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List of works by Lothar Hennighausen

A Single Amino Acid in the DNA Binding Regions of STAT5A and STAT5B Confers Distinct DNA Binding Specificities

scientific article published in Journal of Biological Chemistry

A morphological and immunohistochemical comparison of mammary tissues from the short-tailed fruit bat (Carollia perspicillata) and the mouse

scientific article published on 28 January 2004

Absence of STAT1 in donor-derived plasmacytoid dendritic cells results in increased STAT3 and attenuates murine GVHD

scientific article

Activation of Interferon-Stimulated Transcriptomes and ACE2 Isoforms in Human Airway Epithelium Is Curbed by Janus Kinase Inhibitors

scientific article published on 11 December 2020

Activation of Stat5a and Stat5b by tyrosine phosphorylation is tightly linked to mammary gland differentiation

scientific article published in December 1996

Activation of beta -catenin signaling in differentiated mammary secretory cells induces transdifferentiation into epidermis and squamous metaplasias.

scientific article

Activation of different Wnt/beta-catenin signaling components in mammary epithelium induces transdifferentiation and the formation of pilar tumors.

scientific article

Acute myeloid leukemia-associated Mkl1 (Mrtf-a) is a key regulator of mammary gland function

scientific article (publication date: August 2006)

An Ets site in the whey acidic protein gene promoter mediates transcriptional activation in the mammary gland of pregnant mice but is dispensable during lactation

scientific article published on 01 June 1995

An autoregulatory enhancer controls mammary-specific STAT5 functions.

scientific article published on 7 October 2015

An indirect effect of Stat5a in IL-2-induced proliferation: a critical role for Stat5a in IL-2-mediated IL-2 receptor alpha chain induction

scientific article published on 01 November 1997

BH3-only protein bid participates in the Bcl-2 network in healthy liver cells

scientific article published on December 2009

BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant

scientific article published on 22 February 2022

Bcl-x and Bax regulate mouse primordial germ cell survival and apoptosis during embryogenesis

scientific journal article

Biogenesis and function of mouse mammary epithelium depends on the presence of functional alpha-catenin

scientific article published on January 2004

Bone resorption is regulated by cell-autonomous negative feedback loop of Stat5-Dusp axis in the osteoclast.

scientific article published on 23 December 2013

Brca2 deficiency does not impair mammary epithelium development but promotes mammary adenocarcinoma formation in p53(+/-) mutant mice.

scientific article published in March 2004

C/EBPdelta is a crucial regulator of pro-apoptotic gene expression during mammary gland involution

scientific article published on 28 September 2005

CRISPR/Cas9 targeting events cause complex deletions and insertions at 17 sites in the mouse genome.

scientific article

Canonical and non-canonical roles of the histone methyltransferase EZH2 in mammary development and cancer.

scientific article published on 17 May 2013

Chromatin structure and protein binding in the putative regulatory region of the c-myc gene in Burkitt lymphoma.

scientific article published in June 1984

Clarifying the role of Stat5 in lymphoid development and Abelson-induced transformation

scientific article

Comparative sequence analysis of the mRNAs coding for mouse and rat whey protein.

scientific article published on June 1982

Comparison of tamoxifen and letrozole response in mammary preneoplasia of ER and aromatase overexpressing mice defines an immune-associated gene signature linked to tamoxifen resistance.

scientific article

Comparison of the regulation of the whey acidic protein gene with that of a hybrid gene containing the whey acidic protein gene promoter in transgenic mice

scientific article published in November 1988

Comparison of the whey acidic protein genra of the rat and mouse ⬇️

scientific article published on November 26, 1984

Comprehensive meta-analysis of Signal Transducers and Activators of Transcription (STAT) genomic binding patterns discerns cell-specific cis-regulatory modules

scientific article

Conditional deletion of the bcl-x gene from mouse mammary epithelium results in accelerated apoptosis during involution but does not compromise cell function during lactation.

scientific article published in December 2001

Conditional mutation of Brca1 in mammary epithelial cells results in blunted ductal morphogenesis and tumour formation.

scientific article

Context-Specific Growth Hormone Signaling through the Transcription Factor STAT5: Implications for the Etiology of Hepatosteatosis and Hepatocellular Carcinoma

scientific article

Coregulation of genetic programs by the transcription factors NFIB and STAT5.

scientific article published on 28 March 2014

Cre-mediated gene deletion in the mammary gland ⬇️

scientific article published on November 1, 1997

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

scientific article

Cytokine receptors and their Stat-mediated mechanisms of action

scientific article published on 01 June 2012

Cytokine-regulated GADD45G induces differentiation and lineage selection in hematopoietic stem cells

scientific article

Deficiency in mouse oxytocin prevents milk ejection, but not fertility or parturition.

scientific article

Deletion of Stat3 blocks mammary gland involution and extends functional competence of the secretory epithelium in the absence of lactogenic stimuli.

scientific article published in September 2002

Deletion of the carboxyl-terminal transactivation domain of MGF-Stat5 results in sustained DNA binding and a dominant negative phenotype.

scientific article published on October 1996

Differential cytokine sensitivities of STAT5-dependent enhancers rely on Stat5 autoregulation.

scientific article published on 30 September 2016

Differential requirements for shh in mammary tissue and hair follicle morphogenesis

scientific article published on 01 September 2002

Direct activation of STAT5 by ETV6-LYN fusion protein promotes induction of myeloproliferative neoplasm with myelofibrosis.

scientific article

Direct glucocorticoid receptor-Stat5 interaction in hepatocytes controls body size and maturation-related gene expression

scientific article published on May 2007

Distinct tyrosine residues within the interleukin-2 receptor beta chain drive signal transduction specificity, redundancy, and diversity

scientific journal article

Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption

scientific article published in March 1999

Early onset of neoplasia in the prostate and skin of mice with tissue-specific deletion of Pten

scientific article

Ectopic TGF beta 1 expression in the secretory mammary epithelium induces early senescence of the epithelial stem cell population

scientific article published on 01 March 1995

Epithelial-specific and stage-specific functions of insulin-like growth factor-I during postnatal mammary development

scientific article published on 10 August 2006

Essential role for Stat5 in the neurotrophic but not in the neuroprotective effect of erythropoietin

scientific article published on 8 February 2008

Essential role for Stat5a/b in myeloproliferative neoplasms induced by BCR-ABL1 and JAK2(V617F) in mice.

scientific article published on 10 January 2012

Experimental mouse genetics-- answering fundamental questions about mammary gland biology.

scientific article

Expression from the HIV-LTR is stimulated by glucocorticoids and pregnancy

scientific article published on 01 April 1990

Expression of genomic and cDNA transgenes after co-integration in transgenic mice

scientific article published on 01 January 1995

Expression of the whey acidic protein in transgenic pigs impairs mammary development.

scientific article published on May 1992

Facultative CTCF sites moderate mammary super-enhancer activity and regulate juxtaposed gene in non-mammary cells

scientific article

Formation of several specific nucleoprotein complexes on the human cytomegalovirus immediate early enhancer ⬇️

scientific article published on July 11, 1991

Forskolin inducibility and tissue-specific expression of the fibronectin promoter

scientific article published on April 1989

Functional assessment of CTCF sites at cytokine-sensing mammary enhancers using CRISPR/Cas9 gene editing in mice

scientific article

Functional mammary gland development and oncogene-induced tumor formation are not affected by the absence of the retinoblastoma gene

scientific article published on 01 October 2001

GPCR-induced migration of breast carcinoma cells depends on both EGFR signal transactivation and EGFR-independent pathways.

scientific article published on September 2005

Gene Transfer into Mammalian Cells by Jet Injection ⬇️

scientific article published on April 1, 1995

Gene transfer into somatic tissues by jet injection

scientific article published on September 1, 1992

Genetic ablation of Bcl-x attenuates invasiveness without affecting apoptosis or tumor growth in a mouse model of pancreatic neuroendocrine cancer

scientific article

Genetic evidence supporting selection of the Valpha14i NKT cell lineage from double-positive thymocyte precursors

scientific article published in June 2005

Genome-wide regulation of electro-acupuncture on the neural Stat5-loss-induced obese mice.

scientific article published on 14 August 2017

Genome-wide target site triplication of Alu elements in the human genome

scientific article published on 19 February 2015

Genomic and bioinformatics tools to understand the biology of signal transducers and activators of transcription

scientific article published on June 2012

Growth hormone–STAT5 regulation of growth, hepatocellular carcinoma, and liver metabolism ⬇️

scientific article published on July 1, 2011

Helper T cell IL-2 production is limited by negative feedback and STAT-dependent cytokine signals.

scientific article

Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression

scientific article published on 13 June 2008

Hepatocyte-specific disruption of Bcl-xL leads to continuous hepatocyte apoptosis and liver fibrotic responses

scientific article published in October 2004

Hierarchy within the mammary STAT5-driven Wap super-enhancer.

scientific article published on 04 July 2016

Histone Demethylase KDM6A Controls the Mammary Luminal Lineage through Enzyme-Independent Mechanisms.

scientific article published on 23 May 2016

Identification of an acquired mutation in Jak2 provides molecular insights into the pathogenesis of myeloproliferative disorders

scientific article published on 01 August 2005

Identification of genes differentially expressed in mouse mammary epithelium transformed by an activated beta-catenin

scientific article published on 01 July 2003

Immune transcriptomes of highly exposed SARS-CoV-2 asymptomatic seropositive versus seronegative individuals from the Ischgl community

scientific article published on 23 September 2020

Impaired mammary gland development and function in mice lacking LAR receptor-like tyrosine phosphatase activity

scientific article published in August 1997

In vitro transcription of the mouse whey acidic protein promoter is affected by upstream sequences.

scientific article published in July 1989

Inactivation of Stat5 in mouse mammary epithelium during pregnancy reveals distinct functions in cell proliferation, survival, and differentiation

scientific article published on September 2004

Induction of alternatively activated macrophages enhances pathogenesis during severe acute respiratory syndrome coronavirus infection

scientific article

Information networks in the mammary gland.

scientific article

Interaction of protein with DNA in vitro

scientific article published on 01 January 1987

Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system

scientific article published on 13 August 2006

Interleukin 7 signaling in dendritic cells regulates the homeostatic proliferation and niche size of CD4+ T cells.

scientific article published on 11 January 2009

Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B

scientific article published on March 2008

JAK inhibitors dampen activation of interferon-stimulated transcription of ACE2 isoforms in human airway epithelial cells

scientific article published on 02 June 2021

Jak2 is an essential tyrosine kinase involved in pregnancy-mediated development of mammary secretory epithelium

scientific article published in March 2002

Janus Kinase 1 Is Essential for Inflammatory Cytokine Signaling and Mammary Gland Remodeling.

scientific article published on 04 April 2016

Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 ERK2 mitogen-activated protein kinase activity

scientific article published on 01 December 1996

Lineage-Specific and Non-specific Cytokine-Sensing Genes Respond Differentially to the Master Regulator STAT5.

scientific article published on December 2016

Lineage-specific STAT5 target gene activation in hematopoietic progenitor cells predicts the FLT3(+)-mediated leukemic phenotype

scientific article published on 5 April 2016

Linear and cooperative signaling: roles for Stat proteins in the regulation of cell survival and apoptosis in the mammary epithelium.

scientific article

Loss of EZH2 results in precocious mammary gland development and activation of STAT5-dependent genes.

scientific article

Loss of STAT1 from mouse mammary epithelium results in an increased Neu-induced tumor burden.

scientific article

Loss of STAT5 causes liver fibrosis and cancer development through increased TGF-{beta} and STAT3 activation.

scientific article published on 30 March 2009

Loss of cytokine-STAT5 signaling in the CNS and pituitary gland alters energy balance and leads to obesity

scientific article

Loss of interleukin 6 results in delayed mammary gland involution: a possible role for mitogen-activated protein kinase and not signal transducer and activator of transcription 3

scientific article published on 01 December 2002

Loss of sexually dimorphic liver gene expression upon hepatocyte-specific deletion of Stat5a-Stat5b locus

scientific article published on 22 February 2007

Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration

scientific article published on 01 August 2007

MMTV-Cre transgenes can adversely affect lactation: Considerations for conditional gene deletion in mammary tissue ⬇️

scientific article published on January 19, 2011

Mammary epithelial cells are not able to undergo pregnancy-dependent differentiation in the absence of the helix-loop-helix inhibitor Id2

scientific journal article

Mammary gland remodeling depends on gp130 signaling through Stat3 and MAPK.

scientific article

Mammary-derived signals activate programmed cell death during the first stage of mammary gland involution

scientific article

Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks

scientific article

Matrix-attachment regions can impart position-independent regulation of a tissue-specific gene in transgenic mice ⬇️

scientific article published on August 1, 1992

Mcl-1 and Bcl-xL cooperatively maintain integrity of hepatocytes in developing and adult murine liver

scientific article published on October 2009

Metformin Inhibits Growth Hormone–Mediated Hepatic PDK4 Gene Expression Through Induction of Orphan Nuclear Receptor Small Heterodimer Partner ⬇️

scientific article published on June 14, 2012

MiR-193b and miR-365-1 are not required for the development and function of brown fat in the mouse

scientific article

MiR-21 is under control of STAT5 but is dispensable for mammary development and lactation

scientific article published on 30 January 2014

Multiple sequence-specific transcription factors modulate cytomegalovirus enhancer activity in vitro.

scientific article published on April 1988

Muscle-specific deletion of signal transducer and activator of transcription 5 augments lipid accumulation in skeletal muscle and liver of mice in response to high-fat diet.

scientific article published on 18 November 2015

Mutation frequency is not increased in CRISPR-Cas9-edited mice

scientific article published on 01 October 2018

Myeloproliferative disease induced by TEL-PDGFRB displays dynamic range sensitivity to Stat5 gene dosage.

scientific article published on 11 January 2007

Neuronal STAT5 signaling is required for maintaining lactation but not for postpartum maternal behaviors in mice.

scientific article published on 17 April 2015

Nonredundant roles for Stat5a/b in directly regulating Foxp3

scientific article published on 16 January 2007

Nuclear proteins from lactating mammary glands bind to the promoter of a milk protein gene

scientific article

Oxytocin and milk removal are required for post-partum mammary-gland development

scientific article published on 01 November 1997

Postnatal body growth is dependent on the transcription factors signal transducers and activators of transcription 5a/b in muscle: a role for autocrine/paracrine insulin-like growth factor I

scientific article published on 07 December 2006

Primary cancer cell culture: mammary-optimized vs conditional reprogramming

scientific article published on 07 June 2016

Production of Human Tissue Plasminogen Activator in Transgenic Mouse Milk

article

Prolactin signaling in mammary gland development.

scientific article published on March 1997

Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.

scientific article published on May 1997

Prolactin, growth hormone, and epidermal growth factor activate Stat5 in different compartments of mammary tissue and exert different and overlapping developmental effects.

scientific article

Proteotyping of Mammary Tissue from Transgenic and Gene Knockout Mice with Immunohistochemical Markers: a Tool To Define Developmental Lesions ⬇️

scientific article published on May 1, 2003

RIP-Cre revisited, evidence for impairments of pancreatic beta-cell function

scientific article

Regulation of human protein C gene expression by the mouse WAP promoter

scientific article published on 01 May 1995

Regulation of mammary differentiation by extracellular matrix involves protein-tyrosine phosphatases

scientific article published on 01 April 1998

Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.

scientific article

SOCS3 negatively regulates the gp130-STAT3 pathway in mouse skin wound healing

scientific article published on 10 January 2008

SOCS3 promotes apoptosis of mammary differentiated cells

scientific article published on 02 November 2005

SOCS3 protein developmentally regulates the chemokine receptor CXCR4-FAK signaling pathway during B lymphopoiesis

scientific article published in November 2007

STAT1 Signaling in Astrocytes Is Essential for Control of Infection in the Central Nervous System

scientific article

STAT5 is a key transcription factor for IL-3-mediated inhibition of RANKL-induced osteoclastogenesis

scientific article published on 03 August 2016

STAT5 is crucial to maintain leukemic stem cells in acute myelogenous leukemias induced by MOZ-TIF2.

scientific article

STAT5 requires the N-domain to maintain hematopoietic stem cell repopulating function and appropriate lymphoid-myeloid lineage output

scientific article

STAT5-regulated microRNA-193b controls haematopoietic stem and progenitor cell expansion by modulating cytokine receptor signalling

scientific article

Selective regulatory function of Socs3 in the formation of IL-17-secreting T cells

scientific article

Selective removal of the selenocysteine tRNA [Ser]Sec gene (Trsp) in mouse mammary epithelium

scientific article

Sequential activation of genetic programs in mouse mammary epithelium during pregnancy depends on STAT5A/B concentration ⬇️

scientific article published on December 28, 2012

Signal transducer and activator of transcription (Stat) 5 controls the proliferation and differentiation of mammary alveolar epithelium ⬇️

scientific article published on November 12, 2001

Signal transducer and activator of transcription 5 (STAT5) paralog dose governs T cell effector and regulatory functions.

scientific article published on 21 March 2016

Signal transducer and activator of transcription 5 plays a crucial role in hepatic lipid metabolism through regulation of CD36 expression.

scientific article

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells.

scientific article published on 31 January 2010

Signaling pathways in mammary gland development.

scientific article

Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways.

scientific article published on December 1996

Socs 3 modulates the activity of the transcription factor Stat3 in mammary tissue and controls alveolar homeostasis

scientific article published in March 2007

Spatial and temporal expression of the Cre gene under the control of the MMTV-LTR in different lines of transgenic mice.

scientific article

Stat5 is essential for early B cell development but not for B cell maturation and function

scientific article published on 01 July 2007

Stat5 is indispensable for the maintenance of bcr/abl-positive leukaemia

scientific article published on March 2010

Stat5a is mandatory for adult mammary gland development and lactogenesis.

scientific article published in January 1997

Studying development of disease through temporally controlled gene expression in the salivary gland

scientific article published on 01 April 1998

Subset- and tissue-defined STAT5 thresholds control homeostasis and function of innate lymphoid cells

scientific article published on 15 September 2017

Suppression of signal transducers and activators of transcription 1 in hepatocellular carcinoma is associated with tumor progression.

scientific article published on 28 June 2012

Targeted expression of HGF/SF in mouse mammary epithelium leads to metastatic adenosquamous carcinomas through the activation of multiple signal transduction pathways.

scientific article published in November 2003

Temporal control of gene expression in transgenic mice by a tetracycline-responsive promoter.

scientific article published on September 1994

The BH3-only protein BIM contributes to late-stage involution in the mouse mammary gland.

scientific article published on 5 June 2015

The STAT5-regulated miR-193b locus restrains mammary stem and progenitor cell activity and alveolar differentiation

scientific article

The Stat3/5 locus encodes novel endoplasmic reticulum and helicase-like proteins that are preferentially expressed in normal and neoplastic mammary tissue

scientific journal article

The aryl hydrocarbon receptor (AhR) and its nuclear translocator (Arnt) are dispensable for normal mammary gland development but are required for fertility

scientific article published on 01 March 2002

The canonical Notch/RBP-J signaling pathway controls the balance of cell lineages in mammary epithelium during pregnancy

scientific article

The cyclin-dependent kinase inhibitor p27 (Kip1) regulates both DNA synthesis and apoptosis in mammary epithelium but is not required for its functional development during pregnancy

scientific article published on 21 August 2003

The gene encoding the hematopoietic stem cell regulator CCN3/NOV is under direct cytokine control through the transcription factors STAT5A/B.

scientific article

The genetics and pathology of mouse mammary cancer

scientific article published on 01 June 2001

The interdependence of mammary-specific super-enhancers and their native promoters facilitates gene activation during pregnancy

scientific article published on 22 April 2020

The interleukin-4 receptor activates STAT5 by a mechanism that relies upon common gamma-chain

scientific article published on November 1998

The liver-specific tumor suppressor STAT5 controls expression of the reactive oxygen species-generating enzyme NOX4 and the proapoptotic proteins PUMA and BIM in mice ⬇️

scientific article published on December 1, 2012

The methyltransferase EZH2 is not required for mammary cancer development, although high EZH2 and low H3K27me3 correlate with poor prognosis of ER-positive breast cancers

scientific article

The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration

scientific journal article

The miR-17/92 cluster is targeted by STAT5 but dispensable for mammary development.

scientific article published on 31 March 2012

The prospects for domesticating milk protein genes

scientific article published on August 1, 1992

The right time and place for molecular scissors

scientific article published on 01 November 1999

The role of prolactin and growth hormone in mammary gland development

scientific article

The transcription factor STAT5 is critical in dendritic cells for the development of TH2 but not TH1 responses

scientific article

The transcription factor Stat3 is dispensable for pancreatic beta-cell development and function.

scientific article published in September 2005

The transcription factors STAT5A/B regulate GM-CSF-mediated granulopoiesis.

scientific article

The transcription factors signal transducer and activator of transcription 5A (STAT5A) and STAT5B negatively regulate cell proliferation through the activation of cyclin-dependent kinase inhibitor 2b (Cdkn2b) and Cdkn1a expression

scientific article

The versatile regulation of cellular events by Jak-Stat signaling: from transcriptional control to microtubule dynamics and energy metabolism

scientific article published on 01 June 2012

Think globally, act locally: the making of a mouse mammary gland.

scientific article published on February 1998

Transgenic animals--production of foreign proteins in milk

scientific article

Transgenic factor VIII: The milky way and beyond ⬇️

scientific article published on 01 October 1997

Trp63 is regulated by STAT5 in mammary tissue and subject to differentiation in cancer.

scientific article

Tsg101 is essential for cell growth, proliferation, and cell survival of embryonic and adult tissues

scientific article

Tumor suppression by phospholipase C-beta3 via SHP-1-mediated dephosphorylation of Stat5.

scientific article

Two Discrete Regions of Interleukin-2 (IL2) Receptor β Independently Mediate IL2 Activation of a PD98059/Rapamycin/Wortmannin-insensitive Stat5a/b Serine Kinase

scientific article published in Journal of Biological Chemistry

Understanding mammary gland development through the imbalanced expression of growth regulators

scientific article published in June 1996

Validation of transgenic mammary cancer models: goals of the NCI Mouse Models of Human Cancer Consortium and the mammary cancer CD-ROM

scientific article published on 01 December 2002

bcl-xL is critical for dendritic cell survival in vivo.

scientific article published in October 2004

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