List of works - Lachlan D. Rash

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

scientific article

ASIC3: first the heartache, now a migraine!

scientific article published on 01 September 2013

Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….

scientific article published on 21 March 2017

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms.

scientific article

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

scientific article published on 21 March 2009

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

scientific article

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

scientific article

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

scientific article published on 01 April 2019

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina).

scientific article

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

scientific article published on 18 March 2017

Erratum: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

article

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi) ⬇️

scientific article published on February 1, 1998

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

scientific article

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

scientific article

Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.

scientific article

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

scientific article published on 19 February 2014

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

scientific article

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

scientific article published on 24 November 2014

NaV1.7 as a pain target - From gene to pharmacology.

scientific article published on December 2016

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

scientific article

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

scientific article published on 24 April 2019

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

scientific article published on 28 August 2015

Pharmacology and biochemistry of spider venoms.

scientific article

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

scientific article published on 20 March 2017

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

scientific article

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

scientific article

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata).

scientific article published in August 2000

Spider-venom peptides as therapeutics.

scientific article

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

scientific article published on 27 October 2017

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

scientific article

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

scientific article

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

scientific article

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

scientific article published on 30 June 2015

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

scientific article

Venomics: a new paradigm for natural products-based drug discovery.

scientific article published on 24 February 2010

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.

scientific article

List of works by Lachlan D. Rash

A dynamic pharmacophore drives the interaction between Psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

ASIC3: first the heartache, now a migraine!

Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….

Acid-sensing ion channel (ASIC) structure and function: Insights from spider, snake and sea anemone venoms.

Chemical synthesis and folding of APETx2, a potent and selective inhibitor of acid sensing ion channel 3.

Chemical synthesis, 3D structure, and ASIC binding site of the toxin mambalgin-2

Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3

D. russelii Venom Mediates Vasodilatation of Resistance Like Arteries via Activation of Kv and KCa Channels

De novo sequencing of peptides from the parotid secretion of the cane toad, Bufo marinus (Rhinella marina).

Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.

Erratum: Corrigendum: Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

Evidence that histamine is the principal pharmacological component of venom from an Australian wolf spider (Lycosa godeffroyi) ⬇️

Functional expression in Escherichia coli of the disulfide-rich sea anemone peptide APETx2, a potent blocker of acid-sensing ion channel 3.

Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.

Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.

Isolation, synthesis and characterization of ω-TRTX-Cc1a, a novel tarantula venom peptide that selectively targets L-type Cav channels

Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.

Mutations in the voltage-gated potassium channel gene KCNH1 cause Temple-Baraitser syndrome and epilepsy

NaV1.7 as a pain target - From gene to pharmacology.

Neurotoxicity and other pharmacological activities of the snake venom phospholipase A2 OS2: the N-terminal region is more important than enzymatic activity

Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels

PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.

Pharmacology and biochemistry of spider venoms.

Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.

Production of recombinant disulfide-rich venom peptides for structural and functional analysis via expression in the periplasm of E. coli.

Selective inhibition of ASIC1a confers functional and morphological neuroprotection following traumatic spinal cord injury

Sex differences in the pharmacological activity of venom from the white-tailed spider (Lampona cylindrata).

Spider-venom peptides as therapeutics.

THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Ion channels

The Aromatic Head Group of Spider Toxin Polyamines Influences Toxicity to Cancer Cells

The receptor site of the spider toxin PcTx1 on the proton-gated cation channel ASIC1a

The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant.

The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity.

Three Peptide Modulators of the Human Voltage-Gated Sodium Channel 1.7, an Important Analgesic Target, from the Venom of an Australian Tarantula

Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophores

Venomics: a new paradigm for natural products-based drug discovery.

Xenopus borealis as an alternative source of oocytes for biophysical and pharmacological studies of neuronal ion channels.