List of works - Gijsbertus van der Horst

Interacting molecular loops in the mammalian circadian clock

scientific article (publication date: 12 May 2000)

The cryptochromes: blue light photoreceptors in plants and animals.

scientific article published on January 2011

DNA damage and ageing: new-age ideas for an age-old problem

scientific article

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

scientific journal article

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

scientific article

Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock

scientific article published on 01 December 1999

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

scientific article (publication date: November 2002)

Measurement of internal body time by blood metabolomics.

scholarly article

Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases

scientific article

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

scientific article published on March 2014

Assembling a clock for all seasons: are there M and E oscillators in the genes?

scientific article published in April 2001

Delayed and accelerated aging share common longevity assurance mechanisms

scientific article

The BMAL1 C terminus regulates the circadian transcription feedback loop.

scholarly article

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

scientific journal article

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

scientific article

Cockayne syndrome: defective repair of transcription?

scientific article published on July 16, 1997

Powerful skin cancer protection by a CPD-photolyase transgene.

scientific article published on January 2005

Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

scientific journal article

Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

scientific article published in May 1998

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

scientific article published on 10 February 2006

Phase responses to light pulses in mice lacking functional per or cry genes.

scientific article published in December 2004

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

scientific article

Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney

scientific journal article

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice

scientific journal article

Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

scientific article

Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage

scientific journal article

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.

scientific article

Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes

scientific article published on October 30, 2001

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.

scientific article published on December 2002

Characterization of photolyase/blue-light receptor homologs in mouse and human cells

scientific article published on November 15, 1998

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

scientific article published in August 2011

Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.

scientific article published on December 2003

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

scientific article published on July 2015

The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.

scientific article published on 11 February 2009

Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA

scientific article published on February 24, 1984

Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.

scientific article published on September 2002

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction

scientific article published on 22 August 2005

Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock

scientific article published on February 13, 2013

Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis

scientific journal article

Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1

scientific article

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome

scientific journal article

Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.

scientific article published in October 2004

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

scientific article

An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.

scientific article

Vagal regulation of respiratory clocks in mice.

scientific article

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

scientific article published on December 8, 2011

Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex

scientific article published on 01 December 1982

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis.

scientific article

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.

scientific article published on 4 August 2014

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.

scientific article

List of works by Gijsbertus van der Horst

Interacting molecular loops in the mammalian circadian clock

The cryptochromes: blue light photoreceptors in plants and animals.

DNA damage and ageing: new-age ideas for an age-old problem

Defective transcription-coupled repair in Cockayne syndrome B mice is associated with skin cancer predisposition

Nucleocytoplasmic shuttling and mCRY-dependent inhibition of ubiquitylation of the mPER2 clock protein

Photic induction of mPer1 and mPer2 in cry-deficient mice lacking a biological clock

A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue

Measurement of internal body time by blood metabolomics.

Expression of cDNA encoding the human "protective protein" associated with lysosomal beta-galactosidase and neuraminidase: homology to yeast proteases

The circadian clock regulates rhythmic activation of the NRF2/glutathione-mediated antioxidant defense pathway to modulate pulmonary fibrosis.

Assembling a clock for all seasons: are there M and E oscillators in the genes?

Delayed and accelerated aging share common longevity assurance mechanisms

The BMAL1 C terminus regulates the circadian transcription feedback loop.

Hypermutation of immunoglobulin genes in memory B cells of DNA repair-deficient mice

Phase locking and multiple oscillating attractors for the coupled mammalian clock and cell cycle.

Cockayne syndrome: defective repair of transcription?

Powerful skin cancer protection by a CPD-photolyase transgene.

Cell type-specific hypersensitivity to oxidative damage in CSB and XPA mice

Biochemical and biological characterization of wild-type and ATPase-deficient Cockayne syndrome B repair protein.

Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice

Phase responses to light pulses in mice lacking functional per or cry genes.

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation

Circadian clock genes directly regulate expression of the Na(+)/H(+) exchanger NHE3 in the kidney

High-fat diet-induced hyperinsulinemia and tissue-specific insulin resistance in Cry-deficient mice

Functional evolution of the photolyase/cryptochrome protein family: importance of the C terminus of mammalian CRY1 for circadian core oscillator performance.

Different effects of CSA and CSB deficiency on sensitivity to oxidative DNA damage

UVB radiation-induced cancer predisposition in Cockayne syndrome group A (Csa) mutant mice.

Early postnatal ataxia and abnormal cerebellar development in mice lacking Xeroderma pigmentosum Group A and Cockayne Syndrome Group B DNA repair genes

Mitochondrial repair of 8-oxoguanine is deficient in Cockayne syndrome group B.

Characterization of photolyase/blue-light receptor homologs in mouse and human cells

Accelerated age-related cognitive decline and neurodegeneration, caused by deficient DNA repair.

Nucleocytoplasmic shuttling and phosphorylation of BMAL1 are regulated by circadian clock in cultured fibroblasts.

Chronically Alternating Light Cycles Increase Breast Cancer Risk in Mice.

The circadian clock components CRY1 and CRY2 are necessary to sustain sex dimorphism in mouse liver metabolism.

Initiation of transcription in yeast mitochondria: analysis of origins of replication and of genes coding for a messenger RNA and a transfer RNA

Enhanced repair of cyclobutane pyrimidine dimers and improved UV resistance in photolyase transgenic mice.

Accelerated aging pathology in ad libitum fed Xpd(TTD) mice is accompanied by features suggestive of caloric restriction

Mammalian TIMELESS Is Involved in Period Determination and DNA Damage-Dependent Phase Advancing of the Circadian Clock

Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis

Flexible phase adjustment of circadian albumin D site-binding protein (DBP) gene expression by CRYPTOCHROME1

Retinal degeneration and ionizing radiation hypersensitivity in a mouse model for Cockayne syndrome

Relative levels of the two mammalian Rad23 homologs determine composition and stability of the xeroderma pigmentosum group C protein complex.

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts.

An Xpb mouse model for combined xeroderma pigmentosum and cockayne syndrome reveals progeroid features upon further attenuation of DNA repair.

Vagal regulation of respiratory clocks in mice.

Age-Related Neuronal Degeneration: Complementary Roles of Nucleotide Excision Repair and Transcription-Coupled Repair in Preventing Neuropathology

Isolation and characterization of nuclear genes coding for subunits of the yeast ubiquinol-cytochrome c reductase complex

Human papillomavirus mediated inhibition of DNA damage sensing and repair drives skin carcinogenesis.

Colorectal liver metastases with a disrupted circadian rhythm phase shift the peripheral clock in liver and kidney.

The DNA damage signal for Mdm2 regulation, Trp53 induction, and sunburn cell formation in vivo originates from actively transcribed genes.