List of works - Isabel Cardoso

4 ′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters ⬇️

scientific article published on May 1, 2003

4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid

scientific article published on June 2000

Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation

scientific article published in February 2015

Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy

scientific article published on 3 March 2006

Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli

scientific article

Aprotinin binding to amyloid fibrils.

scientific article

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

scientific article

Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?

scientific article published on 16 July 2013

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery

scientific article published on 18 March 2020

Collagen type IV in brain vessels of an AD mouse model: modulation by transthyretin?

scientific article published on 01 January 2019

Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design

scientific article

Controlling amyloid-beta peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles

scientific article published on September 2010

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

scientific article

Design and biological activity of beta-sheet breaker peptide conjugates.

scientific article

Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.

scientific article published in February 2006

Dual ligand immunoliposomes for drug delivery to the brain.

scientific article published on 3 July 2015

Gender-dependent transthyretin modulation of brain amyloid-β levels: evidence from a mouse model of Alzheimer's disease

scientific article published in January 2011

Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

scientific article

Impairment of the ubiquitin–proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy

scientific article published on 01 October 2007

In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)

scientific article

Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal

scientific article published on 6 June 2017

Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins

scientific article

Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties

scientific article published on 24 August 2021

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

scientific article published on 4 December 2014

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

scientific article published on 20 September 2019

Randomization of amyloid-β-peptide(1-42) conformation by sulfonated and sulfated nanoparticles reduces aggregation and cytotoxicity

scientific article

Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer

scientific article published on 28 September 2020

Resveratrol administration increases Transthyretin protein levels ameliorating AD features - importance of transthyretin tetrameric stability

scientific article published on 30 June 2016

S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation

scientific article

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

scientific article published on July 2004

Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation

scientific article published on 17 September 2013

Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease

scientific article

Structural Heterogeneity and Bioimaging of S100 Amyloid Assemblies

Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models

scientific article

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

scientific article published on 31 January 2014

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease

scientific article published on 13 October 2011

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

scientific article published in Journal of Biological Chemistry

The effect of a fluorinated cholesterol derivative on the stability and physical properties of cationic DNA vectors

The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.

scientific article

Transthyretin Aggregation and Toxicity

article

Transthyretin and Alzheimer's disease: where in the brain?

scientific article

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

scientific article

Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation.

scientific article published in October 2012

Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis

scientific article published on 15 July 2017

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

scientific article published on 3 February 2016

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

scientific article

Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.

scientific article published in June 2017

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model

scientific article published in January 2014

Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease

scientific article published on 18 March 2020

X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization

scientific article published on 21 January 2003

List of works by Isabel Cardoso

4 ′‐iodo‐4′‐Deoxydoxorubicin and tetracyclines disrupt transthyretin amyloid fibrils in vitro producing noncytotoxic species: screening for TTR fibril disrupters ⬇️

4'-Iodo-4'-deoxydoxorubicin disrupts the fibrillar structure of transthyretin amyloid

Aberrant zinc binding to immature conformers of metal-free copper-zinc superoxide dismutase triggers amorphous aggregation

Activation of ERK1/2 MAP kinases in familial amyloidotic polyneuropathy

Amyloidogenic properties of transthyretin-like protein (TLP) from Escherichia coli

Aprotinin binding to amyloid fibrils.

Binding of epigallocatechin-3-gallate to transthyretin modulates its amyloidogenicity

Calcium ions promote superoxide dismutase 1 (SOD1) aggregation into non-fibrillar amyloid: a link to toxic effects of calcium overload in amyotrophic lateral sclerosis (ALS)?

Calorimetric Studies of Binary and Ternary Molecular Interactions between Transthyretin, Aβ Peptides, and Small-Molecule Chaperones toward an Alternative Strategy for Alzheimer's Disease Drug Discovery

Collagen type IV in brain vessels of an AD mouse model: modulation by transthyretin?

Comparative in vitro and ex vivo activities of selected inhibitors of transthyretin aggregation: relevance in drug design

Controlling amyloid-beta peptide(1-42) oligomerization and toxicity by fluorinated nanoparticles

Deposition of transthyretin in early stages of familial amyloidotic polyneuropathy: evidence for toxicity of nonfibrillar aggregates

Design and biological activity of beta-sheet breaker peptide conjugates.

Doxycycline disrupts transthyretin amyloid: evidence from studies in a FAP transgenic mice model.

Dual ligand immunoliposomes for drug delivery to the brain.

Gender-dependent transthyretin modulation of brain amyloid-β levels: evidence from a mouse model of Alzheimer's disease

Human metallothioneins 2 and 3 differentially affect amyloid-beta binding by transthyretin

Impairment of the ubiquitin–proteasome system associated with extracellular transthyretin aggregates in familial amyloidotic polyneuropathy

In vitro inhibition of transthyretin aggregate-induced cytotoxicity by full and peptide derived forms of the soluble receptor for advanced glycation end products (RAGE)

Insights on the Interaction between Transthyretin and Aβ in Solution. A Saturation Transfer Difference (STD) NMR Analysis of the Role of Iododiflunisal

Intrinsically disordered and aggregation prone regions underlie β-aggregation in S100 proteins

Neuroprotection in early stages of Alzheimer's disease is promoted by transthyretin angiogenic properties

Polymer-doxycycline conjugates as fibril disrupters: an approach towards the treatment of a rare amyloidotic disease.

Radiochemical examination of transthyretin (TTR) brain penetration assisted by iododiflunisal, a TTR tetramer stabilizer and a new candidate drug for AD

Randomization of amyloid-β-peptide(1-42) conformation by sulfonated and sulfated nanoparticles reduces aggregation and cytotoxicity

Repurposing Benzbromarone for Familial Amyloid Polyneuropathy: A New Transthyretin Tetramer Stabilizer

Resveratrol administration increases Transthyretin protein levels ameliorating AD features - importance of transthyretin tetrameric stability

S100A6 amyloid fibril formation is calcium-modulated and enhances superoxide dismutase-1 (SOD1) aggregation

Selective binding to transthyretin and tetramer stabilization in serum from patients with familial amyloidotic polyneuropathy by an iodinated diflunisal derivative

Small molecules present in the cerebrospinal fluid metabolome influence superoxide dismutase 1 aggregation

Stability of the transthyretin molecule as a key factor in the interaction with a-beta peptide--relevance in Alzheimer's disease

Structural Heterogeneity and Bioimaging of S100 Amyloid Assemblies

Synergy of combined doxycycline/TUDCA treatment in lowering Transthyretin deposition and associated biomarkers: studies in FAP mouse models

Targeting a rare amyloidotic disease through rationally designed polymer conjugates.

Testing the therapeutic potential of doxycycline in a Drosophila melanogaster model of Alzheimer disease

Tetramer Dissociation and Monomer Partial Unfolding Precedes Protofibril Formation in Amyloidogenic Transthyretin Variants

The effect of a fluorinated cholesterol derivative on the stability and physical properties of cationic DNA vectors

The neuronal S100B protein is a calcium-tuned suppressor of amyloid-β aggregation.

Transthyretin Aggregation and Toxicity

Transthyretin and Alzheimer's disease: where in the brain?

Transthyretin binding to A-Beta peptide--impact on A-Beta fibrillogenesis and toxicity.

Transthyretin decrease in plasma of MCI and AD patients: investigation of mechanisms for disease modulation.

Transthyretin neuroprotection in Alzheimer's disease is dependent on proteolysis

Transthyretin participates in beta-amyloid transport from the brain to the liver--involvement of the low-density lipoprotein receptor-related protein 1?

Transthyretin protects against A-beta peptide toxicity by proteolytic cleavage of the peptide: a mechanism sensitive to the Kunitz protease inhibitor

Transthyretin stability is critical in assisting beta amyloid clearance- Relevance of transthyretin stabilization in Alzheimer's disease.

Transthyretin stabilization by iododiflunisal promotes amyloid-β peptide clearance, decreases its deposition, and ameliorates cognitive deficits in an Alzheimer's disease mouse model

Undiscovered Roles for Transthyretin: From a Transporter Protein to a New Therapeutic Target for Alzheimer's Disease

X-ray absorption spectroscopy reveals a substantial increase of sulfur oxidation in transthyretin (TTR) upon fibrillization