List of works - Hans De Winter

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

scientific article published on February 1, 1992

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

scientific article published on 19 January 2016

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

scientific article

A Computational and Modeling Study of the Reaction Mechanism of Staphylococcus aureus Monoglycosyltransferase Reveals New Insights on the GT51 Family of Enzymes

scientific article published on 13 August 2020

A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution.

scientific article published on 14 July 2005

Aldose reductase as a target for drug design: molecular modeling calculations on the binding of acyclic sugar substrates to the enzyme

scientific article published on 01 July 1995

ClpP Protease, a Promising Antimicrobial Target. ⬇️

scientific article published on 7 May 2019

Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles.

scientific article published in November 2002

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.

scientific article published on 3 March 2005

Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II.

scientific article published on 7 January 2005

LEADD: Lamarckian evolutionary algorithm for de novo drug design

scientific article published on 15 January 2022

Laser diffraction and image analysis as a supportive analytical tool in the pharmaceutical development of immediate release direct compression formulations.

scientific article published on 20 April 2005

Molecular Dynamics Simulations of Membrane Proteins: An Overview

article

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition.

scientific article published on 31 August 2016

Pharao: pharmacophore alignment and optimization

scientific article published on 11 April 2008

Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation

article

Reply to the comment made by Šicho, Vorśilák and Svozil on 'The Power metric: a new statistically robust enrichment-type metric for virtual screening applications with early recovery capability'.

scientific article published on 15 March 2018

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

scientific article published on 4 February 2016

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

scientific article published in November 2017

Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold

article

Spectrophores as one-dimensional descriptors calculated from three-dimensional atomic properties: applications ranging from scaffold hopping to multi-target virtual screening.

scientific article published on 7 March 2018

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

scientific article published on 3 April 2017

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines

article

Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase

article

Synthesis of 3′-Deoxy-3′-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation in Oligonucleotides. Part II 1

article

The power metric: a new statistically robust enrichment-type metric for virtual screening applications with early recovery capability

scientific article (publication date: 2 February 2017)

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death

scientific article published on 13 February 2018

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.

scientific article published on November 1996

List of works by Hans De Winter

1-(2,3-Dideoxy-erythro-beta-D-hexopyranosyl)cytosine: an example of the conformational and stacking properties of pyranosyl pyrimidine nucleosides. A crystallographic and computational approach

2,6-Di(arylamino)-3-fluoropyridine Derivatives as HIV Non-Nucleoside Reverse Transcriptase Inhibitors

2-Amino-3,4-dihydroquinazolines as inhibitors of BACE-1 (beta-site APP cleaving enzyme): Use of structure based design to convert a micromolar hit into a nanomolar lead

A Computational and Modeling Study of the Reaction Mechanism of Staphylococcus aureus Monoglycosyltransferase Reveals New Insights on the GT51 Family of Enzymes

A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution.

Aldose reductase as a target for drug design: molecular modeling calculations on the binding of acyclic sugar substrates to the enzyme

ClpP Protease, a Promising Antimicrobial Target. ⬇️

Design, synthesis, and tripeptidyl peptidase II inhibitory activity of a novel series of (S)-2,3-dihydro-2-(4-alkyl-1H-imidazol-2-yl)-1H-indoles.

Discovery of pyrimidyl-5-hydroxamic acids as new potent histone deacetylase inhibitors.

Inhibitor-based validation of a homology model of the active-site of tripeptidyl peptidase II.

LEADD: Lamarckian evolutionary algorithm for de novo drug design

Laser diffraction and image analysis as a supportive analytical tool in the pharmaceutical development of immediate release direct compression formulations.

Molecular Dynamics Simulations of Membrane Proteins: An Overview

Novel selective glucocorticoid receptor agonists (SEGRAs) with a covalent warhead for long-lasting inhibition.

Pharao: pharmacophore alignment and optimization

Probing for improved selectivity with dipeptide-derived inhibitors of dipeptidyl peptidases 8 and 9: the impact of P1-variation

Reply to the comment made by Šicho, Vorśilák and Svozil on 'The Power metric: a new statistically robust enrichment-type metric for virtual screening applications with early recovery capability'.

Resistance and cross-resistance profile of the diaryltriazine NNRTI and candidate microbicide UAMC01398.

Selective Glucocorticoid Receptor Properties of GSK866 Analogs with Cysteine Reactive Warheads

Selective inhibitors of fibroblast activation protein (FAP) with a xanthine scaffold

Spectrophores as one-dimensional descriptors calculated from three-dimensional atomic properties: applications ranging from scaffold hopping to multi-target virtual screening.

Structure and antagonism of the receptor complex mediated by human TSLP in allergy and asthma

Synthesis and Conformational Study of 3-Hydroxy-4-(Hydroxymethyl)-1-Cyclohexanyl Purines and Pyrimidines

Synthesis of 2?-Deoxy-5-(isothiazol-5-yl)uridine and Its Interaction with the HSV-1 Thymidine Kinase

Synthesis of 3′-Deoxy-3′-C-Hydroxymethyl-aldopentopyranosyl Nucleosides and their Incorporation in Oligonucleotides. Part II 1

The power metric: a new statistically robust enrichment-type metric for virtual screening applications with early recovery capability

Tozasertib Analogues as Inhibitors of Necroptotic Cell Death

Understanding the binding of 5-substituted 2'-deoxyuridine substrates to thymidine kinase of herpes simplex virus type-1.