List of works - Pan Zheng

A Critical Role for Rictor in T Lymphopoiesis ⬇️

scientific article published on July 18, 2012

A critical role for the regulated wnt-myc pathway in naive T cell survival

scientific article

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.

scientific article published on 5 December 2017

A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing

scientific article published in May 2005

A role for cytoplasmic PML in cellular resistance to viral infection

scientific article

A single-nucleotide deletion leads to rapid degradation of TAP-1 mRNA in a melanoma cell line.

scientific article published on 11 February 2003

Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse.

scientific article published on 07 July 2009

An aptamer-based targeted delivery of miR-26a protects mice against chemotherapy toxicity while suppressing tumor growth

scientific article published on 22 June 2017

An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation

scientific article published on 29 January 2015

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

scientific article

Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.

scientific article published on 14 October 2004

Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes ⬇️

scientific article published on May 1, 2003

B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.

scientific article published on May 1998

B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo

scientific article published on 01 April 2002

B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.

scientific article published in February 2007

B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.

scientific article

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.

scientific article

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

scientific article published on 05 March 2009

CD24 is a genetic modifier for risk and progression of multiple sclerosis.

scientific article

CD24 on thymic APCs regulates negative selection of myelin antigen‐specific T lymphocytes ⬇️

scientific article published on January 19, 2012

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

scientific article

CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.

scientific article published on 6 February 2018

CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases.

scientific article published on 24 May 2007

CD24: from A to Z.

scientific article published on 15 February 2010

CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.

scientific article

CD62L is required for the priming of encephalitogenic T cells but does not play a major role in the effector phase of experimental autoimmune encephalomyelitis

scientific article published on 01 August 2006

CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

scientific article

Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator

scientific article published on 01 February 2002

Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity

scientific article published on 01 July 2006

Costimulation by B7 modulates specificity of cytotoxic T lymphocytes: a missing link that explains some bystander T cell activation.

scientific article

Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response

scientific article published on 01 July 2006

Cytopenia and autoimmune diseases: a vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells.

scientific article published on February 2013

Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells

scientific article

Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress

scientific article published on 29 April 2009

Dendritic cells in the thymus contribute to T-regulatory cell induction

scholarly article

FOXP3 Controls an miR-146/NF-κB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells

scientific article

FOXP3 and breast cancer: implications for therapy and diagnosis

scientific article published on 01 November 2007

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.

scientific article

FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.

scientific article published on December 2011

FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1

scientific article published on 14 January 2013

FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus

scientific article

FOXP3: genetic and epigenetic implications for autoimmunity

scientific article

Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.

scientific article published on 20 April 2016

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.

scientific article published on 21 July 2005

Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.

scientific article

Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice

scientific article published on 8 August 2006

Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation

scientific journal article

Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.

scientific article published on 24 January 2012

Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells

scientific article

Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.

scientific article published on 29 September 2008

MYC Drives Group 3 Medulloblastoma through Transformation of Sox2+ Astrocyte Progenitor Cells

scientific article published on 12 March 2019

MYCN Amplification Is Associated with Repressed Cellular Immunity in Neuroblastoma: An In Silico Immunological Analysis of TARGET Database.

scientific article published on 3 November 2017

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.

scientific article

Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation

scientific article

Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.

scientific article

On self-nonself discrimination in pattern recognition.

scientific article published on February 2010

Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes ⬇️

scientific article published on November 1, 2011

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

scientific journal article

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

scientific article

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

scientific article

Sialoside-based pattern recognitions discriminating infections from tissue injuries ⬇️

scientific article published on January 3, 2011

Siglec-G represses DAMP-mediated effects on T cells.

scientific article published on 20 July 2017

Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.

scientific article

Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity.

scientific article

Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation

scientific article

Signalling through FOXP3 as an X-linked tumor suppressor.

scientific article

Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

scientific article

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.

scientific article published on 23 September 2009

The CD24-Siglec G axis protects mice against cuprizone-induced oligodendrocyte loss: targeting danger signal for neuroprotection

scientific article published on 31 July 2017

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression

scientific article published on June 2016

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

scientific journal article

The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells ⬇️

scientific article published on June 27, 2011

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

scientific article published on 07 April 2015

Transgenic expression of P1A induced thymic tumor: a role for onco-fetal antigens in tumorigenesis

scientific article

Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development.

scientific article

Tumor growth decreases NK and B cells as well as common lymphoid progenitor

scientific article

Tumor growth impedes natural-killer-cell maturation in the bone marrow.

scientific article published on 23 March 2006

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

scientific article published on 21 August 2003

Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.

scientific article published on 20 February 2018

X-linked tumor suppressors: perplexing inheritance, a unique therapeutic opportunity.

scientific article

List of works by Pan Zheng

A Critical Role for Rictor in T Lymphopoiesis ⬇️

A critical role for the regulated wnt-myc pathway in naive T cell survival

A population of innate myelolymphoblastoid effector cell expanded by inactivation of mTOR complex 1 in mice.

A rare transporter associated with antigen processing polymorphism overpresented in HLAlow colon cancer reveals the functional significance of the signature domain in antigen processing

A role for cytoplasmic PML in cellular resistance to viral infection

A single-nucleotide deletion leads to rapid degradation of TAP-1 mRNA in a melanoma cell line.

Activating transcription factor 2 and c-Jun-mediated induction of FoxP3 for experimental therapy of mammary tumor in the mouse.

An aptamer-based targeted delivery of miR-26a protects mice against chemotherapy toxicity while suppressing tumor growth

An mTORC1-Mdm2-Drosha axis for miRNA biogenesis in response to glucose- and amino acid-deprivation

Anti-CTLA-4 antibodies in cancer immunotherapy: selective depletion of intratumoral regulatory T cells or checkpoint blockade?

Anti-human CTLA-4 monoclonal antibody promotes T-cell expansion and immunity in a hu-PBL-SCID model: a new method for preclinical screening of costimulatory monoclonal antibodies.

Antigenic drift as a mechanism for tumor evasion of destruction by cytolytic T lymphocytes ⬇️

B7-CTLA4 interaction enhances both production of antitumor cytotoxic T lymphocytes and resistance to tumor challenge.

B7-CTLA4 interaction promotes cognate destruction of tumor cells by cytotoxic T lymphocytes in vivo

B7-deficient autoreactive T cells are highly susceptible to suppression by CD4(+)CD25(+) regulatory T cells.

B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism.

Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1.

CD24 and Siglec-10 selectively repress tissue damage-induced immune responses.

CD24 is a genetic modifier for risk and progression of multiple sclerosis.

CD24 on thymic APCs regulates negative selection of myelin antigen‐specific T lymphocytes ⬇️

CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns

CD24-p53 axis suppresses diethylnitrosamine-induced hepatocellular carcinogenesis by sustaining intrahepatic macrophages.

CD24: a genetic checkpoint in T cell homeostasis and autoimmune diseases.

CD24: from A to Z.

CD28-independent induction of T helper cells and immunoglobulin class switches requires costimulation by the heat-stable antigen.

CD62L is required for the priming of encephalitogenic T cells but does not play a major role in the effector phase of experimental autoimmune encephalomyelitis

CIITA-regulated plexin-A1 affects T-cell-dendritic cell interactions.

Cis elements for transporter associated with antigen-processing-2 transcription: two new promoters and an essential role of the IFN response factor binding element in IFN-gamma-mediated activation of the transcription initiator

Combination therapy with anti-CTL antigen-4 and anti-4-1BB antibodies enhances cancer immunity and reduces autoimmunity

Costimulation by B7 modulates specificity of cytotoxic T lymphocytes: a missing link that explains some bystander T cell activation.

Cutaneous marginal zone B-cell lymphoma in the setting of fluoxetine therapy: a hypothesis regarding pathogenesis based on in vitro suppression of T-cell-proliferative response

Cytopenia and autoimmune diseases: a vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells.

Deletion of CD24 impairs development of heat shock protein gp96-driven autoimmune disease through expansion of myeloid-derived suppressor cells

Deletions and missense mutations of EPM2A exacerbate unfolded protein response and apoptosis of neuronal cells induced by endoplasm reticulum stress

Dendritic cells in the thymus contribute to T-regulatory cell induction

FOXP3 Controls an miR-146/NF-κB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells

FOXP3 and breast cancer: implications for therapy and diagnosis

FOXP3 is a novel transcriptional repressor for the breast cancer oncogene SKP2.

FOXP3 orchestrates H4K16 acetylation and H3K4 trimethylation for activation of multiple genes by recruiting MOF and causing displacement of PLU-1.

FOXP3 regulates sensitivity of cancer cells to irradiation by transcriptional repression of BRCA1

FOXP3 up-regulates p21 expression by site-specific inhibition of histone deacetylase 2/histone deacetylase 4 association to the locus

FOXP3: genetic and epigenetic implications for autoimmunity

Fbxo30 Regulates Mammopoiesis by Targeting the Bipolar Mitotic Kinesin Eg5.

Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies.

Identification of a tumor suppressor relay between the FOXP3 and the Hippo pathways in breast and prostate cancers.

Immune competence of cancer-reactive T cells generated de novo in adult tumor-bearing mice

Induction of Siglec-G by RNA viruses inhibits the innate immune response by promoting RIG-I degradation

Integrated analysis reveals critical genomic regions in prostate tumor microenvironment associated with clinicopathologic phenotypes.

Laforin is required for the functional activation of malin in endoplasmic reticulum stress resistance in neuronal cells

Laforin negatively regulates cell cycle progression through glycogen synthase kinase 3beta-dependent mechanisms.

MYC Drives Group 3 Medulloblastoma through Transformation of Sox2+ Astrocyte Progenitor Cells

MYCN Amplification Is Associated with Repressed Cellular Immunity in Neuroblastoma: An In Silico Immunological Analysis of TARGET Database.

Mammalian target of rapamycin activation underlies HSC defects in autoimmune disease and inflammation in mice.

Modulation of NKT cell development by B7-CD28 interaction: an expanding horizon for costimulation

Myeloid cell TRAF3 promotes metabolic inflammation, insulin resistance, and hepatic steatosis in obesity.

On self-nonself discrimination in pattern recognition.

Protein aggregation of SERCA2 mutants associated with Darier disease elicits ER stress and apoptosis in keratinocytes ⬇️

Proto-oncogene PML controls genes devoted to MHC class I antigen presentation

Ribosomal protein S27-like is a physiological regulator of p53 that suppresses genomic instability and tumorigenesis

SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase.

Sialoside-based pattern recognitions discriminating infections from tissue injuries ⬇️

Siglec-G represses DAMP-mediated effects on T cells.

Siglec-G-CD24 axis controls the severity of graft-versus-host disease in mice.

Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity.

Siglecg limits the size of B1a B cell lineage by down-regulating NFkappaB activation

Signalling through FOXP3 as an X-linked tumor suppressor.

Targeting HIF1α eliminates cancer stem cells in hematological malignancies.

Targeting lymphotoxin-mediated negative selection to prevent prostate cancer in mice with genetic predisposition.

The CD24-Siglec G axis protects mice against cuprizone-induced oligodendrocyte loss: targeting danger signal for neuroprotection

The MicroRNA-183-96-182 Cluster Promotes T Helper 17 Cell Pathogenicity by Negatively Regulating Transcription Factor Foxo1 Expression

The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

The Tuberous Sclerosis Complex–Mammalian Target of Rapamycin Pathway Maintains the Quiescence and Survival of Naive T Cells ⬇️

The methylcytosine dioxygenase Tet2 promotes DNA demethylation and activation of cytokine gene expression in T cells

Transgenic expression of P1A induced thymic tumor: a role for onco-fetal antigens in tumorigenesis

Trap1a is an X-linked and cell-intrinsic regulator of thymocyte development.

Tumor growth decreases NK and B cells as well as common lymphoid progenitor

Tumor growth impedes natural-killer-cell maturation in the bone marrow.

Two-signal requirement for activation and effector function of natural killer cell response to allogeneic tumor cells

Uncoupling therapeutic from immunotherapy-related adverse effects for safer and effective anti-CTLA-4 antibodies in CTLA4 humanized mice.