List of works - Zhude Tu

2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.

scientific article published in December 2001

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

scientific article

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

scientific article published on 25 June 2015

A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands

scientific article published on 17 April 2015

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.

scientific article published on 2 February 2016

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

scientific article published on 16 May 2018

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

scientific article

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent

scientific article

C-11 radiochemistry in cancer imaging applications.

scientific article published on January 2010

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

scientific article

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

scientific article

Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (-)-[18F]TZ3108 in rodent and the nonhuman primate brain

scientific article published on 16 January 2017

Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.

scientific article published in December 2002

Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

scientific article

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

scientific article published on 6 December 2017

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

scientific article

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

scientific article published on 09 June 2016

Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study

scientific article

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain

scientific article published on 19 August 2018

Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.

scientific article published on 19 June 2007

Functional assays to define agonists and antagonists of the sigma-2 receptor.

scientific article published on 12 December 2013

Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies

scientific article

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

scientific article

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter

scientific article

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

scientific article

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates

scientific article published on 7 November 2015

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

scientific article

Neuroprotective effects of high affinity Σ1 receptor selective compounds.

scientific article

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

scientific article published on 14 March 2016

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury.

scientific article

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

scientific article published on 23 March 2017

Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject

scientific article

Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

scientific article

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

scientific article

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

scientific article

Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

scientific article published on 17 January 2012

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter

scientific article

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter

scientific article published on 5 June 2015

Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).

scientific article

Synthesis and characterization of selective dopamine D2 receptor antagonists.

scientific article published on 8 November 2005

Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.

scientific article

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.

scientific article

Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

scientific article

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

scientific article

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.

scientific article

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A.

scientific article

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

scientific article published on 7 December 2017

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

scientific article

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

scientific article

Synthesis and in vitro evaluation of α-synuclein ligands.

scientific article

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

scientific article published on September 2013

Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

scientific article published on 24 February 2011

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.

scientific article published on 12 May 2014

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

scientific article published on 9 August 2012

Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate

scientific article published on 7 June 2017

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. ⬇️

scientific article

Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.

scientific article published on 13 November 2017

List of works by Zhude Tu

2-(2-Piperidyl)- and 2-(2-pyrrolidyl)chromans as nicotine agonists: synthesis and preliminary pharmacological characterization.

4-aroylpiperidines and 4-(α-hydroxyphenyl)piperidines as selective sigma-1 receptor ligands: synthesis, preliminary pharmacological evaluation and computational studies

A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression.

A practical process for the preparation of [(32)P]S1P and binding assay for S1P receptor ligands

A promising carbon-11-labeled sphingosine-1-phosphate receptor 1-specific PET tracer for imaging vascular injury.

Alpha Synuclein Fibrils Contain Multiple Binding Sites for Small Molecules

Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM).

Binding of the radioligand SIL23 to α-synuclein fibrils in Parkinson disease brain tissue establishes feasibility and screening approaches for developing a Parkinson disease imaging agent

C-11 radiochemistry in cancer imaging applications.

Carbon-11 labeled papaverine as a PET tracer for imaging PDE10A: radiosynthesis, in vitro and in vivo evaluation.

Chemical and enzyme-assisted syntheses of norbuprenorphine-3-β-D-glucuronide.

Chiral resolution of serial potent and selective σ1 ligands and biological evaluation of (-)-[18F]TZ3108 in rodent and the nonhuman primate brain

Chromaproline and Chromaperidine, nicotine agonists, and Donepezil, cholinesterase inhibitor, enhance performance of memory tasks in ovariectomized rats.

Comparison of [(11)C]TZ1964B and [(18)F]MNI659 for PET imaging brain PDE10A in nonhuman primates

Design and synthesis of pyrazolopyridine derivatives as sphingosine 1-phosphate receptor 2 ligands.

Design, Synthesis, and Characterization of 3-(Benzylidene)indolin-2-one Derivatives as Ligands for α-Synuclein Fibrils.

Design, Synthesis, and In Vitro and In Vivo Evaluation of an (18)F-Labeled Sphingosine 1-Phosphate Receptor 1 (S1P1) PET Tracer.

Endogenous dopamine (DA) competes with the binding of a radiolabeled D₃ receptor partial agonist in vivo: a positron emission tomography study

Exploration of Sulfur-Containing Analogues for Imaging Vesicular Acetylcholine Transporter in the Brain

Fluorine-18-labeled benzamide analogues for imaging the sigma2 receptor status of solid tumors with positron emission tomography.

Functional assays to define agonists and antagonists of the sigma-2 receptor.

Glycan array analysis of the antigen repertoire targeted by tumor-binding antibodies

Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site.

In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter

In vitro and in vivo characterization of two C-11-labeled pet tracers for vesicular acetylcholine transporter.

Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates

N-benzylisatin sulfonamide analogues as potent caspase-3 inhibitors: synthesis, in vitro activity, and molecular modeling studies.

Neuroprotective effects of high affinity Σ1 receptor selective compounds.

PET Imaging Study of S1PR1 Expression in a Rat Model of Multiple Sclerosis

PET Study of Sphingosine-1-Phosphate Receptor 1 Expression in Response to Vascular Inflammation in a Rat Model of Carotid Injury.

Pharmacologic characterizations of a P2X7 receptor-specific radioligand, [11C]GSK1482160 for neuroinflammatory response

Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase 10A in the brain of living subject

Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging.

Radiosyntheses and in vivo evaluation of carbon-11 PET tracers for PDE10A in the brain of rodent and nonhuman primate

Radiosynthesis and in vivo evaluation of [11C]MP-10 as a PET probe for imaging PDE10A in rodent and non-human primate brain

Sigma-2 ligands induce tumour cell death by multiple signalling pathways.

Syntheses and radiosyntheses of two carbon-11 labeled potent and selective radioligands for imaging vesicular acetylcholine transporter

Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter

Synthesis and biological characterization of stable and radioiodinated (+/-)-trans-2-hydroxy-3-P[4-(3-iodophenyl)piperidyl]-1,2,3,4-tetrahydronaphthalene (3'-IBVM).

Synthesis and characterization of selective dopamine D2 receptor antagonists.

Synthesis and evaluation of 15-(4-(2-[¹⁸F]Fluoroethoxy)phenyl)pentadecanoic acid: a potential PET tracer for studying myocardial fatty acid metabolism.

Synthesis and evaluation of in vitro bioactivity for vesicular acetylcholine transporter inhibitors containing two carbonyl groups.

Synthesis and in vitro and in vivo evaluation of 18F-labeled positron emission tomography (PET) ligands for imaging the vesicular acetylcholine transporter

Synthesis and in vitro binding of N-phenyl piperazine analogs as potential dopamine D3 receptor ligands.

Synthesis and in vitro biological evaluation of carbonyl group-containing analogues for σ1 receptors.

Synthesis and in vitro biological evaluation of pyrazole group-containing analogues for PDE10A.

Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer disease

Synthesis and in vitro characterization of cinnoline and benzimidazole analogues as phosphodiesterase 10A inhibitors.

Synthesis and in vitro evaluation of new analogues as inhibitors for phosphodiesterase 10A.

Synthesis and in vitro evaluation of α-synuclein ligands.

Synthesis and in vitro pharmacological evaluation of indolyl carboxylic amide analogues as D3 dopamine receptor selective ligands

Synthesis and pharmacological evaluation of fluorine-containing D₃ dopamine receptor ligands.

Synthesis and structure-activity relationship studies of conformationally flexible tetrahydroisoquinolinyl triazole carboxamide and triazole substituted benzamide analogues as σ2 receptor ligands.

Synthesis, radiolabeling and initial in vivo evaluation of [(11)C]KSM-01 for imaging PPAR-α receptors.

Synthesis, resolution, and in vitro evaluation of three vesicular acetylcholine transporter ligands and evaluation of the lead fluorine-18 radioligand in a nonhuman primate

The novel sigma-2 receptor ligand SW43 stabilizes pancreas cancer progression in combination with gemcitabine. ⬇️

Upregulated Sphingosine 1-Phosphate Receptor 1 Expression in Human and Murine Atherosclerotic Plaques.