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List of works by Trevor Hambley

A Warburg effect targeting vector designed to increase the uptake of compounds by cancer cells demonstrates glucose and hypoxia dependent uptake

scientific article published on 15 July 2019

A novel class of copper(II)- and zinc(II)-bound non-steroidal anti-inflammatory drugs that inhibits acute inflammation in vivo

scientific article published on 6 February 2016

A ratiometric fluorescent sensor for the mitochondrial copper pool

scientific article published on 23 August 2016

Accumulation of an anthraquinone and its platinum complexes in cancer cell spheroids: the effect of charge on drug distribution in solid tumour models

scientific article

Basis for design and development of platinum(IV) anticancer complexes

scientific article published on 28 June 2007

Binding of [Pt(1C3)(dien)](2+) to the duplex DNA oligonucleotide 5'-d(TGGCCA)-3': the effect of an appended positive charge on the orientation and location of anthraquinone intercalation

scientific article

Bioreductive activation and drug chaperoning in cobalt pharmaceuticals

scientific article published on 08 August 2007

Cellular uptake and distribution of cobalt complexes of fluorescent ligands

scientific article

Cobalt complexes with tripodal ligands: implications for the design of drug chaperones ⬇️

scientific article published on August 10, 2012

Cobalt(III) Chaperone Complexes of Curcumin: Photoreduction, Cellular Accumulation and Light-Selective Toxicity towards Tumour Cells

scientific article published on 7 September 2015

Comparative efficacy of novel platinum(IV) compounds with established chemotherapeutic drugs in solid tumour models

scientific article

Copper and zinc complexes as antiinflammatory drugs.

scientific article published on January 2004

DNA-binding and molecular mechanics modelling studies of the bulky chiral platinum(II) complex [PtCl(2)(mepyrr)] (mepyrr=N-methyl-2-aminomethylpyrrolidine).

scientific article published on 23 September 2006

Developing new metal-based therapeutics: challenges and opportunities

scientific article published on 04 October 2007

Dual Targeting of Hypoxic and Acidic Tumor Environments with a Cobalt(III) Chaperone Complex ⬇️

scientific article published on December 12, 2012

Effects of enzymatic activation on the distribution of fluorescently tagged MMP-2 cleavable peptides in cancer cells and spheroids

scientific article published on 7 June 2012

Enantioselectivity and stereoselectivity in the reactions of the enantiomers of the platinum complex [PtCl2(ahaz)] (ahaz=3(R)- or 3(S)-aminohexahydroazepine) with DNA.

scientific article published on October 2008

Examination of the effects of oxidation and ring closure on the cytotoxicities of the platinum complexes of N-(2-hydroxyethyl)ethane-1,2-diamine and ethane-1,2-diamine-N,N'-diacetic acid

scientific article

Facile preparation of mono-, di- and mixed-carboxylato platinum(IV) complexes for versatile anticancer prodrug design

scientific article

Fluorescent analogues of quinoline reveal amine ligand loss from cis and trans platinum(II) complexes in cancer cells

scientific article

Fluorescent sensing of monofunctional platinum species

scientific article published in April 2015

Gastrointestinal toxicity, antiinflammatory activity, and superoxide dismutase activity of copper and zinc complexes of the antiinflammatory drug indomethacin

scientific article published in January 2003

Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models

scientific article

Hans C. Freeman Preface ⬇️

scientific article published on October 1, 2012

Influence of equatorial and axial carboxylato ligands on the kinetic inertness of platinum(IV) complexes in the presence of ascorbate and cysteine and within DLD-1 cancer cells

scientific article published on 31 October 2013

Inhibition of experimental colorectal cancer and reduction in renal and gastrointestinal toxicities by copper-indomethacin in rats

scientific article

Interactions of cisplatin and the copper transporter CTR1 in human colon cancer cells

scientific article published on 17 May 2017

Intracellular trafficking as a determinant of AS-DACA cytotoxicity in rhabdomyosarcoma cells ⬇️

scientific article published on August 24, 2011

Investigations into the interactions between DNA and conformationally constrained pyridylamineplatinum(II) analogues of AMD473.

scientific article published in June 2003

Investigations using fluorescent ligands to monitor platinum(IV) reduction and platinum(II) reactions in cancer cells

scientific article published on 6 March 2009

Iron(III) complexes of fluorescent hydroxamate ligands: preparation, properties, and cellular processing

scientific article

Is anticancer drug development heading in the right direction?

scientific article published on 10 February 2009

Mechanisms of cell uptake and toxicity of the anticancer drug cisplatin

scientific article published in November 2014

Modulating the Cellular Uptake of Fluorescently Tagged Substrates of Prostate-Specific Antigen before and after Enzymatic Activation

scientific article published on 02 January 2019

Nuclear magnetic resonance analysis of indomethacin-induced gastric ulcers

scientific article

Platinum drug distribution in cancer cells and tumors

scientific article published on October 2009

Platinum(IV) anticancer complexes.

scientific article published on January 2004

Preparation and cell growth inhibitory activity of [PtR(2)L(2)] (R=polyfluorophenyl, L(2)=diene, cyclohexane-1,2-diamine (chxn) or cis-(dimethyl sulfoxide)(2)) and the X-ray crystal structure of [Pt(C(6)F(5))(2)(cis-chxn)].

scientific article

Quantitative measurement of the reduction of platinum(iv) complexes using X-ray absorption near-edge spectroscopy (XANES) ⬇️

scientific article published on May 9, 2012

Specificity in template syntheses of hexaaza-macrobicyclic cages: [Pt(Me5-tricosatrieneN6)]4+ and [Pt(Me5-tricosaneN6)]4+.

scientific article published in May 2003

Stereospecificity and enantioselectivity in the binding of the platinum(II) complex [PtCl2(tmdz)] (tmdz = 5,5,7-trimethyl-1,4-diazacycloheptane) to dinucleotides and oligonucleotides

scientific article

Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: the importance of pKa matching

scientific article

Structural investigations of palladium(II) and platinum(II) complexes of salicylhydroxamic acid

scientific article published in March 2002

Structural measure of metal-ligand covalency from the bonding in carboxylate ligands

scientific article published in May 2003

Studies of the binding of a series of platinum(IV) complexes to plasma proteins

scientific article published in February 2002

Studies on pyridazine azide cyclisation reactions

scientific article

Synthesis, characterisation and in vitro cytotoxicity studies of a series of chiral platinum(II) complexes based on the 2-aminomethylpyrrolidine ligand: X-ray crystal structure of [PtCl2(R-dimepyrr)] (R-dimepyrr=N-dimethyl-2(R)-aminomethylpyrrolidin

scientific article

Systematic differences in electrochemical reduction of the structurally characterized anti-cancer platinum(IV) complexes [Pt{((p-HC6F4)NCH2)2}-(pyridine)2Cl2], [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)2], and [Pt{((p-HC6F4)NCH2)2}(pyridine)2(OH)Cl].

scientific article published on 27 July 2012

Targeted cancer therapeutics

scientific article

The composition and end-group functionality of sterically stabilized nanoparticles enhances the effectiveness of co-administered cytotoxins

scientific article published on 13 August 2013

The effect of charge on the uptake and resistance to reduction of platinum(IV) complexes in human serum and whole blood models

scientific article published on 01 October 2020

The influence of the ancillary ligand on the potential of cobalt(iii) complexes to act as chaperones for hydroxamic acid-based drugs

scientific article published on 8 November 2017

The influence of the ethane-1,2-diamine ligand on the activity of a monofunctional platinum complex

scientific article published on 29 July 2017

The mechanism of action of platinum(IV) complexes in ovarian cancer cell lines

scientific article published on October 2004

The preparation and characterization of trans-platinum(IV) complexes with unusually high cytotoxicity

scientific article published on 8 October 2010

The use of spectroscopic imaging and mapping techniques in the characterisation and study of DLD-1 cell spheroid tumour models

scientific article

Water-Soluble α-Amino Acid Complexes of Molybdenum as Potential Antidotes for Cyanide Poisoning: Synthesis and Catalytic Studies of Threonine, Methionine, Serine, and Leucine Complexes

scientific article published on 28 November 2020

X-ray absorption spectroscopic studies of chromium(V/IV/III)- 2-ethyl-2-hydroxybutanoato(2-/1-) complexes

scientific article published in February 2004

X-ray crystal structure of (eta(5)-pentaphenylcyclopentadienyl)[1-(eta(5/6)-phenyl)-2,3,4,5-tetraphenylcyclopentadienyl]iron(II), [Fe(eta(5)-C(5)Ph(5))[(eta(5/6)-C(6)H(5))C(5)Ph(4)]], a linkage isomer of decaphenylferrocene

scientific article published in September 2002

XAFS studies of anti-inflammatory dinuclear and mononuclear Zn(II) complexes of indomethacin

scientific article

[1H, 15N] heteronuclear single quantum coherence NMR study of the mechanism of aquation of platinum(IV) ammine complexes

scientific article

trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells: 1H NMR and XANES spectroscopy study

scientific article published on 29 May 2020

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