial directed coherence.

scientific article published on 2 November 2005

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesisin lung cancer

scientific article published in July 2013

Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

scientific article published on 28 July 2017

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Variations in substitution rate in human and mouse genomes

scientific article published on 11 November 2004

iRODS metadata management for a cancer genome analysis workflow

scientific article published on 15 January 2019

List of works by Martin Peifer

A crucial requirement for Hedgehog signaling in small cell lung cancer

A framework for identification of actionable cancer genome dependencies in small cell lung cancer

ALK mutations conferring differential resistance to structurally diverse ALK inhibitors.

ATM Deficiency Is Associated with Sensitivity to PARP1- and ATR Inhibitors in Lung Adenocarcinoma

ATM activity in T cells is critical for immune surveillance of lymphoma in vivo

Actionable perturbations of damage responses by TCL1/ATM and epigenetic lesions form the basis of T-PLL.

Activating ERBB2/HER2 mutations indicate susceptibility to pan-HER inhibitors in Lynch and Lynch-like colorectal cancer

Amplification of N-Myc is associated with a T-cell-poor microenvironment in metastatic neuroblastoma restraining interferon pathway activity and chemokine expression

Analysis of compound synergy in high-throughput cellular screens by population-based lifetime modeling

Benchmarking of mutation diagnostics in clinical lung cancer specimens

CD74-NRG1 fusions in lung adenocarcinoma

CGARS: cancer genome analysis by rank sums

Cell-autonomous and non-cell-autonomous mechanisms of transformation by amplified FGFR1 in lung cancer

Characterizing genetic intra-tumor heterogeneity across 2,658 human cancer genomes

Chemogenomic profiling provides insights into the limited activity of irreversible EGFR Inhibitors in tumor cells expressing the T790M EGFR resistance mutation

Clonal dynamics towards the development of venetoclax resistance in chronic lymphocytic leukemia

Comparison of RNA-seq and microarray-based models for clinical endpoint prediction

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing

Comprehensive genomic profiles of small cell lung cancer

Copy-number analysis and inference of subclonal populations in cancer genomes using Sclust

Differential protein stability and ALK inhibitor sensitivity of EML4-ALK fusion variants.

Dissecting intratumour heterogeneity of nodal B-cell lymphomas at the transcriptional, genetic and drug-response levels

Drugging the catalytically inactive state of RET kinase in RET-rearranged tumors.

Frequent and focal FGFR1 amplification associates with therapeutically tractable FGFR1 dependency in squamous cell lung cancer.

Frequent mutations in chromatin-remodelling genes in pulmonary carcinoids

Genomic Amplification of CD274 (PD-L1) in Small-Cell Lung Cancer.

Genomic and transcriptomic heterogeneity of colorectal tumors arising in Lynch Syndrome

Heterogeneous mechanisms of primary and acquired resistance to third-generation EGFR inhibitors

High expression levels of total IGF-1R and sensitivity of NSCLC cells in vitro to an anti-IGF-1R antibody (R1507)

Hybrid optimization method with general switching strategy for parameter estimation

Identification and Targeting of Long-Term Tumor-Propagating Cells in Small Cell Lung Cancer

Identification of novel fusion genes in lung cancer using breakpoint assembly of transcriptome sequencing data

Identifying genotype-dependent efficacy of single and combined PI3K- and MAPK-pathway inhibition in cancer

Implementation of Amplicon Parallel Sequencing Leads to Improvement of Diagnosis and Therapy of Lung Cancer Patients

Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer

Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.

Label-Free Protein-RNA Interactome Analysis Identifies Khsrp Signaling Downstream of the p38/Mk2 Kinase Complex as a Critical Modulator of Cell Cycle Progression

MYC Drives Progression of Small Cell Lung Cancer to a Variant Neuroendocrine Subtype with Vulnerability to Aurora Kinase Inhibition.

Mechanisms of Primary Drug Resistance in FGFR1-Amplified Lung Cancer.

Mixing properties of the Rössler system and consequences for coherence and synchronization analysis.

Mutational analysis of pulmonary tumours with neuroendocrine features using targeted massive parallel sequencing: a comparison of a neglected tumour group

Mutational dynamics between primary and relapse neuroblastomas.

Mutations in the DDR2 kinase gene identify a novel therapeutic target in squamous cell lung cancer

On studentising and blocklength selection for the bootstrap on time series.

PTEN loss contributes to erlotinib resistance in EGFR-mutant lung cancer by activation of Akt and EGFR

Pan-cancer analysis of somatic copy-number alterations implicates IRS4 and IGF2 in enhancer hijacking.

Parameter estimation in ordinary differential equations for biochemical processes using the method of multiple shooting.

Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions

Small Cell Lung Cancer: Can Recent Advances in Biology and Molecular Biology Be Translated into Improved Outcomes?

Somatic copy number alterations by whole-exome sequencing implicates YWHAZ and PTK2 in castration-resistant prostate cancer

Systematic Kinase Inhibitor Profiling Identifies CDK9 as a Synthetic Lethal Target in NUT Midline Carcinoma.

Systematic screen for tyrosine kinase rearrangements identifies a novel C6orf204-PDGFRB fusion in a patient with recurrent T-ALL and an associated myeloproliferative neoplasm

Targeted expression of mutated ALK induces neuroblastoma in transgenic mice.

Targeted next-generation sequencing of DNA regions proximal to a conserved GXGXXG signaling motif enables systematic discovery of tyrosine kinase fusions in cancer

Telomerase activation by genomic rearrangements in high-risk neuroblastoma

Telomere maintenance is pivotal for high-risk neuroblastoma

Testing for directed influences among neural signals using partial directed coherence.

Tumor VEGF:VEGFR2 autocrine feed-forward loop triggers angiogenesisin lung cancer

Two mouse models reveal an actionable PARP1 dependence in aggressive chronic lymphocytic leukemia

UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Variations in substitution rate in human and mouse genomes

iRODS metadata management for a cancer genome analysis workflow