List of works - Robin J Kleiman

A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia

scientific article published on September 2016

An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions

scientific journal article

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

scientific article published on 2 June 2017

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors

scientific article

Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons

scientific article published on 01 November 2018

Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease

scientific article published on 5 October 2010

Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.

scientific article published on 21 April 2010

Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy

scientific article

Data gaps limit the translational potential of preclinical research

scientific article

De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome.

scientific article published on 15 June 2018

Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive

scientific article published on July 25, 2012

Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

scientific article published on 18 March 2015

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

scientific article

Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species

scientific article published on 24 July 2006

Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species

scientific article

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

scientific article published on 23 March 2016

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

scientific article published on 6 February 2012

Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.

scientific article published on 16 February 2016

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo

scientific article published on 10 February 2012

Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma

scientific article published on 7 June 2012

Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

scientific article published on 31 October 2013

Translating genetic and preclinical findings into autism therapies

scientific article published in December 2017

List of works by Robin J Kleiman

A novel de novo mutation in ATP1A3 and childhood-onset schizophrenia

An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor

Application of structure-based drug design and parallel chemistry to identify selective, brain penetrant, in vivo active phosphodiesterase 9A inhibitors

Best Practices for Translational Disease Modeling Using Human iPSC-Derived Neurons

Chronic suppression of phosphodiesterase 10A alters striatal expression of genes responsible for neurotransmitter synthesis, neurotransmission, and signaling pathways implicated in Huntington's disease

Chronic treatment with a selective inhibitor of casein kinase I delta/epsilon yields cumulative phase delays in circadian rhythms.

Current Perspectives in Autism Spectrum Disorder: From Genes to Therapy

Data gaps limit the translational potential of preclinical research

De novo ATP1A3 and compound heterozygous NLRP3 mutations in a child with autism spectrum disorder, episodic fatigue and somnolence, and muckle-wells syndrome.

Design and discovery of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a selective brain penetrant PDE9A inhibitor for the treatment of cognitive

Evaluation of TrkB and BDNF transcripts in prefrontal cortex, hippocampus, and striatum from subjects with schizophrenia, bipolar disorder, and major depressive disorder

Identification of a brain penetrant PDE9A inhibitor utilizing prospective design and chemical enablement as a rapid lead optimization strategy

Immunohistochemical localization of phosphodiesterase 10A in multiple mammalian species

Immunohistochemical localization of phosphodiesterase 2A in multiple mammalian species

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis

MicroRNA-132 dysregulation in schizophrenia has implications for both neurodevelopment and adult brain function

Overlapping 16p13.11 deletion and gain of copies variations associated with childhood onset psychosis include genes with mechanistic implications for autism associated pathways: Two case reports.

Phosphodiesterase 9A regulates central cGMP and modulates responses to cholinergic and monoaminergic perturbation in vivo

Robust changes in expression of brain-derived neurotrophic factor (BDNF) mRNA and protein across the brain do not translate to detectable changes in BDNF levels in CSF or plasma

Select 3',5'-cyclic nucleotide phosphodiesterases exhibit altered expression in the aged rodent brain

Translating genetic and preclinical findings into autism therapies