List of works - Cristina Amaral

A novel GC-MS methodology to evaluate aromatase activity in human placental microsomes: a comparative study with the standard radiometric assay

scientific article published on 22 August 2019

Acquired resistance to aromatase inhibitors: where we stand!

scientific article published on 12 March 2018

Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release

scientific article published on 4 March 2016

Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis.

scientific article published on 20 February 2017

Anandamide targets aromatase: A breakthrough on human decidualization

scientific article published on 24 August 2019

Anti-tumor efficacy of new 7α-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells.

scientific article

Apoptosis and autophagy in breast cancer cells following exemestane treatment

scientific article

C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships

scientific article published on 26 March 2019

Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling

scientific article published on 14 January 2020

Cannabinoid-induced autophagy: Protective or death role?

scientific article

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors.

scientific article published on 13 March 2013

Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5α-reductase activity.

scientific article published on 2 January 2013

Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors

scientific article published on 23 September 2019

Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy

scientific article published on 11 January 2013

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane.

scientific article

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

scientific article published on 28 September 2014

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

scientific article published on 26 April 2016

Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance

scientific article published on 20 May 2018

Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity.

scientific article

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

scientific article published on 18 April 2012

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line

scientific article published on 9 August 2013

Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis.

scientific article published on November 2013

Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells

scientific article published on 12 November 2019

The endocannabinoid anandamide impairs in vitro decidualization of human cells.

scientific article published on October 2016

The potential clinical benefit of targeting androgen receptor (AR) in estrogen-receptor positive breast cancer cells treated with Exemestane

scientific article published on 28 December 2019

The role of soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects.

scientific article published in September 2017

The synthetic cannabinoid WIN-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor

scientific article

Unravelling exemestane: From biology to clinical prospects

scientific article published on 15 March 2016

List of works by Cristina Amaral

A novel GC-MS methodology to evaluate aromatase activity in human placental microsomes: a comparative study with the standard radiometric assay

Acquired resistance to aromatase inhibitors: where we stand!

Anandamide interferes with human endometrial stromal-derived cell differentiation: An effect dependent on inhibition of cyclooxygenase-2 expression and prostaglandin E2 release

Anandamide oxidative metabolism-induced endoplasmic reticulum stress and apoptosis.

Anandamide targets aromatase: A breakthrough on human decidualization

Anti-tumor efficacy of new 7α-substituted androstanes as aromatase inhibitors in hormone-sensitive and resistant breast cancer cells.

Apoptosis and autophagy in breast cancer cells following exemestane treatment

C-6α- vs C-7α-Substituted Steroidal Aromatase Inhibitors: Which Is Better? Synthesis, Biochemical Evaluation, Docking Studies, and Structure-Activity Relationships

Cannabidiol (CBD) but not tetrahydrocannabinol (THC) dysregulate in vitro decidualization of human endometrial stromal cells by disruption of estrogen signaling

Cannabinoid-induced autophagy: Protective or death role?

Design, synthesis and biochemical studies of new 7α-allylandrostanes as aromatase inhibitors.

Development of a new gas chromatography-mass spectrometry (GC-MS) methodology for the evaluation of 5α-reductase activity.

Effects of new C6-substituted steroidal aromatase inhibitors in hormone-sensitive breast cancer cells: Cell death mechanisms and modulation of estrogen and androgen receptors

Effects of steroidal aromatase inhibitors on sensitive and resistant breast cancer cells: aromatase inhibition and autophagy

Exemestane metabolites suppress growth of estrogen receptor-positive breast cancer cells by inducing apoptosis and autophagy: A comparative study with Exemestane.

Exemestane metabolites: Synthesis, stereochemical elucidation, biochemical activity and anti-proliferative effects in a hormone-dependent breast cancer cell line.

Exploring new chemical functionalities to improve aromatase inhibition of steroids.

Hormone-dependent breast cancer: Targeting autophagy and PI3K overcomes Exemestane-acquired resistance

Methylone and MDPV activate autophagy in human dopaminergic SH-SY5Y cells: a new insight into the context of β-keto amphetamines-related neurotoxicity.

New Structure–Activity Relationships of A- and D-Ring Modified Steroidal Aromatase Inhibitors: Design, Synthesis, and Biochemical Evaluation

New steroidal 17β-carboxy derivatives present anti-5α-reductase activity and anti-proliferative effects in a human androgen-responsive prostate cancer cell line

Steroidal aromatase inhibitors inhibit growth of hormone-dependent breast cancer cells by inducing cell cycle arrest and apoptosis.

Synthetic cannabinoids JWH-018, JWH-122, UR-144 and the phytocannabinoid THC activate apoptosis in placental cells

The endocannabinoid anandamide impairs in vitro decidualization of human cells.

The potential clinical benefit of targeting androgen receptor (AR) in estrogen-receptor positive breast cancer cells treated with Exemestane

The role of soybean extracts and isoflavones in hormone-dependent breast cancer: aromatase activity and biological effects.

The synthetic cannabinoid WIN-55,212 induced-apoptosis in cytotrophoblasts cells by a mechanism dependent on CB1 receptor

Unravelling exemestane: From biology to clinical prospects