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List of works by Patrick F Augustijns

A Tribute to Dr. Marcus E. Brewster: October 14, 1957-September 15, 2014.

scientific article published on 22 March 2016

A Tribute to Ronald T. Borchardt--Teacher, Mentor, Scientist, Colleague, Leader, Friend, and Family Man.

scientific article published on 9 October 2015

A liquid chromatography - tandem mass spectrometry method to measure a selected panel of uremic retention solutes derived from endogenous and colonic microbial metabolism

scientific article published on 2 July 2016

A review of drug solubility in human intestinal fluids: implications for the prediction of oral absorption.

scientific article published on 29 August 2013

A screening study of surface stabilization during the production of drug nanocrystals

article

Advances in Capillary Electrophoretically Mediated Microanalysis for On-line Enzymatic and Derivatization Reactions

scientific article published on 17 August 2017

Age-dependent activity of the uptake transporters Ntcp and Oatp1b2 in male rat hepatocytes: from birth till adulthood

scientific article published on 10 October 2014

Aging behavior of pharmaceutical formulations of itraconazole on SBA-15 ordered mesoporous silica carrier material

Alternative matrix formers for nanosuspension solidification: Dissolution performance and X-ray microanalysis as an evaluation tool for powder dispersion

scientific article published on 14 August 2008

An In-Depth View into Human Intestinal Fluid Colloids: Intersubject Variability in Relation to Composition

scientific article published on 31 August 2016

An atmospheric pressure ionization source using a high voltage target compared to electrospray ionization for the LC/MS analysis of pharmaceutical compounds.

scientific article published on 4 May 2017

An improved design to capture magnetic microparticles for capillary electrophoresis based immobilized microenzyme reactors

scientific article

An in vitro biorelevant gastrointestinal transfer (BioGIT) system for forecasting concentrations in the fasted upper small intestine: Design, implementation, and evaluation

scientific article

Apricot extract inhibits the P-gp-mediated efflux of talinolol.

scientific article published in December 2002

Assessment of Passive Intestinal Permeability Using an Artificial Membrane Insert System

scientific article

Associations of Soluble CD14 and Endotoxin with Mortality, Cardiovascular Disease, and Progression of Kidney Disease among Patients with CKD.

scientific article

Atmospheric Pressure Ionization Using a High Voltage Target Compared to Electrospray Ionization.

scientific article published on 28 November 2016

Barriers in the Approach of Obese Patients Undergoing Bariatric Surgery in Flemish Hospitals

scientific article published on 20 April 2015

Beneficial effect of antibiotics on ciliary beat frequency of human nasal epithelial cells exposed to bacterial toxins

scientific article

Bile Salt Micelles and Phospholipid Vesicles Present in Simulated and Human Intestinal Fluids: Structural Analysis by Flow Field-Flow Fractionation/Multiangle Laser Light Scattering.

scientific article

Binary Phase Diagram of Tetraethyl Orthosilicate and Carbon Dioxide

Biochemical characterization of malate synthase G of P. aeruginosa.

scientific article published on 24 June 2009

Biopharmaceutical profiling of a pyrido[4,3-d] pyrimidine compound library ⬇️

scientific article published on August 7, 2013

Boosting of HIV Protease Inhibitors by Ritonavir in the Intestine: The Relative Role of Cytochrome P450 and P-Glycoprotein Inhibition Based on Caco-2 Monolayers versus In Situ Intestinal Perfusion in Mice

article

CADA, a Potential Anti-HIV Microbicide that Specifically Targets the Cellular CD4 Receptor

article

CADA, a potential anti-HIV microbicide that specifically targets the cellular CD4 receptor

scientific article published in May 2008

Capillary zone electrophoresis method development for the analysis of Hippeastrum hybrid agglutinin samples.

scientific article published on 31 December 2008

Cardiovascular disease relates to intestinal uptake of p-cresol in patients with chronic kidney disease

scientific article

Characterization of Human Duodenal Fluids in Fasted and Fed State Conditions.

scientific article published on 30 July 2015

Characterization of fasted-state human intestinal fluids collected from duodenum and jejunum.

scientific article published in August 2006

Characterization of glassy itraconazole: a comparative study of its molecular mobility below T(g) with that of structural analogues using MTDSC.

scientific article

Characterization of physico-chemical properties and pharmaceutical performance of sucrose co-freeze–dried solid nanoparticulate powders of the anti-HIV agent loviride prepared by media milling

article

Chiral capillary electrophoretic method for quantification of apomorphine.

scientific article published in September 2004

Chloroquine accumulates in breast-milk cells: potential impact in the prophylaxis of postnatal mother-to-child transmission of HIV-1

article

Classification of the crystallization behavior of amorphous active pharmaceutical ingredients in aqueous environments

scientific article

Clearance Prediction of HIV Protease Inhibitors in Man: Role of Hepatic Uptake.

scientific article

Combined use of ordered mesoporous silica and precipitation inhibitors for improved oral absorption of the poorly soluble weak base itraconazole

scientific article published on 24 April 2010

Comparison between 2-hydroxypropyl-β-cyclodextrin and 2-hydroxypropyl-γ-cyclodextrin for inclusion complex formation with danazol

Comparison of drug transporter gene expression and functionality in Caco-2 cells from 10 different laboratories.

scientific article

Comparison of the complexation between methylprednisolone and different cyclodextrins in solution by 1H-NMR and molecular modeling studies

scientific article published on September 2010

Comparison of the disposition of ester prodrugs of the antiviral agent 9-(2-phosphonylmethoxyethyl)adenine [PMEA] in Caco-2 monolayers

scientific article published on 01 February 1998

Confocal imaging with a fluorescent bile acid analogue closely mimicking hepatic taurocholate disposition.

scientific article published on 20 March 2014

Correction: López-Yerena, A., et al. "Absorption and Intestinal Metabolic Profile of Oleocanthal in Rats" <i>Pharmaceutics</i> 2020, <i>12</i>, 134

scientific article published on 17 December 2020

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

scientific article

Determination of intraluminal theophylline concentrations after oral intake of an immediate- and a slow-release dosage form.

scientific article published in August 2005

Development and characterization of a solid dispersion film for the vaginal application of the anti-HIV microbicide UAMC01398.

scientific article published on 28 August 2014

Development and in vitro evaluation of a vaginal microbicide gel formulation for UAMC01398, a novel diaryltriazine NNRTI against HIV-1.

scientific article published on 20 November 2013

Development and in vitro evaluation of chloroquine gels as microbicides against HIV-1 infection

scientific article

Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish

scientific article published on 28 June 2017

Development of enteric-coated fixed dose combinations of amorphous solid dispersions of ezetimibe and lovastatin: Investigation of formulation and process parameters.

scientific article

Development of thiolated poly(acrylic acid) microparticles for the nasal administration of exenatide

article

Diminished sedation during diazepam treatment for chloroquine intoxication

scientific article published on April 1993

Downscaling drug nanosuspension production: processing aspects and physicochemical characterization

scientific article

Drug disposition and modelling before and after gastric bypass: immediate and controlled-release metoprolol formulations

scientific article

Drug disposition before and after gastric bypass: fenofibrate and posaconazole.

scientific article published on July 2016

Drug permeability profiling using cell-free permeation tools: Overview and applications

scientific article published on 13 April 2018

Drug precipitation–permeation interplay: Supersaturation in an absorptive environment ⬇️

scientific article published on July 25, 2012

Drug supersaturation in simulated and human intestinal fluids representing different nutritional states.

scientific article published on November 2010

Drying of crystalline drug nanosuspensions-the importance of surface hydrophobicity on dissolution behavior upon redispersion

scientific article published on 3 July 2008

Early identification of availability issues for poorly water-soluble microbicide candidates in biorelevant media: a case study with saquinavir

scientific article published on 6 June 2011

Editorial: In Memoriam Dr. Marcus Brewster

scientific article published on 30 October 2014

Effect of Age on The Hepatocellularity Number for Wistar rats

scientific article published on 23 December 2015

Effect of Cryopreservation on Enzyme and Transporter Activities in Suspended and Sandwich Cultured Rat Hepatocytes

scientific article

Effect of pH and Comedication on Gastrointestinal Absorption of Posaconazole

scientific article published on 01 November 2011

Effect of preservatives on ciliary beat frequency in human nasal epithelial cell culture: single versus multiple exposure.

scientific article published on 21 January 2007

Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers.

scientific article published in April 2004

Effects of T cell-induced colonic inflammation on epithelial barrier function

scientific article published in August 2010

Enhanced absorption of the poorly soluble drug fenofibrate by tuning its release rate from ordered mesoporous silica

scientific article published on 17 September 2010

Enhanced performance for the analysis of prostaglandins and thromboxanes by liquid chromatography-tandem mass spectrometry using a new atmospheric pressure ionization source.

scientific article

Enhanced release of itraconazole from ordered mesoporous SBA-15 silica materials

scientific article

Equilibrium drug solubility measurements in 96-well plates reveal similar drug solubilities in phosphate buffer pH 6.8 and human intestinal fluid

scientific article published on 10 December 2010

Erratum: Hens, B.; et al. Application of the Gastrointestinal Simulator (GIS) Coupled with In Silico Modeling to Measure the Impact of Coca-Cola<sup>®</sup> on the Luminal and Systemic Behavior of Loratadine (BCS Class 2b). <i>Pharmaceutics</i>, 202

scientific article published on 25 November 2020

Ethanol concentrations in the human gastrointestinal tract after intake of alcoholic beverages

scientific article

Evaluation of fasted and fed state simulated and human intestinal fluids as solvent system in the Ussing chambers model to explore food effects on intestinal permeability.

scientific article published on 12 December 2014

Evaluation of fasted state human intestinal fluid as apical solvent system in the Caco-2 absorption model and comparison with FaSSIF.

scientific article published on 26 November 2014

Evaluation of gastrointestinal drug supersaturation and precipitation: strategies and issues.

scientific article

Evaluation of immobilized hFMO3 on magnetic nanoparticles by capillary zone electrophoresis

scientific article published on 13 January 2017

Evaluation of real-life dosing of oral medicines with respect to fluid and food intake in a Dutch-speaking population.

scientific article published on 27 April 2017

Evaluation of the potential of ion pair formation to improve the oral absorption of two potent antiviral compounds, AMD3100 and PMPA

scientific article published on 01 September 1999

Evaluation of various PAMPA models to identify the most discriminating method for the prediction of BBB permeability.

scientific article published on 11 January 2010

Ex vivo permeability experiments in excised rat intestinal tissue and in vitro solubility measurements in aspirated human intestinal fluids support age-dependent oral drug absorption

scientific article published on 29 October 2009

Excipient-Mediated Supersaturation Stabilization in Human Intestinal Fluids

scientific article published on 22 February 2011

Exploring drug solubility in fasted human intestinal fluid aspirates: Impact of inter-individual variability, sampling site and dilution.

scientific article published on 4 June 2017

Exploring food effects on indinavir absorption with human intestinal fluids in the mouse intestine ⬇️

scientific article published on February 9, 2013

Exploring gastrointestinal variables affecting drug and formulation behavior: Methodologies, challenges and opportunities

scientific article published on 30 November 2016

Exploring the Effect of Esomeprazole on Gastric and Duodenal Fluid Volumes and Absorption of Ritonavir

scientific article published on 17 July 2020

Exploring the link between gastric motility and intragastric drug distribution in man

scientific article published on 16 November 2016

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes.

scientific article published on 24 October 2017

Flexible nano- and microliter injections on a single liquid chromatography-mass spectrometry system: Minimizing sample preparation and maximizing linear dynamic range

scientific article published on 27 September 2017

Food-dependent disintegration of immediate release fosamprenavir tablets: in vitro evaluation using magnetic resonance imaging and a dynamic gastrointestinal system.

scientific article

Formulate-ability of ten compounds with different physicochemical profiles in SMEDDS

scientific article published on 24 September 2009

Gastric and Duodenal Diclofenac Concentrations in Healthy Volunteers after Intake of the FDA Standard Meal: In Vivo Observations and in Vitro Explorations

scientific article published on 09 January 2019

Gastric and Duodenal Ethanol Concentrations after Intake of Alcoholic Beverages in Postprandial Conditions.

scientific article published on 21 July 2017

Gastrointestinal Behavior of Weakly Acidic BCS Class II Drugs in Man—Case Study of Diclofenac Potassium

scientific article published on 29 January 2016

Gastrointestinal and Systemic Disposition of Diclofenac under Fasted and Fed State Conditions Supporting the Evaluation of in Vitro Predictive Tools

scientific article published on 16 June 2017

Gastrointestinal and Systemic Monitoring of Posaconazole in Humans After Fasted and Fed State Administration of a Solid Dispersion.

scientific article published on 10 May 2016

Gastrointestinal behavior of itraconazole in humans - Part 1: Supersaturation from a solid dispersion and a cyclodextrin-based solution

scientific article published on 13 April 2017

Gastrointestinal behavior of itraconazole in humans - Part 2: The effect of intraluminal dilution on the performance of a cyclodextrin-based solution.

scientific article published on 24 April 2017

Gastrointestinal behavior of nano- and microsized fenofibrate: In vivo evaluation in man and in vitro simulation by assessment of the permeation potential

scientific article

Gastrointestinal dissolution, supersaturation and precipitation of the weak base indinavir in healthy volunteers

scientific article

Gastrointestinal transfer: in vivo evaluation and implementation in in vitro and in silico predictive tools.

scientific article published on 23 July 2014

Growth of itraconazole nanofibers in supersaturated simulated intestinal fluid

scientific article

Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat.

scientific article

Hepatobiliary and intestinal elimination of darunavir in an integrated preclinical rat model

scientific article

Hepatocyte-based in vitro model for assessment of drug-induced cholestasis.

scientific article published on 7 November 2013

High-speed digital imaging method for ciliary beat frequency measurement.

scientific article

High-throughput study of phenytoin solid dispersions: formulation using an automated solvent casting method, dissolution testing, and scaling-up

scientific article published on 16 July 2008

Higher clearance of micafungin in neonates compared with adults: role of age‐dependent micafungin serum binding ⬇️

scientific article published on March 30, 2011

Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome

scientific article published on 2 January 2016

Human and simulated intestinal fluids as solvent systems to explore food effects on intestinal solubility and permeability

scientific article published on 22 July 2014

Human bioavailability of propranolol from a matrix-in-cylinder system with a HPMC-Gelucire core.

scientific article published in October 2005

Identification of phase-II metabolites of flavonoids by liquid chromatography-ion-mobility spectrometry-mass spectrometry.

scientific article published on 22 November 2017

Improvement of the dissolution rate of artemisinin by means of supercritical fluid technology and solid dispersions.

scientific article published in March 2003

In Silico Modeling Approach for the Evaluation of Gastrointestinal Dissolution, Supersaturation and Precipitation of Posaconazole.

scientific article

In Situ FT-IR Investigation of Etravirine Speciation in Pores of SBA-15 Ordered Mesoporous Silica Material upon Contact with Water

scientific article published on 08 January 2013

In Vitro Evaluation of Viability, Integrity, and Inflammation in Genital Epithelia upon Exposure to Pharmaceutical Excipients and Candidate Microbicides ⬇️

scientific article published on October 4, 2010

In Vitro, Ex Vivo, and In Situ Intestinal Absorption Characteristics of the Antiviral Ester Prodrug Adefovir Dipivoxil

scientific article published on 01 August 2000

In situ intestinal perfusion in knockout mice demonstrates inhibition of intestinal p-glycoprotein by ritonavir causing increased darunavir absorption.

scientific article published on 15 June 2010

In situ perfusion in rodents to explore intestinal drug absorption: challenges and opportunities.

scientific article

In vitro and in vivo investigation of the gastrointestinal behavior of simvastatin

scientific article published on 20 June 2016

In vitro behavior of a phosphate ester prodrug of amprenavir in human intestinal fluids and in the Caco-2 system: Illustration of intraluminal supersaturation

scientific article published on 14 December 2006

In vitro disposition profiling of heterocyclic compounds

scientific article published on June 2015

In vitro evaluation of the impact of gastrointestinal transfer on luminal performance of commercially available products of posaconazole and itraconazole using BioGIT.

scientific article

In vitro hepatic metabolism explains higher clearance of voriconazole in children versus adults: role of CYP2C19 and flavin-containing monooxygenase 3

scientific article

In vitro models for the prediction of in vivo performance of oral dosage forms

scientific article published on 27 August 2013

In vitro profiling of the vaginal permeation potential of anti-HIV microbicides and the influence of formulation excipients

article

In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model

article

In vivo assessment of intestinal, hepatic, and pulmonary first pass metabolism of propofol in the rat.

scientific article published in June 1996

In vivo methods for drug absorption - comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects.

scientific article published on 15 March 2014

In vivo, in vitro and in silico methods for small molecule transfer across the BBB.

scientific article

In-vitro nasal drug delivery studies: comparison of derivatised, fibrillar and polymerised collagen matrix-based human nasal primary culture systems for nasal drug delivery studies.

scientific article published in November 2001

Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-Emulsifying Drug Delivery Systems Solidified by Adsorption onto an Inorganic Mesoporous Carrier

scientific article published on 07 August 2012

Increasing the oral bioavailability of the poorly water soluble drug itraconazole with ordered mesoporous silica

scientific article

Influence of essential and fatty oils on ciliary beat frequency of human nasal epithelial cells.

scientific article

Inhibition of intestinal metabolism of the antiviral ester prodrug bis(POC)-PMPA by nature-identical fruit extracts as a strategy to enhance its oral absorption: an in vitro study

scientific article published on 01 July 1999

Inhibitory effect of fruit extracts on P-glycoprotein-related efflux carriers: an in-vitro screening.

scientific article published in September 2002

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype.

scientific article published on 31 March 2017

Interaction of HIV protease inhibitors with OATP1B1, 1B3, and 2B1.

scientific article

Interaction of eight HIV protease inhibitors with the canalicular efflux transporter ABCC2 (MRP2) in sandwich-cultured rat and human hepatocytes.

scientific article published in March 2010

Interplay of Supersaturation and Solubilization: Lack of Correlation between Concentration-Based Supersaturation Measurements and Membrane Transport Rates in Simulated and Aspirated Human Fluids

scientific article published on 14 November 2019

Intestinal absorption characteristics of the low solubility thiocarboxanilide UC-781.

scientific article published in March 2002

Intestinal absorption enhancement of the ester prodrug tenofovir disoproxil fumarate through modulation of the biochemical barrier by defined ester mixtures.

scientific article

Intestinal behavior of the ester prodrug tenofovir DF in humans

scientific article published on 4 March 2015

Intestinal disposition of quercetin and its phase-II metabolites after oral administration in healthy volunteers

scientific article published on 15 May 2018

Intestinal drug solubility estimation based on simulated intestinal fluids: Comparison with solubility in human intestinal fluids ⬇️

scientific article published on July 17, 2011

Intestinal phase-II metabolism of quercetin in HT29 cells, 3D human intestinal tissues and in healthy volunteers: a qualitative comparison using LC-IMS-MS and LC-HRMS

scientific article published on 28 September 2018

Inulin hydrogels as carriers for colonic drug targeting: I. Synthesis and characterization of methacrylated inulin and hydrogel formation

scientific article published on 01 December 1997

Investigation of Saliva as an Alternative to Plasma Monitoring of Voriconazole.

scientific article published in November 2015

Iron deficiency after bariatric surgery: what is the real problem?

scientific article published on 05 April 2018

Itraconazole/TPGS/Aerosil200 solid dispersions: characterization, physical stability and in vivo performance

scientific article published on 15 August 2009

Lipid-Based Formulations Solidified Via Adsorption onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on In Vitro Pharmaceutical Performance

article

Llama antibody fragments have good potential for application as HIV type 1 topical microbicides.

scientific article published on 24 August 2011

Local immune response to food antigens drives meal-induced abdominal pain

scientific article published on 13 January 2021

Magnetic field assisted nanoparticle dispersion

scientific article published on 30 October 2008

Medication cost is significantly reduced after Roux-en-Y gastric bypass in obese patients

scientific article

Metabolism of stevioside in pigs and intestinal absorption characteristics of stevioside, rebaudioside A and steviol.

scientific article published in November 2003

Metabolism, Protein Binding, and Renal Clearance of Microbiota-Derived p-Cresol in Patients with CKD.

scientific article published on 15 April 2016

Metabonomics and drug development

scientific article published on January 2015

Microbiota-Derived Phenylacetylglutamine Associates with Overall Mortality and Cardiovascular Disease in Patients with CKD.

scientific article

Microcrystalline cellulose, a useful alternative for sucrose as a matrix former during freeze-drying of drug nanosuspensions - a case study with itraconazole

scientific article published on 18 June 2008

Micronutrient intake, from diet and supplements, and association with status markers in pre- and post-RYGB patients.

scientific article published on 23 August 2016

MiniCD4 microbicide prevents HIV infection of human mucosal explants and vaginal transmission of SHIV(162P3) in cynomolgus macaques

scientific article (publication date: 2012)

Molecular organization of hydrophobic molecules and co-adsorbed water in SBA-15 ordered mesoporous silica material

scientific article

Multidrug resistance-associated protein 2 (MRP2) affects hepatobiliary elimination but not the intestinal disposition of tenofovir disoproxil fumarate and its metabolites

scientific article

Nasal toxicological investigations of Carbopol 971P formulation of apomorphine: effects on ciliary beat frequency of human nasal primary cell culture and in vivo on rabbit nasal mucosa

article

Nasal vaccination with N-trimethyl chitosan and PLGA based nanoparticles: nanoparticle characteristics determine quality and strength of the antibody response in mice against the encapsulated antigen

scientific article published on 16 July 2010

Novel generic UPLC/MS/MS method for high throughput analysis applied to permeability assessment in early Drug Discovery

article

One drop chemical derivatization--DESI-MS analysis for metabolite structure identification

scientific article published on July 2015

Oral biopharmaceutics tools - time for a new initiative - an introduction to the IMI project OrBiTo

scientific article

Ordered mesoporous silica induces pH-independent supersaturation of the basic low solubility compound itraconazole resulting in enhanced transepithelial transport

scientific article

Ordered mesoporous silica material SBA-15: a broad-spectrum formulation platform for poorly soluble drugs

scientific article

P-glycoprotein attenuating effect of human intestinal fluid.

scientific article

PXR/CYP3A4-Humanized Mice for Studying Drug–Drug Interactions Involving Intestinal P-Glycoprotein ⬇️

scientific article published on February 19, 2013

Parallel monitoring of plasma and intraluminal drug concentrations in man after oral administration of fosamprenavir in the fasted and fed state.

scientific article published on 19 April 2007

Peptidyl dipeptidase A-catalyzed metabolism of delta sleep-inducing peptide in bovine brain microvessel endothelial cells: a cell culture model of the blood brain barrier.

scientific article published in May 1995

Pharmacokinetics of Posaconazole Oral Suspension in Children Dosed According to Body Surface Area.

scientific article

Phenyl phosphotriester derivatives of AZT: variations upon the SATE moiety.

scientific article published on 18 June 2008

Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25.

scientific article

Physical state of poorly water soluble therapeutic molecules loaded into SBA-15 ordered mesoporous silica carriers: a case study with itraconazole and ibuprofen

scientific article published on 17 July 2008

Posaconazole plasma exposure correlated to intestinal mucositis in allogeneic stem cell transplant patients.

scientific article published on 11 April 2016

Postprandial Evolution in Composition and Characteristics of Human Duodenal Fluids in Different Nutritional States

article

Postprandial changes in solubilizing capacity of human intestinal fluids for BCS class II drugs.

scientific article published on 7 March 2009

Potential of amorphous microporous silica for ibuprofen controlled release

scientific article published on 7 July 2010

Preventing release in the acidic environment of the stomach via occlusion in ordered mesoporous silica enhances the absorption of poorly soluble weakly acidic drugs

scientific article published on 15 July 2011

Rapid conversion of the ester prodrug abiraterone acetate results in intestinal supersaturation and enhanced absorption of abiraterone: In vitro, rat in situ and human in vivo studies

scientific article published on 12 January 2015

Recent advances in CE mediated microanalysis for enzymatic and derivatization reactions.

scientific article published on 03 September 2015

Resolving intraluminal drug and formulation behavior: Gastrointestinal concentration profiling in humans

scientific article published on 02 February 2014

Role of flavin-containing monooxygenase in oxidative metabolism of voriconazole by human liver microsomes

scientific article published on 24 March 2008

Role of the OATP Transporter Family and a Benzbromarone-SensitiveEfflux Transporter in the Hepatocellular Disposition of Vincristine.

scientific article

Safety assessment of thiolated polymers: effect on ciliary beat frequency in human nasal epithelial cells

scientific article published on 02 June 2011

Sandwich-cultured hepatocytes: utility for in vitro exploration of hepatobiliary drug disposition and drug-induced hepatotoxicity

scientific article

Scintigraphic evaluation in rabbits of nasal drug delivery systems based on carbopol 971p® and carboxymethylcellulose

scientific article published on 01 August 2000

Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux.

scientific article

Screening protocol for identifying inorganic oxides with anti-oxidant and pro-oxidant activity for biomedical, environmental and food preservation applications

scholarly article in RSC Advances, vol. 3 no. 3, 2013

Self-Assembly of Cyclodextrins and Their Complexes in Aqueous Solutions.

scientific article published on 12 March 2016

Simulated intestinal fluid as transport medium in the Caco-2 cell culture model.

scientific article published in January 2002

Site dependent intestinal absorption of darunavir and its interaction with ketoconazole.

scientific article published on 7 February 2013

Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3.

scientific article

Solubility increases associated with crystalline drug nanoparticles: methodologies and significance

scientific article

Solubilizing agents in nasal formulations and their effect on ciliary beat frequency ⬇️

scientific article published on October 26, 2011

Species-dependent and site-specific intestinal metabolism of ester prodrugs

article

Species-specific interaction of HIV protease inhibitors with accumulation of cholyl-glycylamido-fluorescein (CGamF) in sandwich-cultured hepatocytes.

scientific article published in June 2010

Specific antibody modulates absorptive transport and metabolic activation of benzo[a]pyrene across Caco-2 monolayers.

scientific article published on 21 January 2005

Stability of apomorphine in plasma and its determination by high-performance liquid chromatography with electrochemical detection

scientific article published on 01 August 1994

Stability of therapeutic albumin solutions used for molecular adsorbent recirculating system-based liver dialysis.

scientific article published on 28 September 2011

Stereoselective pharmacokinetic properties of chloroquine and de-ethyl-chloroquine in humans.

scientific article published on March 1993

Stereoselectivity in the disposition of chloroquine and desethylchloroquine in rabbits

scientific article published on June 1, 1992

Straightforward entry to pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones and their ADME properties.

scientific article published on 16 June 2014

Structure-based identification of OATP1B1/3 inhibitors

scientific article

Sulfasalazine transport in in-vitro, ex-vivo and in-vivo absorption models: contribution of efflux carriers and their modulation by co-administration of synthetic nature-identical fruit extracts.

scientific article

Supersaturating drug delivery systems: fast is not necessarily good enough.

scientific article published on 23 September 2011

Supersaturating drug delivery systems: the answer to solubility-limited oral bioavailability?

scientific article

Supersaturation and Precipitation of Posaconazole Upon Entry in the Upper Small Intestine in Humans.

scientific article published on 22 February 2016

Supersaturation in human gastric fluids

scientific article published on 11 February 2012

Synthesis and characterisation of inulin-azo hydrogels designed for colon targeting.

scientific article

The Effect of Food on the Intraluminal Behavior of Abiraterone Acetate in Man.

scientific article published on 6 April 2016

The Effect of Sparkling Water on Intraluminal Formulation Behavior and Systemic Drug Performance

scientific article published on 6 April 2017

The Influence of CKD on Colonic Microbial Metabolism

scientific article published on 23 September 2015

The Influence of Dietary Protein Intake on Mammalian Tryptophan and Phenolic Metabolites.

scientific article

The Influence of Nebulized Drugs on Nasal Ciliary Activity

scientific article

The Influence of Prebiotic Arabinoxylan Oligosaccharides on Microbiota Derived Uremic Retention Solutes in Patients with Chronic Kidney Disease: A Randomized Controlled Trial

scientific article

The angiotensin converting enzyme inhibitory tripeptides Ile-Pro-Pro and Val-Pro-Pro show increasing permeabilities with increasing physiological relevance of absorption models.

scientific article published on 8 April 2008

The artificial membrane insert system as predictive tool for formulation performance evaluation.

scientific article published on 12 December 2017

The conflict between in vitro release studies in human biorelevant media and the in vivo exposure in rats of the lipophilic compound fenofibrate

scientific article published on 07 May 2011

The dynamic gastric environment and its impact on drug and formulation behaviour.

scientific article

The effect of 2-hydroxypropyl-β-cyclodextrin on the intestinal permeation through mucus.

scientific article published on 20 December 2017

The effect of food components on the absorption of P-gp substrates: a review.

scientific article

The impact of guest compounds on cyclodextrin aggregation behavior: A series of structurally related parabens.

scientific article published on 10 July 2017

The influence of renal transplantation on retained microbial-human co-metabolites

scientific article published on 8 March 2016

The use of human nasal in vitro cell systems during drug discovery and development.

scientific article

The use of supersaturation for the vaginal application of microbicides: a case study with dapivirine.

scientific article published on 17 September 2014

Thiolated chitosan nanoparticles for the nasal administration of leuprolide: Bioavailability and pharmacokinetic characterization

scientific article published on 05 March 2012

Top-down production of drug nanocrystals: nanosuspension stabilization, miniaturization and transformation into solid products.

scientific article published on 31 July 2008

Toxicity and intracellular accumulation of bile acids in sandwich-cultured rat hepatocytes: role of glycine conjugates

scientific article published on 7 November 2013

Transplacental Distribution of Chloroquine in Sheep ⬇️

scientific article published on January 1, 1991

Transport of artemisinin and sodium artesunate in Caco-2 intestinal epithelial cells.

scientific article published in June 1996

Transport, uptake, and metabolism of the bis(pivaloyloxymethyl)-ester prodrug of 9-(2-phosphonylmethoxyethyl)adenine in an in vitro cell culture system of the intestinal mucosa (Caco-2)

scientific article published on 01 April 1997

Transport-Metabolism Interplay of Atazanavir in Rat Hepatocytes.

scientific article published on 28 December 2015

Trapping magnetic nanoparticles for in-line capillary electrophoresis in a liquid based capillary coolant system.

scientific article published on 17 November 2016

Tunability of Pore Diameter and Particle Size of Amorphous Microporous Silica for Diffusive Controlled Release of Drug Compounds

Unbound Ritonavir Concentrations in Rat and Human Hepatocytes

scientific article published on 18 May 2015

Use of Azo Polymers for Colon-Specific Drug Delivery ⬇️

scientific article published on December 1, 1997

Vaginal expression of efflux transporters and the potential impact on the disposition of microbicides in vitro and in rabbits.

scientific article

Validation of Dissolution Testing with Biorelevant Media: An OrBiTo Study.

scientific article published on 24 July 2017

Verapamil hepatic clearance in four preclinical rat models: towards activity-based scaling

scientific article published on 11 May 2015

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