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List of works by Ken G Smith

A CD8<sup>+</sup> NK cell transcriptomic signature associated with clinical outcome in relapsing remitting multiple sclerosis

scientific article published on 27 January 2021

A blood-based prognostic biomarker in IBD

scientific article published on 27 April 2019

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

scientific article

A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.

scientific article

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

scientific article

Absence of hyperacute rejection and preservation of function in HDAF transgenic pig kidneys exposed to prolonged cold ischaemia

scientific article published on 01 August 2000

Affinity maturation of the primary response by V gene diversification.

scientific article published on January 1998

Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.

scientific article published in June 2005

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

scientific article

Antibody repertoire analysis in polygenic autoimmune diseases

scientific article published on 16 April 2018

Association Between Genetic Variation in FOXO3 and Reductions in Inflammation and Disease Activity in Inflammatory Polyarthritis

scientific article published on 23 May 2016

Augmentin-induced jaundice with a fatal outcome

scientific article

Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII

scientific article published on 01 February 2000

B Cell Fcγ Receptor IIb Modulates Atherosclerosis in Male and Female Mice by Controlling Adaptive Germinal Center and Innate B-1-Cell Responses

scientific article published on 16 May 2019

B cell inhibitory receptors and autoimmunity.

scientific article

B cells in glomerulonephritis: focus on lupus nephritis.

scientific article published on 18 October 2007

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

scientific article published in December 1994

Belimumab in kidney transplantation: an experimental medicine, randomised, placebo-controlled phase 2 trial

scientific article published on 14 June 2018

CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

scientific article published on 01 November 1999

CD22 and autoimmune disease.

scientific article published on October 2012

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

scientific article

CTLA4Ig alters the course of autoimmune disease development in Lyn-/- mice

article

Combined Influence of B-Cell Receptor Rearrangement and Somatic Hypermutation on B-Cell Class-Switch Fate in Health and in Chronic Lymphocytic Leukemia

article

Comment on "The inhibiting Fc receptor for IgG, FcγRIIB, is a modifier of autoimmune susceptibility"

scientific article published on 01 December 2011

Comparison of gene expression microarray data with count-based RNA measurements informs microarray interpretation

scientific article

Correction: Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus.

scientific article published on 16 October 2013

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

scientific article published in October 1996

Cross-phenotype analysis of Immunochip data identifies KDM4C as a relevant locus for the development of systemic vasculitis. ⬇️

scientific article

De-functioning polymorphism in the inhibitory receptor FcγRIIB does not impact upon kidney allograft survival

scientific article published on 01 December 2014

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

scientific article published on October 2006

Dependence of surface monoclonal antibody binding on dynamic changes in FcgammaRIIb expression

scientific article published on 24 January 2008

Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa

scientific article published on 06 May 2009

Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

scientific article

EROS mutations: decreased NADPH oxidase function and chronic granulomatous disease

scientific article published on 09 October 2018

Effects of viral inhibitors of apoptosis in models of mammalian cell death

scientific article published on 01 October 1996

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

scientific article

Emerging concepts in the pathogenesis of antineutrophil cytoplasmic antibody-associated vasculitis.

scientific article

Envenomation by the small-scaled snake: the world's most venomous snake

scientific article published on 01 July 1992

Eros is a novel transmembrane protein that controls the phagocyte respiratory burst and is essential for innate immunity

scientific article published on 28 March 2017

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

scientific article

FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.

scientific article published on May 2010

FcgammaRIIB, FcgammaRIIIB, and systemic lupus erythematosus.

scientific article published on January 2010

FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis.

scientific article

FcγRIIB and autoimmunity

scientific article

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

scientific article published on 18 February 2007

FcγRIIb differentially regulates pre-immune and germinal center B cell tolerance in mouse and human

scientific article published on 29 April 2019

FcγRIIb inhibits immune complex-induced VEGF-A production and intranodal lymphangiogenesis

scientific article

Foxp3+ follicular regulatory T cells control the germinal center response.

scientific article

Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice ⬇️

scientific article published on December 27, 2010

Genetic variation, Fcγ receptors, KIRs and infection: the evolution of autoimmunity.

scientific article

Genome-wide association studies in Crohn's disease: Past, present and future.

scientific article published on 31 January 2018

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

scientific article published on 9 January 2017

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

scientific article published on 24 October 2013

Germline selection shapes human mitochondrial DNA diversity

scientific article published on 23 May 2019

Growth of porcine kidneys in their native and xenograft environment

scientific article published on 01 May 2000

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

scientific article published on 01 January 2004

How many memories does it take to make an SLE flare?

scientific article published on 01 July 2015

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

scientific article published on 12 September 2013

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

scientific article

Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance

scientific article published on 30 April 2019

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

scientific article

Increased red cell turnover in a line of CD22‐deficient mice is caused by Gpi1c: A model for hereditary haemolytic anaemia ⬇️

scientific article published on October 16, 2012

Inhibition of the B cell by CD22: a requirement for Lyn

scientific article

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

scientific article

Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.

scientific article

L31. A GWAS in ANCA-associated vasculitis: Will genetics help re-define clinical classification? ⬇️

scientific article published on March 11, 2013

Leucocyte subset-specific type 1 interferon signatures in SLE and other immune-mediated diseases

scientific article

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

scientific article published on 20 February 2013

Lipid Anti-Lipid Antibody Responses Correlate with Disease Activity in Systemic Lupus Erythematosus ⬇️

scientific article published on February 7, 2013

Local Renal Autoantibody Production in Lupus Nephritis ⬇️

scientific article published on November 18, 2010

Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment

scientific article published on 01 September 2006

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

scientific article published on 18 September 2005

Loss of the interleukin-6 receptor causes immunodeficiency, atopy, and abnormal inflammatory responses

scientific article published on 24 June 2019

Lymphangitis carcinomatosa on renal biopsy

scientific article published on 01 January 1994

MT-HESS: an efficient Bayesian approach for simultaneous association detection in OMICS datasets, with application to eQTL mapping in multiple tissues

scientific article

Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.

scientific article

Metabolic exhaustion in infection, cancer and autoimmunity.

scientific article

Metastatic endophthalmitis in dialysis patients

scientific article published on 01 January 1995

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

scientific article

NBEAL2 is required for neutrophil and NK cell function and pathogen defense

scientific article published on 7 August 2017

Novel aspects of autoimmunity.

scientific article published in November 2016

PRedicting Outcomes For Crohn's dIsease using a moLecular biomarkEr (PROFILE): protocol for a multicentre, randomised, biomarker-stratified trial

scientific article published on 05 December 2018

Patient stratification and genomics: flares, fizzlers and foxes.

scientific article published on 28 November 2012

Physiological aspects of pig-to-primate renal xenotransplantation

scientific article published on 01 October 2001

Pregnancy-related anaemia in a haemodialysis patient treated with erythropoietin

scientific article published on 01 January 1993

Prevalence and clinical challenges among adults with primary immunodeficiency and recombination-activating gene deficiency. ⬇️

scientific article published on 22 February 2018

Prognosis in autoimmune and infectious disease: new insights from genetics.

scientific article

Prope tolerance with induction using Campath 1H and low-dose cyclosporin monotherapy in 31 cadaveric renal allograft recipients

scientific article published on 01 March 2000

Randomized trial of enteric-coated mycophenolate sodium versus mycophenolate mofetil in multi-system autoimmune disease

scientific article

Receptor modulators of B-cell receptor signalling--CD19/CD22.

scientific article

Recurrent Kikuchi's disease

scientific article published on 01 July 1992

Reduced monocyte and macrophage TNFSF15/TL1A expression is associated with susceptibility to inflammatory bowel disease

scientific article published on 10 September 2018

Regulatory T cells and control of the germinal centre response

scientific article

Rituximab in Churg-Strauss syndrome.

scientific article published on April 2006

Siglec-G deficiency leads to more severe collagen-induced arthritis and earlier onset of lupus-like symptoms in MRL/lpr mice.

scientific article

Signalling lymphocyte activation molecule family member 9 is found on select subsets of antigen-presenting cells and promotes resistance to Salmonella infection

scientific article published on 28 January 2020

Single-cell multi-omics analysis of the immune response in COVID-19

scientific article published on 20 April 2021

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

scientific article published in May 1995

Soluble antigen can impede affinity maturation and the germinal center reaction but enhance extrafollicular immunoglobulin production.

scientific article published in August 1995

Suppression of the humoral immune response by mycophenolate mofetil

scientific article published on 01 January 1998

Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

scholarly article

T cell activation by anti-CD3 antibodies: function of Fc receptors on B cell blasts, but not resting B cells, and CD18 on the responding T cells

scientific article published on 01 September 1987

T cell activation by anti-T3 antibodies: comparison of IgG1 and IgG2b switch variants and direct evidence for accessory function of macrophage Fc receptors

scientific article published on 01 May 1986

T cell exhaustion and immune-mediated disease-the potential for therapeutic exhaustion.

scientific article

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

scientific article

T-cell exhaustion: understanding the interface of chronic viral and autoinflammatory diseases.

scientific article published on 31 August 2016

Targeted genomic analysis reveals widespread autoimmune disease association with regulatory variants in the TNF superfamily cytokine signalling network

scientific article published on 19 July 2016

The B-cell response to protein antigens in immunity and transplantation

scientific article published on 01 June 2008

The Contribution of Transcriptomics to Biomarker Development in Systemic Vasculitis and SLE.

scientific article published on January 2015

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

scientific article

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response ⬇️

scientific article published on June 2, 1997

The generation and maintenance of serum alloantibody.

scientific article

The immunopathology of ANCA-associated vasculitis

scientific article

The nervous spleen: The nervous spleen.

scientific article published in January 2008

The phenotype and fate of the antibody-forming cells of the splenic foci

scientific article published on 01 February 1996

Treatment of COVID-19 with remdesivir in the absence of humoral immunity: a case report

scientific article published on 14 December 2020

Wild immunology: converging on the real world.

scientific article published in October 2011

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

scientific article

miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease

scientific article published on 01 April 2022

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