List of works - Dario Alessi

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

scientific article (publication date: December 1995)

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

scientific journal article

The selectivity of protein kinase inhibitors: a further update

scientific article

Mechanism of activation of protein kinase B by insulin and IGF-1

scientific article

Metformin and reduced risk of cancer in diabetic patients

scientific article (publication date: 4 June 2005)

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

scientific article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

scientific article

Role of translocation in the activation and function of protein kinase B

scientific journal article

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

scientific article

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

scientific article

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

scientific article

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

scientific article published on 29 June 2009

Mechanism of activation and function of protein kinase B.

scientific article published on February 1998

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

scientific article published on October 1, 1997

LKB1-dependent signaling pathways

scientific article

PDK1, the master regulator of AGC kinase signal transduction

scientific article

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

scientific article

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

scientific article published on January 15, 1998

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

scientific article

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

scientific article (publication date: 16 December 1996)

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

scientific article

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

scientific article

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

scientific article (publication date: 15 July 2007)

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

scientific article (publication date: May 2012)

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

scientific article

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

scientific article published on 01 April 2000

Emerging roles of pseudokinases

scientific article

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

scientific article published on October 1994

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

scientific article published on 12 June 2009

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

scientific article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

scientific article

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

scientific article published on March 1995

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

scientific journal article

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

scientific article published in Journal of Biological Chemistry

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

scientific article

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

scientific article published on September 2010

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

scientific article published on November 28, 1997

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

scientific article

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

scientific article

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

scientific article

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

scientific article published on January 2007

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

scientific article

Role of the WNK-activated SPAK kinase in regulating blood pressure

scientific article

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

scientific article

Essential role of PDK1 in regulating cell size and development in mice

scientific article

LKB1 and AMPK and the cancer-metabolism link - ten years after

scientific article

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

scientific article

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

scientific article

List of works by Dario Alessi

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

The selectivity of protein kinase inhibitors: a further update

Mechanism of activation of protein kinase B by insulin and IGF-1

Metformin and reduced risk of cancer in diabetic patients

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Role of translocation in the activation and function of protein kinase B

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

Mechanism of activation and function of protein kinase B.

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase

LKB1-dependent signaling pathways

PDK1, the master regulator of AGC kinase signal transduction

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

Emerging roles of pseudokinases

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

Role of the WNK-activated SPAK kinase in regulating blood pressure

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

Essential role of PDK1 in regulating cell size and development in mice

LKB1 and AMPK and the cancer-metabolism link - ten years after

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer