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List of works by Peter de Witte

A Comparative Analysis of the Photosensitized Inhibition of Growth-Factor Regulated Protein Kinases by Hypericin-Derivatives

article

A comparative study of the photosensitizing characteristics of some cyanine dyes

scientific article published on 01 March 2000

A dual-targeting anticancer approach: soil and seed principle

scientific article published on 28 June 2011

A novel pathway combining calreticulin exposure and ATP secretion in immunogenic cancer cell death

scientific article

A phenotypic screen in zebrafish identifies a novel small-molecule inducer of ectopic tail formation suggestive of alterations in non-canonical Wnt/PCP signaling

scientific article (publication date: 2013)

A rapid method for the estimation of prostaglandin E2 in intestinal tissues using fluorescence derivatization

article

A robust human norovirus replication model in zebrafish larvae

scientific article published on 19 September 2019

A robust human norovirus replication model in zebrafish larvae: Supplementary data file

A safety study on single intravenous dose of tetrachloro-diphenyl glycoluril [iodogen] dissolved in dimethyl sulphoxide (DMSO).

scientific article published on 8 January 2013

An improved orthotopic rat bladder tumor model using Dil-loaded fluorescent AY-27 cells.

scientific article published on 26 June 2010

An overview of translational (radio)pharmaceutical research related to certain oncological and non-oncological applications

scientific article

Analysis of Phosphorylhydroxyamino Acids Present in Hydrolyzed Cell Extracts Using Dabsyl Derivatization

scientific article published on 01 March 1995

Analysis of the phosphoamino acid content of phosphoproteins

scientific article published on 01 June 1996

Anti-Inflammatory Activity and Cheminformatics Analysis of New Poten t 2-Substituted 1-Methyl-5-Nitroindazolinones

scientific article published on 19 January 2018

Anticonvulsant activity of bisabolene sesquiterpenoids of Curcuma longa in zebrafish and mouse seizure models.

scientific article published on 5 April 2012

Are zebrafish larvae suitable for assessing the hepatotoxicity potential of drug candidates?

scientific article published on 6 February 2015

Assessment of the convulsant liability of antidepressants using zebrafish and mouse seizure models.

scientific article published in October 2011

Automated analysis of brain activity for seizure detection in zebrafish models of epilepsy

scientific article published on 31 May 2017

Autophagy pathways activated in response to PDT contribute to cell resistance against ROS damage

scientific article

Biallelic VARS variants cause developmental encephalopathy with microcephaly that is recapitulated in vars knockout zebrafish

scientific article published in Nature Communications

Bicascarosides in Fluid Extracts of Cascara1 ⬇️

scientific article published on October 1, 1991

Bioassay-guided isolation of anti-seizure principles from Semen Pharbitidis using a zebrafish pentylenetetrazol seizure model

scientific article published on 17 December 2018

Biodistribution and photodynamic effects of polyvinylpyrrolidone-hypericin using multicellular spheroids composed of normal human urothelial and T24 transitional cell carcinoma cells.

scientific article published on January 2011

Biodistribution of Evans blue in an orthotopic AY-27 rat bladder urothelial cell carcinoma model: implication for the improved diagnosis of non-muscle-invasive bladder cancer (NMIBC) using dye-guided white-light cystoscopy

scientific article

Biodistribution of PVP-hypericin and hexaminolevulinate-induced PpIX in normal and orthotopic tumor-bearing rat urinary bladder

scientific article published on 09 June 2010

Biodistribution of hypericin in orthotopic transitional cell carcinoma bladder tumors: implication for whole bladder wall photodynamic therapy.

scientific article

Cannabidiol modulates phosphorylated rpS6 signalling in a zebrafish model of Tuberous Sclerosis Complex

scientific article published on 23 January 2019

Cell Imaging Counting as a Novel Ex Vivo Approach for Investigating Drug-Induced Hepatotoxicity in Zebrafish Larvae.

scientific article published on 08 February 2017

Comparative Antiseizure Analysis of Diverse Natural Coumarin Derivatives in Zebrafish

scientific article published in 2021

Continuing pursuit for ideal systemic anticancer radiotherapeutics

scientific article published on 18 October 2011

Conventionalization of germ-free rats reverses the disability of rhein anthrone to induce laxation

article

Correction: Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

scientific article published on 26 June 2018

Cross-species pharmacological characterization of the allylglycine seizure model in mice and larval zebrafish.

scientific article

Current insights in the complexities underlying drug-induced cholestasis

scientific article published on 01 July 2019

Cystinosis (ctns) zebrafish mutant shows pronephric glomerular and tubular dysfunction.

scientific article

Cytotoxicity of some medicinal plant extracts used in Tanzanian traditional medicine.

scientific article

Determination of hypericin in human plasma by high-performance liquid chromatography after intravesical administration in patients with transitional cell carcinoma of the bladder.

scientific article

Development of a sensitive and quantitative UHPLC-MS/MS method to study the whole-body uptake of pharmaceuticals in zebrafish

scientific article published on 28 June 2017

Development of a sensitive and quantitative capillary LC-UV method to study the uptake of pharmaceuticals in zebrafish brain

Differential accumulation of hypericin in spheroids composed of T-24 transitional cell carcinoma cells expressing different levels of E-cadherin.

scientific article

Differential cytotoxic effects induced after photosensitization by hypericin.

scientific article published on April 1997

Differential diagnosis of gallstones by using hypericin as a fluorescent optical imaging agent

scientific article

Drug repurposing for Dravet syndrome in scn1Lab-/- mutant zebrafish

scientific article published on 20 January 2019

Effect of vehicles and esterification on the penetration and distribution of hypericin in the skin of hairless mice

Elucidation of the tumoritropic principle of hypericin.

scientific article published on April 2005

Ethylenediamine derivatives efficiently react with oxidized RNA 3′ ends providing access to mono and dually labelled RNA probes for enzymatic assays and in vivo translation

scientific article

Evaluation of tumor affinity of mono-[123I]iodohypericin and mono-[123I]iodoprotohypericin in a mouse model with a RIF-1 tumor

article

Evans blue as a selective dye marker for white-light diagnosis of non-muscle-invasive bladder cancer: an in vitro study.

scientific article

Evans blue-mediated white-light detection of non-muscle-invasive bladder cancer: A preclinical feasibility and safety study using a rat bladder urothelial cell carcinoma model

scientific article published on 04 October 2016

Evidence that total extract of Hypericum perforatum affects exploratory behavior and exerts anxiolytic effects in rats.

scientific article published in April 2000

Excretion and distribution of [14C]rhein and [14C]rhein anthrone in rat

scientific article published on 01 September 1988

Exploring theranostic potentials of radioiodinated hypericin in rodent necrosis models

scientific article

First preclinical evaluation of mono-[123I]iodohypericin as a necrosis-avid tracer agent

scientific article published in February 2006

Fishing Anti-Inflammatories from Known Drugs: In Silico Repurposing, Design, Synthesis and Biological Evaluation of Bisacodyl Analogues.

scientific article published on 17 August 2017

G3BPs tether the TSC complex to lysosomes and suppress mTORC1 signaling

scientific article published on 25 January 2021

Genetic Renal Diseases: The Emerging Role of Zebrafish Models

Hypericin as a marker for determination of tissue viability after intratumoral ethanol injection in a murine liver tumor model.

scientific article published in January 2008

Hypericin as a marker for determination of tissue viability after radiofrequency ablation in a murine liver tumor model.

scientific article

Hypericin as a potential phototherapeutic agent in superficial transitional cell carcinoma of the bladder

scientific article published on 2 April 2004

Hypericin-based fluorescence diagnosis of bladder carcinoma.

scientific article published in May 2002

Hypericin-induced photosensitization of HeLa cells leads to apoptosis or necrosis

scientific article published on 01 November 1998

Identification of GSK-3 as a potential therapeutic entry point for epilepsy

article

In vitro and in vivo multidrug resistance reversal activity by a Betti-base derivative of tylosin

scientific article

In vitro transport and uptake of protohypericin and hypericin in the Caco-2 model

article

Induction of heme-oxygenase 1 requires the p38MAPK and PI3K pathways and suppresses apoptotic cell death following hypericin-mediated photodynamic therapy

scientific article published on April 2007

Influence of rhein anthrone and rhein on small intestine transit rate in rats: evidence of prostaglandin mediation

scientific article published on August 6, 1992

Influence of the glycosaminoglycan layer on the permeation of hypericin in rat bladders in vivo.

scientific article published on 14 September 2007

Influence of the vascular damaging agents DMXAA and ZD6126 on hypericin distribution and accumulation in RIF-1 tumors

scientific article

Inhibition of epidermal growth factor receptor tyrosine kinase activity by hypericin

scientific article published on 01 December 1993

Inhibition of glutamate decarboxylase (GAD) by ethyl ketopentenoate (EKP) induces treatment-resistant epileptic seizures in zebrafish.

scientific article published on 03 August 2017

Insights from zebrafish and mouse models on the activity and safety of ar-turmerone as a potential drug candidate for the treatment of epilepsy

scientific article (publication date: 2013)

Integration of Microfractionation, qNMR and zebrafish screening for the in vivo bioassay-guided isolation and quantitative bioactivity analysis of natural products

scientific article

Metabolism of 14C-rhein and 14C-rhein anthrone in rats.

scientific article

Methylated flavonoids as anti-seizure agents: Naringenin 4',7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models.

scientific article published on 21 November 2017

Modeling Neurodevelopmental Disorders and Epilepsy Caused by Loss of Function of <i>kif2a</i> in Zebrafish

scientific article published on 07 September 2021

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

scientific article

Molecular effectors and modulators of hypericin-mediated cell death in bladder cancer cells.

scientific article published on 22 October 2007

Murine liver implantation of radiation-induced fibrosarcoma: characterization with MR imaging, microangiography and histopathology

scientific article

Nephrotoxic Effects in Zebrafish after Prolonged Exposure to Aristolochic Acid

scientific article published on 30 March 2020

Non-canonical mTOR-Independent Role of DEPDC5 in Regulating GABAergic Network Development

article

Optimization and pharmacological validation of a leukocyte migration assay in zebrafish larvae for the rapid in vivo bioactivity analysis of anti-inflammatory secondary metabolites

scientific article (publication date: 2013)

Pathogen response-like recruitment and activation of neutrophils by sterile immunogenic dying cells drives neutrophil-mediated residual cell killing

scientific article published on 24 February 2017

Permeation of hypericin in spheroids composed of different grade transitional cell carcinoma cell lines and normal human urothelial cells.

scientific article published on July 2005

Pharmacological Analysis of the Anti-epileptic Mechanisms of Fenfluramine in scn1a Mutant Zebrafish.

scientific article published on 06 April 2017

Pharmacological characterization of an antisense knockdown zebrafish model of Dravet syndrome: inhibition of epileptic seizures by the serotonin agonist fenfluramine

scientific article

Phosphorylation of Bcl-2 in G2/M phase-arrested cells following photodynamic therapy with hypericin involves a CDK1-mediated signal and delays the onset of apoptosis.

scientific article published on 5 July 2002

Photocytotoxic effect of pseudohypericin versus hypericin

scientific article published on 01 September 1998

Photocytotoxicity of Protohypericin after Photoconversion to Hypericin

article

Photocytotoxicity of hypericin in normoxic and hypoxic conditions

scientific article published on 01 June 2000

Photodynamic therapy efficacy and tissue distribution of hypericin in a mouse P388 lymphoma tumor model

article

Photodynamic therapy using topically applied hypericin: Comparative effect with methyl-aminolevulinic acid on UV induced skin tumours

scientific article published on 28 October 2010

Photodynamic therapy with hypericin induces vascular damage and apoptosis in the RIF-1 mouse tumor model.

scientific article

Photosensitized inhibition of growth factor-regulated protein kinases by hypericin

scientific article published on 01 May 1995

Photosensitizing activity of hypericin and hypericin acetate after topical application on normal mouse skin.

scientific article

Preparation, analysis and biodistribution in mice of iodine-123 labelled derivatives of hypericin

article

Pretargeting of necrotic tumors with biotinylated hypericin using 123I-labeled avidin: evaluation of a two-step strategy

scientific article

Prevention of bladder tumor implantion after fluorescence-guided TUR with photodynamic therapy

Pro-apoptotic signaling induced by photo-oxidative ER stress is amplified by Noxa, not Bim.

scientific article published on 2 August 2013

Proceedings of the First International Conference on PEP005.

scientific article

Pseudochelin A, a siderophore of Pseudoalteromonas piscicida S2040 ⬇️

Purification of Nano-Porous Silicon for Biomedical Applications

scholarly article by Svetoslav Koynov et al published 16 March 2011 in Advanced Engineering Materials

Radioiodinated hypericin: its biodistribution, necrosis avidity and therapeutic efficacy are influenced by formulation

scientific article

Radiolabeled iodohypericin as tumor necrosis avid tracer: diagnostic and therapeutic potential

article published in 2012

Resistance to anticancer vaccination effect is controlled by a cancer cell-autonomous phenotype that disrupts immunogenic phagocytic removal

scientific article

Safety Assessment of Compounds after In Vitro Metabolic Conversion Using Zebrafish Eleuthero Embryos ⬇️

scientific article published on 06 April 2019

Screening of Tanzanian plant extracts for their potential inhibitory effect on P-glycoprotein mediated efflux.

scientific article

Sequential systemic administrations of combretastatin A4 Phosphate and radioiodinated hypericin exert synergistic targeted theranostic effects with prolonged survival on SCID mice carrying bifocal tumor xenografts

scientific article published on 13 February 2013

Serotonergic Modulation as Effective Treatment for Dravet Syndrome in a Zebrafish Mutant Model

scientific article

Serotonergic modulation as a pharmacological modality in the treatment of Dravet syndrome

scientific article published on 10 April 2017

Skin photosensitization with topical hypericin in hairless mice

article

Stability of different formulations and ion pairs of hypericin.

scientific article

Stress-induced inflammation evoked by immunogenic cell death is blunted by the IRE1α kinase inhibitor KIRA6 through HSP60 targeting

scientific article published on 27 August 2021

Structure-based identification of OATP1B1/3 inhibitors

scientific article

Synthesis, in vitro cellular uptake and photo-induced antiproliferative effects of lipophilic hypericin acid derivatives.

scientific article published on 6 October 2005

Tanshinone IIA exhibits anticonvulsant activity in zebrafish and mouse seizure models.

scientific article

Targetability and biodistribution of radioiodinated hypericin: comparison between microdosing and carrier-added preparations

scientific article published in January 2014

Targeted inhibition of p38alpha MAPK suppresses tumor-associated endothelial cell migration in response to hypericin-based photodynamic therapy

scientific article published on 30 September 2005

Targeting of the photocytotoxic compound AlPcS4 to Hela cells by transferrin conjugated PEG-liposomes

scientific article

The Activation of the c-Jun N-terminal Kinase and p38 Mitogen-activated Protein Kinase Signaling Pathways Protects HeLa Cells from Apoptosis Following Photodynamic Therapy with Hypericin

scientific article published in Journal of Biological Chemistry

The antiplasmodial activity of isolates from Ajuga remota

scientific article

The effect of purified extract of Fagopyrum esculentum (buckwheat) on protein kinases involved in signal transduction pathways.

scientific article

The effect of rhein and rhein anthrone on intestinal fluid transport and on large intestine transit in germ-free rats

scientific article published on 01 February 1992

The multifaceted photocytotoxic profile of hypericin

scientific article

The plant decapeptide OSIP108 prevents copper-induced toxicity in various models for Wilson disease

scientific article published on 16 August 2014

Transferrin-conjugated liposome targeting of photosensitizer AlPcS4 to rat bladder carcinoma cells.

scientific article published in November 2004

Up-regulation of cyclooxygenase-2 and apoptosis resistance by p38 MAPK in hypericin-mediated photodynamic therapy of human cancer cells

scientific article published on 13 October 2003

Use of Zebrafish Larvae as a Multi-Endpoint Platform to Characterize the Toxicity Profile of Silica Nanoparticles

scientific article

Validation of the zebrafish pentylenetetrazol seizure model: locomotor versus electrographic responses to antiepileptic drugs.

scientific article

Zebrafish Bioassay-guided Microfractionation for the Rapid in vivo Identification of Pharmacologically Active Natural Products

scientific article published on 01 January 2012

Zebrafish Models of Epilepsy and Epileptic Seizures

Zebrafish bioassay-guided microfractionation identifies anticonvulsant steroid glycosides from the Philippine medicinal plant Solanum torvum

scientific article published on 8 September 2014

Zebrafish bioassay-guided natural product discovery: isolation of angiogenesis inhibitors from East African medicinal plants

scientific article

Zebrafish-Based Discovery of Antiseizure Compounds from the North Sea: Isoquinoline Alkaloids TMC-120A and TMC-120B ⬇️

scientific article published on 25 October 2019

Zebrafish-Based Discovery of Antiseizure Compounds from the Red Sea: Pseurotin A2 and Azaspirofuran A.

scientific article published on 19 April 2018

mTOR-related neuropathology in mutant tsc2 zebrafish: Phenotypic, transcriptomic and pharmacological analysis

scientific article published on 6 September 2017

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