Search filters

List of works by Dario Alessi

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization

scientific article

14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK

scientific article

3'Phosphoinositide-dependent kinase-1 is essential for ischemic preconditioning of the myocardium.

scientific article published on 31 October 2006

3-Phosphoinositide-dependent protein kinase 1 (PDK1) phosphorylates and activates the p70 S6 kinase in vivo and in vitro ⬇️

scientific article published on January 15, 1998

3-Phosphoinositide-dependent protein kinase-1 (PDK1): structural and functional homology with the Drosophila DSTPK61 kinase ⬇️

scientific article published on October 1, 1997

A 3-phosphoinositide-dependent protein kinase-1 (PDK1) docking site is required for the phosphorylation of protein kinase Czeta (PKCzeta ) and PKC-related kinase 2 by PDK1

scientific article (publication date: 7 July 2000)

A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation

scientific article published in 2022

A meeting of minds: overcoming roadblocks in the development of therapies for neurodegenerative disorders

scientific article published in June 2009

A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo

scientific article

A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

scientific article published on 06 November 2018

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

scientific article

Activation of protein kinase B β and γ isoforms by insulin in vivo and by 3-phosphoinositide-dependent protein kinase-1 in vitro: comparison with protein kinase B α ⬇️

scientific article published on April 1, 1998

Activation of the cardiac mTOR/p70(S6K) pathway by leucine requires PDK1 and correlates with PRAS40 phosphorylation

scientific article published on 5 January 2010

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

scientific article

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

scientific article

Activity of LKB1 and AMPK-related kinases in skeletal muscle: effects of contraction, phenformin, and AICAR.

scientific article

Akt is efficiently activated by PIF-pocket- and PtdIns(3,4,5)P3-dependent mechanisms leading to resistance to PDK1 inhibitors

scientific article

Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3.

scientific article published on December 2005

Analysis of the LKB1-STRAD-MO25 complex

scientific article

Angiotensin II signaling increases activity of the renal Na-Cl cotransporter through a WNK4-SPAK-dependent pathway

scientific article

Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium ⬇️

scientific article published on October 25, 1992

Aspirin inhibits mTOR signaling, activates AMP-activated protein kinase, and induces autophagy in colorectal cancer cells

scientific article published on 06 March 2012

BI-D1870 is a specific inhibitor of the p90 RSK (ribosomal S6 kinase) isoforms in vitro and in vivo

scientific article published on January 2007

Bi-functional, substrate mimicking RNA inhibits MSK1-mediated cAMP-response element-binding protein phosphorylation and reveals magnesium ion-dependent conformational changes of the kinase

scientific article

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change

scientific article

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

scientific article

Brain Penetrant LRRK2 Inhibitor

scientific article

Cancer, oncogenes and signal transduction

scientific article

Characterisation of a plant 3-phosphoinositide-dependent protein kinase-1 homologue which contains a pleckstrin homology domain

scientific article published in May 1999

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1.

scientific article published in January 2011

Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1).

scientific article published on October 2010

Characterization of TAE684 as a potent LRRK2 kinase inhibitor

scientific article

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase

scientific article

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases

scientific article published on January 2014

Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells

scientific article

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2.

scientific article published on 6 March 2011

Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms

scientific article published on 15 October 2020

Complexes between the LKB1 tumor suppressor, STRAD alpha/beta and MO25 alpha/beta are upstream kinases in the AMP-activated protein kinase cascade

scientific article

Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies

scientific article published on July 2013

Constitutive activation of protein kinase B alpha by membrane targeting promotes glucose and system A amino acid transport, protein synthesis, and inactivation of glycogen synthase kinase 3 in L6 muscle cells ⬇️

scientific article published on July 1, 1998

Control of AMPK-related kinases by USP9X and atypical Lys(29)/Lys(33)-linked polyubiquitin chains

scientific article

Crystal structure of MO25 alpha in complex with the C terminus of the pseudo kinase STE20-related adaptor

scientific article

Crystal structure of the PTPL1/FAP-1 human tyrosine phosphatase mutated in colorectal cancer: evidence for a second phosphotyrosine substrate recognition pocket

scientific article

DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides

scientific article

Deciphering the function of leucine-rich repeat kinase 2 and targeting its dysfunction in disease ⬇️

scientific article published on October 1, 2012

Deficiency of LKB1 in heart prevents ischemia-mediated activation of AMPKalpha2 but not AMPKalpha1.

scientific article

Deficiency of LKB1 in skeletal muscle prevents AMPK activation and glucose uptake during contraction

scientific article

Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

scientific article

Deficiency of PDK1 in liver results in glucose intolerance, impairment of insulin-regulated gene expression and liver failure

scientific article published on February 2005

Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader

scientific article published on 05 September 2019

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

scientific article published on 17 October 2021

Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation

scientific article published on 16 December 2012

Discovery of PDK1, one of the missing links in insulin signal transduction. Colworth Medal Lecture

scientific article published in May 2001

Discovery of Potent and Selective Covalent Inhibitors of JNK

scientific article published on 27 January 2012

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

scientific article published on November 2011

Disruption of the with no lysine kinase-STE20-proline alanine-rich kinase pathway reduces the hypertension induced by angiotensin II.

scientific article published on 4 September 2017

Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice ⬇️

scientific article published on March 15, 2011

Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

scientific article published in August 2012

Effects of exercise on mitogen- and stress-activated kinase signal transduction in human skeletal muscle

scientific article published on 01 November 2000

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

scientific article published on June 2013

Emerging roles of pseudokinases

scientific article

Essential role of PDK1 in regulating cell size and development in mice

scientific article

Evaluation of Approaches to Generation of Tissue-specific Knock-in Mice

scientific article published in Journal of Biological Chemistry

Evidence That 3-Phosphoinositide-dependent Protein Kinase-1 Mediates Phosphorylation of p70 S6 Kinasein Vivoat Thr-412 as well as Thr-252

scientific article published in Journal of Biological Chemistry

FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P

scientific article

Functional analysis of LKB1/STK11 mutants and two aberrant isoforms found in Peutz-Jeghers Syndrome patients.

scientific article published on February 2003

Functional characterization of human RSK4, a new 90-kDa ribosomal S6 kinase, reveals constitutive activation in most cell types.

scientific article

Functional interactions of the SPAK/OSR1 kinases with their upstream activator WNK1 and downstream substrate NKCC1

scientific article

Further evidence that 3-phosphoinositide-dependent protein kinase-1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms.

scientific article

Further evidence that the inhibition of glycogen synthase kinase‐3β by IGF‐1 is mediated by PDK1/PKB‐induced phosphorylation of Ser‐9 and not by dephosphorylation of Tyr‐216 ⬇️

scientific article published on October 27, 1997

GSK2578215A; a potent and highly selective 2-arylmethyloxy-5-substitutent-N-arylbenzamide LRRK2 kinase inhibitor

scientific article

Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B.

scientific article published in October 1999

Heat-shock protein 90 and Cdc37 interact with LKB1 and regulate its stability

scientific article

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

scientific article

High-content peptide microarrays for deciphering kinase specificity and biology

scientific article published in May 2004

High-resolution structure of the pleckstrin homology domain of protein kinase b/akt bound to phosphatidylinositol (3,4,5)-trisphosphate

scientific article

Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation.

scientific article published on 10 October 2017

How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance

scientific article published on 19 October 2010

Hypomorphic mutation of PDK1 suppresses tumorigenesis in PTEN(+/-) mice

scientific article published in October 2005

Identification and characterization of four novel phosphorylation sites (Ser31, Ser325, Thr336 and Thr366) on LKB1/STK11, the protein kinase mutated in Peutz-Jeghers cancer syndrome

scientific journal article

Identification of Protor as a novel Rictor-binding component of mTOR complex-2

scientific article

Identification of in vitro and in vivo phosphorylation sites in the catalytic subunit of the DNA-dependent protein kinase

scientific article

Identification of the sucrose non-fermenting related kinase SNRK, as a novel LKB1 substrate

scientific article

Impact of 100 LRRK2 variants linked to Parkinson's disease on kinase activity and microtubule binding

scientific article published in 2022

Impaired intestinal NHE3 activity in the PDK1 hypomorphic mouse

scientific article published on 6 July 2006

Impaired intestinal and renal glucose transport in PDK-1 hypomorphic mice

scientific article published on 01 June 2006

Important role of the LKB1-AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

scientific article

In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation

scientific article published in August 2003

In vivo role of the phosphate groove of PDK1 defined by knockin mutation

scientific article published on 11 October 2005

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines.

scientific article published on March 1995

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization

scientific article published on September 2010

Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B

scientific article (publication date: December 1995)

Inhibitor-2 functions like a chaperone to fold three expressed isoforms of mammalian protein phosphatase-1 into a conformation with the specificity and regulatory properties of the native enzyme.

scientific article

Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

scientific article published on September 2003

Interaction of TAPP adapter proteins with phosphatidylinositol (3,4)-bisphosphate regulates B-cell activation and autoantibody production

scientific article published on 8 August 2012

Interaction of the protein tyrosine phosphatase PTPL1 with the PtdIns(3,4)P2-binding adaptor protein TAPP1

scientific article

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1

scientific article

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase

scientific article published on July 2014

Investigation of LKB1 Ser431 phosphorylation and Cys433 farnesylation using mouse knockin analysis reveals an unexpected role of prenylation in regulating AMPK activity

scientific journal article

Kinase and channel activity of TRPM6 are co-ordinated by a dimerization motif and pocket interaction

scientific article published on June 2014

Kinase drug discovery--what's next in the field?

scientific article

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

scientific article

Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)

scientific article published on 12 June 2009

LKB1 and AMPK and the cancer-metabolism link - ten years after

scientific article

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

scientific article

LKB1, a protein kinase regulating cell proliferation and polarity

scientific article

LKB1-dependent signaling pathways

scientific article

LRRK2 activation in idiopathic Parkinson's disease.

scientific article published in July 2018

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

scientific article

LRRK2 phosphorylates moesin at threonine-558: characterization of how Parkinson's disease mutants affect kinase activity

scientific article (publication date: 15 July 2007)

Lithium inhibits caspase 3 activation and dephosphorylation of PKB and GSK3 induced by K+ deprivation in cerebellar granule cells

scientific article

Lithium prevents and ameliorates experimental autoimmune encephalomyelitis

scientific article published on July 2008

MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases

scientific article

MO25alpha/beta interact with STRADalpha/beta enhancing their ability to bind, activate and localize LKB1 in the cytoplasm

scientific article

Mechanism of activation and function of protein kinase B.

scientific article published on February 1998

Mechanism of activation of protein kinase B by insulin and IGF-1

scientific article

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

scientific article published on 17 October 2019

Metformin and reduced risk of cancer in diabetic patients

scientific article (publication date: 4 June 2005)

Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2/p38, and may mediate activation of CREB

scientific article

Mitogenic Activation, Phosphorylation, and Nuclear Translocation of Protein Kinase Bβ ⬇️

scientific article published on November 28, 1997

Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by Serine 312 phosphorylation

scientific article

Molecular basis for the substrate specificity of NIMA-related kinase-6 (NEK6). Evidence that NEK6 does not phosphorylate the hydrophobic motif of ribosomal S6 protein kinase and serum- and glucocorticoid-induced protein kinase in vivo

scientific article (publication date: 2 August 2002)

Molecular basis for the substrate specificity of protein kinase B; comparison with MAPKAP kinase-1 and p70 S6 kinase

scientific article (publication date: 16 December 1996)

Molecular cloning of cDNA encoding the 110 kDa and 21 kDa regulatory subunits of smooth muscle protein phosphatase 1M.

scientific article published in December 1994

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

scientific article

Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search f

N-terminal serine dephosphorylation is required for KCC3 cotransporter full activation by cell swelling

scientific article published on 16 September 2013

Nerve growth factor promotes activation of the alpha, beta and gamma isoforms of protein kinase B in PC12 pheochromocytoma cells

scientific article published on 01 January 1998

New anti-cancer role for PDK1 inhibitors: preventing resistance to tamoxifen

scientific article

New insights into mTOR signaling: mTORC2 and beyond

scientific article published on 21 April 2009

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion

scientific article

New users of metformin are at low risk of incident cancer: a cohort study among people with type 2 diabetes

scientific article published on 29 June 2009

Novel role for the LKB1 pathway in controlling monocarboxylate fuel transporters

scientific article published on October 2008

PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo

scientific journal article

PDK1 deficiency in POMC-expressing cells reveals FOXO1-dependent and -independent pathways in control of energy homeostasis and stress response

scientific article published in April 2008

PDK1, one of the missing links in insulin signal transduction?1 ⬇️

scientific article published on June 23, 1997

PDK1, the master regulator of AGC kinase signal transduction

scientific article

PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65 ⬇️

scientific article (publication date: May 2012)

PKB/SGK-resistant GSK-3 signaling following unilateral ureteral obstruction.

scientific article

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

scientific article published on 30 October 2019

PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12

scientific article

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

scientific article

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1

scientific article published on 01 November 2000

Phenformin as prophylaxis and therapy in breast cancer xenografts

scientific article published on 23 February 2012

Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade.

scientific article

Phosphatidylinositol 3-kinase/Akt signaling pathway activates the WNK-OSR1/SPAK-NCC phosphorylation cascade in hyperinsulinemic db/db mice

scientific article published on 4 September 2012

Phosphoinositide-regulated kinases and phosphoinositide phosphatases.

scientific article

Phosphoprotein analysis using antibodies broadly reactive against phosphorylated motifs

scientific article

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

scientific journal article

Phosphoproteomics reveals that the hVPS34 regulated SGK3 kinase specifically phosphorylates endosomal proteins including Syntaxin-7, Syntaxin-12, RFIP4 and WDR44

scientific article published on 01 October 2019

Phosphorylation and Activation of Heart 6-Phosphofructo-2-kinase by Protein Kinase B and Other Protein Kinases of the Insulin Signaling Cascades

scientific article published in Journal of Biological Chemistry

Phosphorylation of Parkin at Serine65 is essential for activation: elaboration of a Miro1 substrate-based assay of Parkin E3 ligase activity

scientific article published on 19 March 2014

Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry

scientific article published on 24 August 2010

Phosphorylation of synaptic vesicle protein 2A at Thr84 by casein kinase 1 family kinases controls the specific retrieval of synaptotagmin-1.

scientific article

Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth

scientific article

PolyGR and polyPR knock-in mice reveal a conserved neuroprotective extracellular matrix signature in C9orf72 ALS/FTD neurons

scientific article published in 2024

Protein Lipid Overlay Assay

scientific article published on 23 April 2002

Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1

scientific article

Proteinuria in mice expressing PKB/SGK-resistant GSK3.

scientific article

Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney

scientific journal article

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

scientific article published on 6 December 2017

Rab29-dependent asymmetrical activation of leucine-rich repeat kinase 2

scientific article published on 21 December 2023

Rapid and Reversible Knockdown of Endogenously Tagged Endosomal Proteins via an Optimized HaloPROTAC Degrader

scientific article published on 22 April 2019

Reduced intestinal and renal amino acid transport in PDK1 hypomorphic mice

scientific article published on 01 November 2006

Regulation of Akt/PKB Ser473 phosphorylation

scientific article

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress

scientific article

Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase.

scientific article

Regulation of membrane ruffling by polarized STIM1 and ORAI1 in cortactin-rich domains.

scientific article

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways

scientific article published on March 2011

Regulation of the polarity kinases PAR-1/MARK by 14-3-3 interaction and phosphorylation

scientific article

Role of T-loop phosphorylation in PDK1 activation, stability, and substrate binding.

scientific article published on March 2005

Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis

scientific article published on March 2011

Role of phosphatidylinositol 3,4,5-trisphosphate in regulating the activity and localization of 3-phosphoinositide-dependent protein kinase-1

scientific article

Role of the PDK1-PKB-GSK3 pathway in regulating glycogen synthase and glucose uptake in the heart

scientific article published in July 2005

Role of the WNK-activated SPAK kinase in regulating blood pressure

scientific article

Role of translocation in the activation and function of protein kinase B

scientific journal article

Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis

scientific article

SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation

scientific article published on January 2012

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

scientific article

Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer

scientific article

Small-molecule inhibitors of PDK1.

scientific article

Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains

scientific article published on 31 August 2018

Structural and biochemical characterization of the KLHL3–WNK kinase interaction important in blood pressure regulation

scientific article

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition

scientific article

Structural biology: Security measures of a master regulator

scientific article published in May 2013

Structural determinants for ERK5 (MAPK7) and leucine rich repeat kinase 2 activities of benzo[e]pyrimido-[5,4-b]diazepine-6(11H)-ones

scientific article published on 29 October 2013

Structural insights into the activation of MST3 by MO25

scientific article

Structural insights into the recognition of substrates and activators by the OSR1 kinase

scientific article

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates.

scientific article published on 30 September 2004

Structure of the LKB1-STRAD-MO25 complex reveals an allosteric mechanism of kinase activation

scientific article

Structure of the OSR1 kinase, a hypertension drug target

scientific article

Substrate specificity and inhibitors of LRRK2, a protein kinase mutated in Parkinson's disease

scientific article published on 23 October 2009

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis.

scientific article published on 10 November 2017

TSC1–TSC2: a complex tale of PKB-mediated S6K regulation

scientific article published on 01 September 2002

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development

scientific article

Temporal differences in the dependency on phosphoinositide-dependent kinase 1 distinguish the development of invariant Valpha14 NKT cells and conventional T cells

scientific article

The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

scientific article

The IkappaB kinase family phosphorylates the Parkinson's disease kinase LRRK2 at Ser935 and Ser910 during Toll-like receptor signaling

scientific article

The WNK-SPAK/OSR1 pathway: master regulator of cation-chloride cotransporters

scientific article published on 15 July 2014

The WNK-regulated SPAK/OSR1 kinases directly phosphorylate and inhibit the K+-Cl- co-transporters

scientific article

The activation of protein kinase B by H2O2 or heat shock is mediated by phosphoinositide 3-kinase and not by mitogen-activated protein kinase-activated protein kinase-2

scientific article

The control of protein phosphatase-1 by targetting subunits. The major myosin phosphatase in avian smooth muscle is a novel form of protein phosphatase-1.

scientific article

The hVps34-SGK3 pathway alleviates sustained PI3K/Akt inhibition by stimulating mTORC1 and tumour growth

scientific article published on August 2016

The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation

scientific article published on 29 April 2004

The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated prote

scientific article published on October 1994

The insulin signalling pathway

scientific article

The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase-1beta (Rsk-2) and p70 S6 kinase.

scientific article published on February 1997

The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway

scientific article published on October 2008

The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells

scientific article published on 01 April 2000

The role of PI 3-kinase in insulin action

scientific article published on 01 December 1998

The selectivity of protein kinase inhibitors: a further update

scientific article

The serine kinase phosphoinositide-dependent kinase 1 (PDK1) regulates T cell development

scientific article published on 11 April 2004

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation

scientific article published on March 2006

USP45 deubiquitylase controls ERCC1-XPF endonuclease-mediated DNA damage responses

scientific journal article

USP7 small-molecule inhibitors interfere with ubiquitin binding

scientific article published on 18 October 2017

Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop.

scientific article

Uncoupling the Warburg effect from cancer

scientific article

Use of Akt inhibitor and a drug-resistant mutant validates a critical role for protein kinase B/Akt in the insulin-dependent regulation of glucose and system A amino acid uptake

scientific article

Use of kinase inhibitors to dissect signaling pathways.

scientific article published in January 2000

Vomocytosis of live pathogens from macrophages is regulated by the atypical MAP kinase ERK5

scientific article published on 16 August 2017

WNK1, the kinase mutated in an inherited high-blood-pressure syndrome, is a novel PKB (protein kinase B)/Akt substrate

scientific article

[29] Assay and expression of mitogen-activated protein kinase, MAP kinase kinase, and Raf

scientific article published on 01 January 1995

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

scientific article

Paulina is supported by:

About Paulina

Help