List of works - Inke Nathke

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

scientific journal article

A Multicellular Model of Intestinal Crypt Buckling and Fission

scientific article published on 12 December 2017

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

scientific article

A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath

scientific article

APC at a glance.

scientific article published in October 2004

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

scientific article

Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection

scientific article

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

scientific article

Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.

scientific article published on December 1994

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

scientific article

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

scientific article

Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions.

scientific article published in August 2017

Catch and pull a microtubule: getting a grasp on the cortex

scientific article published on 01 October 2001

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

scientific article published on 23 September 2013

Cell polarity in development and cancer.

scientific article published on September 2007

Cell regulation by the Apc protein Apc as master regulator of epithelia.

scientific article published on 24 March 2008

Changes in cell and tissue organization in cancer of the breast and colon.

scientific article published on 05 December 2013

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells

scientific article published on 15 February 2018

Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts.

scientific article published on 6 April 2016

Computational models reveal a passive mechanism for cell migration in the crypt

scientific article (publication date: 2013)

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. ⬇️

scientific article published in January 2018

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

scientific article published on 9 November 2006

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

scientific article

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

scientific article published in June 1994

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

scientific article published on 23 August 2010

Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway.

scientific article published on March 2001

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly

scientific article

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

scientific article

High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

scientific article published on 10 February 2014

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

scientific article published on 03 June 2019

Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

scientific article

Inke Nathke: The ABCs of APC. Interview by Caitlin Sedwick.

scientific article published on May 2010

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.

scientific article

Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids

scientific article

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability

scientific article

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

scientific article published on 29 March 2018

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

scientific article

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

scientific journal article

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

scientific article published on 26 November 2019

Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

scientific article published on 9 February 2010

Novel self-association of the APC molecule affects APC clusters and cell migration.

scientific article

Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis.

scientific article

Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling.

scientific article published on 26 March 2016

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

scientific article

Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy.

scientific article

Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

scientific article published on 18 June 2014

Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.

scientific article

SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo.

scientific article published in November 2017

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

scientific article published in February 2010

Stem cell decisions: a twist of fate or a niche market?

scientific article published on 05 March 2014

The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin

scientific article

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

scientific article

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

scientific article

The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.

scientific article published in January 2004

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

scientific article

The calcium-binding site of clathrin light chains.

scientific article

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

scientific article

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

scientific article

Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.

scientific article published on June 2005

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

scientific article

Ultrasound capsule endoscopy: sounding out the future.

scientific article

Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall

scientific article published on 28 January 2021

List of works by Inke Nathke

A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3-catalysed phosphorylation of axin and beta-catenin

A Multicellular Model of Intestinal Crypt Buckling and Fission

A role for the Adenomatous Polyposis Coli protein in chromosome segregation

A two-dimensional model of the colonic crypt accounting for the role of the basement membrane and pericryptal fibroblast sheath

APC at a glance.

Acoustic Sensing and Ultrasonic Drug Delivery in Multimodal Theranostic Capsule Endoscopy

Adenomatous polyposis coli and hypoxia-inducible factor-1{alpha} have an antagonistic connection

Adenomatous polyposis coli on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1.

Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.

Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation

Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.

Cancer Biology: APC Delivers Kiss of Death to Focal Adhesions.

Catch and pull a microtubule: getting a grasp on the cortex

Cell and tissue polarity in the intestinal tract during tumourigenesis: cells still know the right way up, but tissue organization is lost

Cell polarity in development and cancer.

Cell regulation by the Apc protein Apc as master regulator of epithelia.

Changes in cell and tissue organization in cancer of the breast and colon.

Chir99021 and Valproic acid reduce the proliferative advantage of Apc mutant cells

Combined changes in Wnt signaling response and contact inhibition induce altered proliferation in radiation-treated intestinal crypts.

Computational models reveal a passive mechanism for cell migration in the crypt

Critical research gaps and recommendations to inform research prioritisation for more effective prevention and improved outcomes in colorectal cancer. ⬇️

Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.

DVC1 (C1orf124) recruits the p97 protein segregase to sites of DNA damage

Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells.

Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol.

Developmental expression of catenins and associated proteins during submucosal gland morphogenesis in the airway.

Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly

Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo

High-energy particle-induced tumorigenesis throughout the gastrointestinal tract

Identification of Endogenous Adenomatous Polyposis Coli Interaction Partners and β-Catenin-Independent Targets by Proteomics

Increased variability in Apc(Min)/+ intestinal tissue can be measured with microultrasound.

Inke Nathke: The ABCs of APC. Interview by Caitlin Sedwick.

Interactions and functions of the adenomatous polyposis coli (APC) protein at a glance.

Interkinetic nuclear migration and basal tethering facilitates post-mitotic daughter separation in intestinal organoids

Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

Loss of APC induces polyploidy as a result of a combination of defects in mitosis and apoptosis

Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration

Loss of adenomatous polyposis coli function renders intestinal epithelial cells resistant to the cytokine IL-22

Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.

Novel self-association of the APC molecule affects APC clusters and cell migration.

Open microscopy environment and findspots: integrating image informatics with quantitative multidimensional image analysis.

Opposing actions of the synapse-associated protein of 97-kDa molecular weight (SAP97) and Disrupted in Schizophrenia 1 (DISC1) on Wnt/β-catenin signaling.

Paneth Cell-Rich Regions Separated by a Cluster of Lgr5+ Cells Initiate Crypt Fission in the Intestinal Stem Cell Niche.

Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using two-photon microscopy.

Promoting microtubule assembly: A hypothesis for the functional significance of the +TIP network.

Redefining the subcellular location and transport of APC: new insights using a panel of antibodies.

SAP97 Binding Partner CRIPT Promotes Dendrite Growth In Vitro and In Vivo.

Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissue.

Stem cell decisions: a twist of fate or a niche market?

The adenomatous polyposis coli protein contributes to normal compaction of mitotic chromatin

The adenomatous polyposis coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts.

The adenomatous polyposis coli protein unambiguously localizes to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarized epithelial cells

The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.

The adenomatous polyposis coli tumor suppressor protein localizes to plasma membrane sites involved in active cell migration.

The calcium-binding site of clathrin light chains.

The microtubule poison vinorelbine kills cells independently of mitotic arrest and targets cells lacking the APC tumour suppressor more effectively

The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium

Tumor-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains.

Tumorigenic fragments of APC cause dominant defects in directional cell migration in multiple model systems

Ultrasound capsule endoscopy: sounding out the future.

Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall