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List of works by J. Silvio Gutkind

1 Alpha,25-dihydroxyvitamin D3 and its TX527 analog inhibit the growth of endothelial cells transformed by Kaposi sarcoma-associated herpes virus G protein-coupled receptor in vitro and in vivo.

scientific article

4E-BP1 Is a Tumor Suppressor Protein Reactivated by mTOR Inhibition in Head and Neck Cancer

scientific article published on 20 March 2019

A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK

article

A common requirement for the catalytic activity and both SH2 domains of SHP-2 in mitogen-activated protein (MAP) kinase activation by the ErbB family of receptors. A specific role for SHP-2 in map, but not c-Jun amino-terminal kinase activation

scientific article published in July 1998

A genome-wide RNAi screen reveals a Trio-regulated Rho GTPase circuitry transducing mitogenic signals initiated by G protein-coupled receptors.

scientific article published on 21 November 2012

A human suppressor of c-Jun N-terminal kinase 1 activation by tumor necrosis factor alpha

scientific article

A mutant alpha subunit of G12 potentiates the eicosanoid pathway and is highly oncogenic in NIH 3T3 cells

scientific article

A network of mitogen-activated protein kinases links G protein-coupled receptors to the c-jun promoter: a role for c-Jun NH2-terminal kinase, p38s, and extracellular signal-regulated kinase 5.

scientific article published in June 1999

A new G(q)-initiated MAPK signaling pathway in the heart.

scientific article published in February 2009

A new twist for the tumour suppressor hamartin

scientific article published on 01 May 2000

A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans

scientific article (publication date: 15 June 2006)

A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes ⬇️

scientific article published on March 1, 1991

A novel functional splice variant of AKT3 defined by analysis of alternative splice expression in HPV-positive oropharyngeal cancers

scientific article

A protein network map of head and neck cancer reveals PIK3CA mutant drug sensitivity

A retroinhibition approach reveals a tumor cell-autonomous response to rapamycin in head and neck cancer

scientific article

A role for COX2-derived PGE2 and PGE2-receptor subtypes in head and neck squamous carcinoma cell proliferation.

scientific article

A role for a CXCR2/phosphatidylinositol 3-kinase gamma signaling axis in acute and chronic vascular permeability.

scientific article

A role for p38 MAPK in head and neck cancer cell growth and tumor-induced angiogenesis and lymphangiogenesis

scientific article published on 12 October 2013

A synthetic biology approach reveals a CXCR4-G13-Rho signaling axis driving transendothelial migration of metastatic breast cancer cells

scientific article

A synthetic-lethality RNAi screen reveals an ERK-mTOR co-targeting pro-apoptotic switch in PIK3CA+ oral cancers

scientific article published on 13 February 2016

A systems genetics approach identifies CXCL14, ITGAX, and LPCAT2 as novel aggressive prostate cancer susceptibility genes.

scientific article

Accelerated wound healing by mTOR activation in genetically defined mouse models.

scientific article

Accumulation of dephosphorylated 4EBP after mTOR inhibition with rapamycin is sufficient to disrupt paracrine transformation by the KSHV vGPCR oncogene.

scientific article published on 27 May 2013

Accumulation of the SET protein in HEK293T cells and mild oxidative stress: cell survival or death signaling ⬇️

scientific article published on December 6, 2011

Activating and inactivating mutations of the alpha subunit of Gi2 protein have opposite effects on proliferation of NIH 3T3 cells ⬇️

scientific article published on December 1, 1991

Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma.

scientific article published in July 1998

Activation of GPCR-Gαi signaling increases keratinocyte proliferation and reduces differentiation, leading to epidermal hyperplasia

scientific article published on 07 November 2019

Activation of Ras and Rho GTPases and MAP Kinases by G-protein-coupled receptors.

scientific article published on January 2010

Activation of adenylyl cyclases, regulation of insulin status, and cell survival by G(alpha)olf in pancreatic beta-cells.

scientific article published on March 2002

Activation of the mTOR pathway in primary medullary thyroid carcinoma and lymph node metastases.

scientific article

Activation of the orphan receptor GPR55 by lysophosphatidylinositol promotes metastasis in triple-negative breast cancer.

scientific article published on 21 June 2016

Activation of the protein kinase Akt/PKB by the formation of E-cadherin-mediated cell-cell junctions. Evidence for the association of phosphatidylinositol 3-kinase with the E-cadherin adhesion complex

scientific article published in July 1999

Activation of transforming G protein-coupled receptors induces rapid tyrosine phosphorylation of cellular proteins, including p125FAK and the p130 v-src substrate

scientific article published on October 15, 1992

Agonist-induced Ca2+ sensitization in smooth muscle: redundancy of Rho guanine nucleotide exchange factors (RhoGEFs) and response kinetics, a caged compound study.

scientific article

An NF-kappaB gene expression signature contributes to Kaposi's sarcoma virus vGPCR-induced direct and paracrine neoplasia.

scientific article published on 15 October 2007

An essential role for Rac1 in endothelial cell function and vascular development.

scientific article

An interplay between the p38 MAPK pathway and AUBPs regulates c-fos mRNA stability during mitogenic stimulation

scientific article published on April 2015

Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia.

scientific article published in January 2008

Anti-angiogenic effects of VEGF stimulation on endothelium deficient in phosphoinositide recycling

scientific article published on 05 March 2020

Antitumor activity of UCN-01 in carcinomas of the head and neck is associated with altered expression of cyclin D3 and p27(KIP1).

scientific article published on November 2002

Arrestins as rheostats of GPCR signalling

scientific article published on 01 October 2018

Assembly and activation of the Hippo signalome by FAT1 tumor suppressor

scientific article published in Nature Communications

Assembly and patterning of the vascular network of the vertebrate hindbrain

scientific article

Association of estrogen receptor-alpha and progesterone receptor A expression with hormonal mammary carcinogenesis: role of the host microenvironment

scientific article published on January 2007

Augmented Wnt signaling in a mammalian model of accelerated aging

scientific journal article

Autocrine activation of an osteopontin-CD44-Rac pathway enhances invasion and transformation by H-RasV12.

scientific article

Beyond Synthetic Lethality: Charting the Landscape of Pairwise Gene Expression States Associated with Survival in Cancer

scientific article published on 01 July 2019

Binding-induced folding of a natively unstructured transcription factor.

scientific article

Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling.

scientific article

Biology of advanced uveal melanoma and next steps for clinical therapeutics

scientific article

Brag2 differentially regulates β1- and β3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis

scientific article published on 13 February 2014

CDP-diacylglycerol synthetase-controlled phosphoinositide availability limits VEGFA signaling and vascular morphogenesis.

scientific article

CKA, a novel multidomain protein, regulates the JUN N-terminal kinase signal transduction pathway in Drosophila.

scientific article

Carboxyl-terminal Domain of p27Kip1 Activates CDC2 ⬇️

scientific article published on August 29, 1997

Cardiovascular effects of alpha-adrenergic drugs: differences between clonidine and guanabenz.

scientific article published in April 1986

Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation.

scientific article published in November 1997

Cell growth control by G protein-coupled receptors: from signal transduction to signal integration

scientific article published on 01 September 1998

Cellular Systems for Studying Human Oral Squamous Cell Carcinomas ⬇️

scientific article published on January 1, 2011

Characterization of Brx, a novel Dbl family member that modulates estrogen receptor action

scientific article

Characterization of beta-adrenergic receptors in sections from human blood lymphocyte pellets by quantitative autoradiography

scientific article published on April 1988

Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter

scientific article (publication date: May 1992)

Chemical carcinogenesis models for evaluating molecular-targeted prevention and treatment of oral cancer.

scientific article published on 28 April 2009

Chemopreventive and chemotherapeutic actions of mTOR inhibitor in genetically defined head and neck squamous cell carcinoma mouse model.

scientific article

Chimeric G alpha i2/G alpha 13 proteins reveal the structural requirements for the binding and activation of the RGS-like (RGL)-containing Rho guanine nucleotide exchange factors (GEFs) by G alpha 13.

scientific article

Cholecystokinin receptor antagonist halts progression of pancreatic cancer precursor lesions and fibrosis in mice

scientific article

Circulating Fibroblast Growth Factor-2, HIV-Tat, and Vascular Endothelial Cell Growth Factor-A in HIV-Infected Children with Renal Disease Activate Rho-A and Src in Cultured Renal Endothelial Cells.

scientific article

Class IV semaphorins promote angiogenesis by stimulating Rho-initiated pathways through plexin-B.

scientific article

Classical membrane progesterone receptors in murine mammary carcinomas: agonistic effects of progestins and RU-486 mediating rapid non-genomic effects.

scientific article published on 10 June 2010

Combination chemotherapy and radiation of human squamous cell carcinoma of the head and neck augments CTL-mediated lysis.

scientific article published on March 2006

Combined image guided monitoring the pharmacokinetics of rapamycin loaded human serum albumin nanoparticles with a split luciferase reporter

scientific article published on 28 January 2016

Combining portable Raman probes with nanotubes for theranostic applications

scientific article

Common elements in interleukin 4 and insulin signaling pathways in factor-dependent hematopoietic cells.

scientific article

Complementary roles of intracellular and pericellular collagen degradation pathways in vivo.

scientific article

Conditional expression of K-ras in an epithelial compartment that includes the stem cells is sufficient to promote squamous cell carcinogenesis.

scientific article published on December 2004

Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.

scientific article

Control of the epithelial stem cell epigenome: the shaping of epithelial stem cell identity.

scientific article published on 19 February 2013

Correction to: mTOR co-targeting strategies for head and neck cancer therapy

scientific article published on 01 June 2019

Cross talk between the bombesin neuropeptide receptor and Sonic hedgehog pathways in small cell lung carcinoma.

scientific article

Cross-desensitization and cointernalization of H1 and H2 histamine receptors reveal new insights into histamine signal integration.

scientific article published on 5 March 2013

Cryo-electron microscopy structure and analysis of the P-Rex1-Gβγ signaling scaffold

scientific article published on 16 October 2019

Cyclooxygenase-2 and colorectal cancer chemoprevention: the beta-catenin connection.

scientific article published on December 2006

DSG3 as a biomarker for the ultrasensitive detection of occult lymph node metastasis in oral cancer using nanostructured immunoarrays

scientific article published on 23 September 2012

Decreased lymphangiogenesis and lymph node metastasis by mTOR inhibition in head and neck cancer

scientific article

Deletion of the COOH terminus converts the ST5 p70 protein from an inhibitor of RAS signaling to an activator with transforming activity in NIH-3T3 cells

scientific article (publication date: 3 March 2000)

Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways ⬇️

scientific article published on January 1, 1991

Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation

scientific article

Dermatomyositis paraneoplastic syndrome before symptomatic tonsillar squamous cell carcinoma: a case report

scientific article published on 27 June 2014

Detecting cancer metastasis and accompanying protein biomarkers at single cell levels using a 3D-printed microfluidic immunoarray

scientific article published on 15 October 2020

Detection of plasminogen activators in oral cancer by laser capture microdissection combined with zymography

scientific article published in November 2004

Development of a yeast-based system to identify new hBRAFV600E functional interactors

scientific article published on 20 September 2018

Direct interaction of p21-activated kinase 4 with PDZ-RhoGEF, a G protein-linked Rho guanine exchange factor

scientific article (publication date: 13 February 2004)

Direct targeting of Gαq and Gα11 oncoproteins in cancer cells

scientific article published on 19 March 2019

Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative.

scientific article published on September 2007

Distinct pattern of expression of differentiation and growth-related genes in squamous cell carcinomas of the head and neck revealed by the use of laser capture microdissection and cDNA arrays

scientific article

Distribution and clearance of PEG-single-walled carbon nanotube cancer drug delivery vehicles in mice

scientific article

Divergent signaling pathways link focal adhesion kinase to mitogen-activated protein kinase cascades. Evidence for a role of paxillin in c-Jun NH(2)-terminal kinase activation

scientific article published on October 1999

Diverse activation states of RhoA in human lung cancer cells: contribution of G protein coupled receptors.

scientific article published on March 2007

Diverse biologic properties imparted by the c-fgr proto-oncogene ⬇️

scientific article published on February 15, 1992

Does dysregulated expression of a deregulated viral GPCR trigger Kaposi's sarcomagenesis?

scientific article

Down-regulation of CXCL5 inhibits squamous carcinogenesis.

scientific article published on April 2006

Dual effect of beta-adrenergic receptors on mitogen-activated protein kinase. Evidence for a beta gamma-dependent activation and a G alpha s-cAMP-mediated inhibition

scientific article published on 01 October 1995

E-cadherin and Hakai: signalling, remodeling or destruction?

scientific article

E1a is an exogenous in vivo tumour suppressor.

scientific article published on 14 April 2017

EPS8 upregulates FOXM1 expression, enhancing cell growth and motility

scientific article

Effect of activating and inactivating mutations of Gs- and Gi2-alpha protein subunits on growth and differentiation of 3T3-L1 preadipocytes.

scientific article published on February 1997

Effect of chronic administration of the converting enzyme inhibitor enalapril (MK 421) on brain atrial natriuretic peptide receptors in Wistar-Kyoto and spontaneously hypertensive rats

scientific article published in December 1988

Effector domain mutants of Rho dissociate cytoskeletal changes from nuclear signaling and cellular transformation ⬇️

scientific article published on August 27, 1998

Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

scientific article published on 01 May 2019

Electrochemical Immunosensors for Interleukin-6. Comparison of Carbon Nanotube Forest and Gold Nanoparticle platforms.

scientific article published on January 2009

Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis

scientific article published on 12 August 2019

Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi's sarcomagenesis and can promote the tumorigenic potential of viral latent genes

scientific article published on 01 January 2003

Epidermal growth factor receptor is a co-receptor for adeno-associated virus serotype 6.

scientific article

Epidermal loss of Gαq confers a migratory and differentiation defect in keratinocytes

scientific article

Epigenetics, noncoding RNAs, and cell signaling--crossroads in the regulation of cell fate decisions

scientific article published on 13 March 2013

Erlotinib and the Risk of Oral Cancer: The Erlotinib Prevention of Oral Cancer (EPOC) Randomized Clinical Trial.

scientific article published on 5 November 2015

Establishment of a novel cancer cell line derived from vulvar carcinoma associated with lichen sclerosus exhibiting a fibroblast-dependent tumorigenic potential

scientific article published on 23 October 2019

Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters

scientific journal article

Exploiting PI3K/mTOR signaling to accelerate epithelial wound healing ⬇️

scientific article published on February 4, 2013

Exploiting the head and neck cancer oncogenome: widespread PI3K-mTOR pathway alterations and novel molecular targets

scientific article

Expression of an active Gαs mutant in skeletal stem cells is sufficient and necessary for fibrous dysplasia initiation and maintenance.

scientific article

Expression of heme oxygenase-1 in non-small cell lung cancer (NSCLC) and its correlation with clinical data.

scientific article

Flavopiridol, a novel cyclin-dependent kinase inhibitor, suppresses the growth of head and neck squamous cell carcinomas by inducing apoptosis

scientific article

Fluorescent, bioactive protein nanoparticles (prodots) for rapid, improved cellular uptake.

scientific article

Functional roles of Akt signaling in mouse skin tumorigenesis.

scientific article published on January 2002

Further evidence of interaction between vasodilator beta 2- and vasoconstrictor alpha 2-adrenoceptor-mediated responses in maintaining vascular tone in anesthetized rats.

scientific article published in December 1989

Future directions and treatment strategies for head and neck squamous cell carcinomas

scientific article

G Protein Coupled Receptors and Heterotrimeric G Proteins as Cancer Drivers

scientific article published on 03 December 2020

G-protein-coupled receptors and cancer.

scientific article

G-protein-coupled receptors and signaling networks: emerging paradigms.

scientific article

GENIPAC: A Genomic Information Portal for Head and Neck Cancer Cell Systems

scientific article published in March 2018

GNASR201C Induces Pancreatic Cystic Neoplasms in Mice That Express Activated KRAS by Inhibiting YAP1 Signaling

scientific article published on 22 August 2018

Gene discovery in oral squamous cell carcinoma through the Head and Neck Cancer Genome Anatomy Project: confirmation by microarray analysis.

scientific article

Gene expression changes in a patient presenting nonleukaemic nasal granulocytic sarcoma to acute myelogenous leukaemia using 40 K cDNA microarray

scientific article published on 01 August 2006

Gene expression in human oral squamous cell carcinoma is influenced by risk factor exposure.

scientific article

Gene expression profiles in squamous cell carcinomas of the oral cavity: use of laser capture microdissection for the construction and analysis of stage-specific cDNA libraries.

scientific article

Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma

scientific article

Genetic evidence that β-arrestins are dispensable for the initiation of β2-adrenergic receptor signaling to ERK.

scientific article published on 20 June 2017

Genetic variants affecting equivalent protein family positions reflect human diversity.

scientific article published on 6 October 2017

Genetically-defined novel oral squamous cell carcinoma cell lines for the development of molecular therapies.

scientific article published on April 2016

Genome-wide prediction of synthetic rescue mediators of resistance to targeted and immunotherapy

scientific article published on 11 March 2019

Germline genetic variation modulates tumor progression and metastasis in a mouse model of neuroendocrine prostate carcinoma.

scientific article

Global gene expression profile of nasopharyngeal carcinoma by laser capture microdissection and complementary DNA microarrays.

scholarly article

Global gene expression profiles of human head and neck squamous carcinoma cell lines.

scientific article published on November 2004

Growth factor-sensitive molecular targets identified in primary and metastatic head and neck squamous cell carcinoma using microarray analysis.

scientific article published on 2 November 2005

Gα12 Requires Acylation for Its Transforming Activity ⬇️

scientific article published on March 3, 1998

Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins

scientific article published on 16 November 2018

HPV E2, E4, E5 drive alternative carcinogenic pathways in HPV positive cancers

scientific article published on 26 August 2020

HPV16 E5 Mediates Resistance to PD-L1 Blockade and Can Be Targeted with Rimantadine in Head and Neck Cancer

scientific article published on 17 December 2019

Head and Neck Cancer in the New Era of Precision Medicine

scientific article published on 01 June 2018

Heparin inhibits angiotensin II-induced vasoconstriction on isolated mouse mesenteric resistance arteries through Rho-A- and PKA-dependent pathways

scientific article published on 23 December 2012

Heterotrimeric G-protein alpha-12 (Gα12) subunit promotes oral cancer metastasis.

scientific article

Hippo-independent activation of YAP by the GNAQ uveal melanoma oncogene through a trio-regulated rho GTPase signaling circuitry.

scientific article

Homo- and hetero-oligomerization of PDZ-RhoGEF, LARG and p115RhoGEF by their C-terminal region regulates their in vivo Rho GEF activity and transforming potential

scientific article (publication date: 8 January 2004)

How mitogen-activated protein kinases recognize and phosphorylate their targets: A QM/MM study.

scientific article published on May 2009

Human JIK, a novel member of the STE20 kinase family that inhibits JNK and is negatively regulated by epidermal growth factor

scientific article

Hypoxia-induced energy stress inhibits the mTOR pathway by activating an AMPK/REDD1 signaling axis in head and neck squamous cell carcinoma.

scientific article published on November 2008

IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells ⬇️

scientific article published on December 1, 1992

Identification and characterization of a novel Ste20/germinal center kinase-related kinase, polyploidy-associated protein kinase

scientific journal article

Identification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes.

scientific article

Identification of the Rac-GEF P-Rex1 as an essential mediator of ErbB signaling in breast cancer.

scientific article

Illuminating G-Protein-Coupling Selectivity of GPCRs

scientific article published on 31 May 2019

Illuminating the Onco-GPCRome: Novel G protein-coupled receptor-driven oncocrine networks and targets for cancer immunotherapy

scientific article published on 05 June 2019

Imaging the distribution of individual platinum-based anticancer drug molecules attached to single-wall carbon nanotubes

scientific article published on October 2009

Immune Modulation of Head and Neck Squamous Cell Carcinoma and the Tumor Microenvironment by Conventional Therapeutics

scientific article published on 27 February 2019

Immunolocalization of c-Fos and c-Jun in human oral mucosa and in oral squamous cell carcinoma.

scientific article

Impairing squamous differentiation by Klf4 deletion is sufficient to initiate tongue carcinoma development upon K-Ras activation in mice

scientific article published on 22 October 2013

Improved clearance during treatment of HPV-positive head and neck cancer through mTOR inhibition.

scientific article published on June 2013

Inactivating mutations in GNA13 and RHOA in Burkitt's lymphoma and diffuse large B-cell lymphoma: a tumor suppressor function for the Gα13/RhoA axis in B cells.

scientific article published on 30 November 2015

Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.

scientific article published on 11 May 2015

Increased angiotensin II receptors in brain nuclei of DOCA-salt hypertensive rats ⬇️

scientific article published on September 1, 1988

Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats ⬇️

scientific article published on January 1, 1988

Induction of apoptosis in head-and-neck squamous carcinoma cells by gamma-irradiation and bleomycin is p53-independent

scientific article published on 01 December 2000

Induction of ovarian cancer by defined multiple genetic changes in a mouse model system

scientific article

Inhibition of Mammalian target of rapamycin by rapamycin causes the regression of carcinogen-induced skin tumor lesions.

scientific article

Inhibition of Pin1 reduces glutamate-induced perikaryal accumulation of phosphorylated neurofilament-H in neurons

scientific article

Inhibition of basic leucine zipper transcription is a major mediator of atrial dilatation

scientific article (publication date: June 2006)

Inhibition of mTOR Signaling and Clinical Activity of Rapamycin in Head and Neck Cancer in a Window of Opportunity Trial

scientific article published on 12 November 2018

Insights into epithelial cell senescence from transcriptome and secretome analysis of human oral keratinocytes

scientific article published on 12 February 2021

Insights into β2-adrenergic receptor binding from structures of the N-terminal lobe of ARRDC3.

scientific article

Insulin-like Growth Factor-I Inhibits the Stress-activated Protein Kinase/c-Jun N-terminal Kinase ⬇️

scientific article published on October 2, 1998

Integrative computational analysis of transcriptional and epigenetic alterations implicates DTX1 as a putative tumor suppressor gene in HNSCC

scientific article published on 27 January 2017

Integrin function: molecular hierarchies of cytoskeletal and signaling molecules

scientific article (publication date: November 1995)

Integrin αβ1, αvβ, α6β effectors p130Cas, Src and talin regulate carcinoma invasion and chemoresistance

scientific article

Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors

scientific article

Interaction Landscape of Inherited Polymorphisms with Somatic Events in Cancer.

scientific article published on 10 February 2017

Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer.

scientific article published on 4 April 2011

Interleukin-21 expression and its association with proinflammatory cytokines in untreated chronic periodontitis patients.

scientific article published on 19 December 2011

Interpretation of cancer mutations using a multiscale map of protein systems

scientific article published on 01 October 2021

Investigation of the catalytic mechanism of farnesyl pyrophosphate synthase by computer simulation

scientific article published on 01 September 2006

Kaposi sarcoma-associated herpesvirus promotes tumorigenesis by modulating the Hippo pathway.

scientific article

Kaposi's sarcoma virally encoded, G-protein-coupled receptor: a paradigm for paracrine transformation.

scientific article published in January 2009

Keeping the epidermal stem cell niche in shape

scientific article published on 01 August 2010

LAG-3 confers poor prognosis and its blockade reshapes antitumor response in head and neck squamous cell carcinoma.

scientific article published on 7 October 2016

LKB1/AMPK and PKA control ABCB11 trafficking and polarization in hepatocytes

scientific article

Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.

scientific article

Laser capture microdissection-based in vivo genomic profiling of wound keratinocytes identifies similarities and differences to squamous cell carcinoma

scientific article

Levels of sirolimus in saliva and blood following mouthwash application

scientific article published on 24 March 2014

Levels of sirolimus in saliva and blood following oral topical sustained-release varnish delivery system application

scientific article published on 11 March 2015

Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma

scientific article published on 01 January 1997

Liver kinase B1 regulates hepatocellular tight junction distribution and function in vivo

scientific article published on 11 July 2016

Longitudinal imaging studies of tumor microenvironment in mice treated with the mTOR inhibitor rapamycin.

scientific article

Loss of TGF-β signaling and PTEN promotes head and neck squamous cell carcinoma through cellular senescence evasion and cancer-related inflammation.

scientific article published on 31 October 2011

Lower number of atrial natriuretic peptide receptors in thymocytes and spleen cells of spontaneously hypertensive rats.

scientific article published in December 1987

MPA-induced gene expression and stromal and parenchymal gene expression profiles in luminal murine mammary carcinomas with different hormonal requirements.

scientific article

MT1-MMP controls tumor-induced angiogenesis through the release of semaphorin 4D.

scientific article

Massively parallel sequencing reveals an accumulation of de novo mutations and an activating mutation of LPAR1 in a patient with metastatic neuroblastoma

scientific article

Matrix metalloproteinase-activated anthrax lethal toxin demonstrates high potency in targeting tumor vasculature

scientific article published on November 2007

Measurement of biomarker proteins for point-of-care early detection and monitoring of cancer

scientific article

Meeting report--the NIDCR 2(nd) Salivary Gland Tumor Meeting, November 2008

scientific article published on 01 December 2009

Melanoma cell lysate induces CCR7 expression and in vivo migration to draining lymph nodes of therapeutic human dendritic cells.

scientific article published on July 2014

Metabotropic glutamate receptors activate phospholipase D in astrocytes through a protein kinase C-dependent and Rho-independent pathway.

scientific article published in February 2003

Metformin Inhibits Progression of Head and Neck Squamous Cell Carcinoma by Acting Directly on Carcinoma-Initiating Cells

scientific article published on 10 July 2019

Metformin Is Associated With Reduced Odds for Colorectal Cancer Among Persons With Diabetes

scientific article published on 11 November 2019

Metformin prevents the development of oral squamous cell carcinomas from carcinogen-induced premalignant lesions

scientific article

Microfluidic electrochemical immunoarray for ultrasensitive detection of two cancer biomarker proteins in serum

scientific article

Mitogen-activated protein kinases promote WNT/beta-catenin signaling via phosphorylation of LRP6.

scientific article

Modular architecture and novel protein-protein interactions regulating the RGS-containing Rho guanine nucleotide exchange factors.

scientific article

Modulation of canonical Wnt signaling by the extracellular matrix component biglycan

scientific article

Molecular cross-talk between the NFkappaB and STAT3 signaling pathways in head and neck squamous cell carcinoma

scientific article

Molecular mechanisms deployed by virally encoded G protein-coupled receptors in human diseases

scientific article

Multiple PPPS/TP motifs act in a combinatorial fashion to transduce Wnt signaling through LRP6.

scientific article

Multiple mitogen-activated protein kinase signaling pathways connect the cot oncoprotein to the c-jun promoter and to cellular transformation

scientific article

Muscarinic receptors promote castration-resistant growth of prostate cancer through a FAK-YAP signaling axis

scientific article published on 23 March 2020

Mutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells ⬇️

scientific article published on October 1, 1992

NOTCH1 inhibition enhances the efficacy of conventional chemotherapeutic agents by targeting head neck cancer stem cell.

scientific article published on 25 April 2016

Nano delivers big: designing molecular missiles for cancer therapeutics

scientific article published on January 2011

Nanostructured immunosensor for attomolar detection of cancer biomarker interleukin-8 using massively labeled superparamagnetic particles

scientific article published on 30 June 2011

Neuronal nuclear organization is controlled by cyclin-dependent kinase 5 phosphorylation of Ras Guanine nucleotide releasing factor-1.

scientific article published on 18 August 2006

Non-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesis

scientific article

Novel 1-Phenylcycloalkanecarboxylic Acid Derivatives Are Potent and Selective .sigma.1 Ligands

scientific article published on 01 July 1994

Novel Molecular Mediators in the Pathway Connecting G-protein-coupled Receptors to MAP Kinase Cascades

scientific article published on 01 May 1999

Novel insights into G protein and G protein-coupled receptor signaling in cancer

scientific article

Nuclear localization of heme oxygenase-1 is associated with tumor progression of head and neck squamous cell carcinomas.

scientific article

Nuclear mapping of nanodrug delivery systems in dynamic cellular environments

scientific article

Onco-GPCR signaling and dysregulated expression of microRNAs in human cancer.

scientific article

Oncotargeting G proteins: The Hippo in the room.

scientific article

Oral Cancer: Integration of Studies for Diagnostic and Therapeutic Precision

scientific article published on 01 November 2019

Oral and Pharyngeal Epithelial Keratinocyte Culture ⬇️

scientific article published on January 1, 2013

Overexpression of mammalian protein kinase C-zeta does not affect the growth characteristics of NIH 3T3 cells.

scientific article published on August 1995

P-REX2, a novel PI-3-kinase sensitive Rac exchange factor.

scientific article

P-Rex1 links mammalian target of rapamycin signaling to Rac activation and cell migration

scientific article

PD-1 blockade attenuates immunosuppressive myeloid cells due to inhibition of CD47/SIRPα axis in HPV negative head and neck squamous cell carcinoma

scientific article published on 7 November 2015

PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.

scientific article

PDZ-RhoGEF and LARG are essential for embryonic development and provide a link between thrombin and LPA receptors and Rho activation

scientific article published on 6 March 2013

PI3K pathway is involved in ERK signaling cascade activation by histamine H2R agonist in HEK293T cells

scientific article published on 15 June 2016

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

scientific article

PLC-γ activation is required for PDGF-βR-mediated mitogenesis and monocytic differentiation of myeloid progenitor cells

scientific article published on 01 July 1997

PRECOG: PREdicting COupling probabilities of G-protein coupled receptors

scientific article published on 01 July 2019

PTEN deficiency contributes to the development and progression of head and neck cancer.

scientific article published on May 2013

Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis.

scientific article published on September 2010

Persistent activation of Rac1 in squamous carcinomas of the head and neck: evidence for an EGFR/Vav2 signaling axis involved in cell invasion.

scientific article published on 18 January 2007

Persistent activation of the Akt pathway in head and neck squamous cell carcinoma: a potential target for UCN-01.

scientific article published on June 2004

Pharmacologic stem cell based intervention as a new approach to osteoporosis treatment in rodents

scientific article

Phase 1 dose-finding study of metformin in combination with concurrent cisplatin and radiotherapy in patients with locally advanced head and neck squamous cell cancer

scientific article published on 18 October 2019

Phase II trial of everolimus in patients with previously treated recurrent or metastatic head and neck squamous cell carcinoma.

scientific article published on 27 May 2016

Phosphatidylinositol-4-phosphate 5-kinase and GEP100/Brag2 protein mediate antiangiogenic signaling by semaphorin 3E-plexin-D1 through Arf6 protein

scientific article

Phosphoinositide 3-kinase gamma is a mediator of Gbetagamma-dependent Jun kinase activation

scientific article published on 01 January 1998

Phosphorylation of c-Fos by members of the p38 MAPK family. Role in the AP-1 response to UV light.

scientific article published on 10 February 2005

Phosphorylation of the carboxyl-terminal transactivation domain of c-Fos by extracellular signal-regulated kinase mediates the transcriptional activation of AP-1 and cellular transformation induced by platelet-derived growth factor.

scientific article published in October 2003

Plexin B regulates Rho through the guanine nucleotide exchange factors leukemia-associated Rho GEF (LARG) and PDZ-RhoGEF

scientific article (publication date: 8 November 2002)

Plexin B1 is downregulated in renal cell carcinomas and modulates cell growth.

scientific article published on 7 January 2008

Plexin-B1 utilizes RhoA and Rho kinase to promote the integrin-dependent activation of Akt and ERK and endothelial cell motility

scientific article published on 12 September 2007

Polymeric Nanovehicle Regulated Spatiotemporal Real-Time Imaging of the Differentiation Dynamics of Transplanted Neural Stem Cells after Traumatic Brain Injury

scientific article published on 02 June 2015

Potent activation of RhoA by Galpha q and Gq-coupled receptors.

scientific article

Prevention of irradiation-induced salivary hypofunction by rapamycin in swine parotid glands.

scientific article published on 06 March 2016

Prevention of tumor growth driven by PIK3CA and HPV oncogenes by targeting mTOR signaling with metformin in oral squamous carcinomas expressing OCT3.

scientific article

Preventive and therapeutic effects of Smad7 on radiation-induced oral mucositis

scientific article published on 10 March 2013

Profiling EGFR activity in head and neck squamous cell carcinoma by using a novel layered membrane Western blot technology.

scientific article

Progressive tumor formation in mice with conditional deletion of TGF-beta signaling in head and neck epithelia is associated with activation of the PI3K/Akt pathway.

scientific article published on 07 July 2009

Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis.

scientific article published on 17 November 2005

Protein kinase C-zeta reverts v-raf transformation of NIH-3T3 cells

scientific article published on June 1996

Proteome-wide analysis of head and neck squamous cell carcinomas using laser-capture microdissection and tandem mass spectrometry.

scientific article

Proteomic analysis of laser-captured paraffin-embedded tissues: a molecular portrait of head and neck cancer progression.

scientific article

Proteomic profiling of the cancer microenvironment by antibody arrays ⬇️

scientific article published on October 1, 2001

RCAS/SCL-TVA animal model allows targeted delivery of polyoma middle T oncogene to vascular endothelial progenitors in vivo and results in hemangioma development.

scientific article

RGS-containing RhoGEFs: the missing link between transforming G proteins and Rho?

scientific article (publication date: 26 March 2001)

Rab25 regulates invasion and metastasis in head and neck cancer.

scientific article published on 22 January 2013

Rac inhibits thrombin-induced Rho activation: evidence of a Pak-dependent GTPase crosstalk

scientific article published on 6 December 2006

Rac1 and RhoG promote cell survival by the activation of PI3K and Akt, independently of their ability to stimulate JNK and NF-kappaB

scientific article (publication date: 10 January 2002)

Rac1 is required for epithelial stem cell function during dermal and oral mucosal wound healing but not for tissue homeostasis in mice.

scientific article

Rapamycin prevents early onset of tumorigenesis in an oral-specific K-ras and p53 two-hit carcinogenesis model.

scientific article published on 12 May 2009

Rapid development of salivary gland carcinomas upon conditional expression of K-ras driven by the cytokeratin 5 promoter

scientific article

Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm

scientific article published on 23 July 2019

Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits.

scientific article published on June 1994

Receptor tyrosine kinases activate canonical WNT/β-catenin signaling via MAP kinase/LRP6 pathway and direct β-catenin phosphorylation

scientific article

Reciprocal negative regulation between S100A7/psoriasin and beta-catenin signaling plays an important role in tumor progression of squamous cell carcinoma of oral cavity.

scientific article published on 28 January 2008

Reduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activation

scientific article

Reducing the burden of oral and pharyngeal cancers.

scientific article published in June 1998

Regulation of G protein-linked guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and LARG by tyrosine phosphorylation: evidence of a role for focal adhesion kinase

scientific article (publication date: 5 April 2002)

Regulation of c-myc expression by PDGF through Rho GTPases.

scientific article published on June 2001

Regulation of gene expression by the small GTPase Rho through the ERK6 (p38 gamma) MAP kinase pathway.

scientific article

Regulation of mitogen-activated protein kinase signaling networks by G protein-coupled receptors.

scientific article

Regulation of p73 by c-Abl through the p38 MAP kinase pathway.

scientific article published on January 2002

Regulation of reactive-oxygen-species generation in fibroblasts by Rac1.

scientific article published on September 1996

Regulation of the transcriptional activity of c-Fos by ERK. A novel role for the prolyl isomerase PIN1.

scientific article published on 25 August 2005

Remodeling of VE-cadherin junctions by the human herpes virus 8 G-protein coupled receptor.

scientific article published on 6 September 2010

Requirement of Rac1 distinguishes follicular from interfollicular epithelial stem cells

scientific article published on 05 March 2007

Requirement of phosphatidylinositol-3 kinase for activation of JNK/SAPKs by PDGF

scientific article published on 01 March 1997

RhoA and ROCK mediate histamine-induced vascular leakage and anaphylactic shock.

scientific article

Robo4 signaling in endothelial cells implies attraction guidance mechanisms.

scientific article published on 15 February 2006

Role for EPS8 in squamous carcinogenesis.

scientific article

Role of GRB2‐associated binder 1 in epidermal growth factor receptor‐induced signaling in head and neck squamous cell carcinoma ⬇️

scientific article published on August 28, 2012

Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts.

scientific article published on January 1999

SDF-1/CXCL12 induces directional cell migration and spontaneous metastasis via a CXCR4/Gαi/mTORC1 axis

scientific article published on 2 December 2014

SET overexpression decreases cell detoxification efficiency: ALDH2 and GSTP1 are downregulated, DDR is impaired and DNA damage accumulates.

scientific article

SOX2 Epidermal Overexpression Promotes Cutaneous Wound Healing via Activation of EGFR/MEK/ERK Signaling Mediated by EGFR Ligands

scientific article published on 14 February 2019

Scaffold proteins dictate Rho GTPase-signaling specificity

scientific article

Scientific progress in understanding oral and pharyngeal cancers ⬇️

scientific article published on June 1, 1998

Selective effects of activation of protein kinase C isozymes on cyclic AMP accumulation ⬇️

scientific article published on February 1, 1991

Semaphorin 3E initiates antiangiogenic signaling through plexin D1 by regulating Arf6 and R-Ras.

scientific article

Semaphorin 4D provides a link between axon guidance processes and tumor-induced angiogenesis.

scholarly article

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

scientific article

Semaphorin signaling in angiogenesis, lymphangiogenesis and cancer

scientific article published on 2 February 2012

Signaling circuitries controlling stem cell fate: to be or not to be ⬇️

scientific article published on August 29, 2011

Signaling from E-cadherins to the MAPK pathway by the recruitment and activation of epidermal growth factor receptors upon cell-cell contact formation.

scientific article published on December 2000

Signaling from G protein-coupled receptors to the c-jun promoter involves the MEF2 transcription factor. Evidence for a novel c-jun amino-terminal kinase-independent pathway.

scientific article published on August 1997

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret.

scientific article published on May 1998

Signals and Receptors

scientific article published on April 2016

Single-wall carbon nanotube forest arrays for immunoelectrochemical measurement of four protein biomarkers for prostate cancer

scientific article

Snail up-regulates proinflammatory mediators and inhibits differentiation in oral keratinocytes

scientific article published on June 2008

Somatic mutation of GRIN2A in malignant melanoma results in loss of tumor suppressor activity via aberrant NMDAR complex formation

scientific article

Sonic Hedgehog in SCLC.

scientific article published on 26 September 2015

Stable SET knockdown in head and neck squamous cell carcinoma promotes cell invasion and the mesenchymal-like phenotype in vitro, as well as necrosis, cisplatin sensitivity and lymph node metastasis in xenograft tumor models

scientific article published on 20 February 2014

Structural and Biochemical Basis for Ubiquitin Ligase Recruitment by Arrestin-related Domain-containing Protein-3 (ARRDC3)

scientific article

Structure of the C-terminal guanine nucleotide exchange factor module of Trio in an autoinhibited conformation reveals its oncogenic potential

scientific article published on 19 February 2019

Syngeneic animal models of tobacco-associated oral cancer reveal the activity of in situ anti-CTLA-4

scientific article published on 05 December 2019

TGF-beta receptor I conditional knockout mice develop spontaneous squamous cell carcinoma.

scientific article published on 5 June 2007

TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation.

scientific article published on 9 June 2008

TRAIL induces apoptosis in oral squamous carcinoma cells--a crosstalk with oncogenic Ras regulated cell surface expression of death receptor 5.

scientific article published on February 2013

Targeted killing of cancer cells in vivo and in vitro with EGF-directed carbon nanotube-based drug delivery.

scientific article

Targeted therapeutic nanotubes influence the viscoelasticity of cancer cells to overcome drug resistance

scientific article

Targeting mTOR in Head and Neck Cancer-Response

scientific article published on 01 November 2019

Temporal-specific roles of Rac1 during vascular development and retinal angiogenesis.

scientific article published on 10 February 2016

The Constitutively Active Mutant Gα13Transforms Mouse Fibroblast Cells Deficient in Insulin-like Growth Factor-I Receptor ⬇️

scientific article published on November 21, 1997

The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4.

scientific article

The Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor as a therapeutic target for the treatment of Kaposi's sarcoma.

scientific article published on January 2006

The NOTCH4-HEY1 pathway induces epithelial mesenchymal transition in head and neck squamous cell carcinoma

scientific article published on 16 November 2017

The Next Frontier: Head and Neck Cancer Immunoprevention.

scientific article published on 14 November 2017

The P34G mutation reduces the transforming activity of K-Ras and N-Ras in NIH 3T3 cells but not of H-Ras.

scientific article published on 4 June 2004

The PH domain of Ras-GAP is sufficient for in vitro binding to beta gamma subunits of heterotrimeric G proteins.

scientific article

The Pathways Connecting G Protein-coupled Receptors to the Nucleus through Divergent Mitogen-activated Protein Kinase Cascades ⬇️

scientific article published on January 23, 1998

The basic domain of HIV-tat transactivating protein is essential for its targeting to lipid rafts and regulating fibroblast growth factor-2 signaling in podocytes isolated from children with HIV-1-associated nephropathy

scientific article

The beta-catenin axis integrates multiple signals downstream from RET/papillary thyroid carcinoma leading to cell proliferation.

scientific article published on 17 February 2009

The biology of tobacco and nicotine: bench to bedside.

scientific article

The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer.

scientific article

The expression of sphingosine kinase-1 in head and neck carcinoma

scientific article

The head and neck cancer cell oncogenome: a platform for the development of precision molecular therapies

scientific article

The homozygous CX3CR1-M280 mutation impairs human monocyte survival.

scientific article published on 8 February 2018

The p53 tumor suppressor targets a novel regulator of G protein signaling ⬇️

scientific article published on July 22, 1997

The pathway connecting muscarinic acetylcholine receptors to the nucleus involves small GTP-binding proteins

scientific article published on 01 January 1998

The platelet-derived growth factor controls c-myc expression through a JNK- and AP-1-dependent signaling pathway.

scientific article published on 30 September 2003

The ras-related GTPase rac1 regulates a proliferative pathway selectively utilized by G-protein coupled receptors ⬇️

scientific article published on September 24, 1998

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG

scientific article

The small GTP-binding protein Rho links G protein-coupled receptors and Galpha12 to the serum response element and to cellular transformation.

scientific article published on September 1997

The small GTP-binding protein RhoA regulates c-jun by a ROCK-JNK signaling axis.

scientific article published on April 2004

The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway

scientific article (publication date: 30 June 1995)

Thrombin protease-activated receptor-1 signals through Gq- and G13-initiated MAPK cascades regulating c-Jun expression to induce cell transformation.

scientific article published on 3 September 2003

Transcriptional signature primes human oral mucosa for rapid wound healing.

scientific article published in July 2018

Transforming G protein-coupled receptors potently activate JNK (SAPK). Evidence for a divergence from the tyrosine kinase signaling pathway.

scientific article published on March 1995

Translocation of the FGR protein-tyrosine kinase as a consequence of neutrophil activation.

scientific article

Treatment with clorgyline and pargyline differentially decreases clonidine-induced hypotension and bradycardia.

scientific article published on September 1984

Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors

scientific article published on 01 March 1998

Tyrosine phosphorylation coupled to IgE receptor-mediated signal transduction and histamine release ⬇️

scientific article published on July 1, 1990

Tyrosine phosphorylation of the vav proto-oncogene product links FcepsilonRI to the Rac1-JNK pathway

scientific journal article

Ultrasensitive detection of cancer biomarkers in the clinic by use of a nanostructured microfluidic array

scientific article

Ultrasensitive electrochemical immunosensor for oral cancer biomarker IL-6 using carbon nanotube forest electrodes and multilabel amplification.

scientific article

Ultrasensitive immunosensor for cancer biomarker proteins using gold nanoparticle film electrodes and multienzyme-particle amplification.

scientific article published on March 2009

Uncoupling of epidermal growth factor-dependent proliferation and invasion in a model of squamous carcinoma progression.

scientific article published on August 2005

Unraveling the oral cancer lncRNAome: Identification of novel lncRNAs associated with malignant progression and HPV infection

scientific article

Using Heterologous COS-7 Cells to Identify Semaphorin-Signaling Components.

scientific article

VE-cadherin and claudin-5: it takes two to tango.

scientific article published on August 2008

VEGF controls endothelial-cell permeability by promoting the beta-arrestin-dependent endocytosis of VE-cadherin

scientific journal article

Viral hijacking of G-protein-coupled-receptor signalling networks.

scientific article

Voltage-gated Na+ Channel Activity Increases Colon Cancer Transcriptional Activity and Invasion Via Persistent MAPK Signaling

scientific article published on 22 June 2015

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα12/13.

scientific article published on 25 July 2016

[VE-cadherin takes a walk on the wild side]

scientific article published on 01 February 2007

c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptase

scientific article

cAMP-dependent activation of the Rac guanine exchange factor P-REX1 by type I protein kinase A (PKA) regulatory subunits.

scientific article

mTOR Inhibitors and its Role in the Treatment of Head and Neck Squamous Cell Carcinoma ⬇️

scientific article published on March 1, 2012

mTOR as a molecular target in HPV-associated oral and cervical squamous carcinomas

scientific article

mTOR co-targeting in cetuximab resistance in head and neck cancers harboring PIK3CA and RAS mutations

scientific article

mTOR co-targeting strategies for head and neck cancer therapy

scientific article published on 18 August 2017

mTOR inhibition prevents epithelial stem cell senescence and protects from radiation-induced mucositis.

scientific article

mTOR inhibition prevents rapid-onset of carcinogen-induced malignancies in a novel inducible HPV-16 E6/E7 mouse model.

scientific article published on 18 August 2016

mTOR mediates Wnt-induced epidermal stem cell exhaustion and aging.

scientific article

mom identifies a receptor for the Drosophila JAK/STAT signal transduction pathway and encodes a protein distantly related to the mammalian cytokine receptor family

scientific article

p21-Activated kinase 1 is required for efficient tumor formation and progression in a Ras-mediated skin cancer model.

scientific article

p35/cyclin-dependent kinase 5 phosphorylation of ras guanine nucleotide releasing factor 2 (RasGRF2) mediates Rac-dependent Extracellular Signal-regulated kinase 1/2 activity, altering RasGRF2 and microtubule-associated protein 1b distribution in ne

scientific article

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