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List of works by Akira Honda

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity

scientific article published on 21 November 2013

A SNP of NPC1L1 affects cholesterol absorption in Japanese.

scientific article published on 7 April 2010

A new cholesterol biosynthesis and absorption disorder associated with epilepsy, hypogonadism, and cerebro-cerebello-bulbar degeneration

scientific article published on 10 February 2014

Absence of Nceh1 augments 25-hydroxycholesterol-induced ER stress and apoptosis in macrophages

scientific article

Accumulation of 7 alpha-hydroxycholesterol in liver tissue of patients with cholesterol gallstones

scientific article published on 01 October 1995

Agaro-Oligosaccharides Regulate Gut Microbiota and Adipose Tissue Accumulation in Mice.

scientific article

Anti-gp210 and anti-centromere antibodies for the prediction of PBC patients with an incomplete biochemical response to UDCA and bezafibrate

scientific article published on 01 August 2015

Anti-proliferative action of endogenous dehydroepiandrosterone metabolites on human cancer cell lines.

scientific article published in January 2003

Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid ⬇️

scientific article published on April 5, 2013

Assessment of drug concentrations in tears in therapeutic drug monitoring: I. Determination of valproic acid in tears by gas chromatography/mass spectrometry with EC/NCI mode

scientific article published on 01 December 2000

Assessment of tear concentrations on therapeutic drug monitoring. III. Determination of theophylline in tears by gas chromatography/mass spectrometry with electron ionization mode.

scientific article published in January 2003

Bezafibrate Improves GLOBE and UK-PBC Scores and Long-Term Outcomes in Patients With Primary Biliary Cholangitis

scientific article published on 12 April 2019

Bile acid flux through portal but not peripheral veins inhibits CYP7A1 expression without involvement of ileal FGF19 in rabbits

scientific article published on 3 July 2014

Bile acid malabsorption deactivates pregnane X receptor in patients with Crohn's disease.

scientific article published in May 2013

Cholestenoic acids regulate motor neuron survival via liver X receptors

scientific article

Cholesterol 25-hydroxylation activity of CYP3A.

scientific article published on 16 May 2011

Cholesterol Metabolism is Enhanced in the Liver and Brain of Children with Citrin Deficiency

scientific article published on 5 April 2018

Cholesterol and chronic hepatitis C virus infection.

scientific article published on 17 June 2011

Circulating tricarboxylic acid cycle metabolite levels in citrin-deficient children with metabolic adaptation, with and without sodium pyruvate treatment.

scientific article published on 24 December 2016

Clinical features of gastroduodenal injury associated with long-term low-dose aspirin therapy.

scientific article published in March 2013

Clinical features of gastroduodenal ulcer in Japanese patients taking low-dose aspirin.

scientific article published on 20 November 2009

Dehydroepiandrosterone and its derivatives: potentially novel anti-proliferative and chemopreventive agents.

scientific article published on January 2006

Detection of Gut Dysbiosis due to Reduced Clostridium Subcluster XIVa Using the Fecal or Serum Bile Acid Profile

scientific article published in April 2018

Determination of 7 alpha-hydroxy-4-cholesten-3-one level in plasma using isotope-dilution mass spectrometry and monitoring its circadian rhythm in human as an index of bile acid biosynthesis

scientific article published on 01 May 1994

Dietary cholesterol stimulates CYP7A1 in rats because farnesoid X receptor is not activated.

scientific article published on 18 December 2003

Differences in the Serum 4β-hydroxycholesterol Levels of Patients with Chronic HCV Infection: A Possible Impact on the Efficacy and Safety of IFN-free Treatment.

scientific article published on 27 December 2017

Effect of BCAA supplement timing on exercise-induced muscle soreness and damage: a pilot placebo-controlled double-blind study.

scientific article published on 22 September 2017

Effects of the Concomitant Use of Low-dose Clarithromycin with an Anti-TNFα Antibody in a Patient with Intestinal Behçet Disease

scientific article published in November 2017

FGF15/19 protein levels in the portal blood do not reflect changes in the ileal FGF15/19 or hepatic CYP7A1 mRNA levels ⬇️

scientific article published on July 12, 2013

Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice

scientific article published on 06 April 2019

Hepatic cholesterol and bile acid synthesis in Japanese patients with cholesterol gallstones

scientific article published on 01 June 1993

Hepatitis C virus infection causes hypolipidemia regardless of hepatic damage or nutritional state: An epidemiological survey of a large Japanese cohort ⬇️

scientific article published on April 19, 2011

Highly sensitive analysis of sterol profiles in human serum by LC-ESI-MS/MS.

scientific article published on 23 May 2008

Highly sensitive assay of HMG-CoA reductase activity by LC-ESI-MS/MS.

scientific article published in February 2007

Highly sensitive quantification of 7alpha-hydroxy-4-cholesten-3-one in human serum by LC-ESI-MS/MS.

scientific article published on 8 November 2006

Highly sensitive quantification of key regulatory oxysterols in biological samples by LC-ESI-MS/MS.

scientific article published on 24 September 2008

Highly sensitive quantification of serum malonate, a possible marker for de novo lipogenesis, by LC-ESI-MS/MS.

scientific article published on 29 April 2009

Human intestinal spirochaetosis in two ulcerative colitis patients.

scientific article published on 15 September 2014

Hypercholesterolemia in rats with hepatomas: increased oxysterols accelerate efflux but do not inhibit biosynthesis of cholesterol

scientific article published on September 2006

Impaired bile acid metabolism with defectives of mitochondrial-tRNA taurine modification and bile acid taurine conjugation in the taurine depleted cats

scientific article published on 18 March 2020

Increased N-Acetyltaurine in the Skeletal Muscle After Endurance Exercise in Rat.

scientific article

Increased N-acetyltaurine in serum and urine after endurance exercise in human

scientific article

Increased bile acid concentration in liver tissue with cholesterol gallstone disease

scientific article published on 01 February 1995

Increased serum liver X receptor ligand oxysterols in patients with non-alcoholic fatty liver disease.

scientific article published on 9 May 2012

Increased serum oxysterol concentrations in patients with chronic hepatitis C virus infection.

scientific article published on 10 February 2014

Is patient-reported outcome improved by nalfurafine hydrochloride in patients with primary biliary cholangitis and refractory pruritus? A post-marketing, single-arm, prospective study

scientific article published on 16 April 2018

Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes

scientific article

Microanalysis of bile acid composition in intrahepatic calculi and its etiological significance

scientific article published on 01 September 1991

Novel sterol 7 alpha-hydroxylase(s) active towards not cholesterol but side-chain oxygenated steroids in liver microsomes

scientific article published on 01 June 1993

Pathophysiological analysis of primary biliary cirrhosis focusing on choline/phospholipid metabolism

scientific article published on 31 March 2014

Pharmacokinetics of theophylline in Guinea pig tears.

scientific article published in June 2007

Plasma cholesterol-lowering and transient liver dysfunction in mice lacking squalene synthase in the liver

scientific article

Plasma levels of mevalonate and 7alpha-hydroxy-4-cholesten-3-one in chronic liver disease

scientific article published on 01 February 1999

Post-therapeutic needle biopsy in patients with hepatocellular carcinoma is a useful tool to evaluate response to proton irradiation

scientific article published on 10 May 2013

Rapid inhibition of MAPK signaling and anti-proliferation effect via JAK/STAT signaling by interferon-alpha in hepatocellular carcinoma cell lines.

scientific article

Reciprocal interactions between bile acids and gut microbiota in human liver diseases.

scientific article published on 18 November 2017

Regulation of bile acid metabolism in mouse models with hydrophobic bile acid composition

scientific article published on 23 October 2019

Regulation of early cholesterol biosynthesis in rat liver: effects of sterols, bile acids, lovastatin, and BM 15.766 on 3-hydroxy-3-methylglutaryl coenzyme A synthase and acetoacetyl coenzyme A thiolase activities

scientific article published on 01 January 1998

Regulation of taurine conjugation and biosynthesis by bile acids through farnesoid X receptor activation

scientific article published on 01 October 2014

Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle

scientific article published on 19 October 2016

Serum Amino Acid Profiling in Citrin-Deficient Children Exhibiting Normal Liver Function During the Apparently Healthy Period.

scientific article published on 14 April 2018

Serum carnitine as an independent biomarker of malnutrition in patients with impaired oral intake

scientific article

Serum concentration of 27-hydroxycholesterol predicts the effects of high-cholesterol diet on plasma LDL cholesterol level.

scientific article published in February 2009

Severe Smith-Lemli-Opitz syndrome with prolonged survival and lipid abnormalities

scientific article

Short-term effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitor on cholesterol and bile acid synthesis in humans

scientific article published on 01 August 1997

Side chain hydroxylations in bile acid biosynthesis catalyzed by CYP3A are markedly up-regulated in Cyp27-/- mice but not in cerebrotendinous xanthomatosis.

scientific article published on 13 July 2001

Simultaneous assay of the activities of two key enzymes in cholesterol metabolism by gas chromatography-mass spectrometry

scientific article published on 01 April 1991

Simultaneous determination of dehydroepiandrosterone and its 7-oxygenated metabolites in human serum by high-resolution gas chromatography--mass spectrometry.

scientific article published in December 2004

Simultaneous determination of mevalonate and 7 alpha-hydroxycholesterol in human plasma by gas chromatography-mass spectrometry as indices of cholesterol and bile acid biosynthesis

scientific article published on 01 April 1993

Simultaneous quantification of salivary 3-hydroxybutyrate, 3-hydroxyisobutyrate, 3-hydroxy-3-methylbutyrate, and 2-hydroxybutyrate as possible markers of amino acid and fatty acid catabolic pathways by LC-ESI-MS/MS.

scientific article

Skewed X-chromosome inactivation causes intra-familial phenotypic variation of an EBP mutation in a family with X-linked dominant chondrodysplasia punctata

scientific article published on 24 October 2002

Small-bowel mucosal injuries in low-dose aspirin users with obscure gastrointestinal bleeding.

scientific article

Sterols and oxysterols in plasma from Smith-Lemli-Opitz syndrome patients

scientific article

Stigmasterol reduces plasma cholesterol levels and inhibits hepatic synthesis and intestinal absorption in the rat.

scientific article published in March 2006

Symptoms and health-related quality of life in Japanese patients with primary biliary cholangitis

scientific article published in Scientific Reports

Synthesis of [3 alpha-3H]7-dehydrocholesterol via stable tritiated 4-phenyl-1,2,4-triazoline-3,5-dione derivative

scientific article published on 01 November 1997

The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice.

scientific article published on 28 April 2014

The associated markers and their limitations for the primary screening of HCV carriers in public health examination.

scientific article

The protective effect of taurine against hepatic damage in a model of liver disease and hepatic stellate cells.

scientific article published in January 2009

The role of taurine on skeletal muscle cell differentiation.

scientific article published on January 2013

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