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List of works by Manfred Gessler

1q gain is a frequent finding in preoperatively treated Wilms tumors, but of limited prognostic value for risk stratification in the SIOP2001/GPOH trial

article

A 7.5 Mb sequence-ready PAC contig and gene expression map of human chromosome 11p13-p14.1

scientific article

A Sequence-Ready 3-Mb PAC Contig Covering 16 Breakpoints of the Wilms Tumor/Anirida Region of Human Chromosome 11p13 ⬇️

scientific article published on October 15, 1998

A WAGR region gene between PAX-6 and FSHB expressed in fetal brain

scientific article

A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease

scientific journal article

All-trans retinoic acid treatment of Wilms tumor cells reverses expression of genes associated with high risk and relapse in vivo

scientific article

An Ordered NotI Fragment Map of Human Chromosome Band 11p15

scientific article published on 01 September 1994

An essential developmental function for murine phosphoglycolate phosphatase in safeguarding cell proliferation

scientific article published on 12 October 2016

An integrated YAC clone contig for the WAGR region on human chromosome 11p13-p14.1.

scientific article published on November 1995

Analysis of HeyL expression in wild-type and Notch pathway mutant mouse embryos

scientific journal article

Array-based DNA-methylation profiling in sarcomas with small blue round cell histology provides valuable diagnostic information

scientific article published on 23 March 2018

Author Correction: The landscape of genomic alterations across childhood cancers

scientific article published in Nature

Autoantibody signature differentiates Wilms tumor patients from neuroblastoma patients

scientific article

COUP-TFII orchestrates venous and lymphatic endothelial identity by homo- or hetero-dimerisation with PROX1.

scientific article published on 23 January 2013

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires Hes1 to bind diverse DNA sites

scientific article published on 20 February 2019

Characterization of hey bHLH genes in teleost fish

article

Characterization of primary Wilms tumor cultures as an in vitro model

scientific article published on 27 October 2011

Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney

scientific article

Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family

scientific article (publication date: June 2000)

Chibby, a novel antagonist of the Wnt pathway, is not involved in Wilms tumor development.

scientific article published in March 2005

Cloning and expression analysis of the mouse stroma marker Snep encoding a novel nidogen domain protein

scientific article

Cloning of breakpoints of a chromosome translocation identifies the AN2 locus

scientific article published in June 1989

Combined loss of Hey1 and HeyL causes congenital heart defects because of impaired epithelial to mesenchymal transition

scientific journal article

Combining miRNA and mRNA Expression Profiles in Wilms Tumor Subtypes

scientific article published on 30 March 2016

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death

scientific article

Comparative analysis of the human and mouse Hey1 promoter: Hey genes are new Notch target genes

scientific article

Confirmation of the localization of the human recombination activating gene 1 (RAG1) to chromosome 11p13

scientific article published on 01 February 1994

CpG island clones for chromosome 11p--a resource for mapping and gene identification

scientific article published on June 1995

Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria

scientific article

Deletion of GLI3 supports the homology of the human Greig cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra toes (Xt)

Delta-Notch--and then? Protein interactions and proposed modes of repression by Hes and Hey bHLH factors

scientific article published on 22 June 2007

Developmental expression and biochemical characterization of Emu family members

scientific journal article

Developmental expression patterns of mouse sFRP genes encoding members of the secreted frizzled related protein family.

scientific article published in July 1998

Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors

scientific article

Differential expression of the cellular oncogenes c-src and c-yes in embryonal and adult chicken tissues ⬇️

scientific article published on September 1, 1984

Distinct molecular origins for Denys-Drash and Frasier syndromes

scientific article published on 01 April 1993

Dll1 and Dll4: similar, but not the same

DrugTargetInspector: An assistance tool for patient treatment stratification

scientific article

ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

scientific article published on 29 December 2017

Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans

scientific article

Expression of Notch pathway genes in the embryonic mouse metanephros suggests a role in proximal tubule development

scientific article published in October 2003

Expression of mouse dchs1, fjx1, and fat-j suggests conservation of the planar cell polarity pathway identified in Drosophila

scientific article published in November 2005

Expression patterns of the mouse Spir-2 actin nucleator

scientific article published on 17 August 2010

Expression profiling of Wilms tumors reveals new candidate genes for different clinical parameters

scientific article

Fjx1, the murine homologue of the Drosophila four-jointed gene, codes for a putative secreted protein expressed in restricted domains of the developing and adult brain

scientific journal article

Fjx1: a notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain

scientific journal article

Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.

scientific article

Further evidence that imbalance of WT1 isoforms may be involved in Denys – Drash syndrome

article

GATA-dependent regulatory switches establish atrioventricular canal specificity during heart development.

scientific article published on 28 April 2014

GLI3 zinc-finger gene interrupted by translocations in Greig syndrome families

scientific article published in Nature

Gain of 1q is associated with adverse outcome in favorable histology Wilms' tumors

scientific article published on February 2001

Gene expression profiles of brain endothelial cells during embryonic development at bulk and single-cell levels.

scientific article published on 11 July 2017

Hey bHLH Factors in Cardiovascular Development

article

Hey bHLH Proteins Interact with a FBXO45 Containing SCF Ubiquitin Ligase Complex and Induce Its Translocation into the Nucleus

scientific article published on 12 June 2015

Hey bHLH factors in cardiovascular development.

scientific article

Hey bHLH transcription factors

scientific article published on January 2014

Hey basic helix-loop-helix transcription factors are repressors of GATA4 and GATA6 and restrict expression of the GATA target gene ANF in fetal hearts

scientific article

Hey genes in cardiovascular development

scientific article

Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis

scientific article (publication date: July 1999)

Hey2 regulation by FGF provides a Notch-independent mechanism for maintaining pillar cell fate in the organ of Corti

scientific journal article

High-risk blastemal Wilms tumor can be modeled by 3D spheroid cultures in vitro

scientific article published on 27 September 2019

Homozygous deletion in Wilms tumours of a zinc-finger gene identified by chromosome jumping

scientific article (publication date: 22 February 1990)

Homozygous inactivation of WT1 in a Wilms' tumor associated with the WAGR syndrome

scientific article published in July 1993

Human CC10, the homologue of rabbit uteroglobin: genomic cloning, chromosomal localization and expression in endometrial cell lines

scientific article (publication date: September 1992)

Hypoxia-mediated activation of Dll4-Notch-Hey2 signaling in endothelial progenitor cells and adoption of arterial cell fate

scientific article published on 19 September 2006

Identification and Analyses of Extra-Cranial and Cranial Rhabdoid Tumor Molecular Subgroups Reveal Tumors with Cytotoxic T Cell Infiltration

scientific article published on 07 November 2019

Identification of BOIP, a novel cDNA highly expressed during spermatogenesis that encodes a protein interacting with the orange domain of the hairy-related transcription factor HRT1/Hey1 in Xenopus and mouse

scientific journal article

Identification of limited regions of genetic aberrations in patients affected with Wilms' tumor using a tiling-path chromosome 22 array

Identification of the human homolog of the imprinted mouse Air non-coding RNA.

scientific article

Infrequent mutation of theWT1 gene in 77 Wilms' tumors

article

Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways

scientific article published on 30 October 2008

Isolation and characterization of a cosmid contig for the GCPS gene region

Less may be more for stage I epithelial Wilms tumors

scientific article published on 08 April 2020

Loss of 11q and 16q in Wilms tumors is associated with anaplasia, tumor recurrence, and poor prognosis

scientific article published on 01 February 2007

Loss of Fat4 disrupts PCP signaling and oriented cell division and leads to cystic kidney disease

scientific article published on 6 July 2008

Loss of heterozygosity at 2q37 in sporadic Wilms' tumor: putative role for miR-562.

scientific article

Loss or oncogenic mutation of DROSHA impairs kidney development and function, but is not sufficient for Wilms tumor formation

scientific article published on 03 December 2018

MYCN and MAX alterations in Wilms tumor and identification of novel N-MYC interaction partners as biomarker candidates

scientific article published on 24 October 2021

Mechanisms of epigenetic and cell-type specific regulation of Hey target genes in ES cells and cardiomyocytes

scientific article

Molecular analysis of E-cadherin and cadherin-11 in Wilms' tumours

scientific article published on 01 June 2000

Mosaic variegated aneuploidy in mouse BubR1 deficient embryos and pregnancy loss in human

scientific article published in July 2014

Mouse gridlock

scientific article published on 01 September 2002

Multi-omics enrichment analysis using the GeneTrail2 web service

scientific article published on 18 January 2016

Multicenter study identified molecular blood-born protein signatures for Wilms Tumor

scientific article

Mutations in the SIX1/2 pathway and the DROSHA/DGCR8 miRNA microprocessor complex underlie high-risk blastemal type Wilms tumors

scientific article published in February 2015

Mutually exclusive BCOR internal tandem duplications and YWHAE-NUTM2 fusions in clear cell sarcoma of kidney: not the full story

scientific article

New prognostic markers revealed by evaluation of genes correlated with clinical parameters in Wilms tumors.

scientific article

Nierentumoren

Novel familial WT1 read-through mutation associated with Wilms tumor and slow progressive nephropathy

scientific article published in June 2005

Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers

scientific article published in October 2009

Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factors

scientific journal article

Overlapping expression pattern of the actin organizers Spir-1 and formin-2 in the developing mouse nervous system and the adult brain

scientific article published in May 2004

Pericentric intrachromosomal insertion responsible for recurrence of del(11)(p13p14) in a family

scientific article published on 01 May 1993

Phenotypic variability in Hey2 -/- mice and absence of HEY2 mutations in patients with congenital heart defects or Alagille syndrome

scientific article

Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1

scientific article (publication date: 2012)

Placental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryo

scientific journal article

Position paper: Rationale for the treatment of Wilms tumour in the UMBRELLA SIOP-RTSG 2016 protocol

scientific article published on 31 October 2017

Primary intracranial spindle cell sarcoma with rhabdomyosarcoma-like features share a highly distinct methylation profile and DICER1 mutations.

scientific article

Publisher Correction: The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol

scientific article published on 01 September 2019

REGGAE: a novel approach for the identification of key transcriptional regulators

scientific article published on 01 October 2018

Recurrent intragenic rearrangements of EGFR and BRAF in soft tissue tumors of infants.

scientific article published on 18 June 2018

Retinoic acid pathway activity in Wilms tumors and characterization of biological responses in vitro

scientific article published on 8 November 2011

Sarcoma classification by DNA methylation profiling

scientific article published on 21 January 2021

Sequence of the WT1 upstream region including the Wit-1 gene.

scientific article

Six new polymorphic microsatellite markers used for the integration of genetic and physical maps of human chromosome 7

Six new polymorphic microsatellite markers used for the integration of genetic and physical maps of human chromosome 7

scientific article published on 01 June 1996

Structure, use, and risks of biomaterial repositories of embryonal tumors

scientific article published in May 2006

Subtype-specific FBXW7 mutation and MYCN copy number gain in Wilms' tumor.

scientific article published on 23 March 2010

Survival in patients with high-risk prostate cancer is predicted by miR-221, which regulates proliferation, apoptosis, and invasion of prostate cancer cells by inhibiting IRF2 and SOCS3.

scientific article published on 7 March 2014

TP53 alterations in Wilms tumour represent progression events with strong intratumour heterogeneity that are closely linked but not limited to anaplasia

scientific article published on 14 August 2017

TRIM28 haploinsufficiency predisposes to Wilms tumor

scientific article published on 14 February 2019

Target gene analysis by microarrays and chromatin immunoprecipitation identifies HEY proteins as highly redundant bHLH repressors

scientific journal article

Target genes of the WNT/beta-catenin pathway in Wilms tumors

scientific article

The Notch pathway inhibits TGFβ signaling in breast cancer through HEYL-mediated crosstalk

scientific article

The Notch target genes Hey1 and Hey2 are required for embryonic vascular development

scientific journal article

The UMBRELLA SIOP-RTSG 2016 Wilms tumour pathology and molecular biology protocol

scholarly article by Gordan M. Vujanić published in October 2018

The gene encoding the GPI-anchored membrane protein p137GPI (M11S1) maps to human chromosome 11p13 and is highly conserved in the mouse

scientific article

The genomic organization and expression of the WT1 gene

scientific article published on April 1, 1992

The landscape of genomic alterations across childhood cancers

scientific article published on 28 February 2018

The potassium channel gene HK1 maps to human chromosome 11p14.1, close to the FSHB gene

scientific article (publication date: November 1992)

The rodent Four-jointed ortholog Fjx1 regulates dendrite extension

The role of TCF3 as potential master regulator in blastemal Wilms tumors

The transcription factor Hey and nuclear lamins specify and maintain cell identity

scientific article published on 16 July 2019

The transcriptional repressor Hes1 attenuates inflammation by regulating transcription elongation

scientific article published on 20 June 2016

Transcript map of a 900-kb genomic region in Xp22.1-p22.2: identification of 12 novel genes.

scientific article published in July 1998

Transposable elements as a source of genetic innovation: expression and evolution of a family of retrotransposon-derived neogenes in mammals

scientific article (publication date: 17 January 2005)

Treatment-independent miRNA signature in blood of Wilms tumor patients

scientific article

Upregulation of Soluble Vascular Endothelial Growth Factor Receptor 1 Contributes to Angiogenesis Defects in the Placenta of α 2B -Adrenoceptor–Deficient Mice

article published in 2007

Very-KIND is a novel nervous system specific guanine nucleotide exchange factor for Ras GTPases

scientific article published on 15 August 2005

WTX inactivation is a frequent, but late event in Wilms tumors without apparent clinical impact

scientific article published in December 2009

cDNA sequence, genomic organization, and evolutionary conservation of a novel gene from the WAGR region.

scientific article published on September 1995

her7 and hey1, but not lunatic fringe show dynamic expression during somitogenesis in medaka (Oryzias latipes).

scientific article published in September 2004

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