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List of works by Cyrus Chothia

3D complex: a structural classification of protein complexes

scientific article

Absolute configuration of cholinergic molecules; the crystal structure of (plus)-trans-2-aceoxy cyclopropyl trimethylammonium iodide

scientific article published on 01 May 1970

Acetylcholinesterase: The structure of crystals of a globular form from electric eel ⬇️

scientific article published on 01 September 1975

Advances in structural genomics

scientific article

Alignment of the amino acid sequences of distantly related proteins using variable gap penalties

scientific article published on 01 October 1986

Analysis of protein loop closure

article

Analysis of protein loop closure. Two types of hinges produce one motion in lactate dehydrogenase

scientific article

Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs

scientific article (publication date: 5 December 2002)

Antibody structure, prediction and redesign

scientific article

Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships

scientific article published on May 1998

Assignment of homology to genome sequences using a library of hidden Markov models that represent all proteins of known structure ⬇️

scientific article (publication date: 2 November 2001)

Asymmetry in Protein Structures ⬇️

scientific article published on January 1, 1991

Cadherin superfamily proteins in Caenorhabditis elegans and Drosophila melanogaster.

scientific article published in February 2001

Canonical structures for the hypervariable regions of T cell alphabeta receptors

scientific article

Canonical structures for the hypervariable regions of immunoglobulins

scientific article published on 01 August 1987

Coiling of beta-pleated sheets

scientific article published in January 1983

Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains

scientific article

Comparison of the small molecule metabolic enzymes of Escherichia coli and Saccharomyces cerevisiae

scientific article (publication date: June 2002)

Conformation of Cholinergic Molecules relevant to Acetylcholinesterase

scientific article

Conformation of acetylcholine at muscarinic nerve receptors: crystal and molecular structure of 2-trimethylammoniummethyl-5-methyl furan iodide (5-methylfurmethide iodide)

scientific article published on 01 August 1976

Conformation of twisted β-pleated sheets in proteins ⬇️

scientific article published on April 5, 1973

Conformations of acetylcholine.

scientific article published in September 1968

Conformations of immunoglobulin hypervariable regions

scientific article

Conformations of the third hypervariable region in the VH domain of immunoglobulins

scientific article

Conservation of folding and stability within a protein family: the tyrosine corner as an evolutionary cul-de-sac

scientific article published on 01 January 2000

Crystal structure of the complex of porcine trypsin with soybean trypsin inhibitor (Kunitz) at 2.6 Å resolution ⬇️

scientific article published on September 24, 1974

Crystallographic methods for determining the confirmation of cholinergic molecules (T).

scientific article published in May 1970

Data growth and its impact on the SCOP database: new developments

scientific article (publication date: 2008)

Determinants of a protein fold. Unique features of the globin amino acid sequences

scientific article published on 01 July 1987

Determination of protein function, evolution and interactions by structural genomics.

scientific article

Divergence of interdomain geometry in two-domain proteins

scientific article

Domain association in immunoglobulin molecules. The packing of variable domains

scientific article

Domain closure in adenylate kinase. Joints on either side of two helices close like neighboring fingers

scientific article published on 01 January 1993

Domain closure in lactoferrin. Two hinges produce a see-saw motion between alternative close-packed interfaces

scientific article published on November 1993

Domain closure in mitochondrial aspartate aminotransferase

scientific article

Domains in proteins: definitions, location, and structural principles

scientific article (publication date: 1985)

Elbow motion in the immunoglobulins involves a molecular ball-and-socket joint

scientific article published in Nature

Evolution of oligomeric state through geometric coupling of protein interfaces

scientific article

Evolution of proteins formed by beta-sheets. I. Plastocyanin and azurin

scientific article published on 01 September 1982

Evolution of proteins formed by beta-sheets. II. The core of the immunoglobulin domains

scientific article published on 01 September 1982

Evolution of the protein repertoire

scientific article

Exegesis: a procedure to improve gene predictions and its use to find immunoglobulin superfamily proteins in the human and mouse genomes

scientific article

Fast assignment of protein structures to sequences using the intermediate sequence library PDB-ISL

scientific article (publication date: February 2000)

Fibronectin type III domains in yeast detected by a hidden Markov model

scientific article published on 01 December 1996

Fifty years of pepsin crystals

scientific article published on 01 May 1984

Framework residue 71 is a major determinant of the position and conformation of the second hypervariable region in the VH domains of immunoglobulins

scientific article published in September 1990

Gene duplications in H. influenzae

scientific article published in November 1995

Genome3D: a UK collaborative project to annotate genomic sequences with predicted 3D structures based on SCOP and CATH domains

scientific article

Genome3D: exploiting structure to help users understand their sequences

scientific article

Genomic and structural aspects of protein evolution

scientific article

Geometric invariant core for the CL and CH1 domains of immunoglobulin molecules

scientific article published in January 2000

Haemoglobin: The structural changes related to ligand binding and its allosteric mechanism ⬇️

scientific article published on April 5, 1979

Haemoglobin: the surface buried between the alpha 1 beta 1 and alpha 2 beta 2 dimers in the deoxy and oxy structures

scientific article published in May 1985

Helix movements and the reconstruction of the haem pocket during the evolution of the cytochrome c family

scientific article published in March 1985

Helix to helix packing in proteins ⬇️

scientific article published on January 5, 1981

How different amino acid sequences determine similar protein structures: the structure and evolutionary dynamics of the globins

scientific article

How far can sequences diverge?

scientific article published in Nature

Hydrophobic bonding and accessible surface area in proteins ⬇️

scientific article published on March 22, 1974

Immunoglobulin superfamily proteins in Caenorhabditis elegans

scientific article

Interaction of acetylcholine with different cholinergic nerve receptors

scientific article published on 01 January 1970

Interior and surface of monomeric proteins

scientific article

Intermediate sequences increase the detection of homology between sequences

scientific article

Investigating Protein Structure and Evolution with SCOP2.

scientific article

Many of the immunoglobulin superfamily domains in cell adhesion molecules and surface receptors belong to a new structural set which is close to that containing variable domains

scientific article

Mechanisms of domain closure in proteins

scientific article published on 01 March 1984

Members of the immunoglobulin superfamily in bacteria

scientific article

Molecular Structure of LSD ⬇️

scientific article published on November 10, 1972

Molecular models

scientific article published on 01 January 1971

Molecular structure of a new family of ribonucleases

scientific article published on May 1982

Molecular structures of hallucinogenic substances: lysergic acid diethylamide, psilocybin, and 2,4,5-trimethoxyamphetamine

scientific article published on 01 January 1973

New folds for all-beta proteins

scientific article published on December 1993

On the conformations of hallucinogenic molecules and their correlation

scientific article

One thousand families for the molecular biologist ⬇️

scientific article published on June 18, 1992

Orthogonal packing of beta-pleated sheets in proteins

scientific article published on 01 August 1982

Outline structure of the human L1 cell adhesion molecule and the sites where mutations cause neurological disorders

scientific article

Outline structures for the extracellular domains of the fibroblast growth factor receptors

scientific article

Packing at the protein-water interface

scientific article published on September 1996

Packing of alpha-helices onto beta-pleated sheets and the anatomy of alpha/beta proteins

scientific article published on 01 October 1980

Perspectives: signal transduction. Proteins in motion

scientific article published on 01 September 1999

Polyhedra for helical proteins

scientific article published in Nature

Population statistics of protein structures: lessons from structural classifications

scientific article published on June 1997

Principles determining the structure of beta-sheet barrels in proteins. I. A theoretical analysis

scientific article

Principles determining the structure of beta-sheet barrels in proteins. II. The observed structures

scientific article

Principles of protein-protein recognition

scientific article published on August 28, 1975

Principles that determine the structure of proteins

scientific article published on January 1984

Protein families in the metazoan genome

scientific article published on 01 January 1994

Protein family expansions and biological complexity

scientific article

Protein folds in the all-beta and all-alpha classes

scientific article

Protein structure. Selecting buried residues

scientific article published in May 1989

RSDB: representative protein sequence databases have high information content

scientific article published in May 2000

Relative orientation of close-packed beta-pleated sheets in proteins

scientific article

Role of hydrophobicity in the binding of coenzymes. Appendix. Translational and rotational contribution to the free energy of dissociation

scientific article published on July 1978

Role of subunit interfaces in the allosteric mechanism of hemoglobin

scientific article

SCOP database in 2002: refinements accommodate structural genomics ⬇️

scientific article published on January 1, 2002

SCOP database in 2004: refinements integrate structure and sequence family data

scientific article (publication date: 2004)

SCOP, Structural Classification of Proteins database: applications to evaluation of the effectiveness of sequence alignment methods and statistics of protein structural data

scientific article

SCOP2 prototype: a new approach to protein structure mining

scientific article

SCOP: a Structural Classification of Proteins database

scientific article published in January 1999

SCOP: a Structural Classification of Proteins database

scientific article published on 01 January 1997

SCOP: a structural classification of proteins database

scientific article

SCOP: a structural classification of proteins database for the investigation of sequences and structures

scientific article (publication date: 7 April 1995)

SUPERFAMILY 1.75 including a domain-centric gene ontology method

scientific article

SUPERFAMILY--sophisticated comparative genomics, data mining, visualization and phylogeny

scientific article

SUPERFAMILY: HMMs representing all proteins of known structure. SCOP sequence searches, alignments and genome assignments ⬇️

scientific article published on January 1, 2002

Sequence comparisons using multiple sequences detect three times as many remote homologues as pairwise methods

scientific article

Sequence conservation in families whose members have little or no sequence similarity: the four-helical cytokines and cytochromes.

scientific article

Sequence search algorithm assessment and testing toolkit (SAT).

scientific article published in February 2000

Serpin tertiary structure transformation

scientific article published on September 1991

Small-molecule metabolism: an enzyme mosaic

scientific article

Solvent accessibility, protein surfaces, and protein folding

scientific article

Stability and specificity of protein-protein interactions: the case of the trypsin-trypsin inhibitor complexes

scientific article

Standard conformations for the canonical structures of immunoglobulins

scientific article

Structural assignments to the Mycoplasma genitalium proteins show extensive gene duplications and domain rearrangements

scientific article

Structural conservation of hypervariable regions in immunoglobulins evolution

scientific article published in December 1994

Structural determinants in the sequences of immunoglobulin variable domain 1 1Edited by A. R. Fersht ⬇️

scientific article published on 01 May 1998

Structural determinants of the conformations of medium-sized loops in proteins

scientific article published in January 1989

Structural invariants in protein folding ⬇️

scientific article published on March 27, 1975

Structural mechanisms for domain movements in proteins

scientific article

Structural patterns in globular proteins

scientific article published on June 17, 1976

Structural principles of alpha/beta barrel proteins: the packing of the interior of the sheet

scientific article

Structural repertoire of the human VH segments

scientific article published on October 1992

Structure Activity Relationships of some Muscarinic Agonists: a Reply to Shefter and Triggle ⬇️

scientific article published on September 26, 1970

Structure and activity of muscarinic stimulants

scientific article published in April 1971

Structure and stability of an immunoglobulin superfamily domain from twitchin, a muscle protein of the nematode Caenorhabditis elegans

scientific article

Structure of proteins: packing of alpha-helices and pleated sheets ⬇️

scientific article published on October 1, 1977

Structure, function and evolution of multidomain proteins

scientific article published on April 2004

Surface, subunit interfaces and interior of oligomeric proteins

scientific article published on 01 November 1988

The 14th barrel rolls out

scientific article published in Nature

The SUPERFAMILY database in 2004: additions and improvements

scientific article

The SUPERFAMILY database in 2007: families and functions

scientific article

The accessible surface area and stability of oligomeric proteins

scientific article published in Nature

The atomic structure of protein-protein recognition sites

scientific article (publication date: 5 February 1999)

The classification and origins of protein folding patterns

scientific article published on January 1990

The conformation of cholinergic molecules at nicotinic nerve receptors

scientific article

The conformations of cholinergic agonists ⬇️

scientific article published on May 1, 1970

The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli

scientific article

The evolution of protein structures

scientific article published on 01 January 1987

The generation of new protein functions by the combination of domains

scientific article

The geometry of domain combination in proteins

scientific article

The immunoglobulin superfamily in Drosophila melanogaster and Caenorhabditis elegans and the evolution of complexity

scientific article published in December 2003

The linked conservation of structure and function in a family of high diversity: the monomeric cupredoxins

scientific article published in June 2004

The molecular structure of cell adhesion molecules

scientific article

The nature of the accessible and buried surfaces in proteins

scientific article

The outline structure of the T-cell alpha beta receptor.

scientific article published on December 1988

The packing density in proteins: standard radii and volumes.

scientific article published in July 1999

The predicted structure of immunoglobulin D1.3 and its comparison with the crystal structure

scientific article

The relation between the divergence of sequence and structure in proteins

scientific article

The selection of acceptable protein mutations

scholarly article

The sequence determinants of cadherin molecules

scientific article published in September 2001

The structural homology of amicyanin from Thiobacillus versutus to plant plastocyanins.

scientific article published in March 1991

The structural repertoire of the human V kappa domain

scientific article

The structure of a PKD domain from polycystin-1: implications for polycystic kidney disease

scientific article

The structure of protein-protein recognition sites

scientific article

Transmission of conformational change in insulin

scientific article published in Nature

Ubiquitin--molecular mechanisms for recognition of different structures

scientific article published on 22 April 2010

Understanding protein structure: using scop for fold interpretation

scientific article

VH gene segments in the mouse and human genomes

scientific article published on 01 September 2004

Volume changes in protein evolution

scientific article published in March 1994

Volume changes on protein folding

scientific article published in July 1994

beta-Trefoil fold. Patterns of structure and sequence in the Kunitz inhibitors interleukins-1 beta and 1 alpha and fibroblast growth factors

scientific article

β-Trefoil fold

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