List of works - Robert A. Lamb

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

scientific article published on 15 November 2013

A class act

scientific article published in Nature

A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion

scientific article

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

scientific article published on October 1997

A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein ⬇️

scientific article published on November 3, 2010

A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5.

scientific article

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail

scholarly article

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

scientific article

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity ⬇️

scientific article published on February 1, 1992

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

scientific article published on 19 October 2009

Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5.

scientific article

Analysis of the pore structure of the influenza A virus M(2) ion channel by the substituted-cysteine accessibility method

scientific article

Analysis of the posttranslational modifications of the influenza virus M2 protein

scientific article published in February 1995

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus

scientific article published on 17 October 2013

Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering

scientific article

Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia.

scientific article published on July 1992

Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5

scientific article published on 16 December 2011

Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA.

scientific article

Cell surface expression of glycosylated, nonglycosylated, and truncated forms of a cytoplasmic protein pyruvate kinase

scientific article

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

scientific article

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

scientific article published in July 1996

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

scientific article (publication date: 3 June 2005)

Complete nucleotide sequence of the neuraminidase gene of influenza B virus ⬇️

scientific article published on November 1, 1982

Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis

scientific article published on May 2004

Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state

scientific article published on December 2004

Conversion of a class II integral membrane protein into a soluble and efficiently secreted protein: multiple intracellular and extracellular oligomeric and conformational forms

scientific article

Deletion of the cytoplasmic tail of the fusion protein of the paramyxovirus simian virus 5 affects fusion pore enlargement

scientific article

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

scientific article

Different roles of individual N-linked oligosaccharide chains in folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase

scientific article published on May 1990

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

scientific article

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

scientific article published on 2 July 2008

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

scientific article published on 30 June 2014

Editorial overview: Virus structure and functions

scientific article published in June 2017

Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus.

scientific article

Effect of inserting paramyxovirus simian virus 5 gene junctions at the HN/L gene junction: analysis of accumulation of mRNAs transcribed from rescued viable viruses

scientific article

Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins

scientific article published on January 1989

Escaping from the cell: assembly and budding of negative-strand RNA viruses

scientific journal article

Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide.

scientific article

Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus

scientific article

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

scientific article

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

scientific article published on April 2011

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

scientific article published on 05 April 2011

Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus

scientific article published in September 2002

Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells ⬇️

scientific article published on September 1, 1992

Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion

scientific article published on 03 August 2016

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

scientific article

Folding and assembly of viral membrane proteins

scientific article

Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion

scientific article (publication date: 13 February 2009)

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

scientific article published on February 2010

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

scientific article

Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein

scientific article

ICTV Virus Taxonomy Profile: Paramyxoviridae

scientific article published on 11 October 2019

Identification of a membrane targeting and degradation signal in the p42 protein of influenza C virus

scientific article

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

scientific article published on 09 July 2009

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

scientific article published on 11 April 2008

Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins

scientific article published on 22 June 2016

Influenza A virus M2 ion channel protein: a structure-function analysis

scientific article

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes

scientific article published in July 2003

Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence

scientific article published on October 1998

Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport

scientific article published on February 1994

Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins

scientific article published on 24 October 2005

Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins

scientific article

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

scientific article

Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles

scientific article published on 2 May 2007

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay

scientific article

Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers ⬇️

scientific article published on November 1, 2003

Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal-anchor domain of a protein with an ectoplasmic NH2 terminus

scientific article

Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface.

scientific article

Involvement of the cytoplasmic domain of the hemagglutinin-neuraminidase protein in assembly of the paramyxovirus simian virus 5

scientific article

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block ⬇️

scientific article published on September 1, 1993

Ion selectivity and activation of the M2 ion channel of influenza virus

scientific article

Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane

scientific article published on 15 February 2017

Mechanism for proton conduction of the M(2) ion channel of influenza A virus

scientific article (publication date: 24 March 2000)

Mechanisms for enveloped virus budding: can some viruses do without an ESCRT?

scientific article published on 11 December 2007

Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion

scientific article

Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins: comparison of fusion reactions mediated by simian virus 5 F, human parainfluenza virus type 3 F, and influenza virus HA.

scientific article

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

scientific article published on 21 July 2011

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

scientific article published on 3 October 2017

Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity

scientific article published on 22 June 2016

On the stability of parainfluenza virus 5 F proteins

scientific article

Palmitylation of the influenza virus hemagglutinin (H3) is not essential for virus assembly or infectivity

scientific article published in March 1996

Paramyxovirus fusion: real-time measurement of parainfluenza virus 5 virus-cell fusion

scientific article published on 17 August 2006

Paramyxovirus membrane fusion: lessons from the F and HN atomic structures

scientific article

Probing the functions of the paramyxovirus glycoproteins F and HN with a panel of synthetic antibodies

scientific article

Probing the paramyxovirus fusion (F) protein-refolding event from pre- to postfusion by oxidative footprinting

scientific article

Quantitative measurement of paramyxovirus fusion: differences in requirements of glycoproteins between simian virus 5 and human parainfluenza virus 3 or Newcastle disease virus

scientific article published in November 1995

Recombinant parainfluenza virus 5 (PIV5) expressing the influenza A virus hemagglutinin provides immunity in mice to influenza A virus challenge

scientific article

Recovery of paramyxovirus simian virus 5 with a V protein lacking the conserved cysteine-rich domain: the multifunctional V protein blocks both interferon-beta induction and interferon signaling

scientific article published on November 2002

Refolding of a paramyxovirus F protein from prefusion to postfusion conformations observed by liposome binding and electron microscopy

scientific article

Repurposing Papaverine as an Antiviral Agent against Influenza Viruses and Paramyxoviruses

scientific article published on 28 February 2020

Reverse genetics of negative-strand RNA viruses: closing the circle

scientific article

Reversible inhibition of fusion activity of a paramyxovirus fusion protein by an engineered disulfide bond in the membrane-proximal external region

scientific article

Roles for the cytoplasmic tails of the fusion and hemagglutinin-neuraminidase proteins in budding of the paramyxovirus simian virus 5.

scientific article

Single amino acid substitution in the V protein of simian virus 5 differentiates its ability to block interferon signaling in human and murine cells

scientific article

Structural basis for paramyxovirus-mediated membrane fusion

scientific article

Structural studies of the parainfluenza virus 5 hemagglutinin-neuraminidase tetramer in complex with its receptor, sialyllactose

scientific article

Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

scientific article

Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus

scientific article

Structure and stabilization of the Hendra virus F glycoprotein in its prefusion form

scientific article published on 28 December 2015

Structure of the Newcastle disease virus F protein in the post-fusion conformation

scientific article

Structure of the Newcastle disease virus hemagglutinin-neuraminidase (HN) ectodomain reveals a four-helix bundle stalk

scientific article

Structure of the Ulster Strain Newcastle Disease Virus Hemagglutinin-Neuraminidase Reveals Auto-Inhibitory Interactions Associated with Low Virulence

scientific article

Structure of the cleavage-activated prefusion form of the parainfluenza virus 5 fusion protein

scientific article

Structure of the parainfluenza virus 5 F protein in its metastable, prefusion conformation

scientific article

Structure of the paramyxovirus PIV5 nucleoprotein in complex with an amino-terminal peptide of the phosphoprotein

scientific article

Structure of the paramyxovirus parainfluenza virus 5 nucleoprotein-RNA complex

scientific article

Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein

scientific article

Studies on the fusion peptide of a paramyxovirus fusion glycoprotein: roles of conserved residues in cell fusion ⬇️

scientific article published on April 1, 1992

The M2 proton channels of influenza A and B viruses

scientific article

The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells

scientific article

The V proteins of simian virus 5 and other paramyxoviruses inhibit induction of interferon-beta

scientific article published on November 2002

The active oligomeric state of the minimalistic influenza virus M2 ion channel is a tetramer.

scientific article published on May 1997

The amphipathic helix of influenza A virus M2 protein is required for filamentous bud formation and scission of filamentous and spherical particles

scientific article published on 10 July 2013

The gate of the influenza virus M2 proton channel is formed by a single tryptophan residue

scientific article (publication date: 18 October 2002)

The gene structure and replication of influenza virus ⬇️

scientific article published on January 1, 1983

The influenza virus M2 protein cytoplasmic tail interacts with the M1 protein and influences virus assembly at the site of virus budding

scientific article published on 13 August 2008

The interplay of functional tuning, drug resistance, and thermodynamic stability in the evolution of the M2 proton channel from the influenza A virus

scientific article published on July 2008

The ion channel activity of the influenza virus M2 protein affects transport through the Golgi apparatus

scientific article

The oligomeric state of the active BM2 ion channel protein of influenza B virus

scientific article published on 11 December 2007

The paramyxovirus simian virus 5 V protein slows progression of the cell cycle

scientific article

Transposition of domains between the M2 and HN viral membrane proteins results in polypeptides which can adopt more than one membrane orientation

scientific article

Truncation of the COOH-terminal region of the paramyxovirus SV5 fusion protein leads to hemifusion but not complete fusion

scientific article

Type II integral membrane protein, TM of J paramyxovirus promotes cell-to-cell fusion

scientific article

Viral and cellular small integral membrane proteins can modify ion channels endogenous to Xenopus oocytes

scientific article

Virus replication in engineered human cells that do not respond to interferons

scientific article

List of works by Robert A. Lamb

3-Azatetracyclo[5.2.1.1(5,8).0(1,5)]undecane derivatives: from wild-type inhibitors of the M2 ion channel of influenza A virus to derivatives with potent activity against the V27A mutant.

A class act

A dual-functional paramyxovirus F protein regulatory switch segment: activation and membrane fusion

A functionally defined model for the M2 proton channel of influenza A virus suggests a mechanism for its ion selectivity

A pH-Dependent Conformational Ensemble Mediates Proton Transport through the Influenza A/M2 Protein ⬇️

A role for caveolin 1 in assembly and budding of the paramyxovirus parainfluenza virus 5.

Activation of a paramyxovirus fusion protein is modulated by inside-out signaling from the cytoplasmic tail

Activation of the M2 ion channel of influenza virus: a role for the transmembrane domain histidine residue

Alterations to influenza virus hemagglutinin cytoplasmic tail modulate virus infectivity ⬇️

An amantadine-sensitive chimeric BM2 ion channel of influenza B virus has implications for the mechanism of drug inhibition

Analysis of the pH requirement for membrane fusion of different isolates of the paramyxovirus parainfluenza virus 5.

Analysis of the pore structure of the influenza A virus M(2) ion channel by the substituted-cysteine accessibility method

Analysis of the posttranslational modifications of the influenza virus M2 protein

Asp44 stabilizes the Trp41 gate of the M2 proton channel of influenza A virus

Bimolecular complementation of paramyxovirus fusion and hemagglutinin-neuraminidase proteins enhances fusion: implications for the mechanism of fusion triggering

Biological activity of paramyxovirus fusion proteins: factors influencing formation of syncytia.

Capture and imaging of a prehairpin fusion intermediate of the paramyxovirus PIV5

Cell surface expression of biologically active influenza C virus HEF glycoprotein expressed from cDNA.

Cell surface expression of glycosylated, nonglycosylated, and truncated forms of a cytoplasmic protein pyruvate kinase

Characterization of EBV gB indicates properties of both class I and class II viral fusion proteins

Characterization of inhibition of M2 ion channel activity by BL-1743, an inhibitor of influenza A virus

Chemical rescue of histidine selectivity filter mutants of the M2 ion channel of influenza A virus

Complete nucleotide sequence of the neuraminidase gene of influenza B virus ⬇️

Conserved cysteine-rich domain of paramyxovirus simian virus 5 V protein plays an important role in blocking apoptosis

Conserved glycine residues in the fusion peptide of the paramyxovirus fusion protein regulate activation of the native state

Conversion of a class II integral membrane protein into a soluble and efficiently secreted protein: multiple intracellular and extracellular oligomeric and conformational forms

Deletion of the cytoplasmic tail of the fusion protein of the paramyxovirus simian virus 5 affects fusion pore enlargement

Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus

Different roles of individual N-linked oligosaccharide chains in folding, assembly, and transport of the simian virus 5 hemagglutinin-neuraminidase

Discovery of novel dual inhibitors of the wild-type and the most prevalent drug-resistant mutant, S31N, of the M2 proton channel from influenza A virus

Domain architecture and oligomerization properties of the paramyxovirus PIV 5 hemagglutinin-neuraminidase (HN) protein

Easily accessible polycyclic amines that inhibit the wild-type and amantadine-resistant mutants of the M2 channel of influenza A virus

Editorial overview: Virus structure and functions

Effect of cytoplasmic tail truncations on the activity of the M(2) ion channel of influenza A virus.

Effect of inserting paramyxovirus simian virus 5 gene junctions at the HN/L gene junction: analysis of accumulation of mRNAs transcribed from rescued viable viruses

Effect of mutations and deletions in a bicistronic mRNA on the synthesis of influenza B virus NB and NA glycoproteins

Escaping from the cell: assembly and budding of negative-strand RNA viruses

Eukaryotic coupled translation of tandem cistrons: identification of the influenza B virus BM2 polypeptide.

Evidence for a new viral late-domain core sequence, FPIV, necessary for budding of a paramyxovirus

Exploring organosilane amines as potent inhibitors and structural probes of influenza a virus M2 proton channel

Exploring the Requirements for the Hydrophobic Scaffold and Polar Amine in inhibitors of M2 from Influenza A Virus

Exploring the size limit of templates for inhibitors of the M2 ion channel of influenza A virus

Expression and initial structural insights from solid-state NMR of the M2 proton channel from influenza A virus

Expression of the influenza A virus M2 protein is restricted to apical surfaces of polarized epithelial cells ⬇️

Flexibility of the Head-Stalk Linker Domain of Paramyxovirus HN Glycoprotein Is Essential for Triggering Virus Fusion

Flipping in the pore: discovery of dual inhibitors that bind in different orientations to the wild-type versus the amantadine-resistant S31N mutant of the influenza A virus M2 proton channel.

Folding and assembly of viral membrane proteins

Functional Analysis of the Transmembrane Domain in Paramyxovirus F Protein-Mediated Membrane Fusion

Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel

Functional studies indicate amantadine binds to the pore of the influenza A virus M2 proton-selective ion channel

Growth restriction of influenza A virus by M2 protein antibody is genetically linked to the M1 protein

ICTV Virus Taxonomy Profile: Paramyxoviridae

Identification of a membrane targeting and degradation signal in the p42 protein of influenza C virus

Identification of the functional core of the influenza A virus A/M2 proton-selective ion channel

Identification of the pore-lining residues of the BM2 ion channel protein of influenza B virus

Immobilization of the N-terminal helix stabilizes prefusion paramyxovirus fusion proteins

Influenza A virus M2 ion channel protein: a structure-function analysis

Influenza B virus BM2 protein has ion channel activity that conducts protons across membranes

Influenza C virus CM2 integral membrane glycoprotein is produced from a polypeptide precursor by cleavage of an internal signal sequence

Influenza virus M2 protein ion channel activity stabilizes the native form of fowl plague virus hemagglutinin during intracellular transport

Influenza virus assembly and budding in raft-derived microdomains: a quantitative analysis of the surface distribution of HA, NA and M2 proteins

Influenza virus assembly and lipid raft microdomains: a role for the cytoplasmic tails of the spike glycoproteins

Influenza virus hemagglutinin and neuraminidase cytoplasmic tails control particle shape

Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles

Inhibitors of the influenza A virus M2 proton channel discovered using a high-throughput yeast growth restoration assay

Initial structural and dynamic characterization of the M2 protein transmembrane and amphipathic helices in lipid bilayers ⬇️

Integration of a small integral membrane protein, M2, of influenza virus into the endoplasmic reticulum: analysis of the internal signal-anchor domain of a protein with an ectoplasmic NH2 terminus

Intracellular maturation and transport of the SV5 type II glycoprotein hemagglutinin-neuraminidase: specific and transient association with GRP78-BiP in the endoplasmic reticulum and extensive internalization from the cell surface.

Involvement of the cytoplasmic domain of the hemagglutinin-neuraminidase protein in assembly of the paramyxovirus simian virus 5

Ion channel activity of influenza A virus M2 protein: characterization of the amantadine block ⬇️

Ion selectivity and activation of the M2 ion channel of influenza virus

Lateral Organization of Influenza Virus Proteins in the Budozone Region of the Plasma Membrane

Mechanism for proton conduction of the M(2) ion channel of influenza A virus

Mechanisms for enveloped virus budding: can some viruses do without an ESCRT?

Membrane fusion machines of paramyxoviruses: capture of intermediates of fusion

Membrane fusion promoted by increasing surface densities of the paramyxovirus F and HN proteins: comparison of fusion reactions mediated by simian virus 5 F, human parainfluenza virus type 3 F, and influenza virus HA.

Molecular dynamics simulation directed rational design of inhibitors targeting drug-resistant mutants of influenza A virus M2.

Monomeric ephrinB2 binding induces allosteric changes in Nipah virus G that precede its full activation

Mutagenesis of Paramyxovirus Hemagglutinin-Neuraminidase Membrane-Proximal Stalk Region Influences Stability, Receptor Binding, and Neuraminidase Activity