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List of works by Wenhao Chen

"Default" generation of neonatal regulatory T cells

scientific article published on 24 May 2010

A Dynamic Dual Role of IL-2 Signaling in the Two-Step Differentiation Process of Adaptive Regulatory T Cells ⬇️

scientific article published on February 20, 2013

Ablation of Transcription Factor IRF4 Promotes Transplant Acceptance by Driving Allogenic CD4+ T Cell Dysfunction.

scientific article published on 4 December 2017

Ablation of interferon regulatory factor 4 in T cells induces "memory" of transplant tolerance that is irreversible by immune checkpoint blockade

scientific article published on 25 December 2018

An oral formulation for intracellular adhesion molecules-1 antisense oligonucleotides

scientific article published on 01 November 2001

Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice

scientific article published on 01 June 2014

Anti-TCRβ mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice.

scientific article published in October 2017

Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells.

scientific article published on 15 March 2012

Both infiltrating regulatory T cells and insufficient antigen presentation are involved in long-term cardiac xenograft survival

scientific article published on 01 August 2007

CXCR5/CXCL13 interaction is important for double-negative regulatory T cell homing to cardiac allografts

scientific article published on 01 May 2006

Characterization of distinct conventional and plasmacytoid dendritic cell-committed precursors in murine bone marrow

scientific article published in August 2004

Development of an oral formulation for ICAM-1 antisense oligonucleotides

scientific article published on 01 February 2001

Digoxin attenuates acute cardiac allograft rejection by antagonizing RORγt activity

scientific article published on 01 February 2013

Dissonant response of M0/M2 and M1 bone-marrow-derived macrophages to RhoA pathway interference.

scientific article

Donor lymphocyte infusion induces long-term donor-specific cardiac xenograft survival through activation of recipient double-negative regulatory T cells

scientific article published on 01 September 2005

Double-negative T regulatory cells can develop outside the thymus and do not mature from CD8+ T cell precursors

scientific article published in September 2006

Epigenetically modifying the Foxp3 locus for generation of stable antigen-specific Tregs as cellular therapeutics

scientific article published on 13 March 2020

Expanding and converting regulatory T cells: a horizon for immunotherapy.

scientific article

Expression profiling of murine double-negative regulatory T cells suggest mechanisms for prolonged cardiac allograft survival

scientific article published on 01 April 2005

Functional quartet by CD4+ T cells: a concerto of multiple cytokines

scientific article published on 01 January 2008

GM-CSF contributes to aortic aneurysms resulting from SMAD3 deficiency.

scientific article published on 15 April 2013

IL-2-deprivation and TGF-beta are two non-redundant suppressor mechanisms of CD4+CD25+ regulatory T cell which jointly restrain CD4+CD25- cell activation.

scientific article published on 8 June 2010

IL-7, but not thymic stromal lymphopoietin (TSLP), during priming enhances the generation of memory CD4+ T cells.

scientific article published on 11 January 2010

In situ replication of immediate dendritic cell (DC) precursors contributes to conventional DC homeostasis in lymphoid tissue.

scientific article

Infusion of in vitro-generated DN T regulatory cells induces permanent cardiac allograft survival in mice

scientific article published on 01 November 2003

Interferon regulatory factor 4 deficiency in CD8+ T cells abrogates terminal effector differentiation and promotes transplant acceptance

scientific article published on 06 September 2020

Interleukin-21 is a critical regulator of CD4 and CD8 T cell survival during priming under Interleukin-2 deprivation conditions

scientific article published on 09 January 2014

Lentivirally transduced recipient-derived dendritic cells serve to ex vivo expand functional FcRgamma-sufficient double-negative regulatory T cells

scientific article published on 30 January 2007

MAFbx/Atrogin-1 is required for atrophic remodeling of the unloaded heart.

scientific article

Macrophage subpopulations and their impact on chronic allograft rejection versus graft acceptance in a mouse heart transplant model

scientific article published on 17 October 2017

Macrophage/monocyte-specific deletion of Ras homolog gene family member A (RhoA) downregulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts.

scientific article published on 20 August 2016

Mechanistic basis of immunotherapies for type 1 diabetes mellitus

scientific article published on 22 January 2013

Methoxyethyl-modified intercellular adhesion molecule-1 antisense phosphorothiateoligonucleotides inhibit allograft rejection, ischemic-reperfusion injury, and cyclosporine-induced nephrotoxicity.

scientific article

Molecular insights into the development of T cell-based immunotherapy for prostate cancer

scientific article published on 26 September 2014

PD-1-dependent restoration of self-tolerance in the NOD mouse model of diabetes after transient anti-TCRβ mAb therapy

scientific article published on 21 March 2015

PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice.

scientific article

Peptide-activated double-negative T cells can prevent autoimmune type-1 diabetes development

article

Perfusion of kidneys with unformulated "naked" intercellular adhesion molecule-1 antisense oligodeoxynucleotides prevents ischemic/reperfusion injury

scientific article published on 01 September 1999

Phosphorothioate/methoxyethyl-modified ICAM-1 antisense oligonucleotides improves prevention of ischemic/reperfusion injury

scientific article published on 01 November 2001

Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice

scientific article published on 7 May 2015

Protection against allograft rejection with intercellular adhesion molecule-1 antisense oligodeoxynucleotides

scientific article published on 01 September 1998

Role of double-negative regulatory T cells in long-term cardiac xenograft survival

scientific article published on 01 February 2003

Role of the NF-κB Family Member RelB in Regulation of Foxp3+ Regulatory T Cells In Vivo

scientific article published on 3 January 2018

STAT3: an important regulator of multiple cytokine functions.

scientific article published on May 2008

T cell exhaustion is associated with antigen abundance and promotes transplant acceptance

scientific article published on 17 March 2020

TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation

scientific article published on 11 October 2014

The Evolving Roles of Memory Immune Cells in Transplantation.

scientific article published on 22 June 2015

Transient combination therapy targeting the immune synapse abrogates T cell responses and prolongs allograft survival in mice

scientific article published on 24 July 2013

Treatment with interleukin-12/23p40 antibody attenuates acute cardiac allograft rejection.

scientific article

Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy

scientific article published on 01 November 1998

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