List of works - Hisashi Shirakawa

A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons

scientific article published in January 2016

A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice

scientific article published on 8 October 2015

A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide

scientific article published on 27 February 2017

Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration

scientific article

Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.

scientific article published on 28 July 2012

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons

scientific article published on April 2006

An Adenosine A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis

scientific article published on 01 January 2019

Augmentation of serotonin release by sustained exposure to MDMA and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons.

scientific article published on 24 July 2008

Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes in 1321N1 human astrocytoma cells.

scientific article published in September 2008

Calumin, a Ca²⁺-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca²⁺ release-activated Ca²⁺ (CRAC) channels

scientific article published on 16 December 2011

Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release.

scientific article

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

scientific article

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (-)-Lycodine and (-)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities.

scientific article

Differential contribution of spinal mitogen-activated protein kinases to the phase of long-lasting allodynia evoked by intrathecal administration of ATP in rats.

scientific article published in June 2008

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin.

scientific article

Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.

scientific article published on 7 July 2004

Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats

scientific article published on 24 December 2008

Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice

scientific article

Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat

scientific article published on 25 August 2007

Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures.

scientific article published on 18 March 2015

Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models

scientific article published on 18 February 2015

Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model.

scientific article

Involvement of spinally-infiltrated immune cells in peripheral nerve injury-induced neuropathic pain: roles of TRPM2

scientific article published in November 2013

Is the regulation of immune system in Alzheimer's disease effective?

scientific article published in May 2016

Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide

scientific article published on 19 November 2015

Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures.

scientific article published in November 2008

New mechanisms underlying neuronal activity regulates myelination, and its application for drug discovery

scientific article published on 01 July 2016

Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.

scientific article published on 6 March 2006

Novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide.

scientific article published on 30 March 2013

Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus.

scientific article published on 8 April 2015

Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide.

scientific article published on 7 November 2017

Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice

scientific article published on 27 March 2014

Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism

scientific article

Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α₂-adrenoceptors and spinal astrocytes

scientific article published on 04 February 2014

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex.

scientific article published on 23 May 2014

Reactive oxygen species signaling in the regulation of microglial functions - TRP channel-mediated novel mechanisms of microglial activation

scientific article published on 01 January 2016

Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons.

scientific article

Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures

scientific article

Roles of transient receptor potential melastatin 2 expressed on immune cells in neuropathic pain

scientific article

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis

scientific article published in January 2017

Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes

scientific article

Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity.

scientific article

Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures.

scientific article published on 19 May 2010

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion.

scientific article published on 5 March 2018

TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

scientific article published on 10 September 2018

TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia.

scientific article

TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice.

scientific article

TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons

scientific journal article

TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.

scientific article

Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.

scientific article published on September 2010

Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice

scientific article

Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective 5-HT reuptake inhibitors on 5-HT release

scientific article

Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor

scientific article published on 13 October 2012

[EXPRESS] Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages

scientific article

[Pathophysiological roles of transient receptor potential channels in glial cells]

scientific article published on 01 March 2010

[Pathophysiology of immune cells during the progression of cerebral ischemic injury - involvement of TRPM2-mediated induction of iNOS in microglia/macrophage]

scientific article published on 01 September 2014

[Roles of TRPA1 in acute peripheral neuropathy characteristically induced by oxaliplatin]

scientific article published on 01 February 2013

List of works by Hisashi Shirakawa

A new designer drug 5F-ADB activates midbrain dopaminergic neurons but not serotonergic neurons

A pathophysiological role of TRPV1 in ischemic injury after transient focal cerebral ischemia in mice

A rat long-lasting cystitis model induced by intravesical injection of hydrogen peroxide

Activation of mitochondrial transient receptor potential vanilloid 1 channel contributes to microglial migration

Acute cold hypersensitivity characteristically induced by oxaliplatin is caused by the enhanced responsiveness of TRPA1 in mice.

Aminoglutethimide prevents excitotoxic and ischemic injuries in cortical neurons

An Adenosine A Receptor Antagonist Improves Multiple Symptoms of Repeated Quinpirole-Induced Psychosis

Augmentation of serotonin release by sustained exposure to MDMA and methamphetamine in rat organotypic mesencephalic slice cultures containing raphe serotonergic neurons.

Ca2+ mobilization mediated by transient receptor potential canonical 3 is associated with thrombin-induced morphological changes in 1321N1 human astrocytoma cells.

Calumin, a Ca²⁺-binding protein on the endoplasmic reticulum, alters the ion permeability of Ca²⁺ release-activated Ca²⁺ (CRAC) channels

Chronic effects of antidepressants on serotonin release in rat raphe slice cultures: high potency of milnacipran in the augmentation of serotonin release.

Cold sensitivity of TRPA1 is unveiled by the prolyl hydroxylation blockade-induced sensitization to ROS

Competent Route to Unsymmetric Dimer Architectures: Total Syntheses of (-)-Lycodine and (-)-Complanadines A and B, and Evaluation of Their Neurite Outgrowth Activities.

Differential contribution of spinal mitogen-activated protein kinases to the phase of long-lasting allodynia evoked by intrathecal administration of ATP in rats.

Distinct Mechanism of Cysteine Oxidation-Dependent Activation and Cold Sensitization of Human Transient Receptor Potential Ankyrin 1 Channel by High and Low Oxaliplatin.

Endogenous D-serine is involved in induction of neuronal death by N-methyl-D-aspartate and simulated ischemia in rat cerebrocortical slices.

Gene transfer of GLT-1, a glial glutamate transporter, into the spinal cord by recombinant adenovirus attenuates inflammatory and neuropathic pain in rats

Hypoxia-induced sensitisation of TRPA1 in painful dysesthesia evoked by transient hindlimb ischemia/reperfusion in mice

Increased Ca2+ channel currents in cerebellar Purkinje cells of the ataxic groggy rat

Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures.

Involvement of TRPM2 in a wide range of inflammatory and neuropathic pain mouse models

Involvement of TRPM2 in peripheral nerve injury-induced infiltration of peripheral immune cells into the spinal cord in mouse neuropathic pain model.

Involvement of spinally-infiltrated immune cells in peripheral nerve injury-induced neuropathic pain: roles of TRPM2

Is the regulation of immune system in Alzheimer's disease effective?

Long-lasting pain-related behaviors in mouse chronic cystitis model induced by a single intravesical injection of hydrogen peroxide

Mechanisms of substrate transport-induced clustering of a glial glutamate transporter GLT-1 in astroglial-neuronal cultures.

New mechanisms underlying neuronal activity regulates myelination, and its application for drug discovery

Nitric oxide-mediated effect of nipradilol, an alpha- and beta-adrenergic blocker, on glutamate neurotoxicity in rat cortical cultures.

Novel mouse model of chronic inflammatory and overactive bladder by a single intravesical injection of hydrogen peroxide.

Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT₆ receptors in the dorsal raphe nucleus.

Pathophysiological Role of Transient Receptor Potential Ankyrin 1 in a Mouse Long-Lasting Cystitis Model Induced by an Intravesical Injection of Hydrogen Peroxide.

Pharmacological characterization of standard analgesics on oxaliplatin-induced acute cold hypersensitivity in mice

Prevention of antipsychotic-induced hyperglycaemia by vitamin D: a data mining prediction followed by experimental exploration of the molecular mechanism

Preventive and alleviative effect of tramadol on neuropathic pain in rats: roles of α₂-adrenoceptors and spinal astrocytes

Raphe AMPA receptors and nicotinic acetylcholine receptors mediate ketamine-induced serotonin release in the rat prefrontal cortex.

Reactive oxygen species signaling in the regulation of microglial functions - TRP channel-mediated novel mechanisms of microglial activation

Regulation of N-methyl-D-aspartate cytotoxicity by neuroactive steroids in rat cortical neurons.

Repeated exposure to methamphetamine, cocaine or morphine induces augmentation of dopamine release in rat mesocorticolimbic slice co-cultures

Roles of transient receptor potential melastatin 2 expressed on immune cells in neuropathic pain

Sequential PET estimation of cerebral oxygen metabolism with spontaneous respiration of 15O-gas in mice with bilateral common carotid artery stenosis

Sphingosine-1-phosphate induces Ca2+ signaling and CXCL1 release via TRPC6 channel in astrocytes

Superoxide dismutase activity in organotypic midbrain-striatum co-cultures is associated with resistance of dopaminergic neurons to excitotoxicity.

Sustained exposure to 3,4-methylenedioxymethamphetamine induces the augmentation of exocytotic serotonin release in rat organotypic raphe slice cultures.

TRPM2 Channel Aggravates CNS Inflammation and Cognitive Impairment via Activation of Microglia in Chronic Cerebral Hypoperfusion.

TRPM2 Exacerbates Central Nervous System Inflammation in Experimental Autoimmune Encephalomyelitis by Increasing Production of CXCL2 Chemokines.

TRPM2 contributes to LPS/IFNγ-induced production of nitric oxide via the p38/JNK pathway in microglia.

TRPM2 contributes to inflammatory and neuropathic pain through the aggravation of pronociceptive inflammatory responses in mice.

TRPV1 stimulation triggers apoptotic cell death of rat cortical neurons

TRPV4 is functionally expressed in oligodendrocyte precursor cells and increases their proliferation.

Transient receptor potential canonical 3 (TRPC3) mediates thrombin-induced astrocyte activation and upregulates its own expression in cortical astrocytes.

Transient receptor potential canonical 3 inhibitor Pyr3 improves outcomes and attenuates astrogliosis after intracerebral hemorrhage in mice

Utility of organotypic raphe slice cultures to investigate the effects of sustained exposure to selective 5-HT reuptake inhibitors on 5-HT release

Yokukansan inhibits morphine tolerance and physical dependence in mice: the role of α₂A-adrenoceptor

[EXPRESS] Colchicine alleviates acute postoperative pain but delays wound repair in mice: roles of neutrophils and macrophages

[Pathophysiological roles of transient receptor potential channels in glial cells]

[Pathophysiology of immune cells during the progression of cerebral ischemic injury - involvement of TRPM2-mediated induction of iNOS in microglia/macrophage]

[Roles of TRPA1 in acute peripheral neuropathy characteristically induced by oxaliplatin]