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List of works by Jacob M. Hooker

(11)C[double bond, length as m-dash]O bonds made easily for positron emission tomography radiopharmaceuticals

scientific article

11CO2 fixation: a renaissance in PET radiochemistry.

scientific article published on 14 May 2013

18F-Deoxyfluorination of Phenols via Ru π-Complexes

scientific article published on 3 August 2017

A Novel Radiotracer for Imaging Monoacylglycerol Lipase in the Brain Using Positron Emission Tomography.

scientific article published on 22 December 2015

A Transmetalation Reaction Enables the Synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging

scientific article published on 14 February 2016

A chemical strategy for the cell-based detection of HDAC activity.

scientific article published on 30 April 2014

A fluoride-derived electrophilic late-stage fluorination reagent for PET imaging.

scientific article

A metal protein-attenuating compound for PET neuroimaging: Synthesis and preclinical evaluation of [11C]PBT2.

scientific article published on 3 January 2018

A philosophy for CNS radiotracer design

scientific article

A regularized full reference tissue model for PET neuroreceptor mapping.

scientific article published on 27 June 2016

A selective HDAC 1/2 inhibitor modulates chromatin and gene expression in brain and alters mouse behavior in two mood-related tests

scientific article (publication date: 2013)

A systematic review of molecular imaging (PET and SPECT) in autism spectrum disorder: current state and future research opportunities.

scientific article published on 12 February 2015

Activity-dependent Regulation of Histone Lysine Demethylase KDM1A by a Putative Thiol/Disulfide Switch

scientific article

Amylin receptor ligands reduce the pathological cascade of Alzheimer's disease

scientific article published on 28 March 2017

An Isochemogenic Set of Inhibitors To Define the Therapeutic Potential of Histone Deacetylases in β-Cell Protection

scientific article published on 7 December 2015

An efficient and practical radiosynthesis of [11C]temozolomide

scientific article

An efficient and practical synthesis of [2-(11)C]indole via superfast nucleophilic [(11)C]cyanation and RANEY® Nickel catalyzed reductive cyclization.

scientific article published in December 2015

Application of palladium-mediated (18)F-fluorination to PET radiotracer development: overcoming hurdles to translation

scientific article

Brain-penetrant LSD1 inhibitors can block memory consolidation.

scientific article

Bridging the gaps in 18F PET tracer development

scientific article

Characterisation of [¹¹C]PR04.MZ in Papio anubis baboon: a selective high-affinity radioligand for quantitative imaging of the dopamine transporter.

scientific article published on 25 October 2011

Chemical Neuroscience and the Paths to Impact

scientific article published on 01 January 2021

Class I HDAC imaging using [ (3)H]CI-994 autoradiography ⬇️

scientific article

Classics in Neuroimaging: Imaging the Dopaminergic Pathway with PET.

scientific article published on 18 July 2017

Clinical validation of the novel HDAC6 radiotracer [18F]EKZ-001 in the human brain

scientific article published on 08 July 2020

Combination therapy: histone deacetylase inhibitors and platinum-based chemotherapeutics for cancer

scientific article published on 29 September 2012

Concerted nucleophilic aromatic substitution with (19)F(-) and (18)F(-).

scientific article

Cue-induced dopamine release predicts cocaine preference: positron emission tomography studies in freely moving rodents.

scientific article published in May 2009

Development of New Positron Emission Tomography Radiotracer for BET Imaging.

scientific article published on 2 November 2016

Development of [18F]Maleimide-Based Glycogen Synthase Kinase-3β Ligands for Positron Emission Tomography Imaging.

scientific article published on 2 February 2017

Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance

scientific article

Direct 11CN-Labeling of Unprotected Peptides via Palladium-Mediated Sequential Cross-Coupling Reactions

scientific article

Discrepancies in Kappa Opioid Agonist Binding Revealed through PET Imaging

scientific article published on 17 October 2018

Disruption of thalamic functional connectivity is a neural correlate of dexmedetomidine-induced unconsciousness

scientific article

Dynamic functional imaging of brain glucose utilization using fPET-FDG.

scientific article

Editors' Favorites of 2016.

scientific article published in January 2017

Editors' Favorites of 2017.

scientific article published in January 2018

Editors' Favorites: Best of 2018

scientific article published on 01 January 2019

Effects of ferumoxytol on quantitative PET measurements in simultaneous PET/MR whole-body imaging: a pilot study in a baboon model.

scientific article

Evaluation of 6-([(18)F]fluoroacetamido)-1-hexanoicanilide for PET imaging of histone deacetylase in the baboon brain

scientific article

Evaluation of [(11)C]metergoline as a PET radiotracer for 5HTR in nonhuman primates.

scientific article

Evaluation of potential PET imaging probes for the orexin 2 receptors.

scientific article

Evidence for brain glial activation in chronic pain patients

scientific article

Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6

scientific article published on 19 December 2019

Expression of HDAC2 but Not HDAC1 Transcript Is Reduced in Dorsolateral Prefrontal Cortex of Patients with Schizophrenia.

scientific article

FDG-PET imaging reveals local brain glucose utilization is altered by class I histone deacetylase inhibitors.

scientific article

First D1-like receptor PET imaging of the rat and primate kidney: implications for human disease monitoring

scientific article

Functionally Biased D2R Antagonists: Targeting the β-Arrestin Pathway to Improve Antipsychotic Treatment.

scientific article published on 27 February 2018

Glial activation colocalizes with structural abnormalities in amyotrophic lateral sclerosis.

scientific article published on 11 November 2016

High relaxivity gadolinium hydroxypyridonate-viral capsid conjugates: nanosized MRI contrast agents.

scientific article

Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity

scientific article published on 17 August 2018

Histone deacetylase inhibitor, MS-275, exhibits poor brain penetration: PK studies of [C]MS-275 using Positron Emission Tomography

scientific article

Image-guided synthesis reveals potent blood-brain barrier permeable histone deacetylase inhibitors.

scientific article

Imaging Agonist-Induced D2/D3 Receptor Desensitization and Internalization In Vivo with PET/fMRI.

scientific article published on 21 September 2015

Imaging cardiac SCN5A using the novel F-18 radiotracer radiocaine.

scientific article published on 16 February 2017

Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization

scientific article published on 12 February 2014

Immediate and Persistent Effects of Salvinorin A on the Kappa Opioid Receptor in Rodents, Monitored In Vivo with PET.

scientific article published on 10 June 2015

In Vivo Imaging of Human Neuroinflammation

scientific article

In Vivo [18F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates

scientific article

In vivo human brain expression of histone deacetylases in bipolar disorder

scientific article published on 08 July 2020

In vivo imaging of adult human hippocampal neurogenesis: progress, pitfalls and promise

scientific article

In vivo imaging of histone deacetylases (HDACs) in the central nervous system and major peripheral organs

scientific article

In vivo photoactivation without "light": use of Cherenkov radiation to overcome the penetration limit of light.

scientific article published on April 2012

Increased in vivo glial activation in patients with amyotrophic lateral sclerosis: assessed with [(11)C]-PBR28.

scientific article

Insights into neuroepigenetics through human histone deacetylase PET imaging.

scientific article

Interior surface modification of bacteriophage MS2.

scientific article published in March 2004

Kinetic Analysis and Quantification of [¹¹C]Martinostat for in Vivo HDAC Imaging of the Brain

scientific article

Late stage benzylic C-H fluorination with [¹⁸F]fluoride for PET imaging.

scientific article

Magnetic resonance contrast agents from viral capsid shells: a comparison of exterior and interior cargo strategies

scientific article

Modification of aniline containing proteins using an oxidative coupling strategy

scientific article published in December 2006

Modular strategies for PET imaging agents

scientific article

Nasal neuron PET imaging quantifies neuron generation and degeneration

scientific article (publication date: 23 January 2017)

Neuroinflammation in Huntington's Disease: New Insights with 11C-PBR28 PET/MRI

scientific article published on 17 May 2018

Neuroinflammation: Brain on Fire?

scientific article

Neuroinflammatory component of gray matter pathology in multiple sclerosis

scientific article (publication date: 25 October 2016)

Neurovascular coupling to D2/D3 dopamine receptor occupancy using simultaneous PET/functional MRI

scientific article published on 30 May 2013

Nickel-mediated oxidative fluorination for PET with aqueous [18F] fluoride

scientific article

Nicotine blocks brain estrogen synthase (aromatase): in vivo positron emission tomography studies in female baboons

scientific article

Noninvasive Assessment of Losartan-Induced Increase in Functional Microvasculature and Drug Delivery in Pancreatic Ductal Adenocarcinoma

scientific article published on October 2016

Noninvasive Determination of 2-[18F]-Fluoroisonicotinic Acid Hydrazide Pharmacokinetics by Positron Emission Tomography in Mycobacterium tuberculosis-Infected Mice

scholarly article by E. A. Weinstein et al published 28 December 2012 in Antimicrobial Agents and Chemotherapy

Overlapping and Divergent Actions of Structurally Distinct Histone Deacetylase Inhibitors in Cardiac Fibroblasts.

scientific article published on 7 February 2017

PET Neurochemical Imaging Modes.

scientific article

PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat.

scientific article

PET imaging of fatty acid amide hydrolase with [(18)F]DOPP in nonhuman primates

scientific article

PET neuroimaging studies of [(18)F]CABS13 in a double transgenic mouse model of Alzheimer's disease and nonhuman primates

scientific article (publication date: 15 April 2015)

Pharmacokinetics of the potent hallucinogen, salvinorin A in primates parallels the rapid onset and short duration of effects in humans.

scientific article published on 15 March 2008

Polyglucose nanoparticles with renal elimination and macrophage avidity facilitate PET imaging in ischaemic heart disease.

scientific article published on 16 January 2017

Positron Emission Tomography Assessment of the Intranasal Delivery Route for Orexin A.

scientific article published on 16 October 2017

Preclinical PET Neuroimaging of [11C]Bexarotene.

scientific article published on 23 August 2016

Radiolabelling and positron emission tomography of PT70, a time-dependent inhibitor of InhA, the Mycobacterium tuberculosis enoyl-ACP reductase

scientific article

Radionuclide labeling and evaluation of candidate radioligands for PET imaging of histone deacetylase in the brain

scientific article

Radiosynthesis and bioimaging of the tuberculosis chemotherapeutics isoniazid, rifampicin and pyrazinamide in baboons

scientific article

Radiosynthesis and biological evaluation of a novel enoyl-ACP reductase inhibitor for Staphylococcus aureus

scientific article

Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors.

scientific article published on 2 April 2013

Radiosynthesis and preclinical evaluation of [11 C]Cimbi-701 - Towards the imaging of cerebral 5-HT7 receptors

scientific article published on 06 January 2020

Rapid Chemoselective Bioconjugation through Oxidative Coupling of Anilines and Aminophenols ⬇️

scientific article published on September 28, 2011

Reply

scientific article published on 23 January 2017

Response to Comment on "In Vivo [F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates"

scientific article published on 11 October 2018

Simultaneous fMRI-PET of the opioidergic pain system in human brain

scientific article

Solubilization and stabilization of bacteriophage MS2 in organic solvents.

scientific article published in June 2007

Synthesis and Evaluation of Methylated Arylazepine Compounds for PET Imaging of 5-HT2c Receptors ⬇️

scientific article published on 07 December 2012

Synthesis and imaging validation of [¹⁸F]MDL100907 enabled by Ni-mediated fluorination.

scientific article

Synthesis of [(11)C]Bexarotene by Cu-Mediated [(11)C]Carbon Dioxide Fixation and Preliminary PET Imaging

scientific article

Targeted fluorination with the fluoride ion by manganese-catalyzed decarboxylation

scientific article

Time Will Tell the Utility of Biomarkers

scientific article published on 28 May 2020

Toward an immune-mediated subtype of autism spectrum disorder

scientific article

Toward development of epigenetic drugs for central nervous system disorders: Modulating neuroplasticity via H3K4 methylation.

scientific article

Translation of HDAC6 PET Imaging Using [18F]EKZ-001-cGMP Production and Measurement of HDAC6 Target Occupancy in Nonhuman Primates

scientific article published on 19 March 2020

Virtually instantaneous, room-temperature [(11)C]-cyanation using biaryl phosphine Pd(0) complexes

scientific article

Visualizing epigenetics: current advances and advantages in HDAC PET imaging techniques

scientific article

Whole-body pharmacokinetics of HDAC inhibitor drugs, butyric acid, valproic acid and 4-phenylbutyric acid measured with carbon-11 labeled analogs by PET.

scientific article

[11C]Cyanation of arylboronic acids in aqueous solutions

scientific article published on 5 June 2017

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