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List of works by Nick Holford

A Pharmacokinetic Standard for Babies and Adults ⬇️

scientific article published on 06 May 2013

A Time to Event Tutorial for Pharmacometricians ⬇️

scientific article published on May 15, 2013

A combined pharmacokinetic model for the hypoxia-targeted prodrug PR-104A in humans, dogs, rats and mice predicts species differences in clearance and toxicity.

scientific article published on 4 August 2010

A comparison of bootstrap approaches for estimating uncertainty of parameters in linear mixed-effects models.

scientific article

A hemodynamic model to guide blood pressure control during deliberate hypotension with sodium nitroprusside in children.

scientific article published on 28 July 2015

A pharmacodynamic model for the time course of tumor shrinkage by gemcitabine + carboplatin in non-small cell lung cancer patients.

scientific article published in July 2008

A procedure for generating bootstrap samples for the validation of nonlinear mixed-effects population models.

scientific article published in April 1999

A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.

scientific article

A size standard for pharmacokinetics.

scientific article published in May 1996

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.

scientific article published on October 2001

Adrenal venography and ultrasound in the investigation of the adrenal gland: an analysis of 58 cases

scientific article published on 01 June 1975

Allometric size: The scientific theory and extension to normal fat mass

scientific article

Analysis of population pharmacokinetic data using NONMEM and WinBUGS.

scientific article

Antagonism of some spasmogens of the rat seminal vesicle.

scientific article

Application of clinical trial simulation to compare proof-of-concept study designs for drugs with a slow onset of effect; an example in Alzheimer's disease

scientific article published on 12 August 2006

Aspects of theophylline clearance in children.

scientific article

Authors' response to Marras and Oakes, ‘piecing together the puzzle of progression and mortality in Parkinson's disease’ ⬇️

scientific article published on May 1, 2013

Behavioural tolerance to morphine analgesia is supraspinally mediated: a quantitative analysis of dose-response relationships

scientific article published in July 1989

Benzodiazepine receptors in the human cerebellar cortex: a quantitative autoradiographic and pharmacological study demonstrating the predominance of type I receptors

scientific article published on 01 May 1987

Busulfan in infant to adult hematopoietic cell transplant recipients: a population pharmacokinetic model for initial and Bayesian dose personalization.

scientific article

Caffeine overdose in a premature infant: clinical course and pharmacokinetics

scientific article published on 01 June 1999

Clinical pharmacokinetics and pharmacodynamics of warfarin. Understanding the dose-effect relationship.

scientific article

Clinical pharmacology = disease progression + drug action ⬇️

scientific article published on January 1, 2015

Clinical pharmacology: principles and practice of drug therapy in medical education.

scientific article

Complex PK/PD models--an alcoholic experience

scientific article published on 01 October 1997

Concepts and usefulness of pharmacokinetic-pharmacodynamic modelling.

scientific article published on January 1990

DRUGMODEL.

scientific article published in November 1981

Determination of maximum effect

scientific article published on 01 April 2002

Developmental pharmacokinetics of morphine and its metabolites in neonates, infants and young children.

scientific article

Dexmedetomidine pharmacokinetics in the obese

scientific article published on 26 September 2015

Disease progression and neuroscience.

scientific article published on 17 April 2013

Disease progression and pharmacodynamics in Parkinson disease - evidence for functional protection with levodopa and other treatments

scientific article published on 20 April 2006

Disposition of total and unbound prednisolone in renal transplant patients receiving anticonvulsants

scientific article published on 01 January 1984

Divergence in pharmacokinetic parameters of quinidine obtained by specific and nonspecific assay methods

scientific article published on 01 June 1979

Does saturable formation of gemcitabine triphosphate occur in patients?

scientific article

Dose-dependent elimination of propranolol and its major metabolites in humans

scientific article published on 01 July 1983

Dosing in children

scientific article published on 20 January 2010

Drug concentration, binding, and effect in vivo

scientific article published on 01 May 1984

Drug treatment effects on disease progression.

scientific article

Effects of antiarrhythmic drugs on atrioventricular conduction in patients with acute myocardial infarction.

scientific article published in July 1980

Erratum to: does saturable formation of gemcitabine triphosphate occur in patients?

scientific article published on 01 March 2015

Evaluation of a morphine maturation model for the prediction of morphine clearance in children.

scientific article published on September 2011

Evaluation of bootstrap methods for estimating uncertainty of parameters in nonlinear mixed-effects models: a simulation study in population pharmacokinetics.

scientific article published on 8 December 2013

External Evaluation of Population Pharmacokinetic Models of Vancomycin in Neonates: The transferability of published models to different clinical settings.

scientific article published on April 2013

Features and toxicokinetics of clozapine in overdose.

scientific article published on February 1998

Gastrointestinal absorption of quinidine from some solutions and commercial tablets

scientific article published on 01 June 1980

Getting the dose right for obese children.

scientific article published on 21 September 2016

Holford NHG and Sheiner LB "Understanding the Dose-Effect Relationship-Clinical Application of Pharmacokinetic-Pharmacodynamic Models", Clin Pharmacokin 6:429-453 (1981)-The Backstory.

scientific article published on 18 October 2011

Importance of hematocrit for a tacrolimus target concentration strategy.

scientific article published on 27 September 2013

Improved liquid-chromatographic assay of quinidine and its metabolites in biological fluids

scientific article published on 01 July 1982

Improved prediction of tacrolimus concentrations early after kidney transplantation using theory-based pharmacokinetic modelling

scientific article

Induction of quinidine metabolism and plasma protein binding by phenobarbital in dogs

scientific article published on 01 October 1984

Influence of obesity on propofol pharmacokinetics: derivation of a pharmacokinetic model.

scientific article published on 14 August 2010

Input from the deep south compartment. A personal viewpoint

scientific article published on 01 September 1995

Interpreting the results of Parkinson's disease clinical trials: Time for a change ⬇️

scientific article published on March 2, 2011

Lack of association of single-nucleotide polymorphisms in pregnane X receptor, hepatic nuclear factor 4alpha, and constitutive androstane receptor with docetaxel pharmacokinetics.

scientific article published in December 2007

Leaving no stone unturned, or extracting blood from stone?

scientific article published on 23 November 2009

Levodopa slows progression of Parkinson's disease: external validation by clinical trial simulation

scientific article published on 17 February 2007

Limited predictability of amikacin clearance in extreme premature neonates at birth

scientific article (publication date: 2006)

Mechanisms of enhancement of the antitumour activity of melphalan by the tumour-blood-flow inhibitor 5,6-dimethylxanthenone-4-acetic acid

scientific article published on 01 January 1997

Methodologic aspects of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine.

scientific article published on December 1992

Mixed linear and non-linear disposition of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

scientific article

Modeling helps in understanding antidepressants.

scientific article published in August 2012

Models for describing absorption rate and estimating extent of bioavailability: application to cefetamet pivoxil

scientific article published on 01 October 1992

More on heparin lock

scientific article published on 01 June 1977

Negligible excretion of unchanged ketoprofen, naproxen, and probenecid in urine

scientific article published on 01 November 1980

Negligible impact of birth on renal function and drug metabolism

scientific article published on 10 October 2018

Opiate receptor binding-effect relationship: sufentanil and etorphine produce analgesia at the mu-site with low fractional receptor occupancy.

scientific article published in January 1984

PKPD model of interleukin-21 effects on thermoregulation in monkeys--application and evaluation of stochastic differential equations.

scientific article published on 29 September 2006

Paracetamol and metabolite pharmacokinetics in infants.

scientific article published on 22 May 2003

Paracetamol plasma and cerebrospinal fluid pharmacokinetics in children ⬇️

scientific article published on September 1, 1998

Pharmacodynamics of lazabemide, a reversible and selective inhibitor of monoamine oxidase B

scientific article

Pharmacokinetic-pharmacodynamic analysis of unbound disopyramide directly measured in serial plasma samples in man

scientific article published on 01 December 1984

Pharmacokinetics and pharmacodynamics of 1,25-dihydroxyvitamin D3 in the chick

scientific article published on 01 September 1982

Pharmacokinetics and pharmacodynamics of quinidine and its metabolite, quinidine-N-oxide, in beagle dogs

scientific article published on 01 October 1984

Pharmacokinetics of prednisolone and endogenous hydrocortisone levels in cushingoid and non-cushingoid patients

scientific article published on 01 January 1981

Pharmacokinetics of quinidine and three of its metabolites in man.

scientific article

Pharmacokinetics of rectal paracetamol after major surgery in children.

scientific article published in January 1995

Pharmacometrics: opportunity for reducing disease burden in the developing world: the case of Africa

scientific article published on 28 August 2013

Phase 1 clinical results with tandutinib (MLN518), a novel FLT3 antagonist, in patients with acute myelogenous leukemia or high-risk myelodysplastic syndrome: safety, pharmacokinetics, and pharmacodynamics

scientific article published on 10 August 2006

Plasma nitrate clearance in mice: modeling of the systemic production of nitrate following the induction of nitric oxide synthesis

scientific article published on 01 January 1995

Population PKPD modelling of the long-term hypoglycaemic effect of gliclazide given as a once-a-day modified release (MR) formulation.

scientific article published in February 2003

Population clinical pharmacology of children: general principles.

scientific article published on 29 June 2006

Population clinical pharmacology of children: modelling covariate effects.

scientific article published on 29 June 2006

Population pharmacokinetic and adverse event analysis of topotecan in patients with solid tumors.

scientific article

Population pharmacokinetics of humanized monoclonal antibody HuCC49deltaCH2 and murine antibody CC49 in colorectal cancer patients

scientific article published on 01 February 2007

Postoperative analgesia using diclofenac and acetaminophen in children.

scientific article

Predicting concentrations in children presenting with acetaminophen overdose

scientific article published on 01 September 1999

Predicting weight using postmenstrual age--neonates to adults.

scientific article published in March 2011

Prediction of Fat-Free Mass in Children

scientific article published on 5 May 2015

Prediction of morphine dose in humans.

scientific article published on 28 December 2011

Prediction of the outcome of a phase 3 clinical trial of an antischizophrenic agent (quetiapine fumarate) by simulation with a population pharmacokinetic and pharmacodynamic model.

scientific article published on November 2000

Prednisolone pharmacodynamics assessed by inhibition of the mixed lymphocyte reaction

scientific article published on 01 June 1982

Prednisone and prednisolone bioavailability in renal transplant patients

scientific article published on 01 April 1982

Progression of motor and nonmotor features of Parkinson's disease and their response to treatment ⬇️

scientific article published on August 1, 2012

Quantitative analysis of the disopyramide concentration-effect relationship

scientific article

Quantitative justification for target concentration intervention--parameter variability and predictive performance using population pharmacokinetic models for aminoglycosides.

scientific article published in July 2004

Quinidine pharmacokinetics in man: choice of a disposition model and absolute bioavailability studies

scientific article published on 01 August 1979

Quinidine-digoxin interaction

scientific article published on 01 October 1980

Rectal acetaminophen pharmacokinetics

scientific article published on 01 April 1998

Rectal paracetamol dosing regimens: determination by computer simulation.

scientific article published on January 1997

Relationship of metabolism of 2'-, 3'- and 5'-adenine nucleotides to presynaptic inhibition of transmitter release in rat vas deferens

scientific article published on 01 June 1986

Relationship of muscle strength to potassium concentration in a hypokalaemic infant

scientific article published in October 1997

Relative bioavailability of chlorthalidone in humans: adverse influence of polyethylene glycol

scientific article published on 01 May 1982

Relevance of pharmacodynamic principles in therapeutics.

scientific article published on January 1991

Response to Diaz and de Leon "the mathematics of drug dose individualization should be built with random effects linear models".

scientific article published in December 2013

Results and validation of a population pharmacodynamic model for cognitive effects in Alzheimer patients treated with tacrine ⬇️

scientific article published on December 1, 1992

Review: efficient rehabilitation trial designs using disease progress modeling: a pediatric traumatic brain injury example

scientific article published on 03 December 2009

Safe and effective variability-a criterion for dose individualization

scientific article published on 01 October 2012

Simulation of correlated continuous and categorical variables using a single multivariate distribution

scientific article published on 12 October 2006

Size, myths and the clinical pharmacokinetics of analgesia in paediatric patients.

scientific article

Slow release theophylline (Theo-24)

scientific article published on 01 March 1986

Slow-release theophylline (THEO-24)

scientific article published on 01 January 1986

Stereoselective disposition and glucuronidation of propranolol in humans

scientific article published on 01 June 1982

TDM is dead. Long live TCI!

scientific article published on 16 June 2020

Tacrolimus pharmacokinetics after kidney transplantation--Influence of changes in haematocrit and steroid dose

scientific article published on 2 August 2015

Target concentration intervention: beyond Y2K

scientific article published on 01 July 1999

The Absence of Effect of Azathioprine on Prednisolone Pharmacokinetics Following Maintenance Prednisone Doses in Kidney Transplant Patients ⬇️

scientific article published on 01 May 1984

The Effect of Size, Maturation, Global Asphyxia, Cerebral Ischemia, and Therapeutic Hypothermia on the Pharmacokinetics of High-Dose Recombinant Erythropoietin in Fetal Sheep

scientific article published on 25 April 2020

The Pharmacokinetics of Remifentanil in Patients Undergoing Coronary Artery Bypass Grafting with Cardiopulmonary Bypass ⬇️

scientific article published on November 1, 2001

The SLCO1B1 rs4149032 polymorphism is highly prevalent in South Africans and is associated with reduced rifampin concentrations: dosing implications.

scientific article

The digoxin concentration: before and after the fact

scientific article published on October 1, 1977

The effect of quinidine and its metabolites on the electrocardiogram and systolic time intervals: concentration--effect relationships.

scientific article

The effect of tacrine and lecithin in Alzheimer's disease. A population pharmacodynamic analysis of five clinical trials.

scientific article published in January 1994

The ghosts of departed quantities: approaches to dealing with observations below the limit of quantitation.

scientific article published on 24 July 2012

The population pharmacokinetics of allopurinol and oxypurinol in patients with gout

scientific article published on 10 March 2013

The quinidine-digoxin interaction

scientific article published on 01 April 1980

The response to levodopa in Parkinson's disease: imposing pharmacological law and order

scientific article published on May 1996

The target concentration approach to clinical drug development.

scientific article published on November 1995

The use of model-based tumor-size metrics to predict survival.

scientific article

Theophylline target concentration in severe airways obstruction - 10 or 20 mg/L? A randomised concentration-controlled trial

scientific article published on 01 December 1993

Time and theophylline concentration help explain the recovery of peak flow following acute airways obstruction. Population analysis of a randomised concentration controlled trial

scientific article published on 01 December 1993

Time for quantitative clinical pharmacology: a proposal for a pharmacometrics curriculum.

scientific article

Tips and traps analyzing pediatric PK data.

scientific article

Understanding dosing: children are small adults, neonates are immature children.

scientific article published on 05 July 2013

Unit dose calendar packaging and elderly patient compliance

scientific article published on November 27, 1991

Unit dose dispensing

scientific article published on 01 March 1991

Variability of concentrations after rectal paracetamol

scientific article published on January 1, 1998

Volume shifts and protein binding estimates using equilibrium dialysis: application to prednisolone binding in humans

scientific article published in December 1983

Vz, the terminal phase volume: time for its terminal phase?

scientific article published on 01 November 2001

What is the best size predictor for dose in the obese child?

scientific article published on 26 October 2017

beta-blockers vs calcium channel blockers vs ACE inhibitors

scientific article published in June 1992

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