List of works - Ken G Smith

Foxp3+ follicular regulatory T cells control the germinal center response.

scientific article

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

scientific article

FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.

scientific article published on May 2010

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

scientific article published on June 2, 1997

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

scientific article

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

scientific article published in May 1995

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

scientific article published on 18 September 2005

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

scientific article published on 18 February 2007

The phenotype and fate of the antibody-forming cells of the splenic foci

scientific article published on 01 February 1996

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

scientific article published on 12 September 2013

Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

scientific article

Inhibition of the B cell by CD22: a requirement for Lyn

scientific article

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

scientific article

A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.

scientific article

Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment

scientific article published on 01 September 2006

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

scientific article

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

scientific article

Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

scholarly article

CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

scientific article published on 01 November 1999

Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.

scientific article published in June 2005

FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis.

scientific article

Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII

scientific article published on 01 February 2000

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

scientific article published on October 2006

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

scientific article published in October 1996

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

scientific article published in December 1994

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

scientific article

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

scientific article

Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.

scientific article

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

scientific article published on 9 January 2017

FcgammaRIIB, FcgammaRIIIB, and systemic lupus erythematosus.

scientific article published on January 2010

B cell inhibitory receptors and autoimmunity.

scientific article

Local Renal Autoantibody Production in Lupus Nephritis

scientific article published on November 18, 2010

Suppression of the humoral immune response by mycophenolate mofetil

scientific article published on 01 January 1998

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

scientific article

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

scientific article published on 24 October 2013

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

scientific article published on 01 January 2004

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

scientific article

Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.

scientific article

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

scientific article

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

scientific article

Rituximab in Churg-Strauss syndrome.

scientific article published on April 2006

T cell activation by anti-T3 antibodies: comparison of IgG1 and IgG2b switch variants and direct evidence for accessory function of macrophage Fc receptors

scientific article published on 01 May 1986

Physiological aspects of pig-to-primate renal xenotransplantation

scientific article published on 01 October 2001

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

scientific article

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

scientific article published on 20 February 2013

Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice

scientific article published on December 27, 2010

Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa

scientific article published on 06 May 2009

Germline selection shapes human mitochondrial DNA diversity

scientific article published on 23 May 2019

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

scientific article

FcγRIIB and autoimmunity

scientific article

List of works by Ken G Smith

Foxp3+ follicular regulatory T cells control the germinal center response.

A dominant interfering mutant of FADD/MORT1 enhances deletion of autoreactive thymocytes and inhibits proliferation of mature T lymphocytes

FcgammaRIIB in autoimmunity and infection: evolutionary and therapeutic implications.

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection.

Soluble antigen can cause enhanced apoptosis of germinal-centre B cells.

Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts

FcγRIIb controls bone marrow plasma cell persistence and apoptosis

The phenotype and fate of the antibody-forming cells of the splenic foci

Human SNP links differential outcomes in inflammatory and infectious disease to a FOXO3-regulated pathway

Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection.

Inhibition of the B cell by CD22: a requirement for Lyn

bcl-2 transgene expression inhibits apoptosis in the germinal center and reveals differences in the selection of memory B cells and bone marrow antibody-forming cells

A multicenter survey of rituximab therapy for refractory antineutrophil cytoplasmic antibody-associated vasculitis.

Long-term comparison of rituximab treatment for refractory systemic lupus erythematosus and vasculitis: Remission, relapse, and re-treatment

A type I interferon transcriptional signature precedes autoimmunity in children genetically at risk for type 1 diabetes.

Efficient inhibition of miR-155 function in vivo by peptide nucleic acids

Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria.

CAMPATH IH ALLOWS LOW-DOSE CYCLOSPORINE MONOTHERAPY IN 31 CADAVERIC RENAL ALLOGRAFT RECIPIENTS

Alemtuzumab (CAMPATH 1H) induction therapy in cadaveric kidney transplantation--efficacy and safety at five years.

FcgammaRIIb balances efficient pathogen clearance and the cytokine-mediated consequences of sepsis.

Autoimmune-prone mice share a promoter haplotype associated with reduced expression and function of the Fc receptor FcgammaRII

Dendritic cell stimulation by mycobacterial Hsp70 is mediated through CCR5.

CrmA expression in T lymphocytes of transgenic mice inhibits CD95 (Fas/APO-1)-transduced apoptosis, but does not cause lymphadenopathy or autoimmune disease.

Bcl-2 increases memory B cell recruitment but does not perturb selection in germinal centers

Modules, networks and systems medicine for understanding disease and aiding diagnosis.

FAS is highly expressed in the germinal center but is not required for regulation of the B-cell response to antigen

Interleukin 4 reduces expression of inhibitory receptors on B cells and abolishes CD22 and Fc gamma RII-mediated B cell suppression.

Genome-wide association study identifies distinct genetic contributions to prognosis and susceptibility in Crohn's disease.

FcgammaRIIB, FcgammaRIIIB, and systemic lupus erythematosus.

B cell inhibitory receptors and autoimmunity.

Local Renal Autoantibody Production in Lupus Nephritis

Suppression of the humoral immune response by mycophenolate mofetil

Human T-follicular helper and T-follicular regulatory cell maintenance is independent of germinal centers

Genome-wide methylation analyses of primary human leukocyte subsets identifies functionally important cell-type-specific hypomethylated regions.

HSP70 peptide binding mutants separate antigen delivery from dendritic cell stimulation

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

Maintenance triple immunosuppression with cyclosporin A, mycophenolate sodium and steroids allows prolonged survival of primate recipients of hDAF porcine renal xenografts.

Insight into Genotype-Phenotype Associations through eQTL Mapping in Multiple Cell Types in Health and Immune-Mediated Disease

Immune complexes stimulate CCR7-dependent dendritic cell migration to lymph nodes

Rituximab in Churg-Strauss syndrome.

T cell activation by anti-T3 antibodies: comparison of IgG1 and IgG2b switch variants and direct evidence for accessory function of macrophage Fc receptors

Physiological aspects of pig-to-primate renal xenotransplantation

The contribution of genetic variation and infection to the pathogenesis of ANCA-associated systemic vasculitis

Leukocyte and serum S100A8/S100A9 expression reflects disease activity in ANCA-associated vasculitis and glomerulonephritis.

Genetic susceptibility to systemic lupus erythematosus protects against cerebral malaria in mice

Differential signal transduction, membrane trafficking, and immune effector functions mediated by FcgammaRI versus FcgammaRIIa

Germline selection shapes human mitochondrial DNA diversity

Analysis of a wild mouse promoter variant reveals a novel role for FcγRIIb in the control of the germinal center and autoimmunity.

FcγRIIB and autoimmunity