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List of works by Richard Killick

A role for APP in Wnt signalling links synapse loss with β-amyloid production

scientific article published on 20 September 2018

A structural switch of presenilin 1 by glycogen synthase kinase 3beta-mediated phosphorylation regulates the interaction with beta-catenin and its nuclear signaling

scientific article published on 14 March 2007

Alpha-T-catenin is expressed in human brain and interacts with the Wnt signaling pathway but is not responsible for linkage to chromosome 10 in Alzheimer's disease

scientific article published on January 2004

Alzheimer's disease biomarker discovery using SOMAscan multiplexed protein technology

scientific article published on 25 April 2014

Alzheimer-associated C allele of the promoter polymorphism -22C>T causes a critical neuron-specific decrease of presenilin 1 expression.

scientific article

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum.

scientific article published on 24 January 2014

Antibodies to the sulphated, high molecular mass mouse tectorin stain hair bundles and the olfactory mucus layer

scientific article published on 01 January 1997

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

scientific article

Clusterin regulates β-amyloid toxicity via Dickkopf-1-driven induction of the wnt-PCP-JNK pathway

scientific article

Corrigendum to “Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH” [Neurosci. Lett. 533 (2013) 96–99].

scientific article published in June 2013

Deletion of Crry, the murine ortholog of the sporadic Alzheimer's disease risk gene CR1, impacts tau phosphorylation and brain CFH.

scientific article published on 12 November 2012

Deletion of Irs2 reduces amyloid deposition and rescues behavioural deficits in APP transgenic mice

scientific journal article

Distribution of beta-tectorin mRNA in the early posthatch and developing avian inner ear.

scientific article

Does dysregulation of the Notch and wingless/Wnt pathways underlie the pathogenesis of Alzheimer's disease?

scientific article published in February 2000

FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system

scientific article published on 20 July 2017

Functional and genetic analysis of haplotypic sequence variation at the nicastrin genomic locus

scientific article published on 08 March 2012

Functional phenotype in transgenic mice expressing mutant human presenilin-1.

scientific article published in April 2000

GSK3alpha exhibits beta-catenin and tau directed kinase activities that are modulated by Wnt.

scientific article published on December 2006

Glycogen synthase kinase-3 inhibition is integral to long-term potentiation

scientific article

How Does p73 Cause Neuronal Defects?

scientific article published on 13 August 2015

Inhibition of GSK-3 ameliorates Abeta pathology in an adult-onset Drosophila model of Alzheimer's disease

scientific article

Investigating the role of rare coding variability in Mendelian dementia genes (APP, PSEN1, PSEN2, GRN, MAPT, and PRNP) in late-onset Alzheimer's disease

scientific article

Neuronal differentiation by TAp73 is mediated by microRNA-34a regulation of synaptic protein targets

scientific article

Neurotoxic and neurotrophic roles of proNGF and the receptor sortilin in the adult and ageing nervous system

scientific article published on April 2008

OCP1, an F-box protein, co-localizes with OCP2/SKP1 in the cochlear epithelial gap junction region.

scientific article published in July 2001

Oligomeric amyloid-β peptide affects the expression of genes involved in steroid and lipid metabolism in primary neurons

scientific article

Plasma biomarkers of brain atrophy in Alzheimer's disease

scientific article (publication date: 2011)

Plasma transthyretin as a candidate marker for Alzheimer's disease

scientific article published in January 2012

Positional pathway screen of wnt signaling genes in schizophrenia: association with DKK4.

scientific article

Prostate-derived sterile 20-like kinases (PSKs/TAOKs) phosphorylate tau protein and are activated in tangle-bearing neurons in Alzheimer disease

scientific article published on 12 April 2013

Reducing β-amyloid by inhibition of BACE1: how low should you go?

scientific article published in April 2015

Schizophrenia as a GSK-3 dysregulation disorder

scientific article published on 26 February 2007

TAp73 isoforms antagonize Notch signalling in SH-SY5Y neuroblastomas and in primary neurones.

scientific article published on November 2006

TAp73alpha induces tau phosphorylation in HEK293a cells via a transcription-dependent mechanism

scientific article published on 31 March 2006

The GSK3 hypothesis of Alzheimer's disease

scientific article published on 18 December 2007

The Notch intracellular domain represses CRE-dependent transcription

scientific article published on 3 December 2014

The Notch-1 intracellular domain is found in sub-nuclear bodies in SH-SY5Y neuroblastomas and in primary cortical neurons

scientific article published on 27 January 2007

The effect of polyglutamine expansion in the human androgen receptor on its ability to suppress beta-catenin-Tcf/Lef dependent transcription.

scientific article published on January 2004

The protein composition of the avian tectorial membrane

scientific article published on 01 December 1992

Toward an understanding of cochlear homeostasis: the impact of location and the role of OCP1 and OCP2

scientific article (publication date: 2003)

Transcriptomic profiles of Wnt3a and insulin in primary cultured rat cortical neurones

Wnt3a induces exosome secretion from primary cultured rat microglia.

scientific article

p53 is upregulated in Alzheimer's disease and induces tau phosphorylation in HEK293a cells

scientific article published on 15 March 2007

p73: a multifunctional protein in neurobiology

scientific article

β-Amyloid precursor protein and tau protein levels are differently regulated in human cerebellum compared to brain regions vulnerable to Alzheimer's type neurodegeneration

scientific article published on 6 September 2010

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