List of works by Susan Lindquist

. . . but yeast prion offers clues about evolution

scientific article published in Nature

A Fungal-Selective Cytochrome bc1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance

scientific article published on 6 August 2016

A Genetic Tool to Track Protein Aggregates and Control Prion Inheritance

scientific article published on 18 October 2017

A chaperone pathway in protein disaggregation. Hsp26 alters the nature of protein aggregates to facilitate reactivation by Hsp104.

scientific article published on 20 April 2005

A flurry of folding problems: an interview with Susan Lindquist by Jane Gitschier

scientific article published in May 2011

A heritable switch in carbon source utilization driven by an unusual yeast prion

scientific article

A method for probing the mutational landscape of amyloid structure.

scientific article published on July 2011

A natively unfolded yeast prion monomer adopts an ensemble of collapsed and rapidly fluctuating structures.

scholarly article

A network of protein interactions determines polyglutamine toxicity

scholarly article

A neuronal isoform of the aplysia CPEB has prion-like properties

scientific article

A nucleolar protein allows viability in the absence of the essential ER-residing molecular chaperone calnexin.

scientific article published on 7 April 2009

A quantitative chaperone interaction network reveals the architecture of cellular protein homeostasis pathways

scientific article

A suite of Gateway cloning vectors for high-throughput genetic analysis in Saccharomyces cerevisiae

scientific article

A systematic survey identifies prions and illuminates sequence features of prionogenic proteins

scientific article

A yeast TDP-43 proteinopathy model: Exploring the molecular determinants of TDP-43 aggregation and cellular toxicity

scholarly article

A yeast model of FUS/TLS-dependent cytotoxicity

scientific article

Aggregation and Fibril Structure of AβM01-42 and Aβ1-42.

scientific article published on 09 August 2017

Alpha-synuclein blocks ER-Golgi traffic and Rab1 rescues neuron loss in Parkinson's models

scientific article

Alternative assembly pathways of the amyloidogenic yeast prion determinant Sup35-NM

scientific article published on 2 November 2007

Amyloid deposits: protection against toxic protein species?

scientific article

An evolutionarily conserved prion-like element converts wild fungi from metabolic specialists to generalists

scientific article

An inter-species protein-protein interaction network across vast evolutionary distance

scientific article (publication date: 22 April 2016)

An intrinsically disordered yeast prion arrests the cell cycle by sequestering a spindle pole body component

scientific article published on 23 April 2012

Analysis of prion factors in yeast

scientific article

Analysis of the AAA sensor-2 motif in the C-terminal ATPase domain of Hsp104 with a site-specific fluorescent probe of nucleotide binding

scientific article

Asymmetric deceleration of ClpB or Hsp104 ATPase activity unleashes protein-remodeling activity

scientific article published on 28 January 2007

Atypical AAA+ subunit packing creates an expanded cavity for disaggregation by the protein-remodeling factor Hsp104.

scientific article

Author Correction: Mitochondrial metabolism promotes adaptation to proteotoxic stress

scientific article published on 01 July 2019

BETASCAN: probable beta-amyloids identified by pairwise probabilistic analysis

scientific article

Biochemical, Cell Biological, and Genetic Assays to Analyze Amyloid and Prion Aggregation in Yeast

scientific article published on 01 March 2010

Blessings in disguise: biological benefits of prion-like mechanisms

scientific article

Bridging high-throughput genetic and transcriptional data reveals cellular responses to alpha-synuclein toxicity

scientific article

Calcineurin determines toxic versus beneficial responses to α-synuclein

scientific article

Changes in the middle region of Sup35 profoundly alter the nature of epigenetic inheritance for the yeast prion [PSI+]

scientific article

Chaperone-dependent amyloid assembly protects cells from prion toxicity

scholarly article

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells

scientific article published on 30 June 2013

Chemical Genomics-Based Antifungal Drug Discovery: Targeting Glycosylphosphatidylinositol (GPI) Precursor Biosynthesis

scientific article published on 5 December 2014

Clioquinol promotes the degradation of metal-dependent amyloid-β (Aβ) oligomers to restore endocytosis and ameliorate Aβ toxicity

scientific article

Combating neurodegenerative disease with chemical probes and model systems

scientific article

Combining DNP NMR with segmental and specific labeling to study a yeast prion protein strain that is not parallel in-register

scientific article

Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models

scientific article

Compromising the 19S proteasome complex protects cells from reduced flux through the proteasome

scientific article

Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition

scholarly article

Conserved features of intermediates in amyloid assembly determine their benign or toxic states

scientific article

Context dependent neuroprotective properties of prion protein (PrP).

scientific article

Context-dependent perturbation of neural systems in transgenic mice expressing a cytosolic prion protein

scientific article published on 14 October 2009

Conversion of PrP to a self-perpetuating PrPSc-like conformation in the cytosol

scientific article published on 17 October 2002

Conversion of a yeast prion protein to an infectious form in bacteria

scientific article

Cooperative kinetics of both Hsp104 ATPase domains and interdomain communication revealed by AAA sensor-1 mutants

scientific article

Cross-kingdom chemical communication drives a heritable, mutually beneficial prion-based transformation of metabolism

scientific article published on August 2014

Cryptic variation in morphological evolution: HSP90 as a capacitor for loss of eyes in cavefish.

scientific article

Cyclin-G-associated kinase modifies α-synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study

scientific article

Defining a pathway of communication from the C-terminal peptide binding domain to the N-terminal ATPase domain in a AAA protein

scientific article published in April 2002

Destruction or potentiation of different prions catalyzed by similar Hsp104 remodeling activities

scientific article published on August 2006

Detection of compounds that rescue Rab1-synuclein toxicity

scientific article

Different 8-hydroxyquinolines protect models of TDP-43 protein, α-synuclein, and polyglutamine proteotoxicity through distinct mechanisms

scientific article published on 6 December 2011

Dihydropyrimidine-Thiones and Clioquinol Synergize To Target β-Amyloid Cellular Pathologies through a Metal-Dependent Mechanism

scientific article

Diminishing apoptosis by deletion of Bax or overexpression of Bcl-2 does not protect against infectious prion toxicity in vivo

scientific article published on November 2007

Direct and selective elimination of specific prions and amyloids by 4,5-dianilinophthalimide and analogs

scholarly article

Distinct prion strains are defined by amyloid core structure and chaperone binding site dynamics.

scientific article

Dominant gain-of-function mutations in Hsp104p reveal crucial roles for the middle region

scientific article

Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro

scholarly article

Endothelial Thermotolerance Impairs Nanoparticle Transport in Tumors.

scientific article

Epigenetic regulation of translation reveals hidden genetic variation to produce complex traits

scientific article published in Nature

Epigenetics in the Extreme: Prions and the Inheritance of Environmentally Acquired Traits ⬇️

scientific article published on October 29, 2010

Erratum: Transgenerational epigenetic inheritance: how important is it?

article

Evidence that alpha-synuclein does not inhibit phospholipase D

scientific article

FKBP12 contributes to α-synuclein toxicity by regulating the calcineurin-dependent phosphoproteome

scientific article published on 11 December 2017

Fitness trade-offs restrict the evolution of resistance to amphotericin B

scientific article (publication date: October 2013)

Flanking sequences profoundly alter polyglutamine toxicity in yeast

scholarly article

From yeast to patient neurons and back again: powerful new discovery platform

scientific article published on 14 August 2014

Functional links between Aβ toxicity, endocytic trafficking, and Alzheimer's disease risk factors in yeast

scientific article published on 27 October 2011

Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations

scientific article published on 14 July 2011

Genetic architecture of Hsp90-dependent drug resistance

scientific article

Genome-Scale Networks Link Neurodegenerative Disease Genes to α-Synuclein through Specific Molecular Pathways

scientific article

Green tea (-)-epigallocatechin-gallate modulates early events in huntingtin misfolding and reduces toxicity in Huntington's disease models

scientific article published on 7 August 2006

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers

scientific article

HSF2 cooperates with HSF1 to drive a transcriptional program critical for the malignant state

scientific article published on 16 March 2022

HSP90 Shapes the Consequences of Human Genetic Variation

scientific article published on 16 February 2017

HSP90 affects the expression of genetic variation and developmental stability in quantitative traits

scholarly article

HSP90 at the hub of protein homeostasis: emerging mechanistic insights

scientific article (publication date: July 2010)

HSP90 empowers evolution of resistance to hormonal therapy in human breast cancer models

scientific article

HSP90-buffered genetic variation is common in Arabidopsis thaliana

scholarly article

Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease

scholarly article

Harnessing natural diversity to probe metabolic pathways

scientific article

Heat shock factor 1 is a powerful multifaceted modifier of carcinogenesis

scientific article

Heat shock factor 1 regulates lifespan as distinct from disease onset in prion disease

scientific article

Heritable remodeling of yeast multicellularity by an environmentally responsive prion

scientific article published on March 2013

Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures

scientific article

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer

scientific article published on 31 October 2011

Hsp104 antagonizes alpha-synuclein aggregation and reduces dopaminergic degeneration in a rat model of Parkinson disease

scientific article published on September 2008

Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers

scientific article

Hsp104, Hsp70 and Hsp40 interplay regulates formation, growth and elimination of Sup35 prions

scientific article

Hsp110 chaperones regulate prion formation and propagation in S. cerevisiae by two discrete activities

scientific article

Hsp90 and chromatin: where is the link?

scientific article published on May 1, 2003

Hsp90 and environmental stress transform the adaptive value of natural genetic variation

scientific article

Hsp90 potentiates the rapid evolution of new traits: drug resistance in diverse fungi

scientific article

Identification and rescue of α-synuclein toxicity in Parkinson patient-derived neurons

scientific article

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

scientific article published on 17 November 2008

In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons

scientific article published on 25 January 2017

Increase in activity during calorie restriction requires Sirt1

scientific article published on 01 December 2005

Inhibiting GPI anchor biosynthesis in fungi stresses the endoplasmic reticulum and enhances immunogenicity

scientific article

Inhibiting mitochondrial phosphate transport as an unexploited antifungal strategy

scientific article published on 11 December 2017

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease

scientific article published on January 2004

Interview: Protein folding and studies of neurodegenerative diseases

scientific article published on 16 July 2008

Intrinsically Disordered Proteins Drive Emergence and Inheritance of Biological Traits

scientific article

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment

scientific article published on 04 December 2018

Loss of Hsp70 exacerbates pathogenesis but not levels of fibrillar aggregates in a mouse model of Huntington's disease

scientific article published on July 2009

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells

scientific article

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis

scientific article

Luminidependens (LD) is an Arabidopsis protein with prion behavior.

scientific article

Lymphotoxin-Dependent Prion Replication in Inflammatory Stromal Cells of Granulomas

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans

scientific article

Mapping differential interactomes by affinity purification coupled with data-independent mass spectrometry acquisition

scientific article

Mitochondrial metabolism promotes adaptation to proteotoxic stress

scientific article published on 27 May 2019

Modelling neurodegeneration in Saccharomyces cerevisiae: why cook with baker's yeast?

scientific article published on 28 April 2010

Motor mechanism for protein threading through Hsp104.

scientific article published on April 2009

Navigating the ClpB channel to solution.

scientific article

Neurotoxicity and neurodegeneration when PrP accumulates in the cytosol

scientific article published on 17 October 2002

Nontoxic antimicrobials that evade drug resistance

scientific article published on June 2015

Oligopeptide-repeat expansions modulate ‘protein-only’ inheritance in yeast

scientific article published in Nature

Opposing effects of glutamine and asparagine govern prion formation by intrinsically disordered proteins

scientific article

Optical trapping with high forces reveals unexpected behaviors of prion fibrils

scientific article

Orientation of aromatic residues in amyloid cores: structural insights into prion fiber diversity

scientific article

Overcoming fluconazole resistance in Candida albicans clinical isolates with tetracyclic indoles

scientific article

PICALM Rescues Endocytic Defects Caused by the Alzheimer's Disease Risk Factor APOE4

scientific article published on 01 October 2020

PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition

scientific article

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

scientific article published on 01 August 2020

Persistent Activation of mRNA Translation by Transient Hsp90 Inhibition

scientific article published on 01 September 2020

Phenotypic diversity and altered environmental plasticity in Arabidopsis thaliana with reduced Hsp90 levels

scientific article

Phenotypic screens for compounds that target the cellular pathologies underlying Parkinson's disease

scientific article published on January 2013

Physical properties of polymorphic yeast prion amyloid fibers

scientific article

Pioneer cells established by the [SWI+] prion can promote dispersal and out-crossing in yeast

scientific article published on 14 November 2017

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates

scientific article

Plasmodium falciparum heat shock protein 110 stabilizes the asparagine repeat-rich parasite proteome during malarial fevers

scientific article (publication date: 2012)

Polyamine pathway contributes to the pathogenesis of Parkinson disease ⬇️

scientific article published on September 13, 2010

Potent inhibition of huntingtin aggregation and cytotoxicity by a disulfide bond-free single-domain intracellular antibody

scientific article

Prion formation and polyglutamine aggregation are controlled by two classes of genes

scientific article

Prion formation by a yeast GLFG nucleoporin.

scientific article

Prion induction involves an ancient system for the sequestration of aggregated proteins and heritable changes in prion fragmentation

scientific article

Prion pathogenesis is independent of caspase-12.

scientific article published on 8 October 2007

Prion protein (PrPc) positively regulates neural precursor proliferation during developmental and adult mammalian neurogenesis

scholarly article

Prion protein gene polymorphisms in Saccharomyces cerevisiae

scientific article published in August 2003

Prion protein is expressed on long-term repopulating hematopoietic stem cells and is important for their self-renewal

scientific article

Prion proteins: one surprise after another

scientific article

Prion recognition elements govern nucleation, strain specificity and species barriers

scientific article

Prion switching in response to environmental stress

scientific article

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.

scientific article

Prions are a common mechanism for phenotypic inheritance in wild yeasts.

scientific article

Prions as adaptive conduits of memory and inheritance

scientific article

Prions as protein-based genetic elements

scientific article

Prions, protein homeostasis, and phenotypic diversity

scientific article

Probing the role of PrP repeats in conformational conversion and amyloid assembly of chimeric yeast prions

scientific article

Profoundly different prion diseases in knock-in mice carrying single PrP codon substitutions associated with human diseases

scientific article

Protein homeostasis and the phenotypic manifestation of genetic diversity: principles and mechanisms

scientific article published on January 2010

Protein-only mechanism induces self-perpetuating changes in the activity of neuronal Aplysia cytoplasmic polyadenylation element binding protein (CPEB).

scientific article

QnAs with Susan L. Lindquist. Interviewed by Prashant Nair

scientific article

Quantitative analysis of HSP90-client interactions reveals principles of substrate recognition

scientific article

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models

scientific article

Rebalancing Protein Homeostasis Enhances Tumor Antigen Presentation

scientific article published on 18 June 2019

ResponseNet: revealing signaling and regulatory networks linking genetic and transcriptomic screening data

scientific article

Role of HSP90 in the Regulation of de Novo Purine Biosynthesis.

scientific article published on 19 March 2018

SIRT1 protects against α-synuclein aggregation by activating molecular chaperones

scientific article published on January 2012

STITCHER: Dynamic assembly of likely amyloid and prion β-structures from secondary structure predictions

scientific article published on 17 November 2011

Scarless Gene Tagging with One-Step Transformation and Two-Step Selection in Saccharomyces cerevisiae and Schizosaccharomyces pombe

scientific article

Screening for amyloid aggregation by Semi-Denaturing Detergent-Agarose Gel Electrophoresis

scientific article published on 16 July 2008

Self-perpetuating structural states in biology, disease, and genetics

scientific article

Sensitivity-enhanced NMR reveals alterations in protein structure by cellular milieus

scientific article

Splice isoform and pharmacological studies reveal that sterol depletion relocalizes α-synuclein and enhances its toxicity

scientific article published on 10 February 2014

Spontaneous generation of prion infectivity in fatal familial insomnia knockin mice

scientific article

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus.

scientific article

Structural insights into a yeast prion illuminate nucleation and strain diversity

scientific article

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response

scientific article published on 25 March 2014

Suppression of 19S proteasome subunits marks emergence of an altered cell state in diverse cancers.

scientific article published on 27 December 2016

Susan L. Lindquist

scientific article

The Parkinson's disease protein alpha-synuclein disrupts cellular Rab homeostasis

scholarly article

The Schizosaccharomyces pombe Hsp104 disaggregase is unable to propagate the [PSI] prion

scientific article

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

scientific article published on 25 March 2011

The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs

scientific article

The elongation of yeast prion fibers involves separable steps of association and conversion

scholarly article

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

scientific article

The power of automated high-resolution behavior analysis revealed by its application to mouse models of Huntington's and prion diseases

scientific article

The prion protein knockout mouse: a phenotype under challenge

scientific article published on 25 April 2007

The reprogramming of tumor stroma by HSF1 is a potent enabler of malignancy

scientific article

The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration

scientific article published on 30 August 2008

Three Quite Different Things That Matter to Me ⬇️

scientific article published on November 15, 2010

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state

scientific article

TorsinA and the torsinA-interacting protein printor have no impact on endoplasmic reticulum stress or protein trafficking in yeast

scientific article

Toward stem cell-based phenotypic screens for neurodegenerative diseases

scientific article published on 19 May 2015

Transgenerational epigenetic inheritance: how important is it?

scientific article

Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity

scientific article published on 08 March 2018

Under cover: causes, effects and implications of Hsp90-mediated genetic capacitance

scientific article published on April 2004

Unraveling infectious structures, strain variants and species barriers for the yeast prion [PSI+].

scientific article published in June 2009

Using the heat-shock response to discover anticancer compounds that target protein homeostasis

scientific article published on 30 November 2011

Using yeast to understand protein folding diseases: an interview with Susan Lindquist by Kristin Kain

scientific article published in July 2008

Widespread inhibition of posttranscriptional splicing shapes the cellular transcriptome following heat shock

scientific article

Widespread macromolecular interaction perturbations in human genetic disorders

scientific journal article

Widespread regulation of translation by elongation pausing in heat shock

scientific article published on 3 January 2013

Yeast can accommodate phosphotyrosine: v-Src toxicity in yeast arises from a single disrupted pathway.

scientific article

Yeast cells provide insight into alpha-synuclein biology and pathobiology

scientific article

Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein

scientific article

Yeast reveal a "druggable" Rsp5/Nedd4 network that ameliorates α-synuclein toxicity in neurons.

scientific article

α-Synuclein: membrane interactions and toxicity in Parkinson's disease

scientific article published on January 2010

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