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List of works by Daniel Coombs

A biophysical model of cell adhesion mediated by immunoadhesin drugs and antibodies

scientific article

A hidden Markov model for single particle tracks quantifies dynamic interactions between LFA-1 and the actin cytoskeleton

scientific article

A novel Bayesian approach to predicting reductions in HIV incidence following increased testing interventions among gay, bisexual and other men who have sex with men in Vancouver, Canada

scientific article published in March 2018

A role for rebinding in rapid and reliable T cell responses to antigen

scientific article

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients

scientific article

A theoretical and experimental study of competition between solution and surface receptors for ligand in a Biacore flow cell.

scientific article published on 28 June 2006

Activated TCRs remain marked for internalization after dissociation from pMHC

scientific article published on 09 September 2002

An age-structured model of hiv infection that allows for variations in the production rate of viral particles and the death rate of productively infected cells.

scientific article published in September 2004

Analysis of membrane-localized binding kinetics with FRAP.

scientific article published on 26 February 2008

Analysis of peptide/MHC-induced TCR downregulation: deciphering the triggering kinetics.

scientific article published on January 2006

Antigen potency and maximal efficacy reveal a mechanism of efficient T cell activation

scientific article

Applied stretch initiates directional invasion through the action of Rap1 GTPase as a tension sensor.

scientific article published on 19 May 2016

Arp2/3 complex-driven spatial patterning of the BCR enhances immune synapse formation, BCR signaling and B cell activation

scientific article published on 3 June 2019

Assessing the optimal virulence of malaria-targeting mosquito pathogens: a mathematical study of engineered Metarhizium anisopliae

scientific article published on 08 January 2014

Asymptotic analysis of first passage time problems inspired by ecology.

scientific article published on 17 December 2014

Conditions for eradicating hepatitis C in people who inject drugs: A fibrosis aware model of hepatitis C virus transmission.

scientific article published on February 2016

Correction: The Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model

scientific article published on 15 May 2015

Dependence of T cell antigen recognition on T cell receptor-peptide MHC confinement time

scientific article

Design Parameters for Granzyme-Mediated Cytotoxic Lymphocyte Target-Cell Killing and Specificity

scientific article

Distribution of take-home opioid antagonist kits during a synthetic opioid epidemic in British Columbia, Canada: a modelling study

scientific article published on 17 April 2018

Effects of intracellular calcium and actin cytoskeleton on TCR mobility measured by fluorescence recovery

scientific article

Effects of spatiotemporal HSV-2 lesion dynamics and antiviral treatment on the risk of HIV-1 acquisition

scientific article published on 26 April 2018

Effects of the geometry of the immunological synapse on the delivery of effector molecules.

scientific article

Equilibrium thermodynamics of cell-cell adhesion mediated by multiple ligand-receptor pairs

scientific article

Erratum: Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.

scientific article published on 17 April 2015

Evaluating the importance of within- and between-host selection pressures on the evolution of chronic pathogens

scientific article published on 28 August 2007

Improving parameter estimation for cell surface FRAP data

scientific article

In vivo quantitative analysis of Talin turnover in response to force.

scientific article published on 7 October 2015

In vivo regulation of integrin turnover by outside-in activation

scientific article published on 16 June 2016

Kinetic proofreading model.

scientific article published on January 2008

Limitations of Qdot labelling compared to directly-conjugated probes for single particle tracking of B cell receptor mobility

scientific article published on 12 September 2017

Mechanical force regulates integrin turnover in Drosophila in vivo.

scientific article published on 12 August 2012

Modeling within-host evolution of HIV: mutation, competition and strain replacement.

scientific article published on 7 June 2007

Modelling the combined impact of interventions in averting deaths during a synthetic-opioid overdose epidemic

scientific article published on 28 June 2019

On the duration of the period between exposure to HIV and detectable infection

scientific article

Optimal viral production

scientific article published on 01 November 2003

Optimizing within-host viral fitness: infected cell lifespan and virion production rate

scientific article published on 01 July 2004

Periodic chirality transformations propagating on bacterial flagella

scientific article published on 23 August 2002

Probability of a false-negative HIV antibody test result during the window period: a tool for pre- and post-test counselling

scientific article published on 16 July 2014

Quantification and modeling of tripartite CD2-, CD58FC chimera (alefacept)-, and CD16-mediated cell adhesion

scientific article published on 2 October 2007

Quantifying the impact of COVID-19 control measures using a Bayesian model of physical distancing

scientific article published on 03 December 2020

Reverse engineering an amyloid aggregation pathway with dimensional analysis and scaling.

scientific article

SIR-Network Model and Its Application to Dengue Fever

article

Stochastic Dynamics of the Latently Infected Cell Reservoir During HIV Infection

article

Sustained Reduction in Sexual Behavior that May Pose a Risk of HIV Transmission Following Diagnosis During Early HIV Infection Among Gay Men in Vancouver, British Columbia.

scientific article published on 6 February 2017

T cell receptor binding kinetics required for T cell activation depend on the density of cognate ligand on the antigen-presenting cell.

scientific article

The Impact of Implementing a Test, Treat and Retain HIV Prevention Strategy in Atlanta among Black Men Who Have Sex with Men with a History of Incarceration: A Mathematical Model

scientific article published on 23 April 2015

The space and time frames of T cell activation at the immunological synapse ⬇️

scientific article published on October 14, 2010

Toll-like receptor ligands sensitize B-cell receptor signalling by reducing actin-dependent spatial confinement of the receptor.

scientific article

Vaccination against 2009 pandemic H1N1 in a population dynamical model of Vancouver, Canada: timing is everything

scientific article

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