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List of works by Lena Serghides

A phase I clinical study of inhaled nitric oxide in healthy adults.

scientific article published on 18 April 2012

Acceptability of Supplemental Progesterone to Prevent Preterm Labor and Low Birth Weight in Pregnant Zambian Women [32D]

Adjunctive therapy for severe malaria: a review and critical appraisal

scientific article

An In Vitro Model for Measuring Immune Responses to Malaria in the Context of HIV Co-infection.

scientific article published on 6 October 2015

Approaches to studying costimulation of human antiviral T cell responses: prospects for immunotherapeutic vaccines

scientific article published on January 2006

C5 deficiency and C5a or C5aR blockade protects against cerebral malaria

scientific article published on 21 April 2008

C5a enhances dysregulated inflammatory and angiogenic responses to malaria in vitro: potential implications for placental malaria.

scientific article

CD36 and malaria: friends or foes?

scientific article published on October 2003

CD36 deficiency induced by antiretroviral therapy

scientific article published on February 2002

CD36 mediates the phagocytosis of Plasmodium falciparum-infected erythrocytes by rodent macrophages

scientific article

CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum

scientific article

CD47-SIRPα Interactions Regulate Macrophage Uptake of Plasmodium falciparum-Infected Erythrocytes and Clearance of Malaria In Vivo.

scientific article

Caspase-12 dampens the immune response to malaria independently of the inflammasome by targeting NF-kappaB signaling

scientific article published on 27 September 2010

Cerebral malaria: human versus mouse studies

scientific article published on 8 April 2010

Chronic HIV infection impairs nonopsonic phagocytosis of malaria parasites.

scientific article published on February 2015

Disruption of CD36 impairs cytokine response to Plasmodium falciparum glycosylphosphatidylinositol and confers susceptibility to severe and fatal malaria in vivo.

scientific article published in March 2007

Disruption of JNK2 decreases the cytokine response to Plasmodium falciparum glycosylphosphatidylinositol in vitro and confers protection in a cerebral malaria model

scientific article published on November 2006

Effect of HIV-1 antiretroviral drugs on cytoadherence and phagocytic clearance of Plasmodium falciparum-parasitised erythrocytes.

scientific article published in September 2003

Elevated Levels of Estradiol in Human Immunodeficiency Virus-Infected Pregnant Women on Protease Inhibitor-Based Regimens

scientific article

Estradiol Levels Are Altered in Human Immunodeficiency Virus-Infected Pregnant Women Randomized to Efavirenz-Versus Lopinavir/Ritonavir-Based Antiretroviral Therapy

scientific article published on 10 November 2017

Evaluation of OX40 ligand as a costimulator of human antiviral memory CD8 T cell responses: comparison with B7.1 and 4-1BBL.

scientific article published in November 2005

Exploring the Factors Considered by People Living with HIV and Their Partners during Preconception

scientific article published on 19 December 2016

Functional roles for C5a and C5aR but not C5L2 in the pathogenesis of human and experimental cerebral malaria

scientific article

HIV Infection Deregulates Tim-3 Expression on Innate Cells

article

HIV antiretroviral exposure in pregnancy induces detrimental placenta vascular changes that are rescued by progesterone supplementation.

scientific article

HIV impairs opsonic phagocytic clearance of pregnancy-associated malaria parasites

scientific article

HIV infection deregulates innate immunity to malaria despite combination antiretroviral therapy

scientific article published in January 2013

HIV protease inhibitor use during pregnancy is associated with decreased progesterone levels, suggesting a potential mechanism contributing to fetal growth restriction

scientific article

Improving the clinical relevance of a mouse pregnancy model of antiretroviral toxicity; a pharmacokinetic dosing-optimization study of current HIV antiretroviral regimens

article

In utero exposure to protease inhibitor-based antiretroviral regimens delays growth and developmental milestones in mice

scientific article published on 19 November 2020

Inhaled nitric oxide reduces endothelial activation and parasite accumulation in the brain, and enhances survival in experimental cerebral malaria

scientific article (publication date: 2011)

Low Prolactin and High 20-α-Hydroxysteroid Dehydrogenase Levels Contribute to Lower Progesterone Levels in HIV-Infected Pregnant Women Exposed to Protease Inhibitor-Based Combination Antiretroviral Therapy

scientific article published on 5 January 2016

Mechanism of protection induced by vitamin A in falciparum malaria

scientific article

Murine Plasmodium chabaudi malaria increases mucosal immune activation and the expression of putative HIV susceptibility markers in the gut and genital mucosae

scientific article

Nitric oxide for the adjunctive treatment of severe malaria: hypothesis and rationale

scientific article

Nonopsonic phagocytosis of erythrocytes infected with ring-stage Plasmodium falciparum

scientific article published on April 2005

Optimizing Malaria Treatment in the Community

scholarly article published 2015

PPARγ agonists improve survival and neurocognitive outcomes in experimental cerebral malaria and induce neuroprotective pathways in human malaria

scientific article

Perceived acceptability of progesterone to prevent preterm births and low birth weight among HIV-infected and HIV-uninfected Zambian pregnant women

scientific article published on 16 November 2017

Peroxisome proliferator-activated receptor gamma and retinoid X receptor agonists have minimal effects on the interaction of endothelial cells with Plasmodium falciparum-infected erythrocytes

scientific article published on February 2005

Peroxisome proliferator-activated receptor gamma-retinoid X receptor agonists increase CD36-dependent phagocytosis of Plasmodium falciparum-parasitized erythrocytes and decrease malaria-induced TNF-alpha secretion by monocytes/macrophages

scientific article published in June 2001

Placental chondroitin sulfate A-binding malarial isolates evade innate phagocytic clearance

scientific article

Placental vascular abnormalities in the mouse alter umbilical artery wave reflections

scientific article published on 11 January 2019

Progesterone supplementation for HIV-positive pregnant women on protease inhibitor-based antiretroviral regimens (the ProSPAR study): a study protocol for a pilot randomized controlled trial

scientific article published on 12 August 2016

Pyruvate kinase deficiency and malaria

scientific article

Reflected hemodynamic waves influence the pattern of Doppler ultrasound waveforms along the umbilical arteries

scientific article published on 22 February 2019

Rosiglitazone modulates the innate immune response to Plasmodium falciparum infection and improves outcome in experimental cerebral malaria

scientific article

Safety and tolerability of adjunctive rosiglitazone treatment for children with uncomplicated malaria

scientific article

Surviving and Thriving-Shifting the Public Health Response to HIV-Exposed Uninfected Children: Report of the 3rd HIV-Exposed Uninfected Child Workshop.

scientific article

The Case for the Use of PPARγ Agonists as an Adjunctive Therapy for Cerebral Malaria ⬇️

scientific article published on June 9, 2011

The importance of motherhood in HIV-positive women of reproductive age in Ontario, Canada.

scientific article published on 9 November 2013

Use of peroxisome proliferator-activated receptor gamma agonists as adjunctive treatment for Plasmodium falciparum malaria: a randomized, double-blind, placebo-controlled trial

scientific article published on September 2009

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