List of works - Maija K Lahtela-Kakkonen

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling.

scientific article

AROS has a context-dependent effect on SIRT1

scientific article published on 2 May 2014

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

scientific article published on 25 July 2015

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

scientific article published on 24 July 2008

Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.

scientific article

Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes

scientific article published on 3 December 2015

Comparative and pharmacophore model for deacetylase SIRT1

scientific article published on 01 September 2006

Development of a 3D model for the human cannabinoid CB1 receptor.

scientific article published in June 2004

Development of molecules stimulating the activity of KLK3 - an update.

scientific article

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells

scientific article published on 12 December 2012

Drug release from starch-acetate microparticles and films with and without incorporated alpha-amylase.

scientific article published in August 2004

Identification of novel CYP2A6 inhibitors by virtual screening

scientific article published on 4 October 2011

Identification of novel SIRT3 inhibitor scaffolds by virtual screening

scientific article published on 16 March 2013

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

scientific article published on 19 April 2016

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

scientific article

Interactions of inhibitor molecules with the human CYP2E1 enzyme active site

scientific article published on 13 October 2012

N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.

scientific article published on 17 June 2010

N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors

scientific article published on 01 December 2006

N-Acylethanolamines Bind to SIRT6

scientific article published on 26 November 2015

Natural polyphenols as sirtuin 6 modulators.

scientific article published on 7 March 2018

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

scientific article published on 22 July 2008

Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors

scientific article

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.

scientific article published on 21 July 2017

Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods

scientific article published on 12 February 2007

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

scientific article published on 9 September 2014

Quantitative insights for the design of substrate-based SIRT1 inhibitors

scientific article published on 18 April 2014

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

scientific article published on 19 September 2013

Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells

scientific article

Sirtuin 6 (SIRT6) Activity Assays.

scientific article published on January 2016

Sirtuin functions and modulation: from chemistry to the clinic

scientific article

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2

scientific article published on 07 September 2011

Studying SIRT6 regulation using H3K56 based substrate and small molecules

scientific article published on 06 July 2014

Studying the catechol binding cavity in comparative models of human dopamine D2 receptor.

scientific article published on 2 December 2010

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors

scientific article

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

scientific article

Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.

scientific article published on 23 September 2015

Virtual Screening of Small Drug-Like Compounds Stimulating the Enzymatic Activity of Kallikrein-Related Peptidase 3 (KLK3).

scientific article

Virtual screening approach of sirtuin inhibitors results in two new scaffolds.

scientific article published on May 2015

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

scientific article

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.

scientific article published on 23 August 2014

List of works by Maija K Lahtela-Kakkonen

1,3,4-Oxadiazol-2-ones as fatty-acid amide hydrolase and monoacylglycerol lipase inhibitors: Synthesis, in vitro evaluation and insight into potency and selectivity determinants by molecular modelling.

AROS has a context-dependent effect on SIRT1

BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone.

Chroman-4-one- and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells.

Common and Distinct Interactions of Chemical Inhibitors with Cytochrome P450 CYP1A2, CYP2A6 and CYP2B6 Enzymes

Comparative and pharmacophore model for deacetylase SIRT1

Development of a 3D model for the human cannabinoid CB1 receptor.

Development of molecules stimulating the activity of KLK3 - an update.

Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells

Drug release from starch-acetate microparticles and films with and without incorporated alpha-amylase.

Identification of novel CYP2A6 inhibitors by virtual screening

Identification of novel SIRT3 inhibitor scaffolds by virtual screening

Inhibition of BET bromodomains alleviates inflammation in human RPE cells.

Insights into ligand-elicited activation of human constitutive androstane receptor based on novel agonists and three-dimensional quantitative structure-activity relationship

Interactions of inhibitor molecules with the human CYP2E1 enzyme active site

N(epsilon)-Modified lysine containing inhibitors for SIRT1 and SIRT2.

N,N'-Bisbenzylidenebenzene-1,4-diamines and N,N'-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors

N-Acylethanolamines Bind to SIRT6

Natural polyphenols as sirtuin 6 modulators.

Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors.

Peptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors

Potent mechanism-based sirtuin-2-selective inhibition by an in situ-generated occupant of the substrate-binding site, "selectivity pocket" and NAD+-binding site.

Predicting the drug concentration in starch acetate matrix tablets from ATR-FTIR spectra using multi-way methods

Quantitative insight into the design of compounds recognized by the L-type amino acid transporter 1 (LAT1).

Quantitative insights for the design of substrate-based SIRT1 inhibitors

Quinazolinecarboline alkaloid evodiamine as scaffold for targeting topoisomerase I and sirtuins

Screen of pseudopeptidic inhibitors of human sirtuins 1-3: two lead compounds with antiproliferative effects in cancer cells

Sirtuin 6 (SIRT6) Activity Assays.

Sirtuin functions and modulation: from chemistry to the clinic

Structure-based design of pseudopeptidic inhibitors for SIRT1 and SIRT2

Studying SIRT6 regulation using H3K56 based substrate and small molecules

Studying the catechol binding cavity in comparative models of human dopamine D2 receptor.

Synthesis and evaluation of substituted chroman-4-one and chromone derivatives as sirtuin 2-selective inhibitors

The Identification of a SIRT6 Activator from Brown Algae Fucus distichus

Time-Dependent Inhibition of CYP2C19 by Isoquinoline Alkaloids: In Vitro and In Silico Analysis.

Virtual Screening of Small Drug-Like Compounds Stimulating the Enzymatic Activity of Kallikrein-Related Peptidase 3 (KLK3).

Virtual screening approach of sirtuin inhibitors results in two new scaffolds.

Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway

Withaferin A inhibits NF-kappaB activation by targeting cysteine 179 in IKKβ.